Abstract:
:To investigate the possible association between Alzheimer's disease and late maternal age at index birth, we conducted a collaborative re-analysis of existing case-control data sets. Of the 11 studies participating in the EURODEM project, four were included in the analyses regarding maternal age. In all four studies, cases were matched to controls by age and gender, and only population controls were considered. Analyses were conducted on the individual data sets, on the pooled sample, and on subgroups defined by gender, age at onset, and familial aggregation of dementia. Maternal age of 40 years and over was found to be suggestively associated with a higher risk of Alzheimer's disease (overall relative risk = 1.7; 95% confidence intervals: 1.0-2.9). In subgroup analyses, the association was statistically significant for women and for sporadic cases. Adjustments for education or analyses restricted to case-control pairs matched by type of respondent did not modify these results noticeably. The association was confirmed by a test of consistency with the Down's syndrome risk model; results of this test were again more definite for sporadic Alzheimer's disease. In addition, three of the four studies also suggested an increased risk for maternal age at index birth between 15 and 19 years (overall relative risk = 1.5; 95% confidence intervals: 0.8-3.0). Although consistency across studies was not always complete, only some of the increased relative risks reached statistical significance, and information regarding maternal age obtained through a next-of-kin interview may have limitations, our study suggests that both early and late maternal age should be further investigated as possible risk factors for Alzheimer's disease.
journal_name
Int J Epidemioljournal_title
International journal of epidemiologyauthors
Rocca WA,van Duijn CM,Clayton D,Chandra V,Fratiglioni L,Graves AB,Heyman A,Jorm AF,Kokmen E,Kondo Kdoi
10.1093/ije/20.supplement_2.s21subject
Has Abstract,Author List Incompletepub_date
1991-01-01 00:00:00pages
S21-7eissn
0300-5771issn
1464-3685journal_volume
20 Suppl 2pub_type
杂志文章,meta分析abstract:Background:Up to 10% of women are exposed to selective serotonin reuptake inhibitors (SSRIs) during pregnancy. Information on their effect on birthweight and gestational age remains conflicting. The aim of this sibling-controlled prospective cohort study is to address shared geneticand family-level confounding to inves...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyw049
更新日期:2016-12-01 00:00:00
abstract::This article investigates the interrelationship of socioeconemic status, anthropometric status and mortality of young children in rural Bangladesh. Data for this study come from Matlab, the vital registration area of the International Centre for Diarrhoeal Disease Research, Bangladesh, where anthropometric and socioec...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/23.6.1179
更新日期:1994-12-01 00:00:00
abstract::Mildmay Uganda (MUg), an HIV treatment centre near Kampala, the capital of Uganda, has entered into a memorandum of understanding to collaborate with Canadian researchers at the University of Ottawa to develop their research programme and develop an observational cohort database (the MUg observational cohort). The pri...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dys170
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:We assessed the differential and sequential effects of a Government of India conditional cash transfer scheme for the socio-economically disadvantaged (Janani Suraksha Yojana; JSY) and the strengthening of the primary health centre (PHC) network to provide 24/7 obstetric care in promoting institutional deliv...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyt071
更新日期:2013-06-01 00:00:00
abstract::Coronary heart disease (CHD) is regarded as a disease of developed 'western' societies. Within developed societies, however, CHD is typically a disease of the less affluent socioeconomic classes. This has not always been the case. Forty years ago. CHD was reported to be more common among the upper social classes. In N...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/20.2.393
更新日期:1991-06-01 00:00:00
abstract::A questionnaire survey was administered in January 1982 to 3090 junior high school boys and girls in Nagoya, Japan. The proportion of current regular smokers who smoke at least one cigarette per week was 3.6% for boys and 0.5% for girls. By the third grade this had increased to 6.9% and 1.2% respectively for each sex....
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/17.4.814
更新日期:1988-12-01 00:00:00
abstract:BACKGROUND:Melioidosis, or infection with Pseudomonas pseudomallei is an important cause of morbidity and mortality in South East Asia and Northern Australia. The epidemiology of melioidosis in Ubon Ratchatani, Northeast Thailand was studied over a 5-year period from 1987 to 1991. METHODS:Rates and, when possible, the...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/23.5.1082
更新日期:1994-10-01 00:00:00
abstract:BACKGROUND:Several studies have been conducted to estimate the population prevalence of hypertension, or its diagnosis and treatment. There is no multinationally comparable information on the prevalence of hypercholesterolaemia, or its diagnosis and treatment, since individual studies are often not directly comparable....
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyi056
更新日期:2005-02-01 00:00:00
abstract::One task faced by public health surveillance practitioners is the timely identification of data patterns that might suggest the onset of an epidemic period. Many available techniques for analysis of surveillance data are based on sequential procedures, which predict expected numbers of cases and compare this estimate ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/23.2.408
更新日期:1994-04-01 00:00:00
abstract:BACKGROUND:The effect of antioxidant vitamin and mineral supplementation on health is one of the most controversial issues in human nutrition. Our objective was to investigate the effect of nutritional doses of a combination of antioxidant vitamins and minerals on health-related quality of life (HRQoL) in a sample of h...
journal_title:International journal of epidemiology
pub_type: 杂志文章,随机对照试验
doi:10.1093/ije/dyr161
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:Epidemiology in Latin America, as in the rest of the world, has been developed for the purpose of contributing towards understanding the causes and determinants of the phenomena of health and disease in specific contexts. However, in that continent it has specific characteristics. METHODS:The paper explores...
journal_title:International journal of epidemiology
pub_type: 杂志文章,评审
doi:10.1093/ije/dyh113
更新日期:2004-10-01 00:00:00
abstract:Background:In administrative database research, misclassification bias can result from diagnostic codes that imperfectly represent the condition being studied. It is unclear how to correct for this bias. Methods:Severe renal failure and Colles' fracture status were determined in two distinct cohorts using gold standar...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyx253
更新日期:2018-04-01 00:00:00
abstract::The characteristics of 673 mothers of twins were compared to those of a matched sample of mothers of singletons. Both groups of mothers were interviewed just after delivery, and births in each group were matched for time and place. Of the characteristics studied, the use of oral contraceptives (OC) displayed a signifi...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/10.4.319
更新日期:1981-12-01 00:00:00
abstract:BACKGROUND:End-stage renal disease (ESRD) incidence and prevalence are increasing in many countries worldwide. Due to the high cost of therapy, predicting future numbers of patients requiring dialysis and transplantation is necessary for health care planners. Projecting therapy-specific chronic disease prevalence is in...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/27.2.274
更新日期:1998-04-01 00:00:00
abstract:Background:Physical activity is associated with reduced risk of colorectal cancer, but most epidemiological studies have focused on occupational and recreational physical activity. The evidence for other domains of activity, and for sedentary behaviour, is limited. Methods:Medline, Embase and Web of Science were searc...
journal_title:International journal of epidemiology
pub_type: 杂志文章,meta分析,评审
doi:10.1093/ije/dyx137
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Methodological issues in the design and interpretation of cross-sectional interview surveys of the prevalence of acute respiratory infections (ARI) were assessed among young children. METHODS:A cross-sectional survey was conducted in approximately 20,000 children in the north of Ghana. Approximately half we...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/23.3.608
更新日期:1994-06-01 00:00:00
abstract:BACKGROUND:We examined secular changes in resting heart rate (RHR) and their relationship with changes in other cardiovascular risk factors in adult men and women over a 22-year period. METHODS:A single-centre population-based longitudinal study comprised 30,699 men and women aged 30-89 years who participated in at le...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyv061
更新日期:2015-06-01 00:00:00
abstract::This study examined the degree and type of changes in adolescent smoking status that occurred over an eight-year period, when the group was in grades four to six, to late adolescence and early adulthood. Where changes in smoking occurred, they were more likely to be in the direction of increased (57.7%), as compared t...
journal_title:International journal of epidemiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/ije/15.4.519
更新日期:1986-12-01 00:00:00
abstract::The Combatting Childhood Communicable Disease (CCCD) project is a comprehensive public health programme designed to reduce child mortality by 25% through the use of the following strategies: vaccination, oral rehydration therapy, and prompt treatment for malaria. To evaluate this programme, cross-sectional surveys wer...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/22.supplement_1.s15
更新日期:1993-01-01 00:00:00
abstract::Rapid changes in national rates, with little evidence of cohort effects, must substantially reflect changes in incidence rates due to socioeconomic and behavioral influences, operating with a rather short incubation period. Every newly-rich society usually experiences its epidemic of coronary heart disease. Rate chang...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:While dietary patterns that are both predictive of chronic disease and mortality have been identified, the confounding effects of cardiorespiratory fitness have not been properly addressed. The primary objective was to assess the relation between dietary patterns with all-cause mortality, while controlling f...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyp191
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND:Birthweight distributions among second-born infants depend on the birthweights of older siblings, with implications for weight-specific perinatal mortality. We wanted to study whether these relations were explained by socioeconomic levels, and to study time trends in a situation with decreasing perinatal mor...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyg163
更新日期:2003-08-01 00:00:00
abstract:BACKGROUND:Samples of railroad male employees aged 40-59 were examined from companies operating in the northwest quadrant of the US in the late 1950s (n = 2571), and in Rome and surroundings. Italy in the early 1960s (n = 768) in an international co-operative study on cardiovascular diseases. METHODS:A number of cardi...
journal_title:International journal of epidemiology
pub_type: 杂志文章,多中心研究
doi:10.1093/ije/24.3.515
更新日期:1995-06-01 00:00:00
abstract::High-income countries are experiencing an obesity epidemic that follows a socioeconomic gradient, affecting groups of lower socioeconomic status disproportionately. Recent clinical findings have suggested new perspectives for the prevention and treatment of obesity, using personalized dietary approaches. Precision nut...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyy274
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:Acute respiratory infection (ARI) is a major cause of childhood morbidity and mortality in developing countries. Community surveys are used to determine the proportion of children with ARI for whom care is sought by questioning mothers about the signs and symptoms of illness episodes. The validity of this ap...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/24.5.1058
更新日期:1995-10-01 00:00:00
abstract:BACKGROUND:Studies suggest that increased levels of physical activity might decrease the risk of prostate cancer. We ascertained lifetime measures of activity in a population-based case-control study of prostate cancer in Shanghai, China to investigate physical activity in a population where the incidence of prostate c...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/30.2.341
更新日期:2001-04-01 00:00:00
abstract::We investigated whether alternative clinical and microbiological criteria for outcome events affected estimates of vaccine efficacy in a randomized, double-blind field trial of B subunit-killed whole cell (BS-WC) and killed whole cell-only (WC) oral cholera vaccines among 62,285 rural Bangladeshi participants. At one ...
journal_title:International journal of epidemiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/ije/18.2.440
更新日期:1989-06-01 00:00:00
abstract:BACKGROUND:Predictions concerning people and their health are influenced by many factors and have many sources of uncertainty. Even so predictions can give useful guidelines for health care planning. We present a Bayesian model based on past observations and prior knowledge to predict coronary heart disease (CHD) morta...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyl128
更新日期:2006-10-01 00:00:00
abstract:BACKGROUND:Breast cancer is the most frequent cancer in women and the incidence has increased over time. Our objectives were to study: (1) the socioeconomic differences in breast cancer incidence and mortality in Denmark, (2) how different socioeconomic groups have contributed to the increasing incidence, (3) whether t...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyg049
更新日期:2003-04-01 00:00:00
abstract::Involvement of adult Ixodes persulcatus ticks in the transmission of Lyme disease in Hailin County, Heilongjiang Province, China, is reported. In 1986 from April through August adult I. persulcatus was the dominant tick in this endemic area with an infection rate of 43% for the Lyme disease spirochaete, Borrelia burgd...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/19.4.1061
更新日期:1990-12-01 00:00:00