Carcinogenic effects of tritiated water (HTO) in mice: in comparison to those of neutrons and gamma-rays.

abstract：:Differentiation-induction therapy is an attractive approach in leukemia treatment. It has been suggested that the accumulation of intracellular reactive oxygen species (ROS) is involved in megakaryocytic differentiation induced by phorbol 12-myristate 13-acetate (PMA) in the K562 leukemia cell line. Therefore, a ROS-i...

journal_title：Journal of radiation research

authors： Hirose K,Monzen S,Sato H,Sato M,Aoki M,Hatayama Y,Kawaguchi H,Narita Y,Takai Y,Kashiwakura I

更新日期：2013-05-01 00:00:00

abstract：:Radiotherapy-induced toxicity is a major dose-limiting factor in anti-cancer treatment. Ionizing radiation leads to the formation of reactive oxygen and nitrogen species (ROS/RNS) that are associated with radiation-induced cell death. Investigations of biological effects of fullerenol have provided evidence for its RO...

journal_title：Journal of radiation research

authors： Bogdanović V,Stankov K,Icević I,Zikic D,Nikolić A,Solajić S,Djordjević A,Bogdanović G

更新日期：2008-05-01 00:00:00

abstract：:Boron neutron capture therapy (BNCT) is an emerging radiation treatment modality, exhibiting the potential to selectively destroy cancer cells. Currently, BNCT is conducted using a nuclear reactor. However, the future trend is to move toward an accelerator-based system for use in hospital environments. A typical BNCT ...

journal_title：Journal of radiation research

authors： Hu N,Tanaka H,Takata T,Okazaki K,Uchida R,Sakurai Y

更新日期：2020-03-23 00:00:00

abstract：:This study aimed to identify factors that predict prognosis after radiotherapy for brain metastases (BMs) from small-cell lung cancer (SCLC). This study retrospectively evaluated 48 consecutive patients who underwent whole-brain radiotherapy (WBRT) for BMs from SCLC between February 2008 and December 2017. WBRT was de...

journal_title：Journal of radiation research

authors： Anami S,Doi H,Nakamatsu K,Uehara T,Wada Y,Fukuda K,Inada M,Ishikawa K,Kanamori S,Nishimura Y

更新日期：2019-03-01 00:00:00

abstract：:Intrafractional motion and interfractional changes affect the accuracy of the delivered dose in radiotherapy, particularly in charged-particle radiotherapy. Most recent studies are focused on intrafractional motion (respiratory motion). Here, we report a quantitative simulation analysis of the effects of interfraction...

journal_title：Journal of radiation research

authors： Mori S,Lu HM,Wolfgang JA,Choi NC,Chen GT

更新日期：2009-11-01 00:00:00

abstract：:This study was designed to elucidate the dose-response relationships for life-shortening and tumorigenic effect in the dose range below 1 Gy of gamma rays delivered during the infant period. Female B6C3F1 mice were irradiated with 0.10, 0.48 or 0.95 Gy at 7 days of age. All irradiated mice were allowed to live out the...

journal_title：Journal of radiation research

authors： Sasaki S,Fukuda N

更新日期：2006-06-01 00:00:00

abstract：:An interest in the possible cancer causing ability of neutrons began soon after their discovery. Early use of neutrons from radioactive sources and from cyclotrons led to a need to define risk for such exposures. This need was soon followed by a more tangible need to define risk to the general population of high LET r...

journal_title：Journal of radiation research

authors： Hill CK,Williams-Hill D

更新日期：1999-12-01 00:00:00

abstract：:In this study, a mechanism in which low-dose hyper-radiosensitivity (HRS) is permanently removed, induced by low-dose-rate (LDR) (0.2-0.3 Gy/h for 1 h) but not by high-dose-rate priming (0.3 Gy at 40 Gy/h) was investigated. One HRS-negative cell line (NHIK 3025) and two HRS-positive cell lines (T-47D, T98G) were used....

journal_title：Journal of radiation research

authors： Edin NJ,Sandvik JA,Vollan HS,Reger K,Görlach A,Pettersen EO

更新日期：2013-11-01 00:00:00

abstract：:Although salvage external-beam radiation therapy (EBRT) is an attractive treatment option for pelvic lymph nodal recurrence (PeNR) in patients with prostate cancer (PCa), limited data are available regarding its long-term efficacy. This study examined the long-term clinical outcomes of patients who underwent salvage p...

journal_title：Journal of radiation research

authors： Sato GE,Aizawa R,Nakamura K,Takayama K,Inoue T,Yamasaki T,Kobayashi T,Akamatsu S,Ogawa O,Mizowaki T

更新日期：2020-07-06 00:00:00

abstract：:Various kinases, such as tyrosine, protein kinase C (PKC) and MAP kinase, play important role in the cellular response to radiation, but little is known about the specific response in the whole animal. Most studies, except a few, are based on single cells. There is a paucity of data where signaling following whole bod...

journal_title：Journal of radiation research

authors： Varadkar PA,Krishna M

更新日期：2004-03-01 00:00:00

abstract：:Tritium precipitations in European cities and in Osaka, Japan were analyzed before and after the Chernobyl nuclear plant accident by the time series analysis code Census IIX11 developed by US Department of Commerce Bureau of the Census. Results of this analysis showed no significant tritium precipitation was produced ...

journal_title：Journal of radiation research

authors： Koga T,Morishima H,Niwa T,Kawai H

更新日期：1991-09-01 00:00:00

abstract：:Ionizing radiation induces biological effects not only in irradiated cells but also in non-irradiated cells, which is called the bystander effect. Recently, in vivo and in vitro experiments have suggested that both gap junction hemichannel connexin43 (Cx43) and extracellular adenosine triphosphate (ATP) released from ...

journal_title：Journal of radiation research

authors： Ohshima Y,Tsukimoto M,Harada H,Kojima S

更新日期：2012-07-01 00:00:00

abstract：:To evaluate the feasibility of using radiosensitivity of peripheral leukocytes as a predictor of clinical therapeutic responses to radiosurgery in individuals with cerebral arteriovenous malformation (AVM), we enrolled 18 patients years after they had received Gamma Knife radiosurgery for their cerebral AVM. The AVMs ...

journal_title：Journal of radiation research

authors： Guo WY,Pan HC,Wu HM,Hsieh WA,Tsai MH,Chow YM,Chung WY,Shiau CY,Chen SK,Chang WP

更新日期：2004-06-01 00:00:00

abstract：:The radioprotective effect of hawthorn (Crataegus microphylla) fruit extract against genotoxicity induced by gamma irradiation has been investigated in mouse bone marrow cells. A single intraperitoneal (ip) administration of hawthorn extract at doses of 25, 50, 100 and 200 mg/kg 1h prior to gamma irradiation (2 Gy) re...

journal_title：Journal of radiation research

authors： Hosseinimehr SJ,Azadbakht M,Mousavi SM,Mahmoudzadeh A,Akhlaghpoor S

更新日期：2007-01-01 00:00:00

abstract：:The effectiveness of an Electronic Personal Dosemeter (Siemens EPD) for cosmic-radiation dosimetry at aviation altitudes was examined on eight international flights between March and September, 1998. The EPD values (Hepd) of the dose equivalent from penetrating radiation, Hp(10), were assumed to be almost the same as ...

journal_title：Journal of radiation research

authors： Yasuda H,Fujitaka K

更新日期：2001-03-01 00:00:00

abstract：:The purpose of this study was to investigate the radiosensitizing effect of geldanamycin (GA), an inhibitor of heat shock protein 90, on tumour cells and normal cells. We tested the effect of a combination of GA and radiation on cell survival, PI3K/Akt-related proteins and apoptosis induction. GA sensitized tumour cel...

journal_title：Journal of radiation research

authors： Matsumoto Y,Machida H,Kubota N

更新日期：2005-06-01 00:00:00

abstract：:The effect of gamma-irradiation on a major nutritional function of the yolk sac (the uptake and digestion of macromolecular materials) was studied in rat visceral yolk sacs cultured in vitro being used 125I-labeled bovine serum albumin (RISA) as the tracer protein. The uptake of RISA (per g wet weight) by rat yolk sac...

journal_title：Journal of radiation research

authors： Takahashi S,Koshimoto C,Kubota Y

更新日期：1993-06-01 00:00:00

abstract：:The purpose of this study was to analyze the clinical outcomes of simultaneous modulated accelerated radiotherapy (SMART) in patients with nasopharyngeal carcinoma (NPC). A total of 97 patients who underwent SMART for NPC between August 2005 and November 2011 were evaluated. The prescribed dose was 69.9 Gy/30 fraction...

journal_title：Journal of radiation research

authors： Tang JM,Ma XM,Hou YL,Dai LY,Cao HB,Ye M,Bai YR

更新日期：2014-07-01 00:00:00

abstract：:In Japan, the use of adjuvant radiotherapy after prostatectomy for prostate cancer has not increased compared with the use of salvage radiotherapy. We retrospectively evaluated the outcome of adjuvant radiotherapy together with prognostic factors of outcome in Japan. Between 2005 and 2007, a total of 87 patients were ...

journal_title：Journal of radiation research

authors： Aoki M,Mizowaki T,Akimoto T,Nakamura K,Ejima Y,Jingu K,Tamai Y,Nakajima N,Takemoto S,Kokubo M,Katoh H

更新日期：2014-05-01 00:00:00

abstract：:Thyroid cells were given 5.5 Gy X-rays in situ and transplanted after 1 day or after 6 weeks to form colonies in fat pads. The colony-forming efficiency unexpectedly decreased by a factor of about 2 with this increase in delay time before transplantation. In addition, there was a concomitant marked increase above the ...

journal_title：Journal of radiation research

authors： Watanabe H,Hendry JH

更新日期：1994-06-01 00:00:00

abstract：:Our purpose was to develop recommendations for contouring the computed tomography (CT)-based high-risk clinical target volume (CTVHR) for 3D image-guided brachytherapy (3D-IGBT) for cervical cancer. A 15-member Japanese Radiation Oncology Study Group (JROSG) committee with expertise in gynecological radiation oncology...

journal_title：Journal of radiation research

authors： Ohno T,Wakatsuki M,Toita T,Kaneyasu Y,Yoshida K,Kato S,Ii N,Tokumaru S,Ikushima H,Uno T,Noda SE,Kazumoto T,Harima Y,The Working Group of the Gynecological Tumor Committee of the Japanese Radiation Oncology Study Group (JROSG).

更新日期：2017-05-01 00:00:00

abstract：:The purpose of the present study was to develop a hybrid magnetic resonance/computed tomography (MR/CT)-compatible phantom and tissue-equivalent materials for each MR and CT image. Therefore, the essential requirements necessary for the development of a hybrid MR/CT-compatible phantom were determined and the developme...

journal_title：Journal of radiation research

authors： Kim MJ,Lee SR,Song KH,Baek HM,Choe BY,Suh TS

更新日期：2020-03-23 00:00:00

abstract：:Immediately after X-irradiation, monocytic cells can express the gene for interleukin (IL)-1beta, which enhances inflammation and contributes to radioprotection in mice. In order to analyze the mechanism(s) for the immediate-early induction of IL-1beta after X-irradiation at 20 Gy in cultured murine macrophages, we ex...

journal_title：Journal of radiation research

authors： Ishihara H,Tanaka I,Wan H,Cheeramakara C

更新日期：2003-06-01 00:00:00

abstract：:In this study, a novel combination treatment of armed oncolytic adenovirus expressing interleukin 12 (IL-12) and granulocyte-macrophage colony-stimulating factor (GM-CSF) with radiation was investigated for antitumor and antimetastatic effect in a murine hepatic cancer (HCa-I) model. Tumor bearing syngeneic mice were ...

journal_title：Journal of radiation research

authors： Kim W,Seong J,Oh HJ,Koom WS,Choi KJ,Yun CO

更新日期：2011-01-01 00:00:00

abstract：:To understand the biological response of normal cells to fractionated carbon beam irradiation, the effects of potentially lethal damage repair (PLDR) and sublethal damage repair (SLDR) were both taken into account in a linear-quadratic (LQ) model. The model was verified by the results of a fractionated cell survival e...

journal_title：Journal of radiation research

authors： Wada M,Suzuki M,Liu C,Kaneko Y,Fukuda S,Ando K,Matsufuji N

更新日期：2013-09-01 00:00:00

abstract：:The aim of this study was to investigate the radiobiological effects of flattening filter (FF) and flattening filter-free (FFF) modes of linear electron accelerators and to understand whether there is any difference between the effects of these modes. We evaluated the number of chromosome aberrations following irradia...

journal_title：Journal of radiation research

authors： Farkas G,Kocsis ZS,Székely G,Mihály D,Pesznyák C,Pócza T,Major T,Polgár C,Jurányi Z

更新日期：2020-01-23 00:00:00

abstract：:A biological dosimetry system for measuring solar UV-B light was established using bacteriophage T1 with E. coli Bs-1 as the host cell. Also a new physical UV-B dosimeter was developed which can specifically detect the UV spectral region related to inactivation of phage T1. Phage T1 is very stable in liquid suspension...

journal_title：Journal of radiation research

authors： Furusawa Y,Suzuki K,Sasaki M

更新日期：1990-06-01 00:00:00

abstract：:The purpose of this study is to survey the current patterns of practice, and barriers to implementation, of 3D image-guided brachytherapy (3D-IGBT) for cervical cancer in Japan. A 30-item questionnaire was sent to 171 Japanese facilities where high-dose-rate brachytherapy devices were available in 2012. In total, 135 ...

journal_title：Journal of radiation research

authors： Ohno T,Toita T,Tsujino K,Uchida N,Hatano K,Nishimura T,Ishikura S

更新日期：2015-11-01 00:00:00

abstract：:Previous studies have demonstrated that X-ray irradiation affects angiogenesis in tumors. Here, we studied the effects of gamma-ray irradiation on boron-10 compound accumulation in a murine tumor model. The mouse squamous cell carcinoma was irradiated with gamma-ray before BSH ((10)B-enriched borocaptate sodium) admin...

journal_title：Journal of radiation research

authors： Liu Y,Nagata K,Masunaga S,Suzuki M,Kashino G,Kinashi Y,Tanaka H,Sakurai Y,Maruhashi A,Ono K

更新日期：2009-11-01 00:00:00

abstract：:Toll-like receptors (TLRs) are pattern recognition receptors that recognize pathogen-associated molecular patterns and are indispensable for antibacterial and antiviral immunity. Our previous report showed that ionizing radiation increases the cell surface expressions of TLR2 and TLR4 and enhances their responses to a...

journal_title：Journal of radiation research

authors： Yoshino H,Kashiwakura I

更新日期：2017-09-01 00:00:00