Neuromuscular disorders associated with paraproteinemia.

Abstract:

:Neuromuscular disorders associated with monoclonal gammopathies are usually uncovered in approximately 10% of patients presenting with peripheral neuropathy complaints. This discovery should prompt further evaluation for underlying plasma cell dyscrasias. The most frequent monoclonal disorders associated with neuropathy are smoldering myeloma, multiple myeloma, Waldenström macroglobulinemia, solitary plasmacytoma, systemic immunoglobulin light chain (AL) amyloidosis, POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes), and cryoglobulinemia. If these are excluded by careful evaluation the patient is classified as having monoclonal gammopathy of undetermined significance. Diagnostic criteria, risk stratification to determine prognosis, and current management for these disorders are reviewed in this article.

authors

Hoffman-Snyder C,Smith BE

doi

10.1016/j.pmr.2007.10.005

subject

Has Abstract

pub_date

2008-02-01 00:00:00

pages

61-79, vi

issue

1

eissn

1047-9651

issn

1558-1381

pii

S1047-9651(07)00109-X

journal_volume

19

pub_type

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