Orthobiologics and Knee Osteoarthritis: A Recent Literature Review, Treatment Algorithm, and Pathophysiology Discussion.

Abstract:

:This article reviews the current options in orthobiologics for the clinical treatment of knee osteoarthritis (OA). We describe a new model of knee OA that fills the gap in our understanding of it as a purely traumatic and/or inflammation-induced cartilage degenerative condition, to a current model of multinodal pathophysiology. We discuss graft choice and patient selection in the current state of understanding of the treatment of knee OA in a tissue engineering model with orthobiologics. We present a sample treatment algorithm and decision nest for deciding how to proceed with patient care.

authors

Crane DM,Oliver KS,Bayes MC

doi

10.1016/j.pmr.2016.07.004

subject

Has Abstract

pub_date

2016-11-01 00:00:00

pages

985-1002

issue

4

eissn

1047-9651

issn

1558-1381

pii

S1047-9651(16)30062-6

journal_volume

27

pub_type

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