Abstract：
BACKGROUND:Release of cardiac biomarkers is reported in patients with subarachnoid hemorrhage (SAH). Data addressing the impact of cardiac injury on outcome in these patients is sparse. This study was conducted to ascertain the association of elevation of serum cardiac Troponin-I (cTnI) with mortality and neurological outcome in patients with SAH. METHODS:Medical records of all patients admitted with a diagnosis of SAH and at least one measured cTnI were reviewed. Demographic and clinical variables including admission neurological status were collected. Conservative and non-parametric statistics were used to assess association between cTnI and death or neurological outcome at discharge. RESULTS:The study group comprised of 83 patients with a mean age of 59 years. There was a female (60%) and African-American (60%) preponderance. At admission, the median Glasgow Coma Scale (GCS) was 9, and 47% had a severe Hunt-Hess grade (HHG) of > or =4. Elevation of cTnI was found in 31 (37%) patients and was associated with worse baseline Fisher grade (p=0.01) and neurological status: GCS score (p=0.006) and HHG (p=0.007). Patients with abnormal cTnI were more likely to die (55% vs.27%; odds ratio 1.3-8.4, p = 0.01) and had a worse GCS score (p = 0.008) and HHG (p = 0.004) on discharge. On multivariate analysis, peak cTnI (p = 0.04) and admission GCS score of <12 (p = 0.02) were independent predictors of death at discharge. CONCLUSION:Patients with subarachnoid hemorrhage and elevated cTnI are found to have worse neurological status at admission. These patients have a worse neurological outcome and in-hospital mortality.
journal_name
Neurocrit Carejournal_title
Neurocritical careauthors
Ramappa P,Thatai D,Coplin W,Gellman S,Carhuapoma JR,Quah R,Atkinson B,Marsh JDdoi
10.1007/s12028-007-9038-7subject
Has Abstractpub_date
2008-01-01 00:00:00pages
398-403issue
3eissn
1541-6933issn
1556-0961journal_volume
8pub_type
杂志文章abstract：BACKGROUND:Fever is associated with worse outcome after intracerebral hemorrhage (ICH). Autonomic dysfunction, commonly seen after brain injury, results in reduced heart rate variability (HRV). We sought to investigate whether HRV was associated with the development of fever in patients with ICH. METHODS:We prospectiv...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-019-00684-w
更新日期：2019-04-01 00:00:00
abstract：INTRODUCTION:Delayed ischemic neurologic deficits secondary to vasospasm are a major cause of morbidity and mortality after subarachnoid hemorrhage (SAH). Treatment of vasospasm after SAH is associated with complications, and reliable techniques for evaluating effects of treatment of vasospasm in such patients are warr...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1385/ncc:6:1:40
更新日期：2007-01-01 00:00:00
abstract：OBJECTIVES:Prophylactic treatment with antiepileptic drugs is common practice following subarachnoid hemorrhage (SAH) and traumatic brain injury. However, commonly used antiepileptic drugs have multiple drug interactions, require frequent monitoring of serum levels, and are associated with adverse effects that may prom...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1385/NCC:5:1:71
更新日期：2006-01-01 00:00:00
abstract：:Traumatic brain injury (TBI) is a major cause of death and disability worldwide. In large part critical care for TBI is focused on the identification and management of secondary brain injury. This requires effective neuromonitoring that traditionally has centered on intracranial pressure (ICP). The purpose of this pap...
journal_title：Neurocritical care
pub_type： 杂志文章,评审
doi：10.1007/s12028-014-0048-y
更新日期：2014-12-01 00:00:00
abstract：INTRODUCTION:Hyponatremia frequently complicates acute brain injury and may precipitate neurological worsening by promoting cerebral edema. An increase in brain water may be better managed through water excretion than with fluid restriction or hypertonic fluids. Vasopressin-receptor antagonists such as conivaptan, whic...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-008-9179-3
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND:Seizures are a common complication after intracerebral hemorrhage (ICH) but there is a substantial lack of information on the long-term incidence in ICH survivors and whether post-ICH seizures affect functional long-term outcome. METHODS:Over a five-year period 464 consecutive patients with spontaneous ICH ...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-014-9968-9
更新日期：2014-10-01 00:00:00
abstract：:One of the most feared complications after intracranial surgery is development of acute intracranial pathology, which may result in hypoperfusion and brain injury. Thus, early neurological assessment, performed in the operating room immediately after emergence from anesthesia, is a practice that may contribute to time...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1385/NCC:5:3:206
更新日期：2006-01-01 00:00:00
abstract：:Multi-modal monitoring has become an integral part of neurointensive care. However, our approach is at this time neither standardized nor backed by data from randomized controlled trials. The goal of the second Neurocritical Care Research Conference was to discuss research priorities in multi-modal monitoring, what re...
journal_title：Neurocritical care
pub_type： 杂志文章,评审
doi：10.1007/s12028-015-0134-9
更新日期：2015-06-01 00:00:00
abstract：BACKGROUND:Delayed neurological deficit (DND) is the most important cause of morbidity and mortality in patients with subarachnoid hemorrhage (SAH) whose aneurysms have been secured. However, the methods currently used to predict the development of DND, such as trans-cranial Doppler or levels biochemical markers in blo...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-014-0089-2
更新日期：2015-10-01 00:00:00
abstract：:Traumatic brain injury (TBI) was chosen as an Emergency Neurological Life Support topic due to its frequency, the impact of early intervention on outcomes for patients with TBI, and the need for an organized approach to the care of such patients within the emergency setting. This protocol was designed to enumerate the...
journal_title：Neurocritical care
pub_type： 杂志文章,评审
doi：10.1007/s12028-012-9760-7
更新日期：2012-09-01 00:00:00
abstract：INTRODUCTION:The importance of preoperative response to external ventricular drainage (EVD) for treatment of acute hydrocephalus (HCP) following poor grade (Hunt & Hess grade IV or V) aneurysmal subarachnoid hemorrhage (aSAH) has not been clearly defined. The effect of EVD response on preoperative grade and prognosis i...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-007-0019-7
更新日期：2007-01-01 00:00:00
abstract：BACKGROUND AND PURPOSE:In patients with subarachnoid hemorrhage (SAH), higher hemoglobin (HGB) has been associated with better outcomes, but packed red blood cell (PRBC) transfusions with worse outcomes. We performed a prospective pilot trial of goal HGB after SAH. METHODS:Forty-four patients with SAH and high risk fo...
journal_title：Neurocritical care
pub_type： 杂志文章,随机对照试验
doi：10.1007/s12028-010-9424-4
更新日期：2010-12-01 00:00:00
abstract：BACKGROUND:Infection is common following stroke and is independently associated with worse outcome. Clinical studies suggest that infections occur more frequently in those individuals with stroke-induced immunologic dysfunction. This study sought to explore the contribution of immunomodulatory cytokines and hormones to...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-010-9490-7
更新日期：2011-04-01 00:00:00
abstract：INTRODUCTION:Robotic tele-presence (RTP) is a form of mobile telemedicine, which enables a direct face-to-face rapid response by the physician, instead of the traditional telephonic paradigm. We hypothesized that a model of RTP for after-hour ICU rounds and emergencies would be associated with improved ICU nurse satisf...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-012-9712-2
更新日期：2012-08-01 00:00:00
abstract：BACKGROUND:Although hydrocephalus is often treated with permanent cerebrospinal fluid (CSF) shunting during hospitalization for acute aneurysmal subarachnoid hemorrhage (SAH), little is known about the development of delayed hydrocephalus. METHODS:Using administrative data on all visits to nonfederal emergency departm...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-014-0072-y
更新日期：2015-08-01 00:00:00
abstract：INTRODUCTION:The treatment and outcomes of heparin-induced thrombocytopenia (HIT) are not well described in neurosurgery patients. This study reviewed the treatment for HIT in subarachnoid hemorrhage (SAH) patients, and compared outcomes in patients with isolated HIT (iHIT) and HIT with thrombotic syndrome (HITTS). ME...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-012-9725-x
更新日期：2012-10-01 00:00:00
abstract：:Electroencephalography in the setting of hypothermia and anoxia has been studied in humans since the 1950s. Specific patterns after cardiac arrest have been associated with prognosis since the 1960s, with several prognostic rating scales developed in the second half of the twentieth century. In 2002, two pivotal clini...
journal_title：Neurocritical care
pub_type： 杂志文章,评审
doi：10.1007/s12028-014-0018-4
更新日期：2015-02-01 00:00:00
abstract：BACKGROUND:The frequency and associations of spontaneous hyperventilation in subarachnoid hemorrhage (SAH) are unknown. Because hyperventilation decreases cerebral blood flow, it may exacerbate delayed cerebral ischemia (DCI) and worsen neurological outcome. METHODS:This is a retrospective analysis of data from a pros...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-015-0138-5
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND:An alternation of sympathetic and vagal nervous activity has been suggested to be one possible mechanism of neurogenic pulmonary edema (NPE) in patients with subarachnoid hemorrhage (SAH). The study aimed to explore if sympathovagal modulation assessed by frequency domains of heart rate variability (HRV) is ...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-015-0237-3
更新日期：2016-08-01 00:00:00
abstract：BACKGROUND:To investigate the effects of hyperbaric oxygen (HBO) on brain damage and autophagy levels in a rat model of middle cerebral artery occlusion. METHODS:Neurologic injury and infarcted areas were evaluated according to the modified neurological severity score and 2,3,5-triphenyltetrazolium chloride staining. ...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-018-0577-x
更新日期：2019-02-01 00:00:00
abstract：BACKGROUND:Attitudes toward the degree of acceptable disability and the importance of aphasia are critical in deciding on decompressive hemicraniectomy (DHC) in space-occupying middle cerebral artery stroke (SOS). The attitudes of nurses deserve strong attention, because of their close interaction with patients during ...
journal_title：Neurocritical care
pub_type： 杂志文章,多中心研究
doi：10.1007/s12028-018-0586-9
更新日期：2019-02-01 00:00:00
abstract：BACKGROUND:Fever control plays a key role in therapy of patients with acute brain injury. The infusion of cold saline could serve as an alternative or additional method for targeted temperature management. However, it is difficult to estimate the amount of fluid required to achieve normothermia merely on the basis of b...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-018-0588-7
更新日期：2019-02-01 00:00:00
abstract：BACKGROUND:Impaired cerebrovascular reactivity (CR) has been reported to be associated with adverse outcome in patients with aneurysmal subarachnoid hemorrhage (aSAH). However, CR may be determined using different paradigms and it is unclear, which measurement method most suitable reflects the clinical course or is abl...
journal_title：Neurocritical care
pub_type： 杂志文章,评审
doi：10.1007/s12028-009-9287-8
更新日期：2010-04-01 00:00:00
abstract：BACKGROUND:Takotsubo syndrome is a reversible neuromyocardial failure that has been thought to be related to an acute catecholamine toxicity of the myocardium brought upon by a stressful event. The neurocritical care unit population is particularly vulnerable for this condition given the acute presentation of neurologi...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-008-9075-x
更新日期：2008-01-01 00:00:00
abstract：BACKGROUND:This prospective study of an innovative non-invasive ultrasonic cerebrovascular autoregulation (CA) monitoring method is based on real-time measurements of intracranial blood volume (IBV) reactions following changes in arterial blood pressure. In this study, we aimed to determine the clinical applicability o...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-018-0569-x
更新日期：2019-02-01 00:00:00
abstract：:Prophylactic use of hypervolemia and hypertension is believed to present an option to decrease the incidence of symptomatic vasospasm after aneurysmal subarachnoid hemorrhage and improve neurologic outcome. A Medline literature search was conducted to review available evidence regarding volume management after subarac...
journal_title：Neurocritical care
pub_type： 杂志文章,评审
doi：10.1007/s12028-011-9593-9
更新日期：2011-09-01 00:00:00
abstract：BACKGROUND:Cerebral edema, which is associated with increased intracranial fluid, is often a complication of many acute neurological conditions. There is currently no accepted method for real-time monitoring of intracranial fluid volume at the bedside. We evaluated a novel noninvasive technique called "Volumetric Integ...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-017-0409-4
更新日期：2018-02-01 00:00:00
abstract：BACKGROUND:Acute hydrocephalus is a common complication of aneurysmal subarachnoid hemorrhage (aSAH); however, attempts to predict shunt-dependent chronic hydrocephalus using clinical parameters have been equivocal. METHODS:Cohort study of aSAH is treated with external ventricular drainage (EVD) placement at our insti...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-019-00886-2
更新日期：2020-08-01 00:00:00
abstract：:In the original article, Figure 5 has incorrect EEG images and the corrected version is shown below. ...
journal_title：Neurocritical care
pub_type： 杂志文章,已发布勘误
doi：10.1007/s12028-020-00981-9
更新日期：2020-08-01 00:00:00
abstract：BACKGROUND:There are some intracranial insults which are associated with cardiac abnormalities. Studies of these abnormalities have never been carried out in elective intracranial neurosurgery for the removal of brain tumors. Our prospective study aims at quantifying serum cardiac troponin T (cTnT) and N-terminal pro-b...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-012-9684-2
更新日期：2012-12-01 00:00:00
