Abstract：
BACKGROUND:Takotsubo syndrome is a reversible neuromyocardial failure that has been thought to be related to an acute catecholamine toxicity of the myocardium brought upon by a stressful event. The neurocritical care unit population is particularly vulnerable for this condition given the acute presentation of neurological emergencies, which most often can be catastrophic. We present a case series of this syndrome and a review of the literature. METHOD:Our recent experience with three cases that were prospectively identified with the diagnosis of Takotsubo syndrome is reported with clinical presentation, evaluation, and management approach. Review of the literature is presented in the discussion. RESULTS:We present three episodes of Takotsubo neuromyocardial syndrome in two patients that were admitted to our neurointensive care unit that presented with seizures and had typical clinical presentation, echocardiographic and cardiac catheterization findings. All the episodes were treated with vasoactive medications, ventilatory support, afterload and preload reduction, and treatment of the underlying condition. There was complete reversal of their symptoms and findings in each episode. CONCLUSIONS:Patients with critical neurological illnesses such as large ischemic or hemorrhagic stroke, status epilepticus, recurrent seizure activities as in our study may be at a higher risk for Takotsubo neuromyocardial syndrome.
journal_name
Neurocrit Carejournal_title
Neurocritical careauthors
Lemke DM,Hussain SI,Wolfe TJ,Torbey MA,Lynch JR,Carlin A,Fitzsimmons BF,Zaidat OOdoi
10.1007/s12028-008-9075-xsubject
Has Abstractpub_date
2008-01-01 00:00:00pages
112-7issue
1eissn
1541-6933issn
1556-0961journal_volume
9pub_type
杂志文章abstract：:In this article, we review technologies available for direct monitoring of cerebral oxygenation and metabolic status, including jugular venous oxygen saturation, brain tissue oxygen tension, transcranial cerebral oximetry with near-infrared spectroscopy, Positron emission tomography oxidative metabolism, single-photon...
journal_title：Neurocritical care
pub_type： 杂志文章,评审
doi：10.1385/ncc:4:1:083
更新日期：2006-01-01 00:00:00
abstract：BACKGROUND:Physiological reactions of the stress hormone cortisol include hyperglycemia, hypertension, and endothelium dysfunction. In patients with aneurysmal subarachnoid hemorrhage (SAH), hyperglycemia, hypertension, and endothelium dysfunction are associated with the occurrence of delayed cerebral ischemia (DCI). T...
journal_title：Neurocritical care
pub_type： 杂志文章,随机对照试验
doi：10.1007/s12028-010-9331-8
更新日期：2010-06-01 00:00:00
abstract：:Severe intracranial hypertension (IH) in the setting of fulminant hepatic failure (FHF) carries a high mortality and is a challenging disease for the critical care provider. Despite considerable improvements in the understanding of the pathophysiology of cerebral edema during liver failure, therapeutic maneuvers that ...
journal_title：Neurocritical care
pub_type： 杂志文章,评审
doi：10.1385/NCC:4:2:179
更新日期：2006-01-01 00:00:00
abstract：INTRODUCTION:Altered mental status and more subtle cognitive and personality changes after traumatic brain injury (TBI) are pervasive problems in patients who survive initial injury. MRI is not necessarily part of the diagnostic evaluation of these patients. METHODS:Case report with relevant image and review of the li...
journal_title：Neurocritical care
pub_type： 杂志文章,评审
doi：10.1007/s12028-012-9699-8
更新日期：2012-06-01 00:00:00
abstract：BACKGROUND:Apnea testing is an essential step in the clinical diagnosis of brain death. Current international guidelines recommend placement of an oxygen (O2) insufflation catheter into the endotracheal tube to prevent hypoxemia, but use of a continuous positive airway pressure (CPAP) valve may be more effective at lim...
journal_title：Neurocritical care
pub_type： 杂志文章,多中心研究
doi：10.1007/s12028-017-0380-0
更新日期：2017-08-01 00:00:00
abstract：:This review examines the available data on the use of osmotic agents in patients with head injury and ischemic stroke, summarizes the physiological effects of osmotic agents, and presents the leading hypotheses regarding the mechanism by which they reduce ICP. Finally, it addresses the validity of the following common...
journal_title：Neurocritical care
pub_type： 杂志文章,评审
doi：10.1385/NCC:1:2:219
更新日期：2004-01-01 00:00:00
abstract：INTRODUCTION:Robotic tele-presence (RTP) is a form of mobile telemedicine, which enables a direct face-to-face rapid response by the physician, instead of the traditional telephonic paradigm. We hypothesized that a model of RTP for after-hour ICU rounds and emergencies would be associated with improved ICU nurse satisf...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-012-9712-2
更新日期：2012-08-01 00:00:00
abstract：BACKGROUND:Infection is common following stroke and is independently associated with worse outcome. Clinical studies suggest that infections occur more frequently in those individuals with stroke-induced immunologic dysfunction. This study sought to explore the contribution of immunomodulatory cytokines and hormones to...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-010-9490-7
更新日期：2011-04-01 00:00:00
abstract：BACKGROUND:Decompressive hemicraniectomy (DHC) has proven efficacious for the treatment of malignant middle cerebral artery infarction (mMCAI) only in patients less than 60 years. This study aimed to assess the effectiveness of DHC in patients up to 80. METHODS:This is a prospective, randomized, controlled trail compa...
journal_title：Neurocritical care
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s12028-012-9703-3
更新日期：2012-10-01 00:00:00
abstract：BACKGROUND/OBJECTIVE:Intravenous (IV) lacosamide use for status epilepticus has increased in recent years and is recommended for refractory status epilepticus by current guidelines. Per the lacosamide package labeling, the preferred route of administration is diluted and infused over 30-60 min; however, administration ...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-018-0560-6
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND/OBJECTIVE:In recent years, the noble gas argon (Ar) has been extensively studied for its organ protection properties. While mounting in vitro and in vivo evidence indicates that argon provides neuroprotection in ischemic brain injury, its neuroprotective potential in traumatic brain injury (TBI) has not been...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-020-01104-0
更新日期：2020-09-21 00:00:00
abstract：BACKGROUND/OBJECTIVE:Posterior reversible encephalopathy syndrome (PRES) is a clinical and radiologic entity, typically manifesting as reversible neurological symptoms and signs of white matter edema on magnetic resonance imaging. PRES has been widely described in adults. Studies of PRES in children are mostly limited ...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-019-00720-9
更新日期：2020-02-01 00:00:00
abstract：BACKGROUND:This prospective consecutive double-blinded randomized study investigated the effect of prostacyclin on pressure reactivity (PR) in severe traumatic brain injured patients. Other aims were to describe PR over time and its relation to outcome. METHODS:Blunt head trauma patients, Glasgow coma scale ≤8, age 15...
journal_title：Neurocritical care
pub_type： 杂志文章,随机对照试验
doi：10.1007/s12028-014-0030-8
更新日期：2015-02-01 00:00:00
abstract：BACKGROUND:Several methods have been proposed to measure cerebrovascular autoregulation (CA) in traumatic brain injury (TBI), but the lack of a gold standard and the absence of prospective clinical data on risks, impact on care and outcomes of implementation of CA-guided management lead to uncertainty. AIM:To formulat...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-020-01185-x
更新日期：2021-01-25 00:00:00
abstract：OBJECTIVE:Identification of patients with posterior fossa infarction at risk for neurological deterioration remains a challenge. MRI-based assessments of MCA infarction can predict poor outcome. Similar quantitative imaging measures after cerebellar stroke have not been studied. We tested the hypothesis that MRI-based ...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-013-9886-2
更新日期：2013-12-01 00:00:00
abstract：BACKGROUND:There are some intracranial insults which are associated with cardiac abnormalities. Studies of these abnormalities have never been carried out in elective intracranial neurosurgery for the removal of brain tumors. Our prospective study aims at quantifying serum cardiac troponin T (cTnT) and N-terminal pro-b...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-012-9684-2
更新日期：2012-12-01 00:00:00
abstract：:Traumatic brain injury (TBI) is a major cause of death and disability worldwide. In large part critical care for TBI is focused on the identification and management of secondary brain injury. This requires effective neuromonitoring that traditionally has centered on intracranial pressure (ICP). The purpose of this pap...
journal_title：Neurocritical care
pub_type： 杂志文章,评审
doi：10.1007/s12028-014-0048-y
更新日期：2014-12-01 00:00:00
abstract：BACKGROUND:There is some evidence that hyperglycemia increases the rate of poor outcomes in patients with intracerebral hemorrhage (ICH). We explored the relationship between various parameters of serum glucose concentrations measured during acute hospitalization and hematoma expansion, perihematomal edema, and three m...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-011-9541-8
更新日期：2011-12-01 00:00:00
abstract：BACKGROUND:Knowing the individual child's risk is highly useful when deciding on treatment strategies, especially when deciding on invasive procedures. In this study, we aimed to develop a new predictive score for children with bacterial meningitis and compare this with existing predictive scores and individual risk fa...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-019-00792-7
更新日期：2020-04-01 00:00:00
abstract：BACKGROUND:Subarachnoid hemorrhage (SAH) has been associated with pronounced acute sympathetic activation. The purpose of this investigation is to identify demographic, clinical, radiological, and anatomical features of SAH that relate to sympathetic activation. METHODS:Observational study of consecutive Grades 3-5 SA...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-012-9673-5
更新日期：2012-06-01 00:00:00
abstract：INTRODUCTION:The importance of preoperative response to external ventricular drainage (EVD) for treatment of acute hydrocephalus (HCP) following poor grade (Hunt & Hess grade IV or V) aneurysmal subarachnoid hemorrhage (aSAH) has not been clearly defined. The effect of EVD response on preoperative grade and prognosis i...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-007-0019-7
更新日期：2007-01-01 00:00:00
abstract：INTRODUCTION:No proven treatments exist for intracerebral hemorrhage (ICH). Carefully selected patients may benefit from surgery, and an international multicenter trial is ongoing. We sought to determine how many patients in a population-based ICH cohort would have been eligible for surgery using the Surgical Trial in ...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-007-9045-8
更新日期：2008-01-01 00:00:00
abstract：INTRODUCTION:The incidence of spinal epidural abscesses (SEAs) is rising. Although increased awareness has led to decreased mortality, morbidity remains unacceptably high, with rapid deterioration of neurological status when there is a delay in initiation of treatment. Therefore, we need to build a better understanding...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1385/NCC:2:3:245
更新日期：2005-01-01 00:00:00
abstract：PURPOSE:The objective of our trial was to obtain more comprehensive data on the risks and benefits of kinetic therapy in intensive care patients with intracerebral pathology. METHODS:Standardized data of prone positioning in our NeuroIntensive Care Unit were collected from 2007 onward. A post hoc analysis of all avail...
journal_title：Neurocritical care
pub_type： 临床试验,杂志文章
doi：10.1007/s12028-014-0004-x
更新日期：2014-10-01 00:00:00
abstract：BACKGROUND:Stroke is common after aneurysmal subarachnoid hemorrhage (aSAH). Transcranial Doppler ultrasound (TCD) monitoring is often employed to identify vasospasm and allow intervention to avoid infarction. The required duration of monitoring has not been established. We aim to determine if 10 days of TCD monitoring...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-011-9564-1
更新日期：2011-12-01 00:00:00
abstract：BACKGROUND:Infection in the intensive care unit (ICU) empirically requires broad-spectrum antibiotics. Imipenem/cilastatin, often reserved for more serious hospital-acquired infections, is thought to be associated with a higher risk of seizures than other penicillins and carbapenems. We sought to evaluate the safety of...
journal_title：Neurocritical care
pub_type： 杂志文章,评审
doi：10.1007/s12028-008-9170-z
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND:Little data exist regarding the practice of sodium management in acute neurologically injured patients. This study describes the practice variations, thresholds for treatment, and effectiveness of treatment in this population. METHODS:This retrospective, multicenter, observational study identified 400 ICU p...
journal_title：Neurocritical care
pub_type： 杂志文章,多中心研究
doi：10.1007/s12028-016-0343-x
更新日期：2017-10-01 00:00:00
abstract：BACKGROUND:Subclinical seizures are common in critically ill children and are best detected by continuous EEG (cEEG) monitoring. Timely detection of seizures requires pediatric intensive care unit (PICU) physicians to identify patients at risk of seizures and request cEEG monitoring. A recent consensus statement from t...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-020-01053-8
更新日期：2020-07-21 00:00:00
abstract：BACKGROUND:Direct invasive monitoring of brain tissue oxygenation (PbtO(2)) has been routinely utilized to predict cerebral ischemia and to prevent secondary injury in patients with traumatic brain injury (TBI) and vasospasm secondary to subarachnoid hemorrhage (SAH). The safety and utility of these devices in the pedi...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-011-9531-x
更新日期：2011-12-01 00:00:00
abstract：INTRODUCTION:Point-of-care ultrasound of the optic nerve sheath diameter (ONSD) to diagnose increased intracranial pressure (ICP) is of great interest in various clinical scenarios. Yet, the lack of examination standardization has made clinical utility difficult. We compare three ultrasound ocular plane views (inferior...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-019-00881-7
更新日期：2020-08-01 00:00:00
