Eligibility for the surgical trial in intracerebral hemorrhage II study in a population-based cohort.


INTRODUCTION:No proven treatments exist for intracerebral hemorrhage (ICH). Carefully selected patients may benefit from surgery, and an international multicenter trial is ongoing. We sought to determine how many patients in a population-based ICH cohort would have been eligible for surgery using the Surgical Trial in Intracerebral Hemorrhage II (STICH II) criteria. METHODS:We identified all patients aged > or =18 years residing in the five-county Greater Cincinnati region who were hospitalized with first-ever nontraumatic ICH in 2005. STICH II trial criteria were used to determine eligibility for treatment and reasons for exclusion. RESULTS:During 2005, 286 ICH patients were identified (103 lobar, 126 deep cerebral, 23 brainstem, 28 cerebellar, and 6 IVH). Non-lobar hemorrhages are not eligible for STICH II. Among patients with lobar hemorrhage, 22 had no exclusions. The most common (not mutually exclusive) reasons for exclusion were volume <10 cc or >100 cc (n = 46) and presence of IVH (n = 27). No significant age, gender or racial differences existed between eligible and ineligible patients with lobar ICH. Only one (4.5%) of the 22 STICH II eligible patients in our population had surgery, compared with eight of 81 (9.9%) ineligible lobar ICH patients (P = 0.43). Mortality at 180 days in STICH II eligible patients was 36% vs. 49% for ineligible lobar ICH patients (P = 0.19). CONCLUSIONS:In this population-based ICH cohort, 7.7% (22 of 286) of ICH patients would have qualified for STICH II enrollment. Other treatment options need to be explored for most ICH patients.


Neurocrit Care


Neurocritical care


Adeoye O,Woo D,Haverbusch M,Tao H,Sekar P,Moomaw CJ,Shutter L,Kleindorfer D,Kissela B,Broderick J,Flaherty ML




Has Abstract


2008-01-01 00:00:00












  • Real-time Noninvasive Monitoring of Intracranial Fluid Shifts During Dialysis Using Volumetric Integral Phase-Shift Spectroscopy (VIPS): A Proof-of-Concept Study.

    abstract:BACKGROUND:Cerebral edema, which is associated with increased intracranial fluid, is often a complication of many acute neurological conditions. There is currently no accepted method for real-time monitoring of intracranial fluid volume at the bedside. We evaluated a novel noninvasive technique called "Volumetric Integ...

    journal_title:Neurocritical care

    pub_type: 杂志文章


    authors: Venkatasubba Rao CP,Bershad EM,Calvillo E,Maldonado N,Damani R,Mandayam S,Suarez JI

    更新日期:2018-02-01 00:00:00

  • Pharmacology and clinical use of recombinant activated factor seven in neurosciences.

    abstract::Recombinant activated factor VII (rFVIIa, NovoSeven, NovoNordisc, Danemark) has been approved for the treatment of patients with hemophilia with inhibitors, further indications, at least in some countries, include the treatment of factor VII deficiency and Glanzmann thrombasthenia refractory to conventional therapy. A...

    journal_title:Neurocritical care

    pub_type: 杂志文章,评审


    authors: Hartmann M,Sucker C

    更新日期:2007-01-01 00:00:00

  • Does prone positioning increase intracranial pressure? A retrospective analysis of patients with acute brain injury and acute respiratory failure.

    abstract:PURPOSE:The objective of our trial was to obtain more comprehensive data on the risks and benefits of kinetic therapy in intensive care patients with intracerebral pathology. METHODS:Standardized data of prone positioning in our NeuroIntensive Care Unit were collected from 2007 onward. A post hoc analysis of all avail...

    journal_title:Neurocritical care

    pub_type: 临床试验,杂志文章


    authors: Roth C,Ferbert A,Deinsberger W,Kleffmann J,Kästner S,Godau J,Schüler M,Tryba M,Gehling M

    更新日期:2014-10-01 00:00:00

  • Serum neuron-specific enolase levels from the same patients differ between laboratories: assessment of a prospective post-cardiac arrest cohort.

    abstract:BACKGROUND:In comatose post-cardiac arrest patients, a serum neuron-specific enolase (NSE) level of >33 μg/L within 72 h was identified as a reliable marker for poor outcome in a large Dutch study (PROPAC), and this level was subsequently adopted in an American Academy of Neurology practice parameter. Later studies rep...

    journal_title:Neurocritical care

    pub_type: 杂志文章


    authors: Mlynash M,Buckwalter MS,Okada A,Caulfield AF,Venkatasubramanian C,Eyngorn I,Verbeek MM,Wijman CA

    更新日期:2013-10-01 00:00:00

  • Levetiracetam is associated with improved cognitive outcome for patients with intracranial hemorrhage.

    abstract:BACKGROUND:To date, common therapy in patients with intracranial hemorrhage (ICH) includes prophylaxis of seizure using antiepileptic drugs, commonly phenytoin. Phenytoin therapy is associated with a high incidence of cognitive disturbance. Levetiracetam is known to cause less cognitive disruption and may be a suitable...

    journal_title:Neurocritical care

    pub_type: 杂志文章


    authors: Taylor S,Heinrichs RJ,Janzen JM,Ehtisham A

    更新日期:2011-08-01 00:00:00

  • Postpartum trifecta: simultaneous eclamptic intracerebral hemorrhage, PRES, and herniation due to intracranial hypotension.

    abstract:BACKGROUND:In the postpartum patient, sudden depression of consciousness may be caused by a number of etiologies and can result in serious consequences. Rapid, accurate diagnosis allows for specific treatments that optimize outcome, but diagnosis can be challenging in this population. We present a case of postpartum he...

    journal_title:Neurocritical care

    pub_type: 杂志文章


    authors: Orehek EK,Burns JD,Koyfman F,Azocar RJ,Holsapple JW,Green DM

    更新日期:2012-12-01 00:00:00

  • Cerebrovascular events after bevacizumab treatment: an early and severe complication.

    abstract:BACKGROUND:The indications for bevacizumab (a vascular endothelial growth factor inhibitor) have been expanded recently. Despite concerns for cerebrovascular events from bevacizumab treatment, detailed clinical and radiologic information are lacking. METHODS:Using the Mayo Clinic Rochester database (January 2006-Septe...

    journal_title:Neurocritical care

    pub_type: 杂志文章


    authors: Seet RC,Rabinstein AA,Lindell PE,Uhm JH,Wijdicks EF

    更新日期:2011-12-01 00:00:00

  • The epidemiology of status epilepticus in the United States.

    abstract:OBJECTIVE:To summarize trends in status epilepticus (SE) in the United States by age, race, sex, admission source, disposition, incidence rates, and mortality. METHODS:Data from US National Hospital Discharge Survey were used from 1979 to 2010 to identify discharges with SE and common etiologies and complications of S...

    journal_title:Neurocritical care

    pub_type: 杂志文章


    authors: Dham BS,Hunter K,Rincon F

    更新日期:2014-06-01 00:00:00

  • Utilization of recombinant activated factor VII for intracranial hematoma evacuation in coagulopathic nonhemophilic neurosurgical patients with normal international normalized ratios.

    abstract:BACKGROUND:Recombinant activated Factor VII (rFVIIa) has recently gained popularity for rapid reversal of coagulopathy during operative neurosurgery. Patients undergoing chronic subdural hematoma (CSDH) or epidural hematoma (EDH) evacuation often have their coagulation status judged by preoperative international normal...

    journal_title:Neurocritical care

    pub_type: 杂志文章


    authors: McClelland S 3rd,Won EK,Lam CH

    更新日期:2007-01-01 00:00:00

  • Intracerebral Hemorrhage with Intraventricular Extension Associated with Loss of Consciousness at Symptom Onset.

    abstract:BACKGROUND:In patients with spontaneous intracerebral hemorrhage (ICH), pre-hospital markers of disease severity might be useful to potentially triage patients to undergo early interventions. OBJECTIVE:Here, we tested whether loss of consciousness (LOC) at the onset of ICH is associated with intraventricular hemorrhag...

    journal_title:Neurocritical care

    pub_type: 杂志文章


    authors: Witsch J,Falcone GJ,Leasure AC,Matouk C,Endres M,Sansing L,Woo D,Sheth KN

    更新日期:2021-01-21 00:00:00

  • Emergency neurological life support: traumatic brain injury.

    abstract::Traumatic brain injury (TBI) was chosen as an Emergency Neurological Life Support topic due to its frequency, the impact of early intervention on outcomes for patients with TBI, and the need for an organized approach to the care of such patients within the emergency setting. This protocol was designed to enumerate the...

    journal_title:Neurocritical care

    pub_type: 杂志文章,评审


    authors: Swadron SP,LeRoux P,Smith WS,Weingart SD

    更新日期:2012-09-01 00:00:00

  • Levetiracetam use in critically ill patients.

    abstract:INTRODUCTION:Levetiracetam (LEV) is used in the setting of acute brain injury for seizure treatment or prophylaxis but its safety and efficacy in this setting is unknown. METHOD:We retrospectively analyzed the patterns of use and safety/efficacy of LEV in 379 patients treated in the neuroscience intensive care unit (N...

    journal_title:Neurocritical care

    pub_type: 杂志文章


    authors: Szaflarski JP,Meckler JM,Szaflarski M,Shutter LA,Privitera MD,Yates SL

    更新日期:2007-01-01 00:00:00

  • Statins in the management of patients with aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis.

    abstract:BACKGROUND:Delayed ischemic neurological deficits (DINDs) contribute to morbidity and mortality following aneurysmal subarachnoid hemorrhage (SAH). Based on promising preliminary reports, some clinicians routinely administer statins to prevent DINDs. METHODS:Without language restriction, we searched MEDLINE, EMBASE, t...

    journal_title:Neurocritical care

    pub_type: 杂志文章,meta分析,评审


    authors: Kramer AH,Fletcher JJ

    更新日期:2010-04-01 00:00:00

  • Pressures, flow, and brain oxygenation during plateau waves of intracranial pressure.

    abstract:BACKGROUND:Plateau waves are common in traumatic brain injury. They constitute abrupt increases of intracranial pressure (ICP) above 40 mmHg associated with a decrease in cerebral perfusion pressure (CPP). The aim of this study was to describe plateau waves characteristics with multimodal brain monitoring in head injur...

    journal_title:Neurocritical care

    pub_type: 杂志文章


    authors: Dias C,Maia I,Cerejo A,Varsos G,Smielewski P,Paiva JA,Czosnyka M

    更新日期:2014-08-01 00:00:00

  • External Validation of Hematoma Expansion Scores in Spontaneous Intracerebral Hemorrhage in an Asian Patient Cohort.

    abstract:BACKGROUND:Hematoma expansion (HE) occurs in approximately one-third of patients with intracerebral hemorrhage (ICH) and is known to be a strong predictor of neurological deterioration as well as poor functional outcome. This study aims to externally validate three risk prediction models of HE (PREDICT, 9-point, and BR...

    journal_title:Neurocritical care

    pub_type: 杂志文章


    authors: Lim JX,Han JX,See AAQ,Lew VH,Chock WT,Ban VF,Pothiawala S,Lim WEH,McAdory LE,James ML,King NKK

    更新日期:2019-04-01 00:00:00

  • A device for fast mechanical clot retrieval from intracranial arteries (Phenox clot retriever).

    abstract:INTRODUCTION:To describe a new device meant for rapid endovascular thrombectomy of intracranial arteries of various sizes and its first clinical use. METHODS:A device with oriented microfilaments was constructed that consists of a core wires compound surrounded by a dense palisade of perpendicular-oriented stiff polya...

    journal_title:Neurocritical care

    pub_type: 杂志文章


    authors: Henkes H,Reinartz J,Lowens S,Miloslavski E,Roth C,Reith W,Kühne D

    更新日期:2006-01-01 00:00:00

  • Normal pressure "herniation".

    abstract:INTRODUCTION:Hydrocephalus with normal intracranial pressure has rarely been reported to result in herniation. METHODS:Case report. RESULTS:A 52-year-old man became acutely comatose with extensor posturing and ventriculomegaly 17 days after experiencing a primary ventricular hemorrhage. An external ventricular drain ...

    journal_title:Neurocritical care

    pub_type: 杂志文章


    authors: Pratt RW,Mayer SA

    更新日期:2005-01-01 00:00:00

  • Blood Pressure Guideline Adherence in Patients with Ischemic and Hemorrhagic Stroke in the Neurointensive Care Unit Setting.

    abstract:BACKGROUND AND PURPOSE:Patients with acute brain injuries require strict physiologic control to minimize morbidity and mortality. This study aimed to assess in-hospital compliance to strict physiologic parameters (BP, HR, ICP, SpO2) in these populations. METHODS:Patients with severe cerebrovascular events were admitte...

    journal_title:Neurocritical care

    pub_type: 杂志文章


    authors: Porto GB,Spiotta AM,Chalela JA,Kellogg RT,Jauch EC

    更新日期:2015-12-01 00:00:00

  • Neuromonitoring in neurological critical care.

    abstract::In this article, we review technologies available for direct monitoring of cerebral oxygenation and metabolic status, including jugular venous oxygen saturation, brain tissue oxygen tension, transcranial cerebral oximetry with near-infrared spectroscopy, Positron emission tomography oxidative metabolism, single-photon...

    journal_title:Neurocritical care

    pub_type: 杂志文章,评审


    authors: Dunn IF,Ellegala DB,Kim DH,Litvack ZN,Brigham and Women's Hospital Neurosurgery Group.

    更新日期:2006-01-01 00:00:00

  • High Serum DNA and RNA Oxidative Damage in Non-surviving Patients with Spontaneous Intracerebral Hemorrhage.

    abstract:PURPOSE:One study found higher leukocytes 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels in patients with spontaneous intracerebral hemorrhage (ICH) than in healthy subjects due to the oxidation of guanosine from deoxyribonucleic acid (DNA). The objective of this study was to determine whether there is an association betw...

    journal_title:Neurocritical care

    pub_type: 杂志文章


    authors: Lorente L,Martín MM,González-Rivero AF,Pérez-Cejas A,Abreu-González P,Sabatel R,Ramos L,Argueso M,Cáceres JJ,Solé-Violán J,Jiménez A,García-Marín V

    更新日期:2020-08-01 00:00:00

  • ABO Blood Type and Hematoma Expansion After Intracerebral Hemorrhage: An Exploratory Analysis.

    abstract:BACKGROUND/PURPOSE:Blood type has become an increasingly recognized risk factor for coagulopathy. We explored the association between blood type and hematoma expansion (HE) after intracerebral hemorrhage (ICH). METHODS:Spontaneous ICH patients prospectively enrolled in an ongoing ICH cohort study at Columbia Universit...

    journal_title:Neurocritical care

    pub_type: 杂志文章


    authors: Roh D,Martin A,Sun CH,Eisenberger A,Boehme A,Elkind MSV,Pucci JU,Murthy S,Kamel H,Sansing L,Park S,Agarwal S,Connolly ES,Claassen J,Hod E,Francis RO

    更新日期:2019-08-01 00:00:00

  • Spinal epidural abscess.

    abstract:INTRODUCTION:The incidence of spinal epidural abscesses (SEAs) is rising. Although increased awareness has led to decreased mortality, morbidity remains unacceptably high, with rapid deterioration of neurological status when there is a delay in initiation of treatment. Therefore, we need to build a better understanding...

    journal_title:Neurocritical care

    pub_type: 杂志文章


    authors: Kumar K,Hunter G

    更新日期:2005-01-01 00:00:00

  • Determinants of central sympathetic activation in spontaneous primary subarachnoid hemorrhage.

    abstract:BACKGROUND:Subarachnoid hemorrhage (SAH) has been associated with pronounced acute sympathetic activation. The purpose of this investigation is to identify demographic, clinical, radiological, and anatomical features of SAH that relate to sympathetic activation. METHODS:Observational study of consecutive Grades 3-5 SA...

    journal_title:Neurocritical care

    pub_type: 杂志文章


    authors: Moussouttas M,Lai EW,Khoury J,Huynh TT,Dombrowski K,Pacak K

    更新日期:2012-06-01 00:00:00

  • Impact of Sleep Deprivation in the Neurological Intensive Care Unit: A Narrative Review.

    abstract::Sleep is fundamental for everyday functioning, yet it is often negatively impacted in critically ill patients by the intensive care setting. With a focus on the neurological intensive care unit (NeuroICU), this narrative review summarizes methods of measuring sleep and addresses common causes of sleep disturbance in t...

    journal_title:Neurocritical care

    pub_type: 杂志文章


    authors: Chang VA,Owens RL,LaBuzetta JN

    更新日期:2020-04-01 00:00:00

  • Lipid Peroxidation and Antioxidant Consumption as Early Markers of Neurosurgery-Related Brain Injury in Children.

    abstract:BACKGROUND AND AIMS:Lipid peroxidation represents a marker of secondary brain injury both in traumatic and in non-traumatic conditions-as in major neurosurgical procedures-eventually leading to brain edema amplification and further brain damage. Malondialdehyde (MDA), a lipid peroxidation marker, and ascorbate, a marke...

    journal_title:Neurocritical care

    pub_type: 杂志文章


    authors: Piastra M,Caresta E,Massimi L,Picconi E,Luca E,Morena TC,Conti G,Eaton S

    更新日期:2020-08-01 00:00:00

  • Isolated third nerve palsy associated with a ruptured anterior communicating artery aneurysm.

    abstract:INTRODUCTION:An oculomotor palsy in the setting of aneurysmal subarachnoid hemorrhage is often due to compression by a posterior communicating artery aneurysm. Anterior communicating artery (ACOM) aneurysms may produce ophthalmologic symptoms of the anterior visual pathways, but rarely ever lead to a 3rd nerve palsy. T...

    journal_title:Neurocritical care

    pub_type: 杂志文章


    authors: White JB,Layton KF,Cloft HJ

    更新日期:2007-01-01 00:00:00

  • Timing of computed tomography and prediction of vasospasm after aneurysmal subarachnoid hemorrhage.

    abstract:BACKGROUND:The initial noncontrast computed tomography (CT) study of the head after an aneurysmal subarachnoid hemorrhage (SAH) is used to predict the risk of developing vasospasm. Changes in the extent of subarachnoid blood seen on CT images occur as a function of time after SAH, but there is no consensus on the time ...

    journal_title:Neurocritical care

    pub_type: 杂志文章


    authors: Dupont SA,Wijdicks EF,Manno EM,Lanzino G,Brown RD Jr,Rabinstein AA

    更新日期:2009-01-01 00:00:00

  • Informatics for neurocritical care: challenges and opportunities.

    abstract::Neurocritical care relies on the continuous, real-time measurement of numerous physiologic parameters. While our capability to obtain such measurements from patients has grown markedly with multimodal monitoring in many neurologic or neurosurgical intensive care units (ICUs), our ability to transform the raw data into...

    journal_title:Neurocritical care

    pub_type: 杂志文章,评审


    authors: Sivaganesan A,Manley GT,Huang MC

    更新日期:2014-02-01 00:00:00

  • Incidence of Antithrombin Deficiency and Anti-Cardiolipin Antibodies After Severe Traumatic Brain Injury: A Prospective Cohort Study.

    abstract:BACKGROUND:Animal studies suggested that cerebral mitochondrial cardiolipin phospholipids were released after severe traumatic brain injury (TBI), contributing to the pathogenesis of thromboembolism. OBJECTIVES:To determine the incidence of anti-cardiolipin antibodies after severe TBI and whether this was related to t...

    journal_title:Neurocritical care

    pub_type: 杂志文章


    authors: Kalgudi S,Ho KM

    更新日期:2020-06-18 00:00:00

  • Cerebral ischemia and neurogenesis: a two-time comparison.

    abstract:BACKGROUND:This study compares the effect of mild and severe cerebral ischemia on neuronal damage and neurogenesis. METHODS:Sixteen Sprague-Dawley rats, anesthetized with 0.8 vol% halothane in O(2)/air, were subjected to forebrain ischemia by bilateral common carotid artery occlusion plus hemorrhagic hypotension (mean...

    journal_title:Neurocritical care

    pub_type: 杂志文章


    authors: Winkelheide U,Engelhard K,Kaeppel B,Winkler J,Hutzler P,Werner C,Kochs E

    更新日期:2008-01-01 00:00:00