Osmotic therapy: fact and fiction.

Abstract:

:This review examines the available data on the use of osmotic agents in patients with head injury and ischemic stroke, summarizes the physiological effects of osmotic agents, and presents the leading hypotheses regarding the mechanism by which they reduce ICP. Finally, it addresses the validity of the following commonly held beliefs: mannitol accumulates in injured brain; mannitol shrinks only normal brain and can increase midline shift; osmolality can be used to monitor mannitol administration; mannitol should be not be administered if osmolality is >320 mOsm; and hypertonic saline is equally effective as mannitol.

journal_name

Neurocrit Care

journal_title

Neurocritical care

authors

Diringer MN,Zazulia AR

doi

10.1385/NCC:1:2:219

keywords:

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

219-33

issue

2

eissn

1541-6933

issn

1556-0961

pii

NCC:1:2:219

journal_volume

1

pub_type

杂志文章,评审
  • Blood Pressure Guideline Adherence in Patients with Ischemic and Hemorrhagic Stroke in the Neurointensive Care Unit Setting.

    abstract:BACKGROUND AND PURPOSE:Patients with acute brain injuries require strict physiologic control to minimize morbidity and mortality. This study aimed to assess in-hospital compliance to strict physiologic parameters (BP, HR, ICP, SpO2) in these populations. METHODS:Patients with severe cerebrovascular events were admitte...

    journal_title:Neurocritical care

    pub_type: 杂志文章

    doi:10.1007/s12028-015-0116-y

    authors: Porto GB,Spiotta AM,Chalela JA,Kellogg RT,Jauch EC

    更新日期:2015-12-01 00:00:00

  • A device for fast mechanical clot retrieval from intracranial arteries (Phenox clot retriever).

    abstract:INTRODUCTION:To describe a new device meant for rapid endovascular thrombectomy of intracranial arteries of various sizes and its first clinical use. METHODS:A device with oriented microfilaments was constructed that consists of a core wires compound surrounded by a dense palisade of perpendicular-oriented stiff polya...

    journal_title:Neurocritical care

    pub_type: 杂志文章

    doi:10.1385/NCC:5:2:134

    authors: Henkes H,Reinartz J,Lowens S,Miloslavski E,Roth C,Reith W,Kühne D

    更新日期:2006-01-01 00:00:00

  • Postpartum trifecta: simultaneous eclamptic intracerebral hemorrhage, PRES, and herniation due to intracranial hypotension.

    abstract:BACKGROUND:In the postpartum patient, sudden depression of consciousness may be caused by a number of etiologies and can result in serious consequences. Rapid, accurate diagnosis allows for specific treatments that optimize outcome, but diagnosis can be challenging in this population. We present a case of postpartum he...

    journal_title:Neurocritical care

    pub_type: 杂志文章

    doi:10.1007/s12028-012-9742-9

    authors: Orehek EK,Burns JD,Koyfman F,Azocar RJ,Holsapple JW,Green DM

    更新日期:2012-12-01 00:00:00

  • Prediction of poor outcome in cerebellar infarction by diffusion MRI.

    abstract:OBJECTIVE:Identification of patients with posterior fossa infarction at risk for neurological deterioration remains a challenge. MRI-based assessments of MCA infarction can predict poor outcome. Similar quantitative imaging measures after cerebellar stroke have not been studied. We tested the hypothesis that MRI-based ...

    journal_title:Neurocritical care

    pub_type: 杂志文章

    doi:10.1007/s12028-013-9886-2

    authors: Tchopev Z,Hiller M,Zhuo J,Betz J,Gullapalli R,Sheth KN

    更新日期:2013-12-01 00:00:00

  • An unsuccessful trial of immunomodulatory therapy in delayed posthypoxic demyelination.

    abstract:INTRODUCTION:Delayed posthypoxic demyelination may rarely complicate an episode of severe hypoxia, with or without exposure to carbon monoxide. Following recovery from initial coma, progressive neurologic deterioration ensues with outcomes ranging from death to full recovery. Delayed posthypoxic demyelination is hypoth...

    journal_title:Neurocritical care

    pub_type: 杂志文章

    doi:10.1007/s12028-007-0044-6

    authors: Khot S,Walker M,Lacy JM,Oakes P,Longstreth WT Jr

    更新日期:2007-01-01 00:00:00

  • Cerebral regional oxygen saturation and serum neuromarkers for the prediction of adverse neurologic outcome in pediatric cardiac surgery.

    abstract:BACKGROUND:The aim of this study is to determine the utility of non-invasive bedside neuromonitoring, including cerebral regional oxygen saturation (rSO2) measured by near-infrared spectroscopy and serum biomarkers, in identifying children at risk from adverse neurological outcome after heart surgery. METHODS:Prospect...

    journal_title:Neurocritical care

    pub_type: 杂志文章

    doi:10.1007/s12028-013-9934-y

    authors: Sanchez-de-Toledo J,Chrysostomou C,Munoz R,Lichtenstein S,Sao-Avilés CA,Wearden PD,Morell VO,Clark RS,Toney N,Bell MJ

    更新日期:2014-08-01 00:00:00

  • The contrecoup-coup phenomenon: a new understanding of the mechanism of closed head injury.

    abstract::A common observation in closed head injuries is the contrecoup brain injury. As the in vivo brain is less dense than the cerebrospinal fluid (CSF), one hypothesis explaining this observation is that upon skull impact, the denser CSF moves toward the site of skull impact displacing the brain in the opposite direction, ...

    journal_title:Neurocritical care

    pub_type: 杂志文章

    doi:10.1385/NCC:1:3:385

    authors: Drew LB,Drew WE

    更新日期:2004-01-01 00:00:00

  • New Approaches to Critical Illness Polyneuromyopathy: High-Resolution Neuromuscular Ultrasound Characteristics and Cytokine Profiling.

    abstract:BACKGROUND:Diagnosis of intensive care unit acquired weakness (ICUAW) is challenging. Pathogenesis of underlying critical illness polyneuromyopathy (CIPNM) remains incompletely understood. This exploratory study investigated whether longitudinal neuromuscular ultrasound examinations and cytokine analyses in correlation...

    journal_title:Neurocritical care

    pub_type: 杂志文章

    doi:10.1007/s12028-020-01148-2

    authors: Fisse AL,May C,Motte J,Pedreiturria X,Breuer TGK,Schneider-Gold C,Marcus K,Gold R,Yoon MS,Pitarokoili K

    更新日期:2020-11-24 00:00:00

  • ABO Blood Type and Hematoma Expansion After Intracerebral Hemorrhage: An Exploratory Analysis.

    abstract:BACKGROUND/PURPOSE:Blood type has become an increasingly recognized risk factor for coagulopathy. We explored the association between blood type and hematoma expansion (HE) after intracerebral hemorrhage (ICH). METHODS:Spontaneous ICH patients prospectively enrolled in an ongoing ICH cohort study at Columbia Universit...

    journal_title:Neurocritical care

    pub_type: 杂志文章

    doi:10.1007/s12028-018-0655-0

    authors: Roh D,Martin A,Sun CH,Eisenberger A,Boehme A,Elkind MSV,Pucci JU,Murthy S,Kamel H,Sansing L,Park S,Agarwal S,Connolly ES,Claassen J,Hod E,Francis RO

    更新日期:2019-08-01 00:00:00

  • Ventriculo-lumbar perfusion in acute ischemic stroke.

    abstract:INTRODUCTION:Effective treatment for severe ischemic stroke continues to be largely an unmet medical need. Using a nonvascular (paravascular cerebrospinal fluid) pathway to provide oxygen and nutrients to ischemic tissues may be a means of treating this disease. The primary objective of this study was to evaluate the s...

    journal_title:Neurocritical care

    pub_type: 杂志文章

    doi:10.1385/NCC:5:1:21

    authors: Bell RD,Powers BL,Brock D,Provencio JJ,Flanders A,Benetiz R,Rosenwasser R,Strause J,Frazer G,Kramer MS,Hesson D,Barnitz J,Osterholm JL

    更新日期:2006-01-01 00:00:00

  • Expansion-Prone Hematoma: Defining a Population at High Risk of Hematoma Growth and Poor Outcome.

    abstract:BACKGROUND:Noncontrast computed tomography (CT) markers are increasingly used for predicting hematoma expansion. The aim of our study was to investigate the predictive value of expansion-prone hematoma in predicting hematoma expansion and outcome in patients with intracerebral hemorrhage (ICH). METHODS:Between July 20...

    journal_title:Neurocritical care

    pub_type: 杂志文章

    doi:10.1007/s12028-018-0644-3

    authors: Li Q,Shen YQ,Xie XF,Xue MZ,Cao D,Yang WS,Li R,Deng L,Wei M,Lv FJ,Wu GF,Tang ZP,Xie P

    更新日期:2019-06-01 00:00:00

  • Acute Brain Diseases as Triggers for Stress Cardiomyopathy: Clinical Characteristics and Outcomes.

    abstract:OBJECTIVE:To determine the clinical characteristics and outcomes of patients with neurogenic stress cardiomyopathy (NSC) among patients admitted to our neuroscience intensive care unit (NICU). METHODS:Following institutional review board approval, consecutive adult patients admitted to the NICU between 2009 and 2013 w...

    journal_title:Neurocritical care

    pub_type: 杂志文章

    doi:10.1007/s12028-017-0412-9

    authors: Nasr DM,Tomasini S,Prasad A,Rabinstein AA

    更新日期:2017-12-01 00:00:00

  • Surgical treatment of space occupying edema and hemorrhage due to cerebral venous thrombosis during pregnancy.

    abstract:BACKGROUND:During late pregnancy and the puerperium cerebral venous and sinus thrombosis (CVST) is a rare but important cause of stroke. Despite adequate anticoagulation some patients deteriorate, which may warrant the use of more aggressive treatment modalities. CASE REPORT:A 29-year-old pregnant woman (29th week of ...

    journal_title:Neurocritical care

    pub_type: 杂志文章

    doi:10.1007/s12028-010-9389-3

    authors: Ebke M,Jürgens KU,Tomandl B,Merten U,Kastrup A

    更新日期:2011-08-01 00:00:00

  • Significance of a reduced cerebral blood flow during the first 12 hours after traumatic brain injury.

    abstract:BACKGROUND:It is controversial whether a low cerebral blood flow (CBF) simply reflects the severity of injury or whether ischemia contributes to the brain's injury. It is also not clear whether posttraumatic cerebral hypoperfusion results from intracranial hypertension or from pathologic changes of the cerebral vascula...

    journal_title:Neurocritical care

    pub_type: 杂志文章

    doi:10.1385/NCC:1:1:69

    authors: Hlatky R,Contant CF,Diaz-Marchan P,Valadka AB,Robertson CS

    更新日期:2004-01-01 00:00:00

  • Neurologic outcomes from high risk descending thoracic and thoracoabdominal aortic operations in the era of endovascular repair.

    abstract:INTRODUCTION:Spinal cord ischemia and stroke are recognized complications of descending thoracic (DTA) and thoracoabdominal aortic (TAA) operations. However, there are limited data available on outcomes since the advent of thoracic endovascular aortic repair (TEVAR). METHODS:We reviewed charts from consecutive patient...

    journal_title:Neurocritical care

    pub_type: 杂志文章

    doi:10.1007/s12028-008-9104-9

    authors: Messé SR,Bavaria JE,Mullen M,Cheung AT,Davis R,Augoustides JG,Gutsche J,Woo EY,Szeto WY,Pochettino A,Woo YJ,Kasner SE,McGarvey M

    更新日期:2008-01-01 00:00:00

  • Blood pressure regulation to prevent progression of blunt traumatic intracranial hemorrhage in stable patients.

    abstract:BACKGROUND:Target blood pressure (BP) in stable (non-hypotensive) patients with acute isolated blunt traumatic intracranial hemorrhage (TICH) is unknown. To address this issue, our study correlated BP with radiological volumetric progression (RP) and neurological deterioration (ND) in these patients. METHODS:A retrosp...

    journal_title:Neurocritical care

    pub_type: 杂志文章

    doi:10.1007/s12028-014-9957-z

    authors: Bugaev N,Al-Hazmi M,Allcorn M,Arabian SS,Riesenburger R,Safain M,Burke S,Colangelo A,Rabinovici R

    更新日期:2014-08-01 00:00:00

  • Effect of prolonged therapeutic hypothermia on intracranial pressure, organ function, and hospital outcomes among patients with aneurysmal subarachnoid hemorrhage.

    abstract:BACKGROUND:Global cerebral edema (GCE) with subsequent refractory intracranial hypertension complicates some cases of aneurysmal subarachnoid hemorrhage (aSAH), and typically is associated with poorer outcome. Treatment options for refractory intracranial pressure (ICP) cases are limited to decompressive hemicraniectom...

    journal_title:Neurocritical care

    pub_type: 杂志文章

    doi:10.1007/s12028-014-9989-4

    authors: Karnatovskaia LV,Lee AS,Festic E,Kramer CL,Freeman WD

    更新日期:2014-12-01 00:00:00

  • Informatics for neurocritical care: challenges and opportunities.

    abstract::Neurocritical care relies on the continuous, real-time measurement of numerous physiologic parameters. While our capability to obtain such measurements from patients has grown markedly with multimodal monitoring in many neurologic or neurosurgical intensive care units (ICUs), our ability to transform the raw data into...

    journal_title:Neurocritical care

    pub_type: 杂志文章,评审

    doi:10.1007/s12028-013-9872-8

    authors: Sivaganesan A,Manley GT,Huang MC

    更新日期:2014-02-01 00:00:00

  • Intrathecal saline infusion: an emergency procedure in a patient with spontaneous intracranial hypotension.

    abstract:BACKGROUND:Spontaneous intracranial hypotension (SIH) is a neurologic condition with the prototypical symptom of orthostatic headache. We report a dramatic case of SIH with life-threatening bilateral hygroma and uncal herniation. METHODS:Case report. RESULTS:A 44-year-old male patient presenting with orthostatic head...

    journal_title:Neurocritical care

    pub_type: 杂志文章

    doi:10.1007/s12028-012-9783-0

    authors: Sass C,Kosinski C,Schmidt P,Mull M,Schulz J,Schiefer J

    更新日期:2013-08-01 00:00:00

  • Therapy of intracranial hypertension in patients with fulminant hepatic failure.

    abstract::Severe intracranial hypertension (IH) in the setting of fulminant hepatic failure (FHF) carries a high mortality and is a challenging disease for the critical care provider. Despite considerable improvements in the understanding of the pathophysiology of cerebral edema during liver failure, therapeutic maneuvers that ...

    journal_title:Neurocritical care

    pub_type: 杂志文章,评审

    doi:10.1385/NCC:4:2:179

    authors: Raghavan M,Marik PE

    更新日期:2006-01-01 00:00:00

  • Boomerang sign on MRI.

    abstract:INTRODUCTION:Altered mental status and more subtle cognitive and personality changes after traumatic brain injury (TBI) are pervasive problems in patients who survive initial injury. MRI is not necessarily part of the diagnostic evaluation of these patients. METHODS:Case report with relevant image and review of the li...

    journal_title:Neurocritical care

    pub_type: 杂志文章,评审

    doi:10.1007/s12028-012-9699-8

    authors: Hirsch KG,Hoesch RE

    更新日期:2012-06-01 00:00:00

  • Terson's syndrome.

    abstract:BACKGROUND:Terson's syndrome is intraocular hemorrhage (IOH) subsequent to subarachnoid hemorrhage (SAH). Its presence is associated with higher mortality in SAH. We report a case of Terson's syndrome and review the literature. CASE REPORT:A 71-year-old Caucasian gentleman collapsed and became comatose. Past medical h...

    journal_title:Neurocritical care

    pub_type: 杂志文章,评审

    doi:10.1007/s12028-011-9555-2

    authors: Hassan A,Lanzino G,Wijdicks EF,Rabinstein AA,Flemming KD

    更新日期:2011-12-01 00:00:00

  • Cefepime-induced nonconvulsive status epilepticus: case report and review.

    abstract:INTRODUCTION:A case of cefepime-induced nonconvulsive status epilepticus in a 15-year-old child with end stage renal disease on hemodialysis is reported. Clinical symptoms and EEG dramatically improved 48 h after discontinuation of cefepime. METHODS:Twenty-five cases of nonconvulsive status epilepticus associated with...

    journal_title:Neurocritical care

    pub_type: 杂志文章,评审

    doi:10.1007/s12028-008-9166-8

    authors: Thabet F,Al Maghrabi M,Al Barraq A,Tabarki B

    更新日期:2009-01-01 00:00:00

  • Delayed emergence from anesthesia associated with absent brainstem reflexes following suboccipital craniotomy.

    abstract::One of the most feared complications after intracranial surgery is development of acute intracranial pathology, which may result in hypoperfusion and brain injury. Thus, early neurological assessment, performed in the operating room immediately after emergence from anesthesia, is a practice that may contribute to time...

    journal_title:Neurocritical care

    pub_type: 杂志文章

    doi:10.1385/NCC:5:3:206

    authors: Munis JR,Marcukaitis AW,Sprung J

    更新日期:2006-01-01 00:00:00

  • Serum neuron-specific enolase levels from the same patients differ between laboratories: assessment of a prospective post-cardiac arrest cohort.

    abstract:BACKGROUND:In comatose post-cardiac arrest patients, a serum neuron-specific enolase (NSE) level of >33 μg/L within 72 h was identified as a reliable marker for poor outcome in a large Dutch study (PROPAC), and this level was subsequently adopted in an American Academy of Neurology practice parameter. Later studies rep...

    journal_title:Neurocritical care

    pub_type: 杂志文章

    doi:10.1007/s12028-013-9867-5

    authors: Mlynash M,Buckwalter MS,Okada A,Caulfield AF,Venkatasubramanian C,Eyngorn I,Verbeek MM,Wijman CA

    更新日期:2013-10-01 00:00:00

  • Bilateral internal carotid artery occlusions resulting in near total acute brain infraction.

    abstract:INTRODUCTION:Acute bilateral acute carotid arteries occlusion is a very rare condition. We describe a patient with initial right middle cerebral artery syndrome who developed coma and quadriplegia 1 h after thrombolysis with intravenous tPA and was found to have bilateral cervical internal carotid artery occlusion. ...

    journal_title:Neurocritical care

    pub_type: 杂志文章

    doi:10.1007/s12028-007-0076-y

    authors: Zubkov AY,Klassen BT,Burnett MS,Rabinstein AA

    更新日期:2007-01-01 00:00:00

  • Continuous brain tissue oxygenation monitoring in the management of pediatric stroke.

    abstract:BACKGROUND:Direct invasive monitoring of brain tissue oxygenation (PbtO(2)) has been routinely utilized to predict cerebral ischemia and to prevent secondary injury in patients with traumatic brain injury (TBI) and vasospasm secondary to subarachnoid hemorrhage (SAH). The safety and utility of these devices in the pedi...

    journal_title:Neurocritical care

    pub_type: 杂志文章

    doi:10.1007/s12028-011-9531-x

    authors: Allen BB,Hoffman CE,Traube CS,Weinstein SL,Greenfield JP

    更新日期:2011-12-01 00:00:00

  • External Validation of Hematoma Expansion Scores in Spontaneous Intracerebral Hemorrhage in an Asian Patient Cohort.

    abstract:BACKGROUND:Hematoma expansion (HE) occurs in approximately one-third of patients with intracerebral hemorrhage (ICH) and is known to be a strong predictor of neurological deterioration as well as poor functional outcome. This study aims to externally validate three risk prediction models of HE (PREDICT, 9-point, and BR...

    journal_title:Neurocritical care

    pub_type: 杂志文章

    doi:10.1007/s12028-018-0631-8

    authors: Lim JX,Han JX,See AAQ,Lew VH,Chock WT,Ban VF,Pothiawala S,Lim WEH,McAdory LE,James ML,King NKK

    更新日期:2019-04-01 00:00:00

  • A pilot study of fibreoptic endoscopic evaluation of swallowing in patients with cuffed tracheostomies in neurological intensive care.

    abstract:INTRODUCTION:Patients on neurological intensive care units (NICU) who require ventilatory support often suffer from co-existing bulbar dysfunction, either because of their underlying disease or because of their decreased level of consciousness. For this reason, most patients are ventilated through a cuffed tracheostomy...

    journal_title:Neurocritical care

    pub_type: 临床试验,杂志文章

    doi:10.1007/s12028-007-0024-x

    authors: McGowan SL,Gleeson M,Smith M,Hirsch N,Shuldham CM

    更新日期:2007-01-01 00:00:00

  • Treatment outcomes of heparin-induced thrombocytopenia in subarachnoid hemorrhage patients: a 4-year, retrospective single-center review.

    abstract:INTRODUCTION:The treatment and outcomes of heparin-induced thrombocytopenia (HIT) are not well described in neurosurgery patients. This study reviewed the treatment for HIT in subarachnoid hemorrhage (SAH) patients, and compared outcomes in patients with isolated HIT (iHIT) and HIT with thrombotic syndrome (HITTS). ME...

    journal_title:Neurocritical care

    pub_type: 杂志文章

    doi:10.1007/s12028-012-9725-x

    authors: Benken ST,Tesoro EP,Kim KS,Mucksavage JJ

    更新日期:2012-10-01 00:00:00