Abstract：
INTRODUCTION:Delayed posthypoxic demyelination may rarely complicate an episode of severe hypoxia, with or without exposure to carbon monoxide. Following recovery from initial coma, progressive neurologic deterioration ensues with outcomes ranging from death to full recovery. Delayed posthypoxic demyelination is hypothesized to be immunemediated, with support coming from recent animal experiments. METHODS:We report a 46-year-old man who developed progressive cognitive deficits with abulia approximately 3 weeks after recovering from coma related to alcohol and morphine intoxication. RESULTS:Despite treatment with high-dose steroids and plasmapheresis, he continued to deteriorate and remained in a vegetative state until his death under hospice care more than 2 months after his initial hypoxic insult. Serial brain imaging and postmortem examination showed bilateral necrosis of the globi pallidi and extensive demyelination in the centrum semiovale and corona radiata. CONCLUSIONS:Based on an immune-mediated model of disease and given a lack of effective treatments, future use of immunomodulatory therapy may still be worth considering early in the course of this rare and potentially devastating condition.
journal_name
Neurocrit Carejournal_title
Neurocritical careauthors
Khot S,Walker M,Lacy JM,Oakes P,Longstreth WT Jrdoi
10.1007/s12028-007-0044-6subject
Has Abstractpub_date
2007-01-01 00:00:00pages
253-6issue
3eissn
1541-6933issn
1556-0961journal_volume
7pub_type
杂志文章abstract：BACKGROUND:In the postpartum patient, sudden depression of consciousness may be caused by a number of etiologies and can result in serious consequences. Rapid, accurate diagnosis allows for specific treatments that optimize outcome, but diagnosis can be challenging in this population. We present a case of postpartum he...
journal_title：Neurocritical care
pub_type： 杂志文章
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journal_title：Neurocritical care
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doi：10.1007/s12028-020-01026-x
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journal_title：Neurocritical care
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journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-013-9935-x
更新日期：2014-06-01 00:00:00
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journal_title：Neurocritical care
pub_type： 杂志文章,评审
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更新日期：2012-06-01 00:00:00
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journal_title：Neurocritical care
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doi：10.1007/s12028-014-0072-y
更新日期：2015-08-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s12028-012-9673-5
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journal_title：Neurocritical care
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journal_title：Neurocritical care
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更新日期：2013-02-01 00:00:00
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journal_title：Neurocritical care
pub_type： 杂志文章,随机对照试验
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更新日期：2017-04-01 00:00:00
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journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1385/NCC:5:1:21
更新日期：2006-01-01 00:00:00
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pub_type： 临床试验,杂志文章
doi：10.1007/s12028-014-0004-x
更新日期：2014-10-01 00:00:00
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journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-007-0066-0
更新日期：2007-01-01 00:00:00
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pub_type： 杂志文章,随机对照试验
doi：10.1007/s12028-010-9331-8
更新日期：2010-06-01 00:00:00
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journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-015-0138-5
更新日期：2015-12-01 00:00:00
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journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-009-9251-7
更新日期：2009-12-01 00:00:00
abstract：BACKGROUND:The natural history of cerebral aneurysms derived from metastatic spread of cardiac myxomas is not well known, and their management presents many dilemmas. METHODS:Case report and literature review. RESULTS:An 18-year-old man presented with an intraparenchymal hemorrhage several months after resection of a...
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pub_type： 杂志文章
doi：10.1007/s12028-010-9400-z
更新日期：2010-10-01 00:00:00
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更新日期：2020-10-01 00:00:00
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pub_type： 杂志文章
doi：10.1385/NCC:1:4:461
更新日期：2004-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2011-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：2012-02-01 00:00:00
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pub_type： 杂志文章
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更新日期：2020-04-01 00:00:00
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pub_type： 杂志文章,多中心研究
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更新日期：2017-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：2011-12-01 00:00:00
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journal_title：Neurocritical care
pub_type： 杂志文章
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更新日期：2016-12-01 00:00:00
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