A Novel Cooling Device for Targeted Brain Temperature Control and Therapeutic Hypothermia: Feasibility Study in an Animal Model.

Abstract:

BACKGROUND:Therapeutic hypothermia (i.e., temperature management) is an effective option for improving survival and neurological outcome after cardiac arrest and is potentially useful for the care of the critically ill neurological patient. We analyzed the feasibility of a device to control the temperature of the brain by controlling the temperature of the blood flowing through the neck. METHODS:A lumped parameter dynamic model, with one-dimensional heat transfer, was used to predict cooling effects and to test experimental hypotheses. The cooling system consisted of a flexible collar and was tested on 4 adult sheep, in which brain and body temperatures were invasively monitored for the duration of the experiment. RESULTS:Model-based simulations predicted a lowering of the temperature of the brain and the body following the onset of cooling, with a rate of 0.4 °C/h for the brain and 0.2 °C/h for the body. The experimental findings showed comparable cooling rates in the two body compartments, with temperature reductions of 0.6 (0.2) °C/h for the brain and 0.6 (0.2) °C/h for the body. For a 70 kg adult human subject, we predict a temperature reduction of 0.64 °C/h for the brain and 0.43 °C/h for the body. CONCLUSIONS:This work demonstrates the feasibility of using a non-invasive method to induce brain hypothermia using a portable collar. This device demonstrated an optimal safety profile and represents a potentially useful method for the administration of mild hypothermia and temperature control (i.e., treatment of hyperpyrexia) in cardiac arrest and critically ill neurologic patients.

journal_name

Neurocrit Care

journal_title

Neurocritical care

authors

Giuliani E,Magnoni S,Fei M,Addis A,Zanasi R,Stocchetti N,Barbieri A

doi

10.1007/s12028-016-0257-7

subject

Has Abstract

pub_date

2016-12-01 00:00:00

pages

464-472

issue

3

eissn

1541-6933

issn

1556-0961

pii

10.1007/s12028-016-0257-7

journal_volume

25

pub_type

杂志文章
  • Electroencephalography in survivors of cardiac arrest: comparing pre- and post-therapeutic hypothermia eras.

    abstract::Electroencephalography in the setting of hypothermia and anoxia has been studied in humans since the 1950s. Specific patterns after cardiac arrest have been associated with prognosis since the 1960s, with several prognostic rating scales developed in the second half of the twentieth century. In 2002, two pivotal clini...

    journal_title:Neurocritical care

    pub_type: 杂志文章,评审

    doi:10.1007/s12028-014-0018-4

    authors: Crepeau AZ,Britton JW,Fugate JE,Rabinstein AA,Wijdicks EF

    更新日期:2015-02-01 00:00:00

  • Osmotic therapy: fact and fiction.

    abstract::This review examines the available data on the use of osmotic agents in patients with head injury and ischemic stroke, summarizes the physiological effects of osmotic agents, and presents the leading hypotheses regarding the mechanism by which they reduce ICP. Finally, it addresses the validity of the following common...

    journal_title:Neurocritical care

    pub_type: 杂志文章,评审

    doi:10.1385/NCC:1:2:219

    authors: Diringer MN,Zazulia AR

    更新日期:2004-01-01 00:00:00

  • Incidence of Antithrombin Deficiency and Anti-Cardiolipin Antibodies After Severe Traumatic Brain Injury: A Prospective Cohort Study.

    abstract:BACKGROUND:Animal studies suggested that cerebral mitochondrial cardiolipin phospholipids were released after severe traumatic brain injury (TBI), contributing to the pathogenesis of thromboembolism. OBJECTIVES:To determine the incidence of anti-cardiolipin antibodies after severe TBI and whether this was related to t...

    journal_title:Neurocritical care

    pub_type: 杂志文章

    doi:10.1007/s12028-020-01026-x

    authors: Kalgudi S,Ho KM

    更新日期:2020-06-18 00:00:00

  • Statins in the management of patients with aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis.

    abstract:BACKGROUND:Delayed ischemic neurological deficits (DINDs) contribute to morbidity and mortality following aneurysmal subarachnoid hemorrhage (SAH). Based on promising preliminary reports, some clinicians routinely administer statins to prevent DINDs. METHODS:Without language restriction, we searched MEDLINE, EMBASE, t...

    journal_title:Neurocritical care

    pub_type: 杂志文章,meta分析,评审

    doi:10.1007/s12028-009-9306-9

    authors: Kramer AH,Fletcher JJ

    更新日期:2010-04-01 00:00:00

  • Seizures among long-term survivors of conservatively treated ICH patients: incidence, risk factors, and impact on functional outcome.

    abstract:BACKGROUND:Seizures are a common complication after intracerebral hemorrhage (ICH) but there is a substantial lack of information on the long-term incidence in ICH survivors and whether post-ICH seizures affect functional long-term outcome. METHODS:Over a five-year period 464 consecutive patients with spontaneous ICH ...

    journal_title:Neurocritical care

    pub_type: 杂志文章

    doi:10.1007/s12028-014-9968-9

    authors: Madžar D,Kuramatsu JB,Gollwitzer S,Lücking H,Kloska SP,Hamer HM,Köhrmann M,Huttner HB

    更新日期:2014-10-01 00:00:00

  • Monitoring of brain and systemic oxygenation in neurocritical care patients.

    abstract::Maintenance of adequate oxygenation is a mainstay of intensive care, however, recommendations on the safety, accuracy, and the potential clinical utility of invasive and non-invasive tools to monitor brain and systemic oxygenation in neurocritical care are lacking. A literature search was conducted for English languag...

    journal_title:Neurocritical care

    pub_type: 杂志文章,评审

    doi:10.1007/s12028-014-0024-6

    authors: Oddo M,Bösel J,Participants in the International Multidisciplinary Consensus Conference on Multimodality Monitoring.

    更新日期:2014-12-01 00:00:00

  • The role of neurosurgery in status epilepticus.

    abstract:INTRODUCTION:Status epilepticus remains a life-threatening condition that afflicts both adults and children which although occurs in patients with epilepsy, often presents as new-onset seizure activity also. Refractory status epilepticus poses a management challenge for neurological and neurosurgical teams. CASE REPOR...

    journal_title:Neurocritical care

    pub_type: 杂志文章

    doi:10.1007/s12028-007-0038-4

    authors: Ng YT,Bristol RE,Schrader DV,Smith KA

    更新日期:2007-01-01 00:00:00

  • Effect of Desmopressin on Platelet Dysfunction During Antiplatelet Therapy: A Systematic Review.

    abstract:BACKGROUND AND OBJECTIVE:An increasing number of patients receive antiplatelet therapy. Patients exposed to surgery while receiving platelet inhibitors hold an increased bleeding risk. Especially in neurosurgery and neurocritical care patients, bleeding and hematoma expansion are feared complications as even minor blee...

    journal_title:Neurocritical care

    pub_type: 杂志文章,评审

    doi:10.1007/s12028-020-01055-6

    authors: Andersen LK,Hvas AM,Hvas CL

    更新日期:2020-08-04 00:00:00

  • Cerebrovascular events after bevacizumab treatment: an early and severe complication.

    abstract:BACKGROUND:The indications for bevacizumab (a vascular endothelial growth factor inhibitor) have been expanded recently. Despite concerns for cerebrovascular events from bevacizumab treatment, detailed clinical and radiologic information are lacking. METHODS:Using the Mayo Clinic Rochester database (January 2006-Septe...

    journal_title:Neurocritical care

    pub_type: 杂志文章

    doi:10.1007/s12028-011-9552-5

    authors: Seet RC,Rabinstein AA,Lindell PE,Uhm JH,Wijdicks EF

    更新日期:2011-12-01 00:00:00

  • Neuromonitoring in neurological critical care.

    abstract::In this article, we review technologies available for direct monitoring of cerebral oxygenation and metabolic status, including jugular venous oxygen saturation, brain tissue oxygen tension, transcranial cerebral oximetry with near-infrared spectroscopy, Positron emission tomography oxidative metabolism, single-photon...

    journal_title:Neurocritical care

    pub_type: 杂志文章,评审

    doi:10.1385/ncc:4:1:083

    authors: Dunn IF,Ellegala DB,Kim DH,Litvack ZN,Brigham and Women's Hospital Neurosurgery Group.

    更新日期:2006-01-01 00:00:00

  • Neuromuscular and neuropsychological assessments in survivors of acute respiratory distress syndrome: exploratory comparisons with an at-risk cohort.

    abstract:BACKGROUND:Long-term studies of survivors of acute respiratory distress syndrome (ARDS) have reported neuromuscular, quality of life, and neuropsychological impairments. This study aims to determine if development of ARDS was associated with neuromuscular weakness and depression at 6-month following hospital discharge ...

    journal_title:Neurocritical care

    pub_type: 杂志文章

    doi:10.1007/s12028-014-0087-4

    authors: Ofoma UR,Reriani MK,Biehl M,Kashyap R,Ahmed AH,Rabinstein AA,Gajic O

    更新日期:2015-06-01 00:00:00

  • Brain resuscitation in the drowning victim.

    abstract::Drowning is a leading cause of accidental death. Survivors may sustain severe neurologic morbidity. There is negligible research specific to brain injury in drowning making current clinical management non-specific to this disorder. This review represents an evidence-based consensus effort to provide recommendations fo...

    journal_title:Neurocritical care

    pub_type: 杂志文章,评审

    doi:10.1007/s12028-012-9747-4

    authors: Topjian AA,Berg RA,Bierens JJ,Branche CM,Clark RS,Friberg H,Hoedemaekers CW,Holzer M,Katz LM,Knape JT,Kochanek PM,Nadkarni V,van der Hoeven JG,Warner DS

    更新日期:2012-12-01 00:00:00

  • Treatment outcomes of heparin-induced thrombocytopenia in subarachnoid hemorrhage patients: a 4-year, retrospective single-center review.

    abstract:INTRODUCTION:The treatment and outcomes of heparin-induced thrombocytopenia (HIT) are not well described in neurosurgery patients. This study reviewed the treatment for HIT in subarachnoid hemorrhage (SAH) patients, and compared outcomes in patients with isolated HIT (iHIT) and HIT with thrombotic syndrome (HITTS). ME...

    journal_title:Neurocritical care

    pub_type: 杂志文章

    doi:10.1007/s12028-012-9725-x

    authors: Benken ST,Tesoro EP,Kim KS,Mucksavage JJ

    更新日期:2012-10-01 00:00:00

  • Human albumin administration in subarachnoid hemorrhage: results of an international survey.

    abstract:BACKGROUND:Subarachnoid hemorrhage (SAH) is a devastating disease. Nimodipine is the only medical treatment shown to improve outcome of SAH patients. Human albumin (ALB) may exert neuroprotection in SAH. However, current usage of ALB in SAH is not known. We conducted an international survey of clinicians involved in th...

    journal_title:Neurocritical care

    pub_type: 杂志文章

    doi:10.1007/s12028-013-9942-y

    authors: Suarez JI,Martin RH,Calvillo E,Zygun D,Flower O,Wong GK,Bershad EM,Venkatasubba Rao CP,Georgiadis A,Jichici D,Leroux PD

    更新日期:2014-04-01 00:00:00

  • Diagnostic Accuracy of Procalcitonin for Early Aspiration Pneumonia in Critically Ill Patients with Coma: A Prospective Study.

    abstract:BACKGROUND:Early diagnostic orientation for differentiating pneumonia from pneumonitis at the early stage after aspiration would be valuable to avoid unnecessary antibiotic therapy. We assessed the accuracy of procalcitonin (PCT) in diagnosing aspiration pneumonia (AP) in intensive care unit (ICU) patients requiring me...

    journal_title:Neurocritical care

    pub_type: 杂志文章

    doi:10.1007/s12028-018-0623-8

    authors: Legriel S,Grigoresco B,Martel P,Henry-Lagarrigue M,Lvovschi V,Troché G,Amara M,Jacq G,Bruneel F,Bernard M,Marinier A,Bedos JP,PCT INHAL study group.

    更新日期:2019-04-01 00:00:00

  • Correction to: The PET Sandwich: Using Serial FDG-PET Scans with Interval Burst Suppression to Assess Ictal Components of Disease.

    abstract::In the original article, Figure 5 has incorrect EEG images and the corrected version is shown below. ...

    journal_title:Neurocritical care

    pub_type: 杂志文章,已发布勘误

    doi:10.1007/s12028-020-00981-9

    authors: Akbik F,Robertson M,Das AS,Singhal T,Lee JW,Vaitkevicius H

    更新日期:2020-08-01 00:00:00

  • Amantadine and Modafinil as Neurostimulants During Post-stroke Care: A Systematic Review.

    abstract::Amantadine and modafinil are neurostimulants that may improve cognitive and functional recovery post-stroke, but the existing study results vary, and no comprehensive review has been published. This systematic review describes amantadine and modafinil administration practices post-stroke, evaluates timing and impact o...

    journal_title:Neurocritical care

    pub_type: 杂志文章,评审

    doi:10.1007/s12028-020-00977-5

    authors: Gagnon DJ,Leclerc AM,Riker RR,Brown CS,May T,Nocella K,Cote J,Eldridge A,Seder DB

    更新日期:2020-08-01 00:00:00

  • Postpartum trifecta: simultaneous eclamptic intracerebral hemorrhage, PRES, and herniation due to intracranial hypotension.

    abstract:BACKGROUND:In the postpartum patient, sudden depression of consciousness may be caused by a number of etiologies and can result in serious consequences. Rapid, accurate diagnosis allows for specific treatments that optimize outcome, but diagnosis can be challenging in this population. We present a case of postpartum he...

    journal_title:Neurocritical care

    pub_type: 杂志文章

    doi:10.1007/s12028-012-9742-9

    authors: Orehek EK,Burns JD,Koyfman F,Azocar RJ,Holsapple JW,Green DM

    更新日期:2012-12-01 00:00:00

  • Takotsubo cardiomyopathy associated with seizures.

    abstract:BACKGROUND:Takotsubo syndrome is a reversible neuromyocardial failure that has been thought to be related to an acute catecholamine toxicity of the myocardium brought upon by a stressful event. The neurocritical care unit population is particularly vulnerable for this condition given the acute presentation of neurologi...

    journal_title:Neurocritical care

    pub_type: 杂志文章

    doi:10.1007/s12028-008-9075-x

    authors: Lemke DM,Hussain SI,Wolfe TJ,Torbey MA,Lynch JR,Carlin A,Fitzsimmons BF,Zaidat OO

    更新日期:2008-01-01 00:00:00

  • Predictors of nosocomial pneumonia in intracerebral hemorrhage patients: a multi-center observational study.

    abstract:BACKGROUND:Nosocomial pneumonia (NP) is a frequent complication among spontaneous intracerebral hemorrhage (sICH) patients. This study was aimed at identifying in-hospital risk factors that predispose sICH patients to NP. METHODS:We identified 591 consecutive sICH subjects admitted to six tertiary care hospitals betwe...

    journal_title:Neurocritical care

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s12028-014-0065-x

    authors: Divani AA,Hevesi M,Pulivarthi S,Luo X,Souslian F,Suarez JI,Bershad EM

    更新日期:2015-04-01 00:00:00

  • Burst Suppression: Causes and Effects on Mortality in Critical Illness.

    abstract:BACKGROUND:Burst suppression in mechanically ventilated intensive care unit (ICU) patients is associated with increased mortality. However, the relative contributions of propofol use and critical illness itself to burst suppression; of burst suppression, propofol, and critical illness to mortality; and whether preventi...

    journal_title:Neurocritical care

    pub_type: 杂志文章

    doi:10.1007/s12028-020-00932-4

    authors: Hogan J,Sun H,Aboul Nour H,Jing J,Tabaeizadeh M,Shoukat M,Javed F,Kassa S,Edhi MM,Bordbar E,Gallagher J,Junior VM,Ghanta M,Shao YP,Akeju O,Cole AJ,Rosenthal ES,Zafar S,Westover MB

    更新日期:2020-10-01 00:00:00

  • Conivaptan, a Selective Arginine Vasopressin V1a and V2 Receptor Antagonist Attenuates Global Cerebral Edema Following Experimental Cardiac Arrest via Perivascular Pool of Aquaporin-4.

    abstract:BACKGROUND:Cerebral edema is a major cause of mortality following cardiac arrest (CA) and cardiopulmonary resuscitation (CPR). Arginine vasopressin (AVP) and water channel aquaporin-4 (AQP4) have been implicated in the pathogenesis of CA-evoked cerebral edema. In this study, we examined if conivaptan, a V1a and V2 anta...

    journal_title:Neurocritical care

    pub_type: 杂志文章

    doi:10.1007/s12028-015-0236-4

    authors: Nakayama S,Amiry-Moghaddam M,Ottersen OP,Bhardwaj A

    更新日期:2016-04-01 00:00:00

  • Continuous brain tissue oxygenation monitoring in the management of pediatric stroke.

    abstract:BACKGROUND:Direct invasive monitoring of brain tissue oxygenation (PbtO(2)) has been routinely utilized to predict cerebral ischemia and to prevent secondary injury in patients with traumatic brain injury (TBI) and vasospasm secondary to subarachnoid hemorrhage (SAH). The safety and utility of these devices in the pedi...

    journal_title:Neurocritical care

    pub_type: 杂志文章

    doi:10.1007/s12028-011-9531-x

    authors: Allen BB,Hoffman CE,Traube CS,Weinstein SL,Greenfield JP

    更新日期:2011-12-01 00:00:00

  • Argon Inhalation for 24 h After Closed-Head Injury Does not Improve Recovery, Neuroinflammation, or Neurologic Outcome in Mice.

    abstract:BACKGROUND/OBJECTIVE:In recent years, the noble gas argon (Ar) has been extensively studied for its organ protection properties. While mounting in vitro and in vivo evidence indicates that argon provides neuroprotection in ischemic brain injury, its neuroprotective potential in traumatic brain injury (TBI) has not been...

    journal_title:Neurocritical care

    pub_type: 杂志文章

    doi:10.1007/s12028-020-01104-0

    authors: Creed J,Cantillana-Riquelme V,Yan BH,Ma S,Chu D,Wang H,Turner DA,Laskowitz DT,Hoffmann U

    更新日期:2020-09-21 00:00:00

  • Prevention of Hypoxemia During Apnea Testing: A Comparison of Oxygen Insufflation And Continuous Positive Airway Pressure.

    abstract:BACKGROUND:Apnea testing is an essential step in the clinical diagnosis of brain death. Current international guidelines recommend placement of an oxygen (O2) insufflation catheter into the endotracheal tube to prevent hypoxemia, but use of a continuous positive airway pressure (CPAP) valve may be more effective at lim...

    journal_title:Neurocritical care

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s12028-017-0380-0

    authors: Kramer AH,Couillard P,Bader R,Dhillon P,Kutsogiannis DJ,Doig CJ

    更新日期:2017-08-01 00:00:00

  • Methylene blue-associated serotonin syndrome: a 'green' encephalopathy after parathyroidectomy.

    abstract:INTRODUCTION:Methylene blue (MB) infusion is frequently used to localize the parathyroid glands during parathyroidectomy and generally considered safe. Several recent reports suggest neurological toxicity and post-operative altered mental state typically after large dose infusions. The mechanism by which MB has neuroto...

    journal_title:Neurocritical care

    pub_type: 杂志文章

    doi:10.1007/s12028-009-9206-z

    authors: Rowley M,Riutort K,Shapiro D,Casler J,Festic E,Freeman WD

    更新日期:2009-01-01 00:00:00

  • The safety and feasibility of continuous intravenous magnesium sulfate for prevention of cerebral vasospasm in aneurysmal subarachnoid hemorrhage.

    abstract:INTRODUCTION:Cerebral vasospasm in aneurysmal subarachnoid hemorrhage (SAH) is associated with poor outcome. The safety and feasibility of continuous high-dose intravenous magnesium sulfate (MgSO4) for the prevention of cerebral vasospasm and ischemic cerebral injury has not been well studied. METHODS:Patients present...

    journal_title:Neurocritical care

    pub_type: 临床试验,杂志文章

    doi:10.1385/NCC:3:1:016

    authors: Yahia AM,Kirmani JF,Qureshi AI,Guterman LR,Hopkins LN

    更新日期:2005-01-01 00:00:00

  • Implementation of a model of robotic tele-presence (RTP) in the neuro-ICU: effect on critical care nursing team satisfaction.

    abstract:INTRODUCTION:Robotic tele-presence (RTP) is a form of mobile telemedicine, which enables a direct face-to-face rapid response by the physician, instead of the traditional telephonic paradigm. We hypothesized that a model of RTP for after-hour ICU rounds and emergencies would be associated with improved ICU nurse satisf...

    journal_title:Neurocritical care

    pub_type: 杂志文章

    doi:10.1007/s12028-012-9712-2

    authors: Rincon F,Vibbert M,Childs V,Fry R,Caliguri D,Urtecho J,Rosenwasser R,Jallo J

    更新日期:2012-08-01 00:00:00

  • CTA spot sign predicts hematoma expansion in patients with delayed presentation after intracerebral hemorrhage.

    abstract:BACKGROUND:Hematoma expansion after acute intracerebral hemorrhage occurs most frequently in patients presenting within 3 h of symptom onset. However, the majority of patients present outside this window or with an unknown onset time. We investigated the prevalence of hematoma expansion in these patients and assessed t...

    journal_title:Neurocritical care

    pub_type: 杂志文章

    doi:10.1007/s12028-012-9765-2

    authors: Brouwers HB,Falcone GJ,McNamara KA,Ayres AM,Oleinik A,Schwab K,Romero JM,Viswanathan A,Greenberg SM,Rosand J,Goldstein JN

    更新日期:2012-12-01 00:00:00

  • Lumbar drainage for subarachnoid hemorrhage: technical considerations and safety analysis.

    abstract:INTRODUCTION:Recent and on going clinical research trials may indicate that the incidence of vasospasm is less in patients treated with lumbar drains following SAH than with patients treated with external ventricular drainage (EVD) alone. These studies have sparked interest in the more aggressive use of LDs in patients...

    journal_title:Neurocritical care

    pub_type: 杂志文章

    doi:10.1007/s12028-007-0047-3

    authors: Hoekema D,Schmidt RH,Ross I

    更新日期:2007-01-01 00:00:00