Abstract：
BACKGROUND:In comatose post-cardiac arrest patients, a serum neuron-specific enolase (NSE) level of >33 μg/L within 72 h was identified as a reliable marker for poor outcome in a large Dutch study (PROPAC), and this level was subsequently adopted in an American Academy of Neurology practice parameter. Later studies reported that NSE >33 μg/L is not a reliable predictor of poor prognosis. To test whether different clinical laboratories contribute to this variability, we compared NSE levels from the laboratory used in the PROPAC study (DLM-Nijmegen) with those of our hospital's laboratory (ARUP) using paired blood samples. METHODS:We prospectively enrolled cardiac arrest patients who remained comatose after resuscitation. During the first 3 days, paired blood samples for serum NSE were drawn at a median of 10 min apart. After standard preparation for each lab, one sample was sent to ARUP laboratories and the other to DLM-Nijmegen. RESULTS:Fifty-four paired serum samples from 33 patients were included. Although the serum NSE measurements correlated well between laboratories (R = 0.91), the results from ARUP were approximately 30% lower than those from DLM-Nijmegen. Therapeutic hypothermia did not affect this relationship. Two patients had favorable outcomes after hypothermia despite NSE levels measured by DLM-Nijmegen as >33 μg/L. CONCLUSIONS:Absolute serum NSE levels of comatose cardiac arrest patients differ between laboratories. Any specific absolute cut-off levels proposed to prognosticate poor outcome should not be used without detailed data on how neurologic outcomes correspond to a particular laboratory's method, and even then only in conjunction with other prognostic variables.
journal_name
Neurocrit Carejournal_title
Neurocritical careauthors
Mlynash M,Buckwalter MS,Okada A,Caulfield AF,Venkatasubramanian C,Eyngorn I,Verbeek MM,Wijman CAdoi
10.1007/s12028-013-9867-5subject
Has Abstractpub_date
2013-10-01 00:00:00pages
161-6issue
2eissn
1541-6933issn
1556-0961journal_volume
19pub_type
杂志文章abstract：INTRODUCTION:A 38-year-old man with severe head trauma complicated by paroxysmal severe intracranial pressure elevation associated with tachypnea, tachycardia, diaphoresis, and extensor posturing was diagnosed as suffering from paroxysmal autonomic instability with dystonia (PAID). These events were unresponsive to sta...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-007-0066-0
更新日期：2007-01-01 00:00:00
abstract：INTRODUCTION:Fever is common and difficult to control in patients with subarachnoid hemorrhage (SAH). We have previously shown an inverse relationship between fever and outcome in patients with SAH. MATERIALS/METHODS:This was a prospective, single-arm, feasibility trial in which nine patients with SAH underwent temper...
journal_title：Neurocritical care
pub_type： 临床试验,杂志文章
doi：10.1385/NCC:1:2:145
更新日期：2004-01-01 00:00:00
abstract：INTRODUCTION:Hypothermic brain protection has been linked to how rapidly cooling is initiated and how quickly and uniformly the therapeutic hypothermic zone (THZ) is reached. The nasopharyngeal (NP) approach is uniquely suited for preferential brain cooling due to anatomic proximity to the cerebral circulation, caverno...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-008-9064-0
更新日期：2008-01-01 00:00:00
abstract：BACKGROUND:Takotsubo syndrome is a reversible neuromyocardial failure that has been thought to be related to an acute catecholamine toxicity of the myocardium brought upon by a stressful event. The neurocritical care unit population is particularly vulnerable for this condition given the acute presentation of neurologi...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-008-9075-x
更新日期：2008-01-01 00:00:00
abstract：BACKGROUND:Direct invasive monitoring of brain tissue oxygenation (PbtO(2)) has been routinely utilized to predict cerebral ischemia and to prevent secondary injury in patients with traumatic brain injury (TBI) and vasospasm secondary to subarachnoid hemorrhage (SAH). The safety and utility of these devices in the pedi...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-011-9531-x
更新日期：2011-12-01 00:00:00
abstract：BACKGROUND:Delayed ischemic neurological deficits (DINDs) contribute to morbidity and mortality following aneurysmal subarachnoid hemorrhage (SAH). Based on promising preliminary reports, some clinicians routinely administer statins to prevent DINDs. METHODS:Without language restriction, we searched MEDLINE, EMBASE, t...
journal_title：Neurocritical care
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s12028-009-9306-9
更新日期：2010-04-01 00:00:00
abstract：:The Fifth Neurocritical Care Research Network (NCRN) Conference held in Boca Raton, Florida, in September of 2018 was devoted to challenging the current status quo and examining the role of the Neurocritical Care Society (NCS) in driving the science and research of neurocritical care. The aim of this in-person meeting...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-019-00767-8
更新日期：2020-02-01 00:00:00
abstract：INTRODUCTION:Delayed posthypoxic demyelination may rarely complicate an episode of severe hypoxia, with or without exposure to carbon monoxide. Following recovery from initial coma, progressive neurologic deterioration ensues with outcomes ranging from death to full recovery. Delayed posthypoxic demyelination is hypoth...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-007-0044-6
更新日期：2007-01-01 00:00:00
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journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-016-0367-2
更新日期：2017-04-01 00:00:00
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journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-020-01090-3
更新日期：2020-09-09 00:00:00
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journal_title：Neurocritical care
pub_type： 杂志文章,评审
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更新日期：2017-12-01 00:00:00
abstract：INTRODUCTION:Methylene blue (MB) infusion is frequently used to localize the parathyroid glands during parathyroidectomy and generally considered safe. Several recent reports suggest neurological toxicity and post-operative altered mental state typically after large dose infusions. The mechanism by which MB has neuroto...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-009-9206-z
更新日期：2009-01-01 00:00:00
abstract：INTRODUCTION:Liver transplant (LT) recipients are at significant risk for the development of neurological complications, such as altered mental status and seizures, in the postoperative period. Identifying accurate predictors of these events may allow optimal selection and preparation of candidates, and minimize risk a...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-007-9020-4
更新日期：2008-01-01 00:00:00
abstract：INTRODUCTION:Altered mental status and more subtle cognitive and personality changes after traumatic brain injury (TBI) are pervasive problems in patients who survive initial injury. MRI is not necessarily part of the diagnostic evaluation of these patients. METHODS:Case report with relevant image and review of the li...
journal_title：Neurocritical care
pub_type： 杂志文章,评审
doi：10.1007/s12028-012-9699-8
更新日期：2012-06-01 00:00:00
abstract：BACKGROUND:Global cerebral edema (GCE) is a manifestation of early brain injury (EBI) after subarachnoid hemorrhage (SAH) and is an independent risk factor for poor outcome. The lack of a quantitative method to measure GCE limits the study of its pathophysiology. The goal of this study is to develop a quantitative surr...
journal_title：Neurocritical care
pub_type： 临床试验,杂志文章
doi：10.1007/s12028-015-0229-3
更新日期：2016-08-01 00:00:00
abstract：OBJECTIVE:To determine the clinical characteristics and outcomes of patients with neurogenic stress cardiomyopathy (NSC) among patients admitted to our neuroscience intensive care unit (NICU). METHODS:Following institutional review board approval, consecutive adult patients admitted to the NICU between 2009 and 2013 w...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-017-0412-9
更新日期：2017-12-01 00:00:00
abstract：BACKGROUND:The objectives of this study were to determine effects of severe traumatic brain injury (TBI) on cerebrospinal fluid (CSF) concentrations of myelin basic protein (MBP) and to assess relationships between clinical variables and CSF MBP concentrations. METHODS:We measured serial CSF MBP concentrations in chil...
journal_title：Neurocritical care
pub_type： 杂志文章,随机对照试验
doi：10.1007/s12028-012-9767-0
更新日期：2012-12-01 00:00:00
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journal_title：Neurocritical care
pub_type： 杂志文章,评审
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更新日期：2020-08-04 00:00:00
abstract：BACKGROUND:An alternation of sympathetic and vagal nervous activity has been suggested to be one possible mechanism of neurogenic pulmonary edema (NPE) in patients with subarachnoid hemorrhage (SAH). The study aimed to explore if sympathovagal modulation assessed by frequency domains of heart rate variability (HRV) is ...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-015-0237-3
更新日期：2016-08-01 00:00:00
abstract：BACKGROUND:Apnea testing is an essential step in the clinical diagnosis of brain death. Current international guidelines recommend placement of an oxygen (O2) insufflation catheter into the endotracheal tube to prevent hypoxemia, but use of a continuous positive airway pressure (CPAP) valve may be more effective at lim...
journal_title：Neurocritical care
pub_type： 杂志文章,多中心研究
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更新日期：2017-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：2018-02-01 00:00:00
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journal_title：Neurocritical care
pub_type： 杂志文章,评审
doi：10.1007/s12028-017-0386-7
更新日期：2017-08-01 00:00:00
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journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-014-9957-z
更新日期：2014-08-01 00:00:00
abstract：BACKGROUND:Fever is associated with worse outcome after intracerebral hemorrhage (ICH). Autonomic dysfunction, commonly seen after brain injury, results in reduced heart rate variability (HRV). We sought to investigate whether HRV was associated with the development of fever in patients with ICH. METHODS:We prospectiv...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-019-00684-w
更新日期：2019-04-01 00:00:00
abstract：BACKGROUND:This prospective consecutive double-blinded randomized study investigated the effect of prostacyclin on pressure reactivity (PR) in severe traumatic brain injured patients. Other aims were to describe PR over time and its relation to outcome. METHODS:Blunt head trauma patients, Glasgow coma scale ≤8, age 15...
journal_title：Neurocritical care
pub_type： 杂志文章,随机对照试验
doi：10.1007/s12028-014-0030-8
更新日期：2015-02-01 00:00:00
abstract：:The presence of pulmonary dysfunction after brain injury is well recognized. Acute lung injury (ALI) occurs in 20% of patients with isolated brain injury and is associated with a poor outcome. The "blast injury" theory, which proposes combined "hydrostatic" and "high permeability" mechanisms for the formation of neuro...
journal_title：Neurocritical care
pub_type： 杂志文章,评审
doi：10.1007/s12028-009-9242-8
更新日期：2009-12-01 00:00:00
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journal_title：Neurocritical care
pub_type： 杂志文章,评审
doi：10.1007/s12028-008-9090-y
更新日期：2008-01-01 00:00:00
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journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-008-9104-9
更新日期：2008-01-01 00:00:00
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journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1385/NCC:2:1:051
更新日期：2005-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2020-12-01 00:00:00
