Abstract：
BACKGROUND:Global cerebral edema (GCE) is a manifestation of early brain injury (EBI) after subarachnoid hemorrhage (SAH) and is an independent risk factor for poor outcome. The lack of a quantitative method to measure GCE limits the study of its pathophysiology. The goal of this study is to develop a quantitative surrogate marker that represents GCE after SAH. METHODS:Patients with spontaneous SAH were enrolled into a prospective observational database. Initial CT scans were graded for GCE using established qualitative criteria. Selective sulcal volume (SSV) was defined as total mL of sulcal volumes on axial CT slices above the most cranial section of the lateral ventricles to the last visible section. Using a semiautomatic threshold approach, sulcal regions were traced out with manual adjustments when necessary. The volume of sulci in each slice was calculated and multiplied by the slice thickness and number of slices to calculate the SSV. All volumetric analysis was performed using Medical Image Processing, Analysis and Visualization Version 7.0.1 (MIPAV). RESULTS:A total of 109 subjects were included in our analysis. Mean selective sulcal volumes (SSV) differed between subjects with and without GCE 4.5 and 21.2 mL (P < 0.001). When separated into quartiles, the odds of qualitative GCE increases as SSV decreases. Compared to the highest SSV quartile, smaller SSV was associated with worse clinical outcomes. CONCLUSION:GCE can be quantified using volumetric analysis of SSV measurements on routine CT scans. Smaller SSV on admission is predictive of worse clinical outcomes. SSV may be an important marker of EBI after SAH.
journal_name
Neurocrit Carejournal_title
Neurocritical careauthors
Choi HA,Bajgur SS,Jones WH,Savarraj JP,Ko SB,Edwards NJ,Chang TR,Hergenroeder GW,Dannenbaum MJ,Chen PR,Day AL,Kim DH,Lee K,Grotta JCdoi
10.1007/s12028-015-0229-3subject
Has Abstractpub_date
2016-08-01 00:00:00pages
64-70issue
1eissn
1541-6933issn
1556-0961pii
10.1007/s12028-015-0229-3journal_volume
25pub_type
临床试验,杂志文章abstract：INTRODUCTION:Methylene blue (MB) infusion is frequently used to localize the parathyroid glands during parathyroidectomy and generally considered safe. Several recent reports suggest neurological toxicity and post-operative altered mental state typically after large dose infusions. The mechanism by which MB has neuroto...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-009-9206-z
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journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-011-9531-x
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journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-016-0274-6
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journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-020-01140-w
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journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-008-9075-x
更新日期：2008-01-01 00:00:00
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pub_type： 杂志文章
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journal_title：Neurocritical care
pub_type： 临床试验,杂志文章
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更新日期：2007-01-01 00:00:00
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journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-018-0501-4
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journal_title：Neurocritical care
pub_type： 杂志文章
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更新日期：2012-10-01 00:00:00
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更新日期：2013-06-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1007/s12028-013-9941-z
更新日期：2014-04-01 00:00:00
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journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1385/NCC:5:1:21
更新日期：2006-01-01 00:00:00
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pub_type： 杂志文章
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journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-012-9783-0
更新日期：2013-08-01 00:00:00
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journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1385/NCC:1:3:385
更新日期：2004-01-01 00:00:00
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journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-007-0054-4
更新日期：2007-01-01 00:00:00
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journal_title：Neurocritical care
pub_type： 杂志文章,评审
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journal_title：Neurocritical care
pub_type： 杂志文章
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journal_title：Neurocritical care
pub_type： 临床试验,杂志文章
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更新日期：2005-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2005-01-01 00:00:00
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journal_title：Neurocritical care
pub_type： 杂志文章
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更新日期：2015-12-01 00:00:00
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更新日期：2014-12-01 00:00:00
abstract：: ...
journal_title：Neurocritical care
pub_type： 评论,信件
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更新日期：2018-12-01 00:00:00
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journal_title：Neurocritical care
pub_type： 杂志文章,评审
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更新日期：2014-02-01 00:00:00
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journal_title：Neurocritical care
pub_type： 杂志文章,评审
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更新日期：2010-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：2016-12-01 00:00:00
