Cefepime-induced nonconvulsive status epilepticus: case report and review.

Abstract:

INTRODUCTION:A case of cefepime-induced nonconvulsive status epilepticus in a 15-year-old child with end stage renal disease on hemodialysis is reported. Clinical symptoms and EEG dramatically improved 48 h after discontinuation of cefepime. METHODS:Twenty-five cases of nonconvulsive status epilepticus associated with cefepime that have been reported in the literature are reviewed. RESULTS:The average age was 60 years [15-86], our patient is the second pediatric patient reported, and 56% of cases occurred in women. The cefepime dosage was adjusted to the renal function in 5 cases. All except 1 patient have impaired renal function (CRF: 17 cases, ARF: 7 cases). The symptoms start 1-15 days after starting cefepime, mean 6 days. The outcome was good after discontinuation of cefepime therapy and anticonvulsant treatment, but lethal outcome was also reported in 2 cases. One fatality was related to status epilepticus. CONCLUSION:The clinicians' awareness must be increased about cefepime-induced nonconvulsive status epilepticus.

journal_name

Neurocrit Care

journal_title

Neurocritical care

authors

Thabet F,Al Maghrabi M,Al Barraq A,Tabarki B

doi

10.1007/s12028-008-9166-8

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

347-51

issue

3

eissn

1541-6933

issn

1556-0961

journal_volume

10

pub_type

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