Abstract：
BACKGROUND:Infection is common following stroke and is independently associated with worse outcome. Clinical studies suggest that infections occur more frequently in those individuals with stroke-induced immunologic dysfunction. This study sought to explore the contribution of immunomodulatory cytokines and hormones to lymphocyte function and infection risk. METHODS:Patients (N = 112) were enrolled as soon as possible after the onset of ischemic stroke. Blood was drawn to assess plasma cortisol, IL-10, IL-1ra, lymphocyte numbers, and lymphocyte function at 72 h after stroke onset; infections were censored through 21 days after stroke onset. RESULTS:Infection occurred in 25% of patients. Stroke severity was the most important predictor of infection risk. Increased plasma cortisol, IL-10, and IL-1ra, as well as decreased lymphocyte numbers, at 72 h after stroke onset were associated with risk of subsequent infection. After controlling for stroke severity, only IL-1ra was independently associated with infection risk, and the degree of risk was consistent throughout the post-stroke period. Infection, but not IL-1ra itself, was associated with worse outcome at 3 months. CONCLUSIONS:In this study cohort, increased plasma IL-1ra was independently associated with the risk of post-stroke infection. Further studies are needed to validate this finding, which could have important implications for stroke therapy.
journal_name
Neurocrit Carejournal_title
Neurocritical careauthors
Tanzi P,Cain K,Kalil A,Zierath D,Savos A,Gee JM,Shibata D,Hadwin J,Carter K,Becker Kdoi
10.1007/s12028-010-9490-7subject
Has Abstractpub_date
2011-04-01 00:00:00pages
244-52issue
2eissn
1541-6933issn
1556-0961journal_volume
14pub_type
杂志文章abstract：BACKGROUND:Spontaneous intracranial hypotension (SIH) is a neurologic condition with the prototypical symptom of orthostatic headache. We report a dramatic case of SIH with life-threatening bilateral hygroma and uncal herniation. METHODS:Case report. RESULTS:A 44-year-old male patient presenting with orthostatic head...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-012-9783-0
更新日期：2013-08-01 00:00:00
abstract：INTRODUCTION:Prompt management of aneurysmal subarachnoid hemorrhage (SAH) is critical. Literature is inconclusive regarding outcomes for patients directly admitted to specialized centers versus transferred from lower-volume hospitals. Providers are often unclear about the safety of transferring critical patients. This...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-012-9740-y
更新日期：2012-12-01 00:00:00
abstract：BACKGROUND:The initial noncontrast computed tomography (CT) study of the head after an aneurysmal subarachnoid hemorrhage (SAH) is used to predict the risk of developing vasospasm. Changes in the extent of subarachnoid blood seen on CT images occur as a function of time after SAH, but there is no consensus on the time ...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-009-9227-7
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND:In comatose post-cardiac arrest patients, a serum neuron-specific enolase (NSE) level of >33 μg/L within 72 h was identified as a reliable marker for poor outcome in a large Dutch study (PROPAC), and this level was subsequently adopted in an American Academy of Neurology practice parameter. Later studies rep...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-013-9867-5
更新日期：2013-10-01 00:00:00
abstract：BACKGROUND/OBJECTIVE:Infection is the most common complication of external ventricular drain (EVD) placement. National trends in the annual incidence of meningitis among patients with traumatic brain injury (TBI) who have undergone EVD placement have not been reported. METHODS:The Nationwide Inpatient Sample was used ...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-018-0656-z
更新日期：2019-06-01 00:00:00
abstract：BACKGROUND:Subclinical seizures are common in critically ill children and are best detected by continuous EEG (cEEG) monitoring. Timely detection of seizures requires pediatric intensive care unit (PICU) physicians to identify patients at risk of seizures and request cEEG monitoring. A recent consensus statement from t...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-020-01053-8
更新日期：2020-07-21 00:00:00
abstract：BACKGROUND:The correlation between noninvasive (oscillometric) blood pressure (NBP) and intra-arterial blood pressure (IAP) in critically ill patients receiving vasoactive medications in a Neurocritical Care Unit has not been systematically studied. The purpose of this study is to examine the relationship between simul...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-018-0521-0
更新日期：2018-06-01 00:00:00
abstract：BACKGROUND:Acute hydrocephalus is a common complication of aneurysmal subarachnoid hemorrhage (aSAH); however, attempts to predict shunt-dependent chronic hydrocephalus using clinical parameters have been equivocal. METHODS:Cohort study of aSAH is treated with external ventricular drainage (EVD) placement at our insti...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-019-00886-2
更新日期：2020-08-01 00:00:00
abstract：INTRODUCTION:Hyponatremia frequently complicates acute brain injury and may precipitate neurological worsening by promoting cerebral edema. An increase in brain water may be better managed through water excretion than with fluid restriction or hypertonic fluids. Vasopressin-receptor antagonists such as conivaptan, whic...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-008-9179-3
更新日期：2009-01-01 00:00:00
abstract：:This article reports an unusual case of a syphilitic gumma with a clinical and radiographical presentation initially suggestive of glioblastoma multiforme. Pathological evaluation was essential in establishing the diagnosis of neurosyphilis and in excluding neoplastic involvement. Cerebral gumma should be considered a...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1385/NCC:2:3:300
更新日期：2005-01-01 00:00:00
abstract：BACKGROUND:Plateau waves are common in traumatic brain injury. They constitute abrupt increases of intracranial pressure (ICP) above 40 mmHg associated with a decrease in cerebral perfusion pressure (CPP). The aim of this study was to describe plateau waves characteristics with multimodal brain monitoring in head injur...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-013-9918-y
更新日期：2014-08-01 00:00:00
abstract：BACKGROUND:Cerebral edema and raised intracranial pressure are common problems in neurological intensive care. Osmotherapy, typically using mannitol or hypertonic saline (HTS), has become one of the first-line interventions. However, the literature on the use of these agents is heterogeneous and lacking in class I stud...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-010-9477-4
更新日期：2011-04-01 00:00:00
abstract：BACKGROUND:Decompressive hemicraniectomy (DHC) has proven efficacious for the treatment of malignant middle cerebral artery infarction (mMCAI) only in patients less than 60 years. This study aimed to assess the effectiveness of DHC in patients up to 80. METHODS:This is a prospective, randomized, controlled trail compa...
journal_title：Neurocritical care
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s12028-012-9703-3
更新日期：2012-10-01 00:00:00
abstract：BACKGROUND:The management of symptomatic cerebral vasospasm after aneurysmal subarachnoid hemorrhage (aSAH) can be often complicated by the presence of stunned myocardium and left ventricular failure. Vasopressors and inotropes are commonly used to optimize mean arterial pressure (MAP) and cerebral perfusion pressure (...
journal_title：Neurocritical care
pub_type： 杂志文章,评审
doi：10.1007/s12028-010-9358-x
更新日期：2010-08-01 00:00:00
abstract：INTRODUCTION:Point-of-care ultrasound of the optic nerve sheath diameter (ONSD) to diagnose increased intracranial pressure (ICP) is of great interest in various clinical scenarios. Yet, the lack of examination standardization has made clinical utility difficult. We compare three ultrasound ocular plane views (inferior...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-019-00881-7
更新日期：2020-08-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:To propose a novel definition for hydrocephalus growth and to further describe the association between hydrocephalus growth and poor outcome among patients with intracerebral hemorrhage (ICH). METHODS:We analyzed consecutive patients who presented within 6 h after ICH ictus between July 2011 and ...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-020-01140-w
更新日期：2020-11-10 00:00:00
abstract：BACKGROUND:To date, common therapy in patients with intracranial hemorrhage (ICH) includes prophylaxis of seizure using antiepileptic drugs, commonly phenytoin. Phenytoin therapy is associated with a high incidence of cognitive disturbance. Levetiracetam is known to cause less cognitive disruption and may be a suitable...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-010-9341-6
更新日期：2011-08-01 00:00:00
abstract：BACKGROUND/OBJECTIVE:In recent years, the noble gas argon (Ar) has been extensively studied for its organ protection properties. While mounting in vitro and in vivo evidence indicates that argon provides neuroprotection in ischemic brain injury, its neuroprotective potential in traumatic brain injury (TBI) has not been...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-020-01104-0
更新日期：2020-09-21 00:00:00
abstract：:A growing body of clinical literature emphasizes the impact of cerebral edema in early brain injury following aneurysmal subarachnoid hemorrhage (aSAH). Aneurysm rupture itself initiates global cerebral edema in up to two thirds of cases. Although cerebral edema is not a universal feature of aSAH, it portends a poor c...
journal_title：Neurocritical care
pub_type： 杂志文章,评审
doi：10.1007/s12028-016-0354-7
更新日期：2017-04-01 00:00:00
abstract：BACKGROUND:The objectives of this study were to determine effects of severe traumatic brain injury (TBI) on cerebrospinal fluid (CSF) concentrations of myelin basic protein (MBP) and to assess relationships between clinical variables and CSF MBP concentrations. METHODS:We measured serial CSF MBP concentrations in chil...
journal_title：Neurocritical care
pub_type： 杂志文章,随机对照试验
doi：10.1007/s12028-012-9767-0
更新日期：2012-12-01 00:00:00
abstract：IMPORTANCE:The pathophysiological mechanisms of Posterior Reversible Encephalopathy Syndrome (PRES) and related seizures remain poorly understood. The prevalence and clinical significance of nonconvulsive seizures (NCSz) and related epileptiform patterns during continuous electroencephalography monitoring (CEEG) in PRE...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-018-0548-2
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND:The primary objectives of this study were to identify patient and community benefits of mandatory intensivist management in a neurocritical care (NCC) unit. Our hospital recently mandated intensivist management for patients admitted to the NCC unit. As one of the only comprehensive stroke centers in Orlando,...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-015-0148-3
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND AND AIMS:Lipid peroxidation represents a marker of secondary brain injury both in traumatic and in non-traumatic conditions-as in major neurosurgical procedures-eventually leading to brain edema amplification and further brain damage. Malondialdehyde (MDA), a lipid peroxidation marker, and ascorbate, a marke...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-019-00870-w
更新日期：2020-08-01 00:00:00
abstract：BACKGROUND:Knowing the individual child's risk is highly useful when deciding on treatment strategies, especially when deciding on invasive procedures. In this study, we aimed to develop a new predictive score for children with bacterial meningitis and compare this with existing predictive scores and individual risk fa...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-019-00792-7
更新日期：2020-04-01 00:00:00
abstract：BACKGROUND:Noncontrast computed tomography (CT) markers are increasingly used for predicting hematoma expansion. The aim of our study was to investigate the predictive value of expansion-prone hematoma in predicting hematoma expansion and outcome in patients with intracerebral hemorrhage (ICH). METHODS:Between July 20...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-018-0644-3
更新日期：2019-06-01 00:00:00
abstract：INTRODUCTION:Malignant cerebral edema develops in a small subset of patients with hemispheric strokes, precipitating deterioration and death if decompressive hemicraniectomy (DHC) is not performed in a timely manner. Predicting which stroke patients will develop malignant edema is imprecise based on clinical data alone...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-020-01056-5
更新日期：2020-12-01 00:00:00
abstract：BACKGROUND:There has been growing interest in the use of hypertonic sodium lactate (HSL) solution following traumatic brain injury (TBI) in humans. However, little is known about the effects of HSL on functional deficits with respect to the hyperosmotic nature of HSL. METHODS:We have compared the effects of HSL soluti...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-020-01090-3
更新日期：2020-09-09 00:00:00
abstract：:We now recognize that the main breathing generator resides principally in the medulla oblongata. Vivisectionists-specifically, Julien Legallois-discovered "the respiratory center." Cutting through the brainstem stops respiration but not if the medulla remains intact and the brain is sliced in successive portions. Pier...
journal_title：Neurocritical care
pub_type： 历史文章,杂志文章
doi：10.1007/s12028-019-00686-8
更新日期：2019-08-01 00:00:00
abstract：BACKGROUND:Long-term studies of survivors of acute respiratory distress syndrome (ARDS) have reported neuromuscular, quality of life, and neuropsychological impairments. This study aims to determine if development of ARDS was associated with neuromuscular weakness and depression at 6-month following hospital discharge ...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-014-0087-4
更新日期：2015-06-01 00:00:00
abstract：INTRODUCTION:An oculomotor palsy in the setting of aneurysmal subarachnoid hemorrhage is often due to compression by a posterior communicating artery aneurysm. Anterior communicating artery (ACOM) aneurysms may produce ophthalmologic symptoms of the anterior visual pathways, but rarely ever lead to a 3rd nerve palsy. T...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-007-0054-4
更新日期：2007-01-01 00:00:00
