Abstract：
:A growing body of clinical literature emphasizes the impact of cerebral edema in early brain injury following aneurysmal subarachnoid hemorrhage (aSAH). Aneurysm rupture itself initiates global cerebral edema in up to two thirds of cases. Although cerebral edema is not a universal feature of aSAH, it portends a poor clinical course, with quantitative analysis revealing a direct correlation between cerebral edema and poor outcome, including mortality and cognitive deficits. Mechanistically, global cerebral edema has been linked to global ischemia at the time of aneurysm rupture, dysfunction of autoregulation, blood breakdown products, neuroinflammation, and hyponatremia/endocrine abnormalities. At a molecular level, several culprits have been identified, including aquaporin-4, matrix metalloproteinase-9, SUR1-TRPM4 cation channels, vascular endothelial growth factor, bradykinin, and others. Here, we review these cellular and molecular mechanisms of global cerebral edema formation in aSAH. Given the importance of edema to the outcome of patients with aSAH and its status as a highly modifiable pathological process, a better understanding of cerebral edema in aSAH promises to hasten the development of medical therapies to improve outcomes in this frequently devastating disease.
journal_name
Neurocrit Carejournal_title
Neurocritical careauthors
Hayman EG,Wessell A,Gerzanich V,Sheth KN,Simard JMdoi
10.1007/s12028-016-0354-7subject
Has Abstractpub_date
2017-04-01 00:00:00pages
301-310issue
2eissn
1541-6933issn
1556-0961pii
10.1007/s12028-016-0354-7journal_volume
26pub_type
杂志文章,评审abstract：INTRODUCTION:Patients with acute neurological illness may be hypercatabolic. The Harris-Benedict Equation (HBE) is used to estimate energy needs in acute stroke. A "stress factor" for stroke does not exist, and it is not known if the HBE accurately estimates the energy expenditure needs in acute ischemic or hemorrhagic...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1385/NCC:1:3:331
更新日期：2004-01-01 00:00:00
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journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-010-9468-5
更新日期：2011-08-01 00:00:00
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journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-012-9725-x
更新日期：2012-10-01 00:00:00
abstract：OBJECTIVE:To determine the clinical characteristics and outcomes of patients with neurogenic stress cardiomyopathy (NSC) among patients admitted to our neuroscience intensive care unit (NICU). METHODS:Following institutional review board approval, consecutive adult patients admitted to the NICU between 2009 and 2013 w...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-017-0412-9
更新日期：2017-12-01 00:00:00
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journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-014-9989-4
更新日期：2014-12-01 00:00:00
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journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-012-9742-9
更新日期：2012-12-01 00:00:00
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journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-020-01056-5
更新日期：2020-12-01 00:00:00
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journal_title：Neurocritical care
pub_type： 杂志文章,评审
doi：10.1007/s12028-017-0386-7
更新日期：2017-08-01 00:00:00
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journal_title：Neurocritical care
pub_type： 杂志文章,评审
doi：10.1007/s12028-014-0024-6
更新日期：2014-12-01 00:00:00
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journal_title：Neurocritical care
pub_type： 杂志文章,评审
doi：10.1007/s12028-015-0169-y
更新日期：2015-12-01 00:00:00
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journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-011-9552-5
更新日期：2011-12-01 00:00:00
abstract：BACKGROUND:In patients with spontaneous intracerebral hemorrhage (ICH), pre-hospital markers of disease severity might be useful to potentially triage patients to undergo early interventions. OBJECTIVE:Here, we tested whether loss of consciousness (LOC) at the onset of ICH is associated with intraventricular hemorrhag...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-020-01180-2
更新日期：2021-01-21 00:00:00
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journal_title：Neurocritical care
pub_type： 临床试验,杂志文章
doi：10.1385/NCC:3:1:016
更新日期：2005-01-01 00:00:00
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journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-007-0076-y
更新日期：2007-01-01 00:00:00
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journal_title：Neurocritical care
pub_type： 杂志文章,评审
doi：10.1007/s12028-013-9872-8
更新日期：2014-02-01 00:00:00
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journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-019-00881-7
更新日期：2020-08-01 00:00:00
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journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-020-01104-0
更新日期：2020-09-21 00:00:00
abstract：: ...
journal_title：Neurocritical care
pub_type： 评论,信件
doi：10.1007/s12028-018-0664-z
更新日期：2019-04-01 00:00:00
abstract：BACKGROUND:Brain tissue hypoxia (PbtO2 < 20 mmHg) is common after subarachnoid hemorrhage (SAH) and associated with poor outcome. Recent data suggest that brain oxygen optimization is feasible and reduces the time spent with PbtO2 < 20 mmHg from 45 to 16% in patients with severe traumatic brain injury. Here, we intende...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-019-00753-0
更新日期：2019-10-01 00:00:00
abstract：BACKGROUND:Currently, continuous electroencephalographic monitoring (cEEG) is the only available diagnostic tool for continuous monitoring of brain function in intensive care unit (ICU) patients. Yet, the exact relevance of routinely applied ICU cEEG remains unclear, and information on the implementation of cEEG, espec...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-018-0525-9
更新日期：2018-10-01 00:00:00
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journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1385/NCC:5:1:21
更新日期：2006-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s12028-019-00792-7
更新日期：2020-04-01 00:00:00
abstract：BACKGROUND/OBJECTIVE:Intravenous (IV) lacosamide use for status epilepticus has increased in recent years and is recommended for refractory status epilepticus by current guidelines. Per the lacosamide package labeling, the preferred route of administration is diluted and infused over 30-60 min; however, administration ...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-018-0560-6
更新日期：2018-12-01 00:00:00
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journal_title：Neurocritical care
pub_type： 临床试验,杂志文章
doi：10.1007/s12028-014-0004-x
更新日期：2014-10-01 00:00:00
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journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-020-01148-2
更新日期：2020-11-24 00:00:00
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journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-010-9501-8
更新日期：2011-06-01 00:00:00
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journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-015-0236-4
更新日期：2016-04-01 00:00:00
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journal_title：Neurocritical care
pub_type： 杂志文章,多中心研究
doi：10.1007/s12028-018-0586-9
更新日期：2019-02-01 00:00:00
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journal_title：Neurocritical care
pub_type： 历史文章,杂志文章
doi：10.1007/s12028-017-0495-3
更新日期：2018-06-01 00:00:00
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journal_title：Neurocritical care
pub_type： 杂志文章,评审
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更新日期：2010-08-01 00:00:00
