Abstract：
BACKGROUND:The indications for bevacizumab (a vascular endothelial growth factor inhibitor) have been expanded recently. Despite concerns for cerebrovascular events from bevacizumab treatment, detailed clinical and radiologic information are lacking. METHODS:Using the Mayo Clinic Rochester database (January 2006-September 2010), we identified bevacizumab-treated patients who developed intracerebral hemorrhage, ischemic stroke or transient ischemic attack within 3 weeks of bevacizumab treatment. Functional recovery was assessed using the modified Rankin scale 3 months following the onset of cerebrovascular events. RESULTS:Ten consecutive patients (median age 58 years, range 37-86) were included in this study. These patients received bevacizumab for a median duration of 3 months (range 2-4 months) for cancer treatment, and developed cerebrovascular events that comprised intratumoral hemorrhage (n = 7), cerebral watershed infarction (n = 1), transient ischemic attack (n = 1), and left vertebral artery occlusion (n = 1). Seven patients had chronic hypertension which was adequately controlled with a single anti-hypertensive agent. Significant increase in blood pressure was observed in nine patients during their acute presentation as compared with their baseline outpatient readings. Six patients died within 3 months of these cerebrovascular events, and the remaining four patients had modest functional recovery. CONCLUSIONS:Cerebrovascular events are early and serious complications that should be considered in bevacizumab-treated patients who present with an acute neurologic deterioration.
journal_name
Neurocrit Carejournal_title
Neurocritical careauthors
Seet RC,Rabinstein AA,Lindell PE,Uhm JH,Wijdicks EFdoi
10.1007/s12028-011-9552-5subject
Has Abstractpub_date
2011-12-01 00:00:00pages
421-7issue
3eissn
1541-6933issn
1556-0961journal_volume
15pub_type
杂志文章abstract：INTRODUCTION:Despite the recognized deleterious effects of hyperthermia on critically ill neurological patients, few investigations have studied hyperthermia after an ischemic stroke in the intensive care unit (ICU) setting. METHODS:Acute ischemic stroke patients admitted to the ICU were assigned to one of three group...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-008-9056-0
更新日期：2008-01-01 00:00:00
abstract：BACKGROUND:In several instances, the diagnosis of brain death has been questioned due to the presence of movements. This case report and review of the literature illustrates the spectrum of movements that have been encountered in brain death. METHODS:A case report and review of the literature on movements seen in brai...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1385/NCC:3:2:122
更新日期：2005-01-01 00:00:00
abstract：INTRODUCTION:Relative adrenal insufficiency has been shown to occur in the settings of critical illness and septic shock, impairing the body's ability to respond to stress. Studies have demonstrated that the treatment of adrenal insufficiency (AI) results in shock reversal, hemodynamic stability, and a subsequent decre...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-007-9003-5
更新日期：2008-01-01 00:00:00
abstract：BACKGROUND:Oral anticoagulants have been associated with greater hematoma expansion in patients with intracerebral hemorrhage (ICH). The purpose of this study was to determine whether the reported use of antiplatelet agents also results in greater hematoma expansion. METHODS:Retrospective review of patients with spont...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-009-9290-0
更新日期：2010-02-01 00:00:00
abstract：BACKGROUND:Median nerve short-latency somatosensory evoked potentials (SSEPs) are useful in determining prognosis for awakening after coma following hypoxic ischemic encephalopathy, but reliability of interpretation is unclear. OBJECTIVE:To measure inter- and intra-observer reliability of determining presence or absen...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-009-9251-7
更新日期：2009-12-01 00:00:00
abstract：BACKGROUND:Neurogenic pulmonary edema (NPE) is an acute life-threatening complication associated with many forms of central nervous system injury. NPE usually appears within minutes to hours after injury and has a high mortality rate if not recognized and treated appropriately. Lung ultrasound quickly provides at the b...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-013-9828-z
更新日期：2013-06-01 00:00:00
abstract：INTRODUCTION:Altered mental status and more subtle cognitive and personality changes after traumatic brain injury (TBI) are pervasive problems in patients who survive initial injury. MRI is not necessarily part of the diagnostic evaluation of these patients. METHODS:Case report with relevant image and review of the li...
journal_title：Neurocritical care
pub_type： 杂志文章,评审
doi：10.1007/s12028-012-9699-8
更新日期：2012-06-01 00:00:00
abstract：BACKGROUND:Subclinical seizures are common in critically ill children and are best detected by continuous EEG (cEEG) monitoring. Timely detection of seizures requires pediatric intensive care unit (PICU) physicians to identify patients at risk of seizures and request cEEG monitoring. A recent consensus statement from t...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-020-01053-8
更新日期：2020-07-21 00:00:00
abstract：INTRODUCTION:Malignant cerebral edema develops in a small subset of patients with hemispheric strokes, precipitating deterioration and death if decompressive hemicraniectomy (DHC) is not performed in a timely manner. Predicting which stroke patients will develop malignant edema is imprecise based on clinical data alone...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-020-01056-5
更新日期：2020-12-01 00:00:00
abstract：BACKGROUND:Sedation and therapeutic hypothermia (TH) delay neurological responses and might reduce the accuracy of clinical examination to predict outcome after cardiac arrest (CA). We examined the accuracy of quantitative pupillary light reactivity (PLR), using an automated infrared pupillometry, to predict outcome of...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-014-9981-z
更新日期：2014-10-01 00:00:00
abstract：INTRODUCTION:Hypothermic brain protection has been linked to how rapidly cooling is initiated and how quickly and uniformly the therapeutic hypothermic zone (THZ) is reached. The nasopharyngeal (NP) approach is uniquely suited for preferential brain cooling due to anatomic proximity to the cerebral circulation, caverno...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-008-9064-0
更新日期：2008-01-01 00:00:00
abstract：INTRODUCTION:Several studies have been performed to assess the prognostic value of early neurological and neurophysiological findings in patients with postanoxic coma, but they have not led to precise, generally accepted, prognostic rules. This study was performed to assess whether it is possible to create a prognostic...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-008-9178-4
更新日期：2009-01-01 00:00:00
abstract：:Traumatic brain injury (TBI) is a major cause of death and disability worldwide. In large part critical care for TBI is focused on the identification and management of secondary brain injury. This requires effective neuromonitoring that traditionally has centered on intracranial pressure (ICP). The purpose of this pap...
journal_title：Neurocritical care
pub_type： 杂志文章,评审
doi：10.1007/s12028-014-0048-y
更新日期：2014-12-01 00:00:00
abstract：BACKGROUND:To describe a case of auto-immune encephalitis in an adolescent with favorable outcome despite prolonged status epilepticus. METHODS:A 17 year old Asian man without previous medical history developed alteration of consciousness and partial seizures. The diagnosis of anti-N-methyl-D-aspartate receptor enceph...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-012-9788-8
更新日期：2013-02-01 00:00:00
abstract：BACKGROUND:Cerebral edema is a major cause of mortality following cardiac arrest (CA) and cardiopulmonary resuscitation (CPR). Arginine vasopressin (AVP) and water channel aquaporin-4 (AQP4) have been implicated in the pathogenesis of CA-evoked cerebral edema. In this study, we examined if conivaptan, a V1a and V2 anta...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-015-0236-4
更新日期：2016-04-01 00:00:00
abstract：BACKGROUND:Physiological reactions of the stress hormone cortisol include hyperglycemia, hypertension, and endothelium dysfunction. In patients with aneurysmal subarachnoid hemorrhage (SAH), hyperglycemia, hypertension, and endothelium dysfunction are associated with the occurrence of delayed cerebral ischemia (DCI). T...
journal_title：Neurocritical care
pub_type： 杂志文章,随机对照试验
doi：10.1007/s12028-010-9331-8
更新日期：2010-06-01 00:00:00
abstract：INTRODUCTION:Liver transplant (LT) recipients are at significant risk for the development of neurological complications, such as altered mental status and seizures, in the postoperative period. Identifying accurate predictors of these events may allow optimal selection and preparation of candidates, and minimize risk a...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-007-9020-4
更新日期：2008-01-01 00:00:00
abstract：BACKGROUND:The most widely used and most studied coma score to date is the Glasgow Coma Scale (GCS), which is used worldwide to assess level of consciousness and predict outcome after traumatic brain injury (TBI). Our aim was to determine whether the Full Outline of UnResponsiveness (FOUR) score is an accurate predicto...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-011-9617-5
更新日期：2012-02-01 00:00:00
abstract：BACKGROUND/OBJECTIVE:Intravenous (IV) lacosamide use for status epilepticus has increased in recent years and is recommended for refractory status epilepticus by current guidelines. Per the lacosamide package labeling, the preferred route of administration is diluted and infused over 30-60 min; however, administration ...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-018-0560-6
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND/OBJECTIVE:Posterior reversible encephalopathy syndrome (PRES) is a clinical and radiologic entity, typically manifesting as reversible neurological symptoms and signs of white matter edema on magnetic resonance imaging. PRES has been widely described in adults. Studies of PRES in children are mostly limited ...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-019-00720-9
更新日期：2020-02-01 00:00:00
abstract：INTRODUCTION:Robotic tele-presence (RTP) is a form of mobile telemedicine, which enables a direct face-to-face rapid response by the physician, instead of the traditional telephonic paradigm. We hypothesized that a model of RTP for after-hour ICU rounds and emergencies would be associated with improved ICU nurse satisf...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-012-9712-2
更新日期：2012-08-01 00:00:00
abstract：:The objective of this study was to determine the prevalence of intracranial hypertension (IHT) and the associated mortality rate in patients who suffered from primary intracerebral hemorrhage (ICH). A secondary objective was to assess predisposing factors to IHT development. We conducted a systematic literature search...
journal_title：Neurocritical care
pub_type： 杂志文章,meta分析
doi：10.1007/s12028-018-0658-x
更新日期：2019-08-01 00:00:00
abstract：BACKGROUND:It is controversial whether a low cerebral blood flow (CBF) simply reflects the severity of injury or whether ischemia contributes to the brain's injury. It is also not clear whether posttraumatic cerebral hypoperfusion results from intracranial hypertension or from pathologic changes of the cerebral vascula...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1385/NCC:1:1:69
更新日期：2004-01-01 00:00:00
abstract：BACKGROUND:Early diagnostic orientation for differentiating pneumonia from pneumonitis at the early stage after aspiration would be valuable to avoid unnecessary antibiotic therapy. We assessed the accuracy of procalcitonin (PCT) in diagnosing aspiration pneumonia (AP) in intensive care unit (ICU) patients requiring me...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-018-0623-8
更新日期：2019-04-01 00:00:00
abstract：BACKGROUND AND PURPOSE:Patients with acute brain injuries require strict physiologic control to minimize morbidity and mortality. This study aimed to assess in-hospital compliance to strict physiologic parameters (BP, HR, ICP, SpO2) in these populations. METHODS:Patients with severe cerebrovascular events were admitte...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-015-0116-y
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:An increasing number of patients receive antiplatelet therapy. Patients exposed to surgery while receiving platelet inhibitors hold an increased bleeding risk. Especially in neurosurgery and neurocritical care patients, bleeding and hematoma expansion are feared complications as even minor blee...
journal_title：Neurocritical care
pub_type： 杂志文章,评审
doi：10.1007/s12028-020-01055-6
更新日期：2020-08-04 00:00:00
abstract：:Electroencephalography in the setting of hypothermia and anoxia has been studied in humans since the 1950s. Specific patterns after cardiac arrest have been associated with prognosis since the 1960s, with several prognostic rating scales developed in the second half of the twentieth century. In 2002, two pivotal clini...
journal_title：Neurocritical care
pub_type： 杂志文章,评审
doi：10.1007/s12028-014-0018-4
更新日期：2015-02-01 00:00:00
abstract：BACKGROUND:An alternation of sympathetic and vagal nervous activity has been suggested to be one possible mechanism of neurogenic pulmonary edema (NPE) in patients with subarachnoid hemorrhage (SAH). The study aimed to explore if sympathovagal modulation assessed by frequency domains of heart rate variability (HRV) is ...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-015-0237-3
更新日期：2016-08-01 00:00:00
abstract：INTRODUCTION:Delayed ischemic neurologic deficits secondary to vasospasm are a major cause of morbidity and mortality after subarachnoid hemorrhage (SAH). Treatment of vasospasm after SAH is associated with complications, and reliable techniques for evaluating effects of treatment of vasospasm in such patients are warr...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1385/ncc:6:1:40
更新日期：2007-01-01 00:00:00
abstract：IMPORTANCE:The pathophysiological mechanisms of Posterior Reversible Encephalopathy Syndrome (PRES) and related seizures remain poorly understood. The prevalence and clinical significance of nonconvulsive seizures (NCSz) and related epileptiform patterns during continuous electroencephalography monitoring (CEEG) in PRE...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-018-0548-2
更新日期：2018-12-01 00:00:00
