Abstract:
BACKGROUND:Case reports suggest lacosamide may have a role in status epilepticus (SE). The purpose of this case series is to describe the use of lacosamide in refractory SE (RSE) at our institution. METHODS:Observational study of all patients admitted to the neurosciences intensive care unit with RSE who received at least one dose of lacosamide from October 2009 to September 2010. RESULTS:Nine patients received lacosamide after failure of at least two other agents. Lacosamide was started a median of 2 days (range: 0-14 days) after the onset of SE. The most frequently used dosing regimen was an initial intravenous dose of 200 mg followed by 200 mg every 12 h. Most patients had received 3 (range: 2-5) AEDs prior to lacosamide. Levetiracetam was used prior to lacosamide in all cases. No patients evaluated responded to lacosamide according to our predefined criteria. One patient developed angioedema after receiving two doses; another patient developed angioedema where timing in relation to the lacosamide was unclear. Care was withdrawn in three of the nine patients for reasons unrelated to lacosamide. Lacosamide was continued at discharge on all surviving patients except in one case of angioedema. CONCLUSIONS:This is the largest case series to date describing the use of lacosamide in patients with RSE. Despite the novel mechanism of action, we observed no evidence that lacosamide is effective in RSE; however, our sample size was small. Further study is needed to determine the role of lacosamide in SE, especially early in the treatment course.
journal_name
Neurocrit Carejournal_title
Neurocritical careauthors
Goodwin H,Hinson HE,Shermock KM,Karanjia N,Lewin JJ 3rddoi
10.1007/s12028-010-9501-8subject
Has Abstractpub_date
2011-06-01 00:00:00pages
348-53issue
3eissn
1541-6933issn
1556-0961journal_volume
14pub_type
杂志文章abstract::Sleep is fundamental for everyday functioning, yet it is often negatively impacted in critically ill patients by the intensive care setting. With a focus on the neurological intensive care unit (NeuroICU), this narrative review summarizes methods of measuring sleep and addresses common causes of sleep disturbance in t...
journal_title:Neurocritical care
pub_type: 杂志文章
doi:10.1007/s12028-019-00795-4
更新日期:2020-04-01 00:00:00
abstract::A farmer's wife was slapped by her cow's tail during milking. There was no obvious injury, but afterward she first developed unusual headaches of unknown origin and then a severe stroke 7 days later. Further diagnostics, including magnetic resonance imaging techniques, revealed a dissection of the carotid artery to be...
journal_title:Neurocritical care
pub_type: 杂志文章
doi:10.1385/NCC:3:3:254
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:In patients with subarachnoid hemorrhage (SAH), higher hemoglobin (HGB) has been associated with better outcomes, but packed red blood cell (PRBC) transfusions with worse outcomes. We performed a prospective pilot trial of goal HGB after SAH. METHODS:Forty-four patients with SAH and high risk fo...
journal_title:Neurocritical care
pub_type: 杂志文章,随机对照试验
doi:10.1007/s12028-010-9424-4
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND:Therapeutic hypothermia (i.e., temperature management) is an effective option for improving survival and neurological outcome after cardiac arrest and is potentially useful for the care of the critically ill neurological patient. We analyzed the feasibility of a device to control the temperature of the brain...
journal_title:Neurocritical care
pub_type: 杂志文章
doi:10.1007/s12028-016-0257-7
更新日期:2016-12-01 00:00:00
abstract:INTRODUCTION:Several studies have been performed to assess the prognostic value of early neurological and neurophysiological findings in patients with postanoxic coma, but they have not led to precise, generally accepted, prognostic rules. This study was performed to assess whether it is possible to create a prognostic...
journal_title:Neurocritical care
pub_type: 杂志文章
doi:10.1007/s12028-008-9178-4
更新日期:2009-01-01 00:00:00
abstract:INTRODUCTION:Patients with acute neurological illness may be hypercatabolic. The Harris-Benedict Equation (HBE) is used to estimate energy needs in acute stroke. A "stress factor" for stroke does not exist, and it is not known if the HBE accurately estimates the energy expenditure needs in acute ischemic or hemorrhagic...
journal_title:Neurocritical care
pub_type: 杂志文章
doi:10.1385/NCC:1:3:331
更新日期:2004-01-01 00:00:00
abstract:INTRODUCTION:An oculomotor palsy in the setting of aneurysmal subarachnoid hemorrhage is often due to compression by a posterior communicating artery aneurysm. Anterior communicating artery (ACOM) aneurysms may produce ophthalmologic symptoms of the anterior visual pathways, but rarely ever lead to a 3rd nerve palsy. T...
journal_title:Neurocritical care
pub_type: 杂志文章
doi:10.1007/s12028-007-0054-4
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Long-term studies of survivors of acute respiratory distress syndrome (ARDS) have reported neuromuscular, quality of life, and neuropsychological impairments. This study aims to determine if development of ARDS was associated with neuromuscular weakness and depression at 6-month following hospital discharge ...
journal_title:Neurocritical care
pub_type: 杂志文章
doi:10.1007/s12028-014-0087-4
更新日期:2015-06-01 00:00:00
abstract:INTRODUCTION:Fever is common and difficult to control in patients with subarachnoid hemorrhage (SAH). We have previously shown an inverse relationship between fever and outcome in patients with SAH. MATERIALS/METHODS:This was a prospective, single-arm, feasibility trial in which nine patients with SAH underwent temper...
journal_title:Neurocritical care
pub_type: 临床试验,杂志文章
doi:10.1385/NCC:1:2:145
更新日期:2004-01-01 00:00:00
abstract::Drug shortages have become all too familiar in the health care environment, with over 200 drugs currently on shortage. In the wake of Hurricane Maria in September 2017, hospitals across the USA had to quickly and creatively adjust medication preparation and administration techniques in light of decreased availability ...
journal_title:Neurocritical care
pub_type: 杂志文章,评审
doi:10.1007/s12028-019-00730-7
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:In patients with spontaneous intracerebral hemorrhage (ICH), pre-hospital markers of disease severity might be useful to potentially triage patients to undergo early interventions. OBJECTIVE:Here, we tested whether loss of consciousness (LOC) at the onset of ICH is associated with intraventricular hemorrhag...
journal_title:Neurocritical care
pub_type: 杂志文章
doi:10.1007/s12028-020-01180-2
更新日期:2021-01-21 00:00:00
abstract:BACKGROUND/OBJECTIVES:To propose a novel definition for hydrocephalus growth and to further describe the association between hydrocephalus growth and poor outcome among patients with intracerebral hemorrhage (ICH). METHODS:We analyzed consecutive patients who presented within 6 h after ICH ictus between July 2011 and ...
journal_title:Neurocritical care
pub_type: 杂志文章
doi:10.1007/s12028-020-01140-w
更新日期:2020-11-10 00:00:00
abstract:BACKGROUND:Oral anticoagulants have been associated with greater hematoma expansion in patients with intracerebral hemorrhage (ICH). The purpose of this study was to determine whether the reported use of antiplatelet agents also results in greater hematoma expansion. METHODS:Retrospective review of patients with spont...
journal_title:Neurocritical care
pub_type: 杂志文章
doi:10.1007/s12028-009-9290-0
更新日期:2010-02-01 00:00:00
abstract:INTRODUCTION:Spinal cord ischemia and stroke are recognized complications of descending thoracic (DTA) and thoracoabdominal aortic (TAA) operations. However, there are limited data available on outcomes since the advent of thoracic endovascular aortic repair (TEVAR). METHODS:We reviewed charts from consecutive patient...
journal_title:Neurocritical care
pub_type: 杂志文章
doi:10.1007/s12028-008-9104-9
更新日期:2008-01-01 00:00:00
abstract:INTRODUCTION:Syringohydromyelia associated with supratentorial space-occupying lesion has rarely been reported. We present a 28-year-old woman was admitted to the hospital with head and neck pain. Upon examination, there was only left central facial paralisia, with no evidence of papilledema. METHODS AND RESULTS:Crani...
journal_title:Neurocritical care
pub_type: 杂志文章
doi:10.1385/NCC:2:1:051
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Takotsubo syndrome is a reversible neuromyocardial failure that has been thought to be related to an acute catecholamine toxicity of the myocardium brought upon by a stressful event. The neurocritical care unit population is particularly vulnerable for this condition given the acute presentation of neurologi...
journal_title:Neurocritical care
pub_type: 杂志文章
doi:10.1007/s12028-008-9075-x
更新日期:2008-01-01 00:00:00
abstract::Severe intracranial hypertension (IH) in the setting of fulminant hepatic failure (FHF) carries a high mortality and is a challenging disease for the critical care provider. Despite considerable improvements in the understanding of the pathophysiology of cerebral edema during liver failure, therapeutic maneuvers that ...
journal_title:Neurocritical care
pub_type: 杂志文章,评审
doi:10.1385/NCC:4:2:179
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Early diagnostic orientation for differentiating pneumonia from pneumonitis at the early stage after aspiration would be valuable to avoid unnecessary antibiotic therapy. We assessed the accuracy of procalcitonin (PCT) in diagnosing aspiration pneumonia (AP) in intensive care unit (ICU) patients requiring me...
journal_title:Neurocritical care
pub_type: 杂志文章
doi:10.1007/s12028-018-0623-8
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:Spontaneous intracranial hypotension (SIH) is a neurologic condition with the prototypical symptom of orthostatic headache. We report a dramatic case of SIH with life-threatening bilateral hygroma and uncal herniation. METHODS:Case report. RESULTS:A 44-year-old male patient presenting with orthostatic head...
journal_title:Neurocritical care
pub_type: 杂志文章
doi:10.1007/s12028-012-9783-0
更新日期:2013-08-01 00:00:00
abstract::Amantadine and modafinil are neurostimulants that may improve cognitive and functional recovery post-stroke, but the existing study results vary, and no comprehensive review has been published. This systematic review describes amantadine and modafinil administration practices post-stroke, evaluates timing and impact o...
journal_title:Neurocritical care
pub_type: 杂志文章,评审
doi:10.1007/s12028-020-00977-5
更新日期:2020-08-01 00:00:00
abstract::A growing body of clinical literature emphasizes the impact of cerebral edema in early brain injury following aneurysmal subarachnoid hemorrhage (aSAH). Aneurysm rupture itself initiates global cerebral edema in up to two thirds of cases. Although cerebral edema is not a universal feature of aSAH, it portends a poor c...
journal_title:Neurocritical care
pub_type: 杂志文章,评审
doi:10.1007/s12028-016-0354-7
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:During late pregnancy and the puerperium cerebral venous and sinus thrombosis (CVST) is a rare but important cause of stroke. Despite adequate anticoagulation some patients deteriorate, which may warrant the use of more aggressive treatment modalities. CASE REPORT:A 29-year-old pregnant woman (29th week of ...
journal_title:Neurocritical care
pub_type: 杂志文章
doi:10.1007/s12028-010-9389-3
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:Seizures are a common complication after intracerebral hemorrhage (ICH) but there is a substantial lack of information on the long-term incidence in ICH survivors and whether post-ICH seizures affect functional long-term outcome. METHODS:Over a five-year period 464 consecutive patients with spontaneous ICH ...
journal_title:Neurocritical care
pub_type: 杂志文章
doi:10.1007/s12028-014-9968-9
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:There is no uniform definition for cerebral microdialysis (CMD) probe location with respect to focal brain lesions, and the impact of CMD-probe location on measured molecule concentrations is unclear. METHODS:We retrospectively analyzed data of 51 consecutive subarachnoid hemorrhage patients with CMD-monito...
journal_title:Neurocritical care
pub_type: 杂志文章
doi:10.1007/s12028-019-00713-8
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:A pretruncal subarachnoid hemorrhage has been accepted as a "benign" entity. Here we present two patients with delayed cerebral infarction following pretruncal subarachnoid hemorrhage. METHODS:Case report. RESULTS:Two patients with possible delayed cerebral infarction after pretruncal subarachnoid hemorrha...
journal_title:Neurocritical care
pub_type: 杂志文章
doi:10.1007/s12028-010-9403-9
更新日期:2011-04-01 00:00:00
abstract:INTRODUCTION:Acute bilateral acute carotid arteries occlusion is a very rare condition. We describe a patient with initial right middle cerebral artery syndrome who developed coma and quadriplegia 1 h after thrombolysis with intravenous tPA and was found to have bilateral cervical internal carotid artery occlusion. ...
journal_title:Neurocritical care
pub_type: 杂志文章
doi:10.1007/s12028-007-0076-y
更新日期:2007-01-01 00:00:00
abstract:INTRODUCTION:No proven treatments exist for intracerebral hemorrhage (ICH). Carefully selected patients may benefit from surgery, and an international multicenter trial is ongoing. We sought to determine how many patients in a population-based ICH cohort would have been eligible for surgery using the Surgical Trial in ...
journal_title:Neurocritical care
pub_type: 杂志文章
doi:10.1007/s12028-007-9045-8
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Intra-arterial (IA) nicardipine is often used to treat cerebral vasospasm associated with subarachnoid hemorrhage (SAH). While hypotension has been noted to be a dose-limiting side effect of intravenous infusions, this has seldom been reported for IA administration. METHODS:We reviewed a consecutive series ...
journal_title:Neurocritical care
pub_type: 杂志文章
doi:10.1007/s12028-011-9537-4
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:Cerebral edema and raised intracranial pressure are common problems in neurological intensive care. Osmotherapy, typically using mannitol or hypertonic saline (HTS), has become one of the first-line interventions. However, the literature on the use of these agents is heterogeneous and lacking in class I stud...
journal_title:Neurocritical care
pub_type: 杂志文章
doi:10.1007/s12028-010-9477-4
更新日期:2011-04-01 00:00:00
abstract:INTRODUCTION:Prompt management of aneurysmal subarachnoid hemorrhage (SAH) is critical. Literature is inconclusive regarding outcomes for patients directly admitted to specialized centers versus transferred from lower-volume hospitals. Providers are often unclear about the safety of transferring critical patients. This...
journal_title:Neurocritical care
pub_type: 杂志文章
doi:10.1007/s12028-012-9740-y
更新日期:2012-12-01 00:00:00