Blood Metabolomic Predictors of 1-Year Outcome in Subarachnoid Hemorrhage.

Abstract:

BACKGROUND:Delayed neurological deficit (DND) is the most important cause of morbidity and mortality in patients with subarachnoid hemorrhage (SAH) whose aneurysms have been secured. However, the methods currently used to predict the development of DND, such as trans-cranial Doppler or levels biochemical markers in blood and cerebrospinal fluid are not very accurate. METHOD:Venous blood was drawn from 50 patients with SAH, admitted to the neurosurgical department Umeå University Hospital, at day 1-3 and day 7 after the bleed. The clinical status of the patients was followed up approximately 1 year after this episode and classified according to the Glasgow Outcome Score (GOS). RESULTS:Results showed considerable differences in blood metabolomic patterns between day 1-3 and 7 after the hemorrhage. Fifty-six out of 98 metabolites could be identified from our in-house library and 17 of these metabolites changed significantly from day 1-3 to 7 after the bleed. One of these, myo-inositol, was predictive of clinical outcome even after correction for multiple testing. An estimation of the diagnostic accuracy of high levels of this substance in predicting good outcome (GOS 4-5) yielded a sensitivity of .763 and a specificity of .5 at the optimal cut off point. CONCLUSIONS:SAH is an event with a profound effect on blood metabolomics profiles. Myo-inositol might be an interesting compound for future study to focus on in the search for metabolic markers in venous blood of delayed neurological deterioration in SAH patients.

journal_name

Neurocrit Care

journal_title

Neurocritical care

authors

Sjöberg RL,Bergenheim T,Mörén L,Antti H,Lindgren C,Naredi S,Lindvall P

doi

10.1007/s12028-014-0089-2

subject

Has Abstract

pub_date

2015-10-01 00:00:00

pages

225-32

issue

2

eissn

1541-6933

issn

1556-0961

journal_volume

23

pub_type

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