Abstract：
PURPOSE:One study found higher leukocytes 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels in patients with spontaneous intracerebral hemorrhage (ICH) than in healthy subjects due to the oxidation of guanosine from deoxyribonucleic acid (DNA). The objective of this study was to determine whether there is an association between oxidative damage of serum DNA and ribonucleic acid (RNA) and mortality in patients with ICH. METHODS:In this observational and prospective study, patients with severe supratentorial ICH (defined as Glasgow Coma Scale < 9) were included from six Intensive Care Units of Spanish hospitals. At the time of severe ICH diagnosis, concentrations in serum of malondialdehyde (as lipid peroxidation biomarker) and of the three oxidized guanine species (OGS) (8-hydroxyguanosine from RNA, 8-hydroxyguanine from DNA or RNA, and 8-OHdG from DNA) were determined. Thirty-day mortality was considered the end-point study. RESULTS:Serum levels of OGS (p < 0.001) and malondialdehyde (p = 0.002) were higher in non-surviving (n = 46) than in surviving patients (n = 54). There was an association of serum OGS levels with serum malondialdehyde levels (rho = 0.36; p = 0.001) and 30-day mortality (OR = 1.568; 95% CI 1.183-2.078; p = 0.002). CONCLUSIONS:The novel and most important finding of our study was that serum OGS levels in ICH patients are associated with mortality.
journal_name
Neurocrit Carejournal_title
Neurocritical careauthors
Lorente L,Martín MM,González-Rivero AF,Pérez-Cejas A,Abreu-González P,Sabatel R,Ramos L,Argueso M,Cáceres JJ,Solé-Violán J,Jiménez A,García-Marín Vdoi
10.1007/s12028-019-00864-8subject
Has Abstractpub_date
2020-08-01 00:00:00pages
90-96issue
1eissn
1541-6933issn
1556-0961pii
10.1007/s12028-019-00864-8journal_volume
33pub_type
杂志文章abstract：:Traumatic spine injuries (TSIs) carry significantly high risks of morbidity, mortality, and exorbitant health care costs from associated medical needs following injury. For these reasons, TSI was chosen as an ENLS protocol. This article offers a comprehensive review on the management of spinal column injuries using th...
journal_title：Neurocritical care
pub_type： 杂志文章,评审
doi：10.1007/s12028-015-0169-y
更新日期：2015-12-01 00:00:00
abstract：INTRODUCTION:Dynamic testing of cerebral pressure autoregulation is more practical than static testing for critically ill patients. The process of cuff deflation is innocuous in the normal subject, but the systemic and cerebral effects of cuff deflation in severely head-injured patients have not been studied. The purpo...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1385/NCC:4:2:127
更新日期：2006-01-01 00:00:00
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journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-012-9783-0
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journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1385/NCC:2:1:051
更新日期：2005-01-01 00:00:00
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journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1385/NCC:1:3:385
更新日期：2004-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s12028-018-0655-0
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更新日期：2011-12-01 00:00:00
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journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-018-0548-2
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pub_type： 杂志文章
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journal_title：Neurocritical care
pub_type： 杂志文章,评审
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journal_title：Neurocritical care
pub_type： 杂志文章
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更新日期：2006-01-01 00:00:00
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更新日期：2012-12-01 00:00:00
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更新日期：2020-02-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,多中心研究
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abstract：: ...
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pub_type： 评论,信件
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journal_title：Neurocritical care
pub_type： 杂志文章,评审
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更新日期：2006-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2019-02-01 00:00:00
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更新日期：2012-08-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2020-08-01 00:00:00
