Abstract:
:Catechin, a constituent of tea, possesses various bioactivities. In particular, the most abundant catechin in tea is epigallocatechin gallate (EGCg), which has an anti-inflammatory effect. In the present study, the usability of EGCg for osteomyelitis treatment was examined. Osteomyelitis is a difficult disease to cure, partly due to bone lysis caused by infected osteoblasts. Since bone lysis is promoted by proinflammatory cytokines and the receptor activator of NF-kappaB ligand (RANKL), osteoblasts were infected with Staphylococcus aureus and the effect of EGCg on the production of cytokines was examined. It was found that the production of interleukin 6 and RANKL was suppressed in the osteoblasts treated with EGCg, which indicated an inflammation suppression effect of EGCg in osteomyelitis treatment.
journal_name
J Med Microbioljournal_title
Journal of medical microbiologyauthors
Ishida I,Kohda C,Yanagawa Y,Miyaoka H,Shimamura Tdoi
10.1099/jmm.0.47029-0subject
Has Abstractpub_date
2007-08-01 00:00:00pages
1042-1046issue
Pt 8eissn
0022-2615issn
1473-5644journal_volume
56pub_type
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