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Cysteine residue periodicity is a conserved structural feature of variable surface proteins from Paramecium tetraurelia.

Abstract：

:The DNA sequences of the entire coding regions of the A and C type variable surface protein genes from Paramecium tetraurelia, stock 51 have been determined. The 8151 nucleotide open reading frame of the A gene contains several tandem repeats of 210 nucleotides within the central portion of the molecule as well as a periodic structure defined by cysteine residues. The 6699 nucleotide open reading frame of the C gene does not contain any identifiable tandem repeats or internal similarity but maintains a periodicity based on the cysteine residue spacing. The deduced amino acid sequences encoded by the two genes are most similar within the 600 amino-terminal and 600 carboxyl-terminal amino acid residues, the central portions show only limited sequence similarity. We conclude that internal repeats are not a conserved feature of variable surface proteins in Paramecium and discuss the possible importance of the regular pattern of cysteine residues.

journal_name

J Mol Biol

journal_title

Journal of molecular biology

authors

Nielsen E,You Y,Forney J

doi

10.1016/0022-2836(91)90573-o

subject

Has Abstract

pub_date

1991-12-20 00:00:00

pages

835-41

issue

4

eissn

0022-2836

issn

1089-8638

pii

0022-2836(91)90573-O

journal_volume

222

pub_type

杂志文章

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