Abstract：
:The genes for alpha-fetoprotein and albumin arose by duplication of an ancestral gene that contained three genetic domains. These domains were generated by the triplication of a primordial genetic domain composed of five exons or subdomains. That the primordial domain itself arose by amplification of a simpler sequence is suggested by nucleotide sequence homologies among the subdomains of the mouse alpha-fetoprotein gene. A detailed analysis of these homologies reveals that each of the five subdomain families contains remnants of a 27-base-long repeat from which the entire alpha-fetoprotein coding sequence has been assembled. A consensus sequence for the 27 nucleotide repeat is derived, and the positions of the repeats within each subdomain are described. A model is proposed for the evolution of the primordial domain by the amplification and divergence of the 27 base-pair sequence, along with the condensation of the repeats into subdomains separated by intervening sequences. It is postulated that the role of intervening sequences may be to limit sequence amplification in genes such as alpha-fetoprotein and albumin whose protein products cannot tolerate size variation.
journal_name
J Mol Bioljournal_title
Journal of molecular biologyauthors
Alexander F,Young PR,Tilghman SMdoi
10.1016/0022-2836(84)90187-6subject
Has Abstractpub_date
1984-02-25 00:00:00pages
159-73issue
2eissn
0022-2836issn
1089-8638pii
0022-2836(84)90187-6journal_volume
173pub_type
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doi：10.1006/jmbi.1994.1336
更新日期：1994-05-20 00:00:00
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更新日期：1993-09-05 00:00:00
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