Abstract:
:Many intracellular bacterial pathogens previously thought to remain sealed within a vacuole can be recognized by cytosolic innate immune sensors. While a wide array of cytosolic nucleic acid sensors have been characterized in the context of viral infection, we are only now beginning to examine how these same molecules function in the context of bacterial infection. Interestingly, in addition to helping the host control the replication of some intracellular bacteria, cytosolic sensing of bacterial DNA has also been implicated in eliciting immune responses that enhance bacterial survival and promote pathogenesis, suggesting that activation of these host DNA sensing pathways is an evolutionarily conserved bacterial adaptation. Unlocking the mechanistic detail of these paradoxical innate immune events will be crucial for understanding how they influence the overall immune response during bacterial infection and how we may develop therapeutics to tip the balance in favor of the host.
journal_name
J Mol Bioljournal_title
Journal of molecular biologyauthors
Patrick KL,Bell SL,Watson ROdoi
10.1016/j.jmb.2016.04.030subject
Has Abstractpub_date
2016-08-28 00:00:00pages
3372-86issue
17eissn
0022-2836issn
1089-8638pii
S0022-2836(16)30111-5journal_volume
428pub_type
杂志文章,评审abstract::A putative RNase P RNA gene in camelpox virus, one of the orthopoxviruses, was cloned and transcribed in vitro. No RNase P activity could be detected in vitro from camelpox virus RNase P RNA alone, or by addition of the Escherichia coli RNase P protein subunit to reaction mixtures. Camelpox virus RNase P RNA reconstit...
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