Abstract：
:A study of the distribution in heterogeneous nuclear RNP (hnRNP) of the different forms of the first intervening sequence (IVSI) from the E3 transcription unit of adenovirus serotype 2 suggests a three-step pathway for IVS excision and degradation. First, the lariat IVS is formed in a large RNP of the size of premessenger RNP where it is resistant to nuclease attack. Second, the lariat IVS is released from this large structure as a small RNP where it is very susceptible to enzymic degradation. Third, the lariat IVS is linearized after the release of the small RNP. Our studies suggest that only the intact lariat and linear IVS are involved in the excision-degradation pathway in vivo, whereas the lariat nicked in its circular part and the IVS trimmed at its 3' end are not pre-existing but generated during isolation of hnRNA or hnRNP.
journal_name
J Mol Bioljournal_title
Journal of molecular biologyauthors
Sittler A,Gallinaro H,Kister L,Jacob Mdoi
10.1016/0022-2836(87)90480-3subject
Has Abstractpub_date
1987-10-20 00:00:00pages
737-41issue
4eissn
0022-2836issn
1089-8638pii
0022-2836(87)90480-3journal_volume
197pub_type
杂志文章abstract：:Human multi-domain-containing protein UHRF1 has recently been extensively characterized as a key epigenetic regulator for maintaining DNA methylation patterns. UHRF1 SRA domain preferentially binds to hemimethylated CpG sites, and double Tudor domain has been implicated in recognizing H3K9me3 mark, but the role of the...
journal_title：Journal of molecular biology
pub_type： 杂志文章
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journal_title：Journal of molecular biology
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journal_title：Journal of molecular biology
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Journal of molecular biology
pub_type： 杂志文章
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journal_title：Journal of molecular biology
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journal_title：Journal of molecular biology
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journal_title：Journal of molecular biology
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journal_title：Journal of molecular biology
pub_type： 杂志文章
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journal_title：Journal of molecular biology
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更新日期：2003-08-01 00:00:00
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journal_title：Journal of molecular biology
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更新日期：2003-05-30 00:00:00
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journal_title：Journal of molecular biology
pub_type： 杂志文章
doi：10.1006/jmbi.1994.1680
更新日期：1994-10-28 00:00:00
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journal_title：Journal of molecular biology
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更新日期：2002-03-01 00:00:00
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更新日期：1983-11-25 00:00:00
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journal_title：Journal of molecular biology
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journal_title：Journal of molecular biology
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journal_title：Journal of molecular biology
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journal_title：Journal of molecular biology
pub_type： 杂志文章
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更新日期：2002-11-29 00:00:00
