Abstract：
:The purpose of this paper is to present a simple clotting model, based on residence time and shear stress distribution, that can simulate the deposition over time of enzyme-activated milk in an in vitro system. Results for the model are compared with experiments exhibiting clot deposition in the region of a sharp-edged stenosis. The milk experiments have been shown to be a valuable analogue for the experimental representation of flow-induced blood clotting, particularly in the context of separation of hydrodynamic from biochemical factors. The facility to predict the flow-induced clotting of the blood analogue, in which the chemistry reduces to what is effectively a zeroth order reaction, gives confidence in this physics-based approach to simulation of the final part of the coagulation cascade. This type of study is a necessary precursor to the development of a complex, multi-factorial, biochemical model of the process of thrombosis. In addition to the clotting simulations, comparisons are reported between the computed flow patterns prior to clot deposition and flow visualisation studies. Excellent agreement of hydrodynamic parameters is reported for a Reynolds number of 100, and qualitative agreement is seen for the complex, disturbed flow occurring at a physiologically relevant Reynolds number of 550. The explicit, time-stepping lattice Boltzmann approach may have particular merit for the transitional flow at this higher Reynolds number.
journal_name
J Biomechjournal_title
Journal of biomechanicsauthors
Harrison SE,Smith SM,Bernsdorf J,Hose DR,Lawford PVdoi
10.1016/j.jbiomech.2007.01.026subject
Has Abstractpub_date
2007-01-01 00:00:00pages
3023-8issue
13eissn
0021-9290issn
1873-2380pii
S0021-9290(07)00078-4journal_volume
40pub_type
杂志文章abstract：:Knowledge of accurate in-vivo 6 degree-of-freedom (6-DOF) kinematics of total hip arthroplasty (THA) during daily activities is critical for improvement of longevity of the components. Previous studies assessed in-vivo THA kinematics using skin marker-based motion analysis. However, skin markers are prone to move with...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2014.03.012
更新日期：2014-05-07 00:00:00
abstract：:The finite element (FE) method based on high-resolution peripheral quantitative computed tomography (HR-pQCT) use a variety of tissue constitutive properties and boundary conditions at different laboratories making comparison of mechanical properties difficult. Furthermore, the advent of a second-generation HR-pQCT po...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2018.08.030
更新日期：2018-10-26 00:00:00
abstract：:Experiments were performed to study biaxial anisotropy in relaxed canine carotid arteries subjected to a wide range of longitudinal lengths and transmural pressures. In order to encompass the range of vessel lengths which occurs in situ, 120 carotid arteries were studied at 20%, 40%, 60% and 80% extension relative to ...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(86)90011-4
更新日期：1986-01-01 00:00:00
abstract：:This paper presents a novel inverse estimation approach for the active contraction stresses of tongue muscles during speech. The proposed method is based on variational data assimilation using a mechanical tongue model and 3D tongue surface shapes for speech production. The mechanical tongue model considers nonlinear ...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2017.09.008
更新日期：2017-11-07 00:00:00
abstract：:This study investigates the nature of deformation and differences in the mechanisms of fracture and properties of dentine where there has been a loss of moisture, as may occur with removal of the pulp in the endodontic treatment of teeth. Controlled fracture toughness testing was conducted on bovine teeth to determine...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(02)00327-5
更新日期：2003-02-01 00:00:00
abstract：:A new software tool to assign the material properties of bone to an ABAQUS finite element mesh was created and compared with Bonemat, a similar tool originally designed to work with Ansys finite element models. Our software tool (py_bonemat_abaqus) was written in Python, which is the chosen scripting language for ABAQ...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2016.07.037
更新日期：2016-09-06 00:00:00
abstract：:The forces and moments acting at the hip joint influence the long-term stability of the fixation of endoprostheses and the course of coxarthrosis. These loads may depend on the kind of footwear and the walking or running style. These factors were investigated in a patient with instrumented hip implants. He wore differ...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(94)00129-r
更新日期：1995-07-01 00:00:00
abstract：:Accurate modeling of soft tissue motion effects relative to bone during impact requires knowledge of the mass of soft and rigid tissues in living people. Holmes et al., [2005. Predicting in vivo soft tissue masses of the lower extremity using segment anthropometric measures and DXA. Journal of Applied Biomechanics, 21...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2008.02.013
更新日期：2008-01-01 00:00:00
abstract：:Progress in medicine and higher expectation of quality of life has led to a higher demand for several dental and medical treatments. This increases the occurrence of situations in which orthodontic treatment is complicated by pathological conditions, medical therapies and drugs. Together with experiments, computer mod...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2012.10.037
更新日期：2013-02-01 00:00:00
abstract：:An experimental setup was developed for statically measuring seven vertical and three horizontal reaction forces on the foot. In the setup, the leg can be simultaneously loaded (1) by a vertical force, (2) by an externally applied axial moment, and (3) by simulated muscle forces. The foot is free to invert under influ...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(89)90080-8
更新日期：1989-01-01 00:00:00
abstract：:Bone remodelling is a dynamic process that requires the coordinated interaction of osteocytes, osteoblasts, and osteoclasts, collaborating in basic multicellular units (BMUs). Communication between these cells can be by extracellular soluble molecules as well as directly propagating intercellular signalling molecules....
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2007.02.015
更新日期：2007-01-01 00:00:00
abstract：:Movement variability has become an important field of research and has been studied to gain a better understanding of the neuro-muscular control of human movements. In addition to studies investigating "amplitude variability" there are a growing number of studies assessing the "temporal variability" in movements by ap...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2012.02.008
更新日期：2012-04-30 00:00:00
abstract：:The purpose of this study was to investigate the effects of a total-contact insole with and without subthreshold mechanical random noise on the balance control in diabetic patients with mild-to-moderate peripheral neuropathy. Twenty diabetic patients with mild-to-moderate neuropathy was recruited to this study. A tota...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2020.109656
更新日期：2020-04-16 00:00:00
abstract：:The effect of screw-bone interface modelling strategies was evaluated in the setting of a tibial mid-shaft fracture stabilised using locking plates. Three interface models were examined: fully bonded interface; screw with sliding contact with bone; and screw with sliding contact with bone in an undersized pilot hole. ...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2012.04.008
更新日期：2012-06-01 00:00:00
abstract：:In this study, we tested the compressive stress relaxation behaviors of the mandibular condylar and temporal cartilages in the porcine temporomandibular joint (TMJ). The aim was to determine the quantitative and qualitative similarities and differences of compressive stress relaxation behaviors between the two cartila...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2014.03.007
更新日期：2014-05-07 00:00:00
abstract：:Body segment parameters (BSP) are essential input for the computations in kinetics of motion applied in the field of biomechanics. These data are usually obtained from population-specific predictive equations which present limitations in being representative of the population under study. More recently, medical imagin...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2008.10.036
更新日期：2009-02-09 00:00:00
abstract：:Spinal intervertebral joints are complex structures allowing motion in multiple directions, and many experimental studies have reported moment-rotation response. However, experimental methods, reporting of results, and levels of the spine tested vary widely, and a comprehensive assessment of moment-rotation response a...
journal_title：Journal of biomechanics
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.jbiomech.2019.109579
更新日期：2020-02-13 00:00:00
abstract：:The finite element method described in this study provides an easy method to simulate the kinetics of multibody mechanisms. It is used in order to develop a musculoskeletal model of the shoulder mechanism. Each relevant morphological structure has been represented by an appropriate element. For the shoulder mechanism ...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(94)90065-5
更新日期：1994-05-01 00:00:00
abstract：:To date, the diagnosis of whiplash injuries has been very difficult and largely based on subjective, clinical assessment. The work by Winters and Peles Multiple Muscle Systems--Biomechanics and Movement Organization. Springer, New York (1990) suggests that the use of finite helical axes (FHAs) in the neck may provide ...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(94)90192-9
更新日期：1994-12-01 00:00:00
abstract：:The relative motion of the brain with respect to the skull has been widely studied to investigate brain injury mechanisms under impacts, but the motion patterns are not yet thoroughly understood. This work analyzes brain motion patterns using the most recent and advanced experimental relative brain/skull motion data c...
journal_title：Journal of biomechanics
pub_type： 杂志文章,评审
doi：10.1016/j.jbiomech.2006.06.018
更新日期：2007-01-01 00:00:00
abstract：:Stress analysis in the individual parts of the scapula under normal physiological conditions is necessary to understand the load transfer mechanism, its relation with morphology of bone and to analyse the deviations in stress patterns due to implantation of the glenoid. The purpose of this study was to obtain stress d...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2003.11.025
更新日期：2004-07-01 00:00:00
abstract：:The purpose of this study was to investigate the effect of thickness, cross-sectional area and stiffness of intrinsic foot muscles on performance in single-leg stance balance tasks in healthy sedentary young females. This study included a total of 40 healthy sedentary young females between the ages of 19 and 35 years....
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2019.109530
更新日期：2020-01-23 00:00:00
abstract：:In this paper, a novel multi-slice ultrasound (US) image calibration of an intelligent skin-marker used for soft tissue artefact compensation is proposed to align and orient image slices in an exact H-shaped pattern. Multi-slice calibration is complex, however, in the proposed method, a phantom based visual alignment ...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2016.12.030
更新日期：2017-09-06 00:00:00
abstract：:The purpose of this study was to determine the swimmers' loss of speed during the underwater gliding motion of a grab start. This study also set out to determine the kinematical variables influencing this loss of speed. Eight French national-level swimmers participated in this study. The swimmers were filmed using 4 m...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2009.03.032
更新日期：2009-06-19 00:00:00
abstract：:In order to gain better understanding for rheology of an isolated red blood cell (RBC) and a group of multiple RBCs, new continuum models for describing mechanical properties of cellular structures of an RBC and inter-cellular interactions among multiple RBCs are developed. The viscous property of an RBC membrane, whi...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2015.11.027
更新日期：2016-07-26 00:00:00
abstract：:In label-free biodetections based on microcantilever technology, double-stranded DNA (dsDNA) structures form through the linkage between probe single-stranded DNA (ssDNA) molecules immobilized on solid substrates and target ssDNA molecules in solutions. Mechanical/electrical properties of these biolayers are important...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2009.03.050
更新日期：2009-07-22 00:00:00
abstract：:This study is aimed at the analysis of articular contact in a three-dimensional mathematical model of the human knee-joint. In particular the effect of articular contact on the passive motion characteristics is assessed in relation to experimentally obtained joint kinematics. Two basically different mathematical conta...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(91)90019-j
更新日期：1991-01-01 00:00:00
abstract：:Nowadays in various daily, occupational and training activities, there are many occasions with forces supported in hands acting at various magnitudes, elevations, and orientations with substantial horizontal components. In this work, we aim to compute trunk muscle forces, stability, and spinal loads under pulling exte...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2015.09.036
更新日期：2016-04-11 00:00:00
abstract：:This study suggests a method that, on the basis of concurrent cinematographic and dynamometric measurements, detects the motion of the visceral part of the body, provided that an estimate of its mass has been given in advance and the periodicity of the system dynamics can be assumed. The mathematical model provides eq...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(94)90036-1
更新日期：1994-01-01 00:00:00
abstract：:Spinal arthrodesis continues to expand in clinical indications and surgical practice. Despite a century of study, failure of bone formation or pseudarthrosis can occur in individual patients with debilitating clinical symptoms. Here we review biological and technical aspects of spinal fusion under active investigation...
journal_title：Journal of biomechanics
pub_type： 杂志文章,评审
doi：10.1016/j.jbiomech.2010.10.021
更新日期：2011-01-11 00:00:00
