Abstract：
:In order to gain better understanding for rheology of an isolated red blood cell (RBC) and a group of multiple RBCs, new continuum models for describing mechanical properties of cellular structures of an RBC and inter-cellular interactions among multiple RBCs are developed. The viscous property of an RBC membrane, which characterizes dynamic behaviors of an RBC under stress loading and unloading processes, is determined using a generalized Maxwell model. The present model is capable of predicting stress relaxation and stress-strain hysteresis, of which prediction is not possible using the commonly used Kelvin-Voigt model. Nonlinear elasticity of an RBC is determined using the Yeoh hyperelastic material model in a framework of continuum mechanics using finite-element approximation. A novel method to model inter-cellular interactions among multiple adjacent RBCs is also developed. Unlike the previous modeling approaches for aggregation of RBCs, where interaction energy for aggregation is curve-fitted using a Morse-type potential function, the interaction energy is analytically determined. The present aggregation model, therefore, allows us to predict various effects of physical parameters such as the osmotic pressure, the thickness of a glycocalyx layer, the penetration depth, and the permittivity, on the depletion and electrostatic energy among RBCs. Simulations for elongation and recovery deformation of an RBC and for aggregation of multiple RBCs are conducted to evaluate the efficacy of the present continuum modeling methods.
journal_name
J Biomechjournal_title
Journal of biomechanicsauthors
Yoon D,You Ddoi
10.1016/j.jbiomech.2015.11.027subject
Has Abstractpub_date
2016-07-26 00:00:00pages
2267-2279issue
11eissn
0021-9290issn
1873-2380pii
S0021-9290(15)00669-7journal_volume
49pub_type
杂志文章abstract：:As humans walk or run, external (environmental) and internal (physiological) disturbances induce variability. How humans regulate this variability from stride-to-stride can be critical to maintaining balance. One cannot infer what is "controlled" based on analyses of variability alone. Assessing control requires quant...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2018.05.034
更新日期：2018-07-25 00:00:00
abstract：:Poisson's ratio has not been experimentally measured earlier for meniscus in compression. It is however an important intrinsic material property needed in biomechanical analysis and computational models. In this study, equilibrium Poisson's ratio of bovine meniscus (n = 6) was determined experimentally by combining st...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2018.07.001
更新日期：2018-08-22 00:00:00
abstract：:This paper shows how information on the fatigue behaviour of microcracks can be obtained by the analysis of stiffness changes measured during cyclic loading. Relationships between crack length, growth rate and cyclic stress intensity were deduced, and compared with previous empirical equations. Results show that the c...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(98)00050-5
更新日期：1998-07-01 00:00:00
abstract：:Stiff-knee gait is characterized by diminished and delayed knee flexion during swing. Rectus femoris transfer surgery, a common treatment for stiff-knee gait, is often recommended when a patient exhibits prolonged activity of the rectus femoris muscle during swing. Treatment outcomes are inconsistent, in part, due to ...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2008.05.030
更新日期：2008-08-07 00:00:00
abstract：:This paper presents a three-dimensional finite element model of skeletal muscle which was developed to simulate active and passive non-linear mechanical behaviours of the muscle during lengthening or shortening under either quasi-static or dynamic condition. Constitutive relation of the muscle was determined by using ...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2009.01.021
更新日期：2009-05-11 00:00:00
abstract：:We present a comparison of the flow characteristics in an idealized smooth trachea model and a second model which has a roughness simulating cartilaginous rings. We use refractive index-matched particle image velocimetry (PIV) to measure the velocity field in a two-generation model of the trachea and main bronchi. The...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2016.03.043
更新日期：2016-06-14 00:00:00
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journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2007.04.014
更新日期：2007-01-01 00:00:00
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journal_title：Journal of biomechanics
pub_type： 临床试验,杂志文章
doi：10.1016/S0021-9290(03)00251-3
更新日期：2004-09-01 00:00:00
abstract：:The hemodynamic influence of vessel shape such as bifurcation angle is not fully understood with clinical and quantitative observations being equivocal. The aim of this study is to use computational modeling to study the hemodynamic effect of shape characteristics, in particular bifurcation angle (BA), for non-stented...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2016.03.038
更新日期：2016-06-14 00:00:00
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journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(03)00083-6
更新日期：2003-08-01 00:00:00
abstract：:The effect of non-habitual physical activity on bone architecture in the rat humeral shaft was examined. Two groups of rats were trained to swim for 1 h a day, for 20 weeks, at two training levels. The control group consisted of sedentary rats. Parameters of cross-sectional bone morphology (cross-section areas, princi...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(89)90068-7
更新日期：1989-01-01 00:00:00
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journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(00)00020-8
更新日期：2000-07-01 00:00:00
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journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：
更新日期：1996-12-01 00:00:00
abstract：:Muscle force is modulated by varying the number of active motor units and their firing rates. For the past five decades, the notion that the magnitude of the firing rates is directly related to motor unit size and recruitment threshold has been widely accepted. This construct, here named the After-hyperpolarization sc...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2014.12.003
更新日期：2015-01-21 00:00:00
abstract：:The Ramberg-Osgood equation is used to model the viscoplastic properties of compact bone. Because of the exponential nature of this equation a special optimization technique is used to curve fitting. Results are presented for the application of this equation to three sets of strain rate dependent stress-strain curves ...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(83)90076-3
更新日期：1983-01-01 00:00:00
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journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2015.03.011
更新日期：2015-07-16 00:00:00
abstract：:Response surface methodology is used to establish robust and user-friendly predictive equations that relate responses of a complex detailed trunk finite element biomechanical model to its input variables during sagittal symmetric static lifting activities. Four input variables (thorax flexion angle, lumbar/pelvis rati...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2010.08.028
更新日期：2011-01-04 00:00:00
abstract：:Knee joint sounds contain information on joint health, morphology and loading. These acoustic signals may be elicited by further, as yet unknown factors. By assessing potential elicitors and their relative contributions to the acoustic signal, we investigated the validity of vibroarthrographic assessments during diffe...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2020.109939
更新日期：2020-08-26 00:00:00
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journal_title：Journal of biomechanics
pub_type： 杂志文章,评审
doi：10.1016/j.jbiomech.2012.11.027
更新日期：2013-01-18 00:00:00
abstract：:This paper discusses the manner in which random Gaussian errors affect the determination of body segment kinematics. For the process of modelling rigid body (RB) motion, three types of kinematic errors, input, measured and theoretical, are identified. These correspond to errors in: the determination of three-dimension...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(96)00008-5
更新日期：1996-09-01 00:00:00
abstract：:Mechanical forces regulate the function of bone cells. In this paper, the effects of cyclic stretching on osteoblasts derived from rat calvaria were studied at a magnitude occurring in physiological loaded bone tissue. A four-point bending apparatus was used to apply cyclic stretching on osteoblasts. Stretching at 500...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(03)00237-9
更新日期：2004-01-01 00:00:00
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journal_title：Journal of biomechanics
pub_type： 杂志文章
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更新日期：1994-08-01 00:00:00
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journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2009.09.048
更新日期：2010-02-10 00:00:00
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journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2012.04.003
更新日期：2012-06-01 00:00:00
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journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(99)00054-8
更新日期：1999-07-01 00:00:00
abstract：:The mechanical properties of vertebrate erythrocytes depend on their cytoskeletal protein networks. Membrane skeleton proteins spectrin and protein 4.1 (4.1R) cross-link with actin to maintain membrane stability under mechanical stress. Phosphorylation of 4.1R alters the affinity of 4.1R for spectrin-actin binding and...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2014.07.022
更新日期：2014-10-17 00:00:00
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journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2006.07.020
更新日期：2007-01-01 00:00:00
abstract：:Pulsatile flow in abdominal aortic aneurysm (AAA) models has been examined in order to understand the hemodynamics that may contribute to growth of an AAA. The model studies were conducted by experiments (flow visualization and laser Doppler velocimetry) and by numerical simulation using physiologically realistic rest...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(99)00134-7
更新日期：1999-12-01 00:00:00
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journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2018.04.009
更新日期：2018-06-06 00:00:00
abstract：:To study the effect of pressure changes on the opening angle of arteries in organ culture, tubular segments of porcine common carotid arteries were cultured with pulsatile flow perfusion under hypertensive (150+/-20 mmHg), normotensive (100+/-20 mmHg), or hypotensive (30+/-10 mmHg) pressure while maintaining the arter...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2005.08.003
更新日期：2006-01-01 00:00:00
