Abstract：
BACKGROUND:Surveys in USA and UK have shown inconsistencies between practice of sweat testing and guidelines of the National Committee for Clinical Laboratory Standards (NCCLS), which could increase the risk of false-positive and -negative results. To determine the current practice of sweat testing in German cystic fibrosis (CF)-centres a survey was performed. METHOD:A questionnaire was mailed to all 123 German CF-centres that join the German CF-register. The results were compared with the NCCLS-guidelines. RESULTS:88 out of 113 responding centres perform 30-1100 (median 200) sweat tests by pilocarpine iontophoresis per year. The recommended sweat sample time of 20-30 min was accepted by 33% of all centres. Minimum acceptable sweat rates were quoted between 100 and 7500 (median 1000) mg/m (2)/min differing from the recommended 1000 mg/m (2)/min. Osmolality was measured in 3%, sodium in 24% and conductivity in 53% of the centres. Chloride, the only accepted diagnostic measurement by the NCCLS, was investigated by only 58% of all centres. The recommended chloride CF-reference value of >60 mmol/l was used in 78% of centres that perform chloride testing. CONCLUSIONS:Major areas of inconsistencies between sweat testing practice in German CF-centres and NCCLS-guidelines are sweat collection, analyzing method and reference values. Chloride, the only accepted diagnostic measurement by the NCCLS, was investigated only by 58% of all centres.
journal_name
Klin Padiatrjournal_title
Klinische Padiatrieauthors
Naehrlich Ldoi
10.1055/s-2007-872458subject
Has Abstractpub_date
2007-03-01 00:00:00pages
70-3issue
2eissn
0300-8630issn
1439-3824journal_volume
219pub_type
杂志文章abstract：:The pros and cons of home monitoring especially for premature infants with continuing apneic episodes and/or chronic lung disease are an ongoing discussion. The controversy spans socio-economic requirements, medical indication as well as patient and family needs. Here, the costs of home monitoring and follow-up care o...
journal_title：Klinische Padiatrie
pub_type： 杂志文章
doi：10.1055/s-0034-1395663
更新日期：2015-03-01 00:00:00
abstract：:We studied the influence of preload augmentation on Doppler-derived left ventricular diastolic function parameters in infants with a birth weight <1500 g. In 44 neonates with a closed duct and 29 neonates with an open ductus arteriosus a complete echocardiographic study including Doppler investigations of the mitral i...
journal_title：Klinische Padiatrie
pub_type： 杂志文章
doi：10.1055/s-2004-817684
更新日期：2004-01-01 00:00:00
abstract：:Infants exposed to opiates antenatally display withdrawal symptoms after birth referred to as neonatal abstinence syndrome (NAS).A total of 366 newborns (166 females, 10 twins) from 361 mothers were diagnosed with NAS from 2000 to 2011 at a single large metropolitan referral center.Retrospective chart review of all ne...
journal_title：Klinische Padiatrie
pub_type： 杂志文章
doi：10.1055/s-0042-115300
更新日期：2017-01-01 00:00:00
abstract：:Centralized treatment of critically ill pediatric patients and related problems are presented. Pediatric intensive care allows to overbridge deranged or interrupted organ functions while simultaneously treating the disease causing the disturbance. Its efficiency depends on continuity of medical care. Medical and nursi...
journal_title：Klinische Padiatrie
pub_type： 杂志文章,评审
doi：10.1055/s-2008-1035616
更新日期：1980-09-01 00:00:00
abstract：:Report on two babies, 5 and 6 months old with severe salt depletion were admitted to our hospital with fever and gastro-enteritis. One of them failed to thrive despite normal nutrition, the other one had a protracted gastro-enteritis. Both of them had a great loss of weight, a strong dehydration and were in reduced ge...
journal_title：Klinische Padiatrie
pub_type： 杂志文章
doi：10.1055/s-2008-1043976
更新日期：1997-11-01 00:00:00
abstract：:A case of a severe heroin withdrawal syndrom in a newborn infant is reported. Diagnostic and therapeutic aspects of the disease are reviewed. ...
journal_title：Klinische Padiatrie
pub_type： 杂志文章
doi：
更新日期：1976-11-01 00:00:00
abstract：:We have performed in situ hybridization (ISH) studies predominantly on paraffin sections and on isolated nuclei of 22 pediatric germ cell tumors (GCTs) from 18 patients including 4 recurrences from three patients. In addition, we performed conventional cytogenetic analyses in three tumor samples. Because reports on cy...
journal_title：Klinische Padiatrie
pub_type： 杂志文章
doi：10.1055/s-2008-1046547
更新日期：1995-07-01 00:00:00
abstract：:Transfusion-induced hemochromatosis remains a major therapeutic complication in the management of patients with chronic hemolytic anemias. Red cell units harvested with blood cell separators have an average estimated mean cell age of 30 days, compared to 60 days for unfractionated blood. Our initial experience with tr...
journal_title：Klinische Padiatrie
pub_type： 杂志文章
doi：10.1055/s-2008-1033936
更新日期：1985-03-01 00:00:00
abstract：:Infectious complications are a major cause of morbidity and mortality in pediatric and adult patients undergoing hematopoietic stem cell transplantation. The incidence and the severity code of infections depend on the function of the host's immune system. This function is strongly correlated to the application of immu...
journal_title：Klinische Padiatrie
pub_type： 杂志文章,评审
doi：10.1055/s-2005-872508
更新日期：2005-11-01 00:00:00
abstract：:We report about two patients with compression of the spinal cord caused by lymphosarcomas. In the first patient the tumour was localized in the lumbal region and destroyed two vertebrae. In the second patient the lymphosarcoma also infiltrated the meninx, the cord, and some internal organs. Both children died. ...
journal_title：Klinische Padiatrie
pub_type： 杂志文章
doi：
更新日期：1979-03-01 00:00:00
abstract：:Interferons are components of the nonspecific defense system. Their most prominent biological roles are the antiviral, the antiproliferative, and the immunoregulatory activities. However, their primary functions within the organism remains to be determined. Three types of IFNs have been described so far (IFN alpha, IF...
journal_title：Klinische Padiatrie
pub_type： 杂志文章
doi：10.1055/s-2008-1033980
更新日期：1985-07-01 00:00:00
abstract：BACKGROUND:Flank swelling and pseudotumors of the kidney are unusual manifestations of obstructive uropathies in small children. Our case illustrates typical problems and briefly reviews management options. CASE REPORT:A 5-week-old boy presented with a large, palpable urinoma due to posterior urethral valves. Sonograp...
journal_title：Klinische Padiatrie
pub_type： 杂志文章
doi：10.1055/s-2006-933545
更新日期：2006-09-01 00:00:00
abstract：:The phagocytic and NBT reduction indices of 94 preterm and underweight babies, divided into 7 groups and two weight classes, were observed over a period of six weeks while they were observed over a period of six weeks while they were given four commercial baby foods (Humana 0, Meb, Multival, Pomil). In all groups the ...
journal_title：Klinische Padiatrie
pub_type： 杂志文章
doi：
更新日期：1978-03-01 00:00:00
abstract：:The article reports on a case of visceral leishmaniasis in a 3-year-old child of German residents in Rome who had passed two vacations on the isle of Ischia. Initial signs were intermittent temperatures, marked anorexia, hepatosplenomegaly and pancytopenia, with spontaneous recovery after three weeks. At that time, le...
journal_title：Klinische Padiatrie
pub_type： 杂志文章
doi：
更新日期：1979-05-01 00:00:00
abstract：:The aetiology and pathogenesis of the Duchenne-type muscular dystrophy (pseudohypertrophic muscular dystrophy) are still largely unknown. The possibilities of treating the disease are rather limited. Treatment is the more successful, the earlier diagnosis was possible, and the earlier treatment is initiated. The CK-Sc...
journal_title：Klinische Padiatrie
pub_type： 杂志文章,评审
doi：
更新日期：1978-11-01 00:00:00
abstract：:Scoring systems for evaluation of the degree of severity in patients with cystic fibrosis are critically evaluated. Cross-sectional comparison of Shwachman's score, Cooperman's score, Taussig-NIH score, Bernese score and Huang score reveals that advantages and disadvantages of each score exist. In early days used as a...
journal_title：Klinische Padiatrie
pub_type： 杂志文章,评审
doi：10.1055/s-2007-1025188
更新日期：1993-01-01 00:00:00
abstract：:We report the first case of non-immune hydrops fetalis (NIHF) with trisomy 15q11/17q22.5 resulting from a familial translocation 15/17. Furthermore the cytogenetic findings of 50 cases with hydrops fetalis are presented. Of the 30 cytogenetic analyzable cases 7 showed chromosomal abnormalities (4x45,X; 2x47,XY,+21; 1x...
journal_title：Klinische Padiatrie
pub_type： 杂志文章
doi：10.1055/s-2008-1026810
更新日期：1987-07-01 00:00:00
abstract：:Within the scope of an observation study 40 premature low birth weight infants requiring parenteral nutrition received either 10% or 20% lipid emulsions (Lipovenös) for 7 days. The 10% lipid emulsion differs from the 20% lipid emulsion in the higher phospholipid/triglyceride-ratio (0.06 resp. 0.12). Lipid infusion was...
journal_title：Klinische Padiatrie
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1055/s-2007-1025318
更新日期：1992-01-01 00:00:00
abstract：BACKGROUND:Most recent studies analyzing candidate biological prognostic factors in childhood medulloblastoma (MB) are limited by small patient numbers due to dependence on fresh-frozen tumor material. By contrast, large archives of formalin-fixed, paraffin-embedded MB samples exist from homogeneously treated patients....
journal_title：Klinische Padiatrie
pub_type： 杂志文章
doi：10.1055/s-2007-985843
更新日期：2007-11-01 00:00:00
abstract：:Wegener's granulomatosis is together with Churg-Strauss syndrome and microscopic polyangiitis a very rare cause of hemoptysis in childhood. We report on a 14 years old girl who developed arthralgia, purpura, glomerulonephritis and a diffuse alveolar haemorrhage with hemoptysis after a short time period of unspecific s...
journal_title：Klinische Padiatrie
pub_type： 杂志文章
doi：10.1055/s-2005-836847
更新日期：2006-01-01 00:00:00
abstract：:From 1975-1986 6 boys with congenital nephrogenic diabetes insipidus were diagnosed at the age of 3 months to 10 years. Symptoms appeared within the first few weeks of life. The diagnosis was confirmed by polyuria, low urinary osmolality (97-225 mosm/kg H20), hypernatraemia (max. 171 mmol/l) and the missing response t...
journal_title：Klinische Padiatrie
pub_type： 杂志文章
doi：10.1055/s-2008-1026741
更新日期：1989-11-01 00:00:00
abstract：:Cytological examination of cerebrospinal fluid needs special techniques of cell collecting and staining. On condition of realizing the methodical requirements cytology of the cerebrospinal fluid brings more advancement in diagnostics than other laboratory examinations. The advantages of this procedure are: 1. Meningit...
journal_title：Klinische Padiatrie
pub_type： 杂志文章
doi：
更新日期：1975-03-01 00:00:00
abstract：:Low birth weight babies and sick full-term babies, who require total parenteral nutrition and repeated intravenous applications of drugs, which irritate peripheral veins, very often need a reliable central venous catheter. The aim of our paper was to study prospectively the efficiency and the complications of peripher...
journal_title：Klinische Padiatrie
pub_type： 杂志文章
doi：10.1055/s-2008-1046574
更新日期：1994-01-01 00:00:00
abstract：:Central nervous system (CNS) tumors account for the highest mortality among pediatric malignancies. Accurate diagnosis is essential for optimal clinical management. The increasing use of molecular diagnostics has opened up novel possibilities for more precise classification of CNS tumors. We here report a single-insti...
journal_title：Klinische Padiatrie
pub_type： 杂志文章
doi：10.1055/a-0637-9653
更新日期：2018-10-01 00:00:00
abstract：:Bacterial endocarditis belongs to the rare diseases in childhood. It occurs usually as a single episode and almost exclusively in children with congenital heart disease. In recent years, however, an increased number of renewed endocarditis after the first episode were reported, especially in drug addicts. We present a...
journal_title：Klinische Padiatrie
pub_type： 杂志文章,评审
doi：10.1055/s-2008-1046498
更新日期：1995-01-01 00:00:00
abstract：:Possibilities of recognizing cerebral function disturbances in newborns as early as the acute phase of the condition, and of prognosticating permanent brain damage are described. Clinical findings such as lethargy or spasms in the second and third weeks of life following hypoxia indicate severe function disturbances w...
journal_title：Klinische Padiatrie
pub_type： 杂志文章,评审
doi：10.1055/s-2008-1034092
更新日期：1984-11-01 00:00:00
abstract：:In case of painful scoliosis, a search for etiologic factors in the vertebral spinal canal and adjacent structures should be made. MRI with Gadolinium is useful to look for various pathology in and around the spine in particular of spinal cord. CT scanning is indispensible for bony details. Thus CT and MRI are complem...
journal_title：Klinische Padiatrie
pub_type： 杂志文章,评审
doi：10.1055/s-2008-1043932
更新日期：1997-03-01 00:00:00
abstract：:The article reports on the case history of a 8 month old baby who fell ill of a ileocolic intussusception. The barium enema demonstrated the typical cupping in the head of the barium. The successful reposition by hydrostatic pressure was manifest by barium reflux in the small intestine. ...
journal_title：Klinische Padiatrie
pub_type： 杂志文章
doi：10.1055/s-2008-1034383
更新日期：1983-07-01 00:00:00
abstract：BACKGROUND:Children with Epidermolysis bullosa (EB) suffer from an intractable, burdensome skin disease that may result in cognitive as well as social and emotional problems. PATIENTS:To assess cognitive problems in patients with EB, we investigated 20 affected children and adolescents, 6-17 years of age (mean: 10.8 y...
journal_title：Klinische Padiatrie
pub_type： 杂志文章
doi：10.1055/s-0031-1295437
更新日期：2012-01-01 00:00:00
abstract：:Members of the histone deacetylase (HDAC) family exhibit great promise as potential drug targets in pediatric tumors including neuroblastoma, medulloblastoma, ependymoma and Ewing's sarcoma. HDAC inhibitors of various structural classes have shown anti-tumoral effects in pre-clinical pediatric tumor models as single a...
journal_title：Klinische Padiatrie
pub_type： 杂志文章,多中心研究
doi：10.1055/s-0032-1323692
更新日期：2012-10-01 00:00:00
