[Doppler echocardiographic investigation of left ventricular diastolic function in preterm infants with and without a patent ductus arteriosus].

Abstract:

:We studied the influence of preload augmentation on Doppler-derived left ventricular diastolic function parameters in infants with a birth weight <1500 g. In 44 neonates with a closed duct and 29 neonates with an open ductus arteriosus a complete echocardiographic study including Doppler investigations of the mitral inflow signals and analysis of diastolic time intervals was performed. Neonates with an open duct had a lower median gestational age (27.1 vs. 29, P<0.01), a higher cardiac index (425 vs. 260 ml/min/kg, P<0.001), and a different M-mode left atrial to aortic diameter ratio (1.36 vs. 0.79, P<0.001), but birth weight, age at examination (6.6 vs. 7.9 days), and heart rate were similar compared to the neonates with a closed duct. Main differences in diastolic indexes existed in early and atrial filling integrals and peak velocities, early filling acceleration time, and isovolumic relaxation time. Most informative in neonates with an open ductus peak early filling velocity (41.2 vs. 30.4 cm, P<0.01) and peak atrial filling velocity (49.2 vs. 35.9, P<0.001) are higher, and isovolumic relaxation time is shorter (45 vs. 53 ms, P<0.001) than in closed duct peers. Isovolumic relaxation time is inversely correlated with the cardiac index (R = -0.78). These parameter changes can be interpreted as incipient left ventricular diastolic failure in extremely low birth weight infants in the presence of a preload challenge. The coincidence of higher peak velocities with a shortened isovolumic relaxation time is very likely a result of left atrial pressure elevation. Preload mismatch has to be considered in preterm infants with a persistent ductus arteriosus. The results of this study can be helpful to find the indication for PDA-closure and to adjust volume replacement therapy, and catecholamine medication to a level appropriate for the individual cardiac performance.

journal_name

Klin Padiatr

journal_title

Klinische Padiatrie

authors

Schmitz L,Stiller B,Koehne P,Koch H,Lange PE

doi

10.1055/s-2004-817684

keywords:

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

36-40

issue

1

eissn

0300-8630

issn

1439-3824

journal_volume

216

pub_type

杂志文章
  • [Purulent pericarditis during abscess-forming pneumonia].

    abstract::The case is described of a 6 months old infant who developed purulent pericarditis during the course of pneumonia. Pericarditis probably developed in this condition by contiguous spread from the pleura. Diagnosis of impending cardiac tamponade was masked by the occurrence of massive unilateral empyema. The management ...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2008-1033831

    authors: Beitzke A,Trittenwein G,Rigler B,Grubbauer HM,Suppan C

    更新日期:1982-09-01 00:00:00

  • [Ductus aneurysm as a rare cause of inspiratory stridor in the newborn infant].

    abstract::A paralysis of the left vocal cord was seen by laryngoscopy in a 3-days-old boy with inspiratory stridor. A ductus aneurysm was established by angiocardiography, which was believed to be the cause of the vocal cord paralysis. Within 8 days after the angiocardiography the aneurysm became smaller and the stridor disappe...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2008-1026854

    authors: Scharf J,Richter K,Singer H,Deeg KH

    更新日期:1986-01-01 00:00:00

  • X-linked agammaglobulinemia in community-acquired pneumonia cases revealed by immunoglobulin level screening at hospital admission.

    abstract::In children with primary immunodeficiencies, the onset of symptoms precedes the diagnosis and the initiation of appropriate treatment by months or years. This delay in diagnosis is due to the fact that while these disorders are rare, some of the infections seen in immunodeficient patients are common. Defective antibod...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-0033-1354415

    authors: Vancikova Z,Freiberger T,Vach W,Trojanek M,Rizzi M,Janda A

    更新日期:2013-11-01 00:00:00

  • Symptom patterns in childhood arterial ischemic stroke: Analysis of a population-based study in Germany.

    abstract:HINTERGRUND: Die zeitliche Verzögerung zwischen Symptombeginn und Diagnose ist eine Herausforderung in der Behandlung von Kindern mit arteriell ischämischem Schlaganfall. Frühere Studien zur klinischen Präsentation beschäftigten sich v. a. mit kumulativen Symptomen. ZIELSETZUNG: Ziel dieser Studie ist es, mögliche Sym...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/a-0684-9794

    authors: Gerstl L,Weinberger R,von Kries R,Heinen F,Sebastian Schroeder A,Veronika Bonfert M,Borggräfe I,Tacke M,Vill K,N Landgraf M,Kurnik K,Olivieri M

    更新日期:2018-10-01 00:00:00

  • [Septicaemia in the neonatal and infant period (author's transl)].

    abstract::The paper reported about septicaemia in the neonatal and infant period. Continuing former investigations by Kienitz in the same pediatric clinic we have got a survey from 1933 to 1974. In the last years we saw increasingly more infections with gram-negative organisms, especially by Pyocyaneus with a severe prognosis. ...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:

    authors: Diekmann L,Kotzur J

    更新日期:1976-03-01 00:00:00

  • [Duchenne-type muscular dystrophy: problems, early diagnosis, early treatment (author's transl)].

    abstract::The aetiology and pathogenesis of the Duchenne-type muscular dystrophy (pseudohypertrophic muscular dystrophy) are still largely unknown. The possibilities of treating the disease are rather limited. Treatment is the more successful, the earlier diagnosis was possible, and the earlier treatment is initiated. The CK-Sc...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章,评审

    doi:

    authors: Beckmann R

    更新日期:1978-11-01 00:00:00

  • [Acute Ethanol Intoxication among Children and Adolescents - Analysis of 287 Hospitalized Cases Severity and Characteristics in Children under 14 Years].

    abstract:BACKGROUND:  Despite a reduction in hospitalizations due to acute alcohol intoxication in minors, alcohol consumption among children and adolescents still presents an alarming social and clinical phenomenon. This is amplified by presumably more severe clinical symptoms of the alcohol intoxication in children and adoles...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/a-1186-2155

    authors: Lozada CAQ,Bartels MB,Kieslich M

    更新日期:2020-09-01 00:00:00

  • [Early childhood intervention - access to risk families and support through actors from the health-care sector].

    abstract::Interdisciplinary cooperation and networking determine the success of activities for supporting families at risk for early childhood abuse. The integration of the healthcare sector might be important.The medical standard of perinatal care at the University hospital includes information exchange about family risk facto...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-0034-1374603

    authors: Clauß D,Deutsch J,Krol I,Haase R,Willard P,Müller-Bahlke T,Mauz-Körholz C,Körholz D

    更新日期:2014-07-01 00:00:00

  • [Cerebral AV fistula with cardiac insufficiency in newborns (author's transl)].

    abstract::A case of arteriovenous aneurysm of the great vein of Galen with congestive heart failure in a newborn infant is presented. Efficiancy of medical management and stop of growth of the head circumference point towards a good prognosis. Patients with this malformation have been divided into four clinical groups presentin...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:

    authors: Beitzke A,Zach M,Gypser G,Schreyer H

    更新日期:1977-09-01 00:00:00

  • [Rheumatic iridocyclitis in childhood--differentiation on the basis of clinical and immunological parameters (author's transl)].

    abstract::In approximately 10% of the children suffering from juvenile chronic arthritis (JCA), rheumatic iridocyclitis was also diagnosed. In 90 JCA and iridocyclitis patients we studied relative risk, clinical course and prognosis by means of several clinical and immunological parameters. Antinuclear antibodies (ANA), selecti...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2008-1033783

    authors: Michels H,Schuchmann L,Truckenbrodt H,Renz K

    更新日期:1982-03-01 00:00:00

  • [Progress and change in nuclear magnetic resonance diagnosis of congenital and acquired heart defects].

    abstract::Since 1987, the authors have examined 186 patients (76 girls, 110 boys) with a variety of congenital and acquired heart diseases by means of magnetic resonance imaging (MRI). The patients' ages ranged from 2 days to 20 years (mean age 3.97 years). During the study new techniques were developed, which extend the applic...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2007-1025369

    authors: Sieverding L,Jung WI,Fleiter TH,Klose U,Steil E,Hassberg D,Rosendahl W

    更新日期:1992-09-01 00:00:00

  • [Thorax drainage with the Matthys-tube].

    abstract::The Thorax-Tube according to Matthys and its successful application in 18 premature and mature newborns and older children is described. The advantages of this new device are discussed. ...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:

    authors: Töllner U,Hofstetter R

    更新日期:1977-03-01 00:00:00

  • Prospective multicenter registration of major late sequelae in sarcoma patients using the Late Effects Surveillance System (LESS).

    abstract:BACKGROUND:Late effects become progressively more important for the evaluation of therapeutic success in paediatric oncology. Thus, in 1998, the Late Effects Surveillance System (LESS) started to register and assess multicentrally, prospectively and longitudinally late effects of treatment for the group of Ewing's, sof...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2005-836503

    authors: Langer T,Stöhr W,Paulides M,Kremers A,Dörr HG,Göbel U,Beck JD

    更新日期:2005-05-01 00:00:00

  • [Symptoms, Comorbidities and Therapy of Children and Adolescents with Gender Dysphoria].

    abstract:INTRODUCTION:Gender dysphoria (GD) in childhood and adolescence is characterized by an incongruence between sex at birth and gender identity, which usually increases during puberty. Gender dysphoric children and adolescents often suffer from psychological comorbidities such as depression. The purpose of our study is to...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章,评审

    doi:10.1055/a-1066-4625

    authors: Specht AA,Gesing J,Pfaeffle R,Koerner A,Kiess W

    更新日期:2020-01-01 00:00:00

  • Diagnostic and therapeutic considerations on inherited platelet disorders in neonates and children.

    abstract::Inherited disorders of platelets constitute a group of rare diseases that give rise to bleeding syndromes of variety severity, with more severe cases being first diagnosed during infancy and childhood. To appropriate diagnose a platelet function disorder during early childhood the knowledge of the physiological charac...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-0030-1249065

    authors: Schlegel N,Bardet V,Kenet G,Muntean W,Zieger B,Nowak-Göttl U,Working Group on Standardisation in Perinatal and Pediatric Hemostasis.

    更新日期:2010-05-01 00:00:00

  • [Sweat testing practices in German cystic fibrosis centres].

    abstract:BACKGROUND:Surveys in USA and UK have shown inconsistencies between practice of sweat testing and guidelines of the National Committee for Clinical Laboratory Standards (NCCLS), which could increase the risk of false-positive and -negative results. To determine the current practice of sweat testing in German cystic fib...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2007-872458

    authors: Naehrlich L

    更新日期:2007-03-01 00:00:00

  • [Concordance of prune belly syndrome and VACTERL association].

    abstract::We report on a male premature infant with hypoplastic abdominal wall musculature, urinary tract anomalies and kryptorchism--the main features of Prune-Belly-syndrome. Furthermore the patient showed cardiac anomalies, urinary tract anomalies, limb defects, vertebral anomalies and anal atresia, which belong to the main ...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:

    authors: Oztürk B,Weber HP,Ganz A

    更新日期:1994-09-01 00:00:00

  • Pathology and molecular biology of teratomas in childhood and adolescence.

    abstract::The biologic behaviour of teratomas depends on various interdependent clinical and epidemiologic variables such as the age at diagnosis, sex, tumor site, histology which all correlate to different cytogenetic and molecular biologic aberrations. Thus, testicular teratomas of infancy are generally benign. Accordingly, p...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2006-942271

    authors: Harms D,Zahn S,Göbel U,Schneider DT

    更新日期:2006-11-01 00:00:00

  • [Influence of nutrition on the cellular defence mechanism (phagocytosis) of preterm and underweight babies during the first six weeks of life (author's transl)].

    abstract::The phagocytic and NBT reduction indices of 94 preterm and underweight babies, divided into 7 groups and two weight classes, were observed over a period of six weeks while they were observed over a period of six weeks while they were given four commercial baby foods (Humana 0, Meb, Multival, Pomil). In all groups the ...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:

    authors: Jeschke R,Ströder J

    更新日期:1978-03-01 00:00:00

  • [Delay of constitutional development--studies on therapy with growth hormone].

    abstract::Human growth hormone was given to 6 boys with constitutional delay of growth and development. Three patients had normal growth hormone responses following exercise or insulin-induced hypoglycemia. Subnormal growth rate (less than 2 SD below normal for bone age) was found in 4 patients. The mean growth rate of the pati...

    journal_title:Klinische Padiatrie

    pub_type: 临床试验,杂志文章

    doi:10.1055/s-2007-1025580

    authors: Butenandt O

    更新日期:1984-03-01 00:00:00

  • [The West-Berlin therapy study of acute lymphoblastic leukemia in childhood--report after 6 years].

    abstract::During the last 6 years 73 previously untreated children and adolescents with acute lymphoblastic leukemia were enrolled on a non-randomized therapy protocol. In this longitudinal study the specific accent was put on the intensified induction treatment of 8 weeks' duration which was thought to achieve a higher remissi...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-0033-1337959

    authors: Riehm H,Gadner H,Welte K

    更新日期:2013-05-01 00:00:00

  • [Thrombocyte morphology and function during high-dose immunoglobulin therapy in acute and chronic idiopathic thrombocytopenic purpura. 1].

    abstract::We examined the effectiveness of a high-dose Immunglobulin therapy in 8 patients with idiopathic thrombocytopenic purpura (ITP) and measured the number, the morphology and the function of Thrombocytes as well as thrombocyte dependent clotting parameters. 0.5 g/kg/B.W. 7s-Immunglobulin (7s-IgG) per treatment led to nor...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2008-1034034

    authors: Wahlen W,Graf N,Nienhaus KH,Müller J

    更新日期:1983-01-01 00:00:00

  • [The predictive value of the GRF-stimulation test].

    abstract::48 patients between one and seventeen years of age were stimulated with GRF (1-29) NH2. Seventeen of them showed a constitutional delay in growth and puberty, twenty-three suffered from growth-hormone deficiency (GHD) and eight had a suspected GHD as a result of pharmacological tests. Although the results demonstrate ...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2007-1025510

    authors: Andler W,Eiden S

    更新日期:1990-05-01 00:00:00

  • [Achalasia, alacrimia and cortisol deficiency--Allgrove syndrome].

    abstract::Review of a rare multisystem disorder with the main symptoms achalasia of the esophagus, alacrimia and glucocorticoid deficiency as well as multiple other symptoms especially of the nervous system. Report of one case diagnosed in the age of 11.5 years with a case history of about 7 years. Description of the danger to ...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章,评审

    doi:10.1055/s-2008-1046527

    authors: Hübschmann K

    更新日期:1995-05-01 00:00:00

  • [Acute spinal syndromes in children and adolescents].

    abstract::23 children with acute spinal syndromes are presented. The clinical signs were caused by trauma in 11 patients, by extramedullary tumors in 6, by operations (coarctation of the aorta, scoliosis) in 4 and by encephalomyelitis in 2. Motor signs (flaccid paraplegia or paraparesis, monoplegia, bilateral weakness) and chan...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2007-1025246

    authors: Bode H,Bubl R,Hefti F,Signer E,Wyler F

    更新日期:1993-09-01 00:00:00

  • [Preparation of a compatibility chart for intravenous drug therapy in neonatal and pediatric intensive care units].

    abstract:BACKGROUND:Modern neonatal and pediatric intensive care includes a sophisticated pharmacotherapy with numerous drugs, mainly administered intravenously. Often, despite the use of multi-lumen central venous lines, more peripheral venous accesses are required. To reduce the necessity of numerous venous lines on one hand ...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2005-836937

    authors: Höpner JH,Schulte A,Thiessen J,Knuf M,Huth RG

    更新日期:2007-01-01 00:00:00

  • [5-day therapy of bacterial pharyngitis and tonsillitis with cefixime. Comparison with 10 day treatment with penicillin V. Cefixime Study Group].

    abstract::160 children aged 1 to 12 years with clinical diagnosis of bacterial pharyngitis and/or tonsillitis were treated either with cefixime ready-to-use-suspension or penicillin V in an open, controlled and randomized multicenter study. Before treatment a rapid antigen detection test was accomplished and throat swabs were t...

    journal_title:Klinische Padiatrie

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1055/s-2008-1046489

    authors: Adam D,Hostalek U,Tröster K

    更新日期:1996-09-01 00:00:00

  • [De Barsy-Moens-Dierckx syndrome: unusual course in a neonate].

    abstract::We report about a premature infant with a De Barsy-Moens-Dierckx-syndrome, which is a rare cutaneo-oculo-cerebral malformation-syndrome. It is defined by the combination of a progeroid aspect, cutis laxa, growth retardation, cornea clouding, mental retardation and athetoid movements. Furthermore, the reported case sho...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2008-1046648

    authors: Schierenberg M,Donné W,Schiafone P,Bald R,Gembruch U,Hansmann M,Rister M

    更新日期:1994-11-01 00:00:00

  • [Hearing screening of newborn infants at risk for perinatal hearing damage].

    abstract::630 neonates with risk factors of perinatal hearing impairment were screened of hearing loss by means of registration of transient otoacoustic emissions before discharge from the newborn nursery. Neonates were screened additionally by means of brainstem evoked response audiometry, if they had bilateral negative emissi...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2008-1043853

    authors: Sitka U,Rehm K,Rasinski C

    更新日期:1998-03-01 00:00:00

  • [Changes on platelet adhesion, aggregation and production in course of mumps and mumps meningitis (author's transl)].

    abstract::In 20 children with mumps and mumps meningitis thrombocyte functions, the thrombopoiesis and the platelet count were examinated over a four week period. The spontaneous, standardized platelet adhesion and aggregation on silikonized glass surface showed a statistically significant increase from the 5th to the 15th day ...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:

    authors: Lemanczyk S,Podolsak B

    更新日期:1977-09-01 00:00:00