Abstract:
:The amazing feature of ionising radiation (IR) as a DNA damaging agent is the range of lesions it induces. Such lesions include base damage, single strand breaks (SSBs), double strand breaks (DSBs) of varying complexity and DNA cross links. A range of DNA damage response mechanisms operate to help maintain genomic stability in the face of such damage. Such mechanisms include pathways of DNA repair and signal transduction mechanisms. Increasing evidence suggests that these pathways operate co-operatively. In addition, the relative impact of one mechanism over another most probably depends upon the cell cycle phase and tissue type. Here, the distinct damage response pathways are reviewed and the current understanding of the interplay between them is considered. Since DNA DSBs are the major lethal lesion induced by IR, the focus lies in the mechanisms responding to direct or indirectly induced DSBs.
journal_name
Radiat Prot Dosimetryjournal_title
Radiation protection dosimetryauthors
Jeggo P,Löbrich Mdoi
10.1093/rpd/ncl495subject
Has Abstractpub_date
2006-01-01 00:00:00pages
124-7issue
1-4eissn
0144-8420issn
1742-3406pii
ncl495journal_volume
122pub_type
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