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Acquired haemophilia masked by warfarin therapy.

Abstract：

:Acquired haemophilia is a rare phenomenon and prompt diagnosis is essential for successful treatment. Early laboratory detection could minimize its potentially devastating consequences and reduce mortality but when a masking element such as anticoagulant therapy is present, delay in diagnosis is not uncommon. A prolonged activated partial thromboplastin time (APTT) may be falsely attributed to warfarin alone, particularly when it is associated with oral anticoagulant overdose. We describe two patients on treatment with warfarin who presented with a bleeding diathesis and disproportionately prolonged APTT, which led to the diagnosis of antibodies directed against factor VIII.

journal_name

Int J Lab Hematol

journal_title

International journal of laboratory hematology

authors

Vadikolia CM,Riddell A,Brooks S,Yee TT,Brown S,Lee C

doi

10.1111/j.1365-2257.2006.00867.x

subject

Has Abstract

pub_date

2007-02-01 00:00:00

pages

64-8

issue

1

eissn

1751-5521

issn

1751-553X

pii

CLH867

journal_volume

29

pub_type

杂志文章

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