Antigenic Differences Between Normal and Malignant Cells as a Basis for Treatment of Intracerebral Neoplasms Using a DNA-Based Vaccine.


:Antigenic differences between normal and malignant cells of the cancer patient form the rationale for clinical immunotherapeutic strategies. Because the antigenic phenotype of neoplastic cells varies widely among different cells within the same malignant cell-population, immunization with a vaccine that stimulates immunity to the broad array of tumor antigens expressed by the cancer cells is likely to be more efficacious than immunization with a vaccine for a single antigen. A vaccine prepared by transfer of DNA from the tumor into a highly immunogenic cell line can encompass the array of tumor antigens that characterize the patient's neoplasm. Poorly immunogenic tumor antigens, characteristic of malignant cells, can become strongly antigenic if they are expressed by highly immunogenic cells. A DNA-based vaccine was prepared by transfer of genomic DNA from a breast cancer that arose spontaneously in a C3H/He mouse into a highly immunogenic mouse fibroblast cell line, where genes specifying tumor-antigens were expressed. The fibroblasts were modified in advance of DNA-transfer to secrete an immune augmenting cytokine and to express allogeneic MHC class I-determinants. In an animal model of breast cancer metastatic to the brain, introduction of the vaccine directly into the tumor bed stimulated a systemic cellular anti-tumor immune response measured by two independent in vitro assays and prolonged the lives of the tumor-bearing mice. Furthermore, using antibodies against the various T-cell subsets, it was determined that the systemic cellular anti-tumor immunity was mediated by CD8(+), CD4(+) and NK/LAK cells. The application of DNA-based genomic vaccines for the treatment of a variety of brain tumors is being explored.


Curr Genomics


Current genomics


Lichtor T,Glick RP,O-Sullivan I,Cohen EP




Has Abstract


2006-06-01 00:00:00












  • Molecular Population Genetics and Evolution of the Chagas' Disease Vector Triatoma infestans (Hemiptera: Reduviidae).

    abstract::Triatoma infestans (Klug) is the main vector of Chagas' disease in the Southern Cone of Latin America between the latitudes 10° S and 46° S. The long-term effectiveness of the control campaigns is greatly dependent upon the vector population structure. Mitochondrial DNA (mtDNA) genes have been used in a number of T. i...

    journal_title:Current genomics

    pub_type: 杂志文章


    authors: García BA,de Rosas AR,Blariza MJ,Grosso CG,Fernández CJ,Stroppa MM

    更新日期:2013-08-01 00:00:00

  • Familial Colorectal Cancer Type X.

    abstract::The genetic background is unknown for the 50-60% of the HNPCC families, who fulfill the Amsterdam criteria, but do not have a mutation in an MMR gene, and is referred to as FCCTX. This study reviews the clinical, morphological and molecular characteristics of FCCTX, and discusses the molecular genetic methods used to ...

    journal_title:Current genomics

    pub_type: 杂志文章,评审


    authors: Zetner DB,Bisgaard ML

    更新日期:2017-08-01 00:00:00

  • DNA instability at chromosomal fragile sites in cancer.

    abstract::Human chromosomal fragile sites are specific genomic regions which exhibit gaps or breaks on metaphase chromosomes following conditions of partial replication stress. Fragile sites often coincide with genes that are frequently rearranged or deleted in human cancers, with over half of cancer-specific translocations con...

    journal_title:Current genomics

    pub_type: 杂志文章


    authors: Dillon LW,Burrow AA,Wang YH

    更新日期:2010-08-01 00:00:00

  • WITMSG: Large-scale Prediction of Human Intronic m6A RNA Methylation Sites from Sequence and Genomic Features.

    abstract:Introduction:N6-methyladenosine (m6A) is one of the most widely studied epigenetic modifications. It plays important roles in various biological processes, such as splicing, RNA localization and degradation, many of which are related to the functions of introns. Although a number of computational approaches have been p...

    journal_title:Current genomics

    pub_type: 杂志文章


    authors: Liu L,Lei X,Meng J,Wei Z

    更新日期:2020-01-01 00:00:00

  • Haploinsufficiency of DNA Damage Response Genes and their Potential Influence in Human Genomic Disorders.

    abstract::Genomic disorders are a clinically diverse group of conditions caused by gain, loss or re-orientation of a genomic region containing dosage-sensitive genes. One class of genomic disorder is caused by hemizygous deletions resulting in haploinsufficiency of a single or, more usually, several genes. For example, the hete...

    journal_title:Current genomics

    pub_type: 杂志文章


    authors: O'Driscoll M

    更新日期:2008-05-01 00:00:00

  • Changing Faces of Transcriptional Regulation Reflected by Zic3.

    abstract::The advent of genomics in the study of developmental mechanisms has brought a trove of information on gene datasets and regulation during development, where the Zic family of zinc-finger proteins plays an important role. Genomic analysis of the modes of action of Zic3 in pluripotent cells demonstrated its requirement ...

    journal_title:Current genomics

    pub_type: 杂志文章


    authors: Winata CL,Kondrychyn I,Korzh V

    更新日期:2015-04-01 00:00:00

  • Compounds From Celastraceae Targeting Cancer Pathways and Their Potential Application in Head and Neck Squamous Cell Carcinoma: A Review.

    abstract::Squamous cell carcinoma of the head and neck is one of the most common cancer types worldwide. It initiates on the epithelial lining of the upper aerodigestive tract, at most instances as a consequence of tobacco and alcohol consumption. Treatment options based on conventional therapies or targeted therapies under dev...

    journal_title:Current genomics

    pub_type: 杂志文章,评审


    authors: Hernandes C,Pereira AMS,Severino P

    更新日期:2017-02-01 00:00:00

  • A Postgenomic Perspective on Molecular Cytogenetics.

    abstract:Background:The postgenomic era is featured by massive data collection and analyses from various large scale-omics studies. Despite the promising capability of systems biology and bioinformatics to handle large data sets, data interpretation, especially the translation of -omics data into clinical implications, has been...

    journal_title:Current genomics

    pub_type: 杂志文章


    authors: Heng HH,Horne SD,Chaudhry S,Regan SM,Liu G,Abdallah BY,Ye CJ

    更新日期:2018-04-01 00:00:00

  • Epigenetic Programming of Adipose Tissue in the Progeny of Obese Dams.

    abstract::According to the Developmental Origin of Health and Disease (DOHaD) concept, maternal obesity and the resulting accelerated growth in neonates predispose offspring to obesity and associated metabolic diseases that may persist across generations. In this context, the adipose tissue has emerged as an important player du...

    journal_title:Current genomics

    pub_type: 杂志文章,评审


    authors: Lecoutre S,Kwok KHM,Petrus P,Lambert M,Breton C

    更新日期:2019-09-01 00:00:00

  • MDM4 (MDMX) and its Transcript Variants.

    abstract::MDM family proteins are crucial regulators of the oncosuppressor p53. Alterations of their gene status, mainly amplification events, have been frequently observed in human tumors.MDM4 is one of the two members of the MDM family. The human gene is located on chromosome 1 at q32-33 and codes for a protein of 490aa. In a...

    journal_title:Current genomics

    pub_type: 杂志文章


    authors: Mancini F,Di Conza G,Moretti F

    更新日期:2009-03-01 00:00:00

  • Reverse Engineering of Genome-wide Gene Regulatory Networks from Gene Expression Data.

    abstract::Transcriptional regulation plays vital roles in many fundamental biological processes. Reverse engineering of genome-wide regulatory networks from high-throughput transcriptomic data provides a promising way to characterize the global scenario of regulatory relationships between regulators and their targets. In this r...

    journal_title:Current genomics

    pub_type: 杂志文章


    authors: Liu ZP

    更新日期:2015-02-01 00:00:00

  • Single-cell RNA Sequencing: In-depth Decoding of Heart Biology and Cardiovascular Diseases.

    abstract:Background:The cardiac system is a combination of a complex structure, various cells, and versatile specified functions and sophisticated regulatory mechanisms. Moreover, cardiac diseases that encompass a wide range of endogenous conditions, remain a serious health burden worldwide. Recent genome-wide profiling techniq...

    journal_title:Current genomics

    pub_type: 杂志文章,评审


    authors: Chen Z,Wei L,Duru F,Chen L

    更新日期:2020-12-01 00:00:00

  • Alström syndrome: genetics and clinical overview.

    abstract::Alström syndrome is a rare autosomal recessive genetic disorder characterized by cone-rod dystrophy, hearing loss, childhood truncal obesity, insulin resistance and hyperinsulinemia, type 2 diabetes, hypertriglyceridemia, short stature in adulthood, cardiomyopathy, and progressive pulmonary, hepatic, and renal dysfunc...

    journal_title:Current genomics

    pub_type: 杂志文章


    authors: Marshall JD,Maffei P,Collin GB,Naggert JK

    更新日期:2011-05-01 00:00:00

  • Remodeling of Proteostasis Upon Transition to Adulthood is Linked to Reproduction Onset.

    abstract::Protein folding and clearance networks sense and respond to misfolded and aggregation-prone proteins by activating cytoprotective cell stress responses that safeguard the proteome against damage, maintain the health of the cell, and enhance lifespan. Surprisingly, cellular proteostasis undergoes a sudden and widesprea...

    journal_title:Current genomics

    pub_type: 杂志文章


    authors: Shai N,Shemesh N,Ben-Zvi A

    更新日期:2014-04-01 00:00:00

  • Vegetable Oil: Nutritional and Industrial Perspective.

    abstract::Oils of plant origin have been predominantly used for food-based applications. Plant oils not only represent a non-polluting renewable resource but also provide a wide diversity in fatty acids (FAs) composition with diverse applications. Besides being edible, they are now increasingly being used in industrial applicat...

    journal_title:Current genomics

    pub_type: 杂志文章


    authors: Kumar A,Sharma A,Upadhyaya KC

    更新日期:2016-06-01 00:00:00

  • Application of functional genomics and proteomics to plant cryopreservation.

    abstract::Plant cryobiology has primarily emerged from the classical fields of cryobiology and plant stress physiology. Cryopreservation tools are now available to geneticists for germplasm preservation and the field itself is advancing significantly through the use of molecular techniques. Long-term preservation of vegetativel...

    journal_title:Current genomics

    pub_type: 杂志文章


    authors: Volk GM

    更新日期:2010-03-01 00:00:00

  • miR-15b and miR-21 as Circulating Biomarkers for Diagnosis of Glioma.

    abstract::Malignant gliomas are lethal primary intracranial tumors. To date, little information on the role of deregulated genes in gliomas have been identified. As the involvement of miRNAs in the carcinogenesis is well known, we carried out a pilot study to identify, as potential biomarkers, differentially expressed microRNAs...

    journal_title:Current genomics

    pub_type: 杂志文章


    authors: Ivo D'Urso P,Fernando D'Urso O,Damiano Gianfreda C,Mezzolla V,Storelli C,Marsigliante S

    更新日期:2015-10-01 00:00:00

  • Genetic variants in diseases of the extrapyramidal system.

    abstract::Knowledge on the genetics of movement disorders has advanced significantly in recent years. It is now recognized that disorders of the basal ganglia have genetic basis and it is suggested that molecular genetic data will provide clues to the pathophysiology of normal and abnormal motor control. Progress in molecular g...

    journal_title:Current genomics

    pub_type: 杂志文章


    authors: Oczkowska A,Kozubski W,Lianeri M,Dorszewska J

    更新日期:2014-02-01 00:00:00

  • Repurposing Pathogenic Variants of DMD Gene and its Isoforms for DMD Exon Skipping Intervention.

    abstract:Background:Duchenne Muscular Dystrophy (DMD) is a progressive, fatal neuromuscular disorder caused by mutations in the DMD gene. Emerging antisense oligomer based exon skipping therapy provides hope for the restoration of the reading frame. Objectives:Population-based DMD mutation database may enable exon skipping to ...

    journal_title:Current genomics

    pub_type: 杂志文章


    authors: Tyagi R,Kumar S,Dalal A,Mohammed F,Mohanty M,Kaur P,Anand A

    更新日期:2019-11-01 00:00:00

  • MicroRNAs in Lung Cancer Oncogenesis and Tumor Suppression: How it Can Improve the Clinical Practice?

    abstract:Background:Lung cancer (LC) development is a process that depends on genetic mutations. The DNA methylation, an important epigenetic modification, is associated with the expression of non-coding RNAs, such as microRNAs. MicroRNAs are particularly essential for cell physiology, since they play a critical role in tumor s...

    journal_title:Current genomics

    pub_type: 杂志文章,评审


    authors: Pozza DH,De Mello RA,Araujo RLC,Velcheti V

    更新日期:2020-08-01 00:00:00

  • MicroRNA and Cancer: Tiny Molecules with Major Implications.

    abstract::Cancer is currently a major public health problem and, as such, emerging research is making significant progress in identifying major players in its biology. One recent topic of interest involves microRNAs (miRNAs) which are small, non-coding RNA molecules that inhibit gene expression post-transcriptionally. They acco...

    journal_title:Current genomics

    pub_type: 杂志文章


    authors: Vandenboom Ii TG,Li Y,Philip PA,Sarkar FH

    更新日期:2008-04-01 00:00:00

  • Clinical and Rehabilitative Management of Retinitis Pigmentosa: Up-to-Date.

    abstract::The term retinitis pigmentosa (RP) indicates a heterogeneous group of genetic rare ocular diseases in which either rods or cones are prevalently damaged. RP represents the most common hereditary cause of blindness in people from 20 to 60 years old. In general, the different RP forms consist of progressive photo-recept...

    journal_title:Current genomics

    pub_type: 杂志文章


    authors: Parmeggiani F,Sato G,De Nadai K,Romano MR,Binotto A,Costagliola C

    更新日期:2011-06-01 00:00:00

  • Metabolic Modeling of Microbial Community Interactions for Health, Environmental and Biotechnological Applications.

    abstract::In nature, microbes do not exist in isolation but co-exist in a variety of ecological and biological environments and on various host organisms. Due to their close proximity, these microbes interact among themselves, and also with the hosts in both positive and negative manners. Moreover, these interactions may modula...

    journal_title:Current genomics

    pub_type: 杂志文章,评审


    authors: Ang KS,Lakshmanan M,Lee NR,Lee DY

    更新日期:2018-12-01 00:00:00

  • CENPA a genomic marker for centromere activity and human diseases.

    abstract::Inheritance of genetic material requires that chromosomes segregate faithfully during cell division. Failure in this process can drive to aneuploidy phenomenon. Kinetochores are unique centromere macromolecular protein structures that attach chromosomes to the spindle for a proper movement and segregation. A unique ty...

    journal_title:Current genomics

    pub_type: 杂志文章


    authors: Valdivia MM,Hamdouch K,Ortiz M,Astola A

    更新日期:2009-08-01 00:00:00

  • A Comprehensive Review of Dysregulated miRNAs Involved in Cervical Cancer.

    abstract::MicroRNAs(miRNAs) have become the center of interest in oncology. In recent years, various studies have demonstrated that miRNAs regulate gene expression by influencing important regulatory genes and thus are responsible for causing cervical cancer. Cervical cancer being the third most diagnosed cancer among the femal...

    journal_title:Current genomics

    pub_type: 杂志文章


    authors: Sharma G,Dua P,Agarwal SM

    更新日期:2014-08-01 00:00:00

  • Application of genomic tools in plant breeding.

    abstract::Plant breeding has been very successful in developing improved varieties using conventional tools and methodologies. Nowadays, the availability of genomic tools and resources is leading to a new revolution of plant breeding, as they facilitate the study of the genotype and its relationship with the phenotype, in parti...

    journal_title:Current genomics

    pub_type: 杂志文章


    authors: Pérez-de-Castro AM,Vilanova S,Cañizares J,Pascual L,Blanca JM,Díez MJ,Prohens J,Picó B

    更新日期:2012-05-01 00:00:00

  • Overview of Genomic Tools for Circular Visualization in the Next-generation Genomic Sequencing Era.

    abstract::After human genome sequencing and rapid changes in genome sequencing methods, we have entered into the era of rapidly accumulating genome-sequencing data. This has derived the development of several types of methods for representing results of genome sequencing data. Circular genome visual-ization tools are also criti...

    journal_title:Current genomics

    pub_type: 杂志文章,评审


    authors: Parveen A,Khurana S,Kumar A

    更新日期:2019-02-01 00:00:00

  • A Comprehensive Investigation of Potential Novel Marine Psychrotolerant Actinomycetes sp. Isolated from the Bay-of-Bengal.

    abstract:BACKGROUND:This study was carried out to classify the diversity of the deep marine psychrotolerant actinomycetes sp. nov., in the Bay of Bengal and exploit the production of cold-active industrial and pharmaceutical biomolecules. OBJECTIVE:1) Characterization, optimum the growth conditions and classify the diversity o...

    journal_title:Current genomics

    pub_type: 杂志文章


    authors: Ghosh M,Gera M,Singh J,Prasad R,Pulicherla KK

    更新日期:2020-05-01 00:00:00

  • Genomics of Metal Stress-Mediated Signalling and Plant Adaptive Responses in Reference to Phytohormones.

    abstract:Introduction:As a consequence of a sessile lifestyle, plants often have to face a number of life threatening abiotic and biotic stresses. Plants counteract the stresses through morphological and physiological adaptations, which are imparted through flexible and well-coordinated network of signalling and effector molecu...

    journal_title:Current genomics

    pub_type: 杂志文章,评审


    authors: Shukla A,Srivastava S,Suprasanna P

    更新日期:2017-12-01 00:00:00

  • Genomic instability and carcinogenesis: an update.

    abstract::Cancers arise as a result of stepwise accumulation of mutations which may occur at the nucleotide level and/or the gross chromosomal level. Many cancers particularly those of the colon display a form of genomic instability which may facilitate and speed up tumor initiation and development. In few instances, a "mutator...

    journal_title:Current genomics

    pub_type: 杂志文章


    authors: Abdel-Rahman WM

    更新日期:2008-12-01 00:00:00