Abstract:
:Since the sequencing of the nuclear genome of Arabidopsis thaliana ten years ago, various large-scale analyses of gene function have been performed in this model species. In particular, the availability of collections of lines harbouring random T-DNA or transposon insertions, which include mutants for almost all of the ~27,000 A. thaliana genes, has been crucial for the success of forward and reverse genetic approaches. In the foreseeable future, genome-wide phenotypic data from mutant analyses will become available for Arabidopsis, and will stimulate a flood of novel in-depth gene-function analyses. In this review, we consider the present status of resources and concepts for systematic studies of gene function in A. thaliana. Current perspectives on the utility of loss-of-function and gain-of-function mutants will be discussed in light of the genetic and functional redundancy of many A. thaliana genes.
journal_name
Curr Genomicsjournal_title
Current genomicsauthors
Bolle C,Schneider A,Leister Ddoi
10.2174/138920211794520187subject
Has Abstractpub_date
2011-03-01 00:00:00pages
1-14issue
1eissn
1389-2029issn
1875-5488pii
CG-12-1journal_volume
12pub_type
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