Abstract:
:Cancer is currently a major public health problem and, as such, emerging research is making significant progress in identifying major players in its biology. One recent topic of interest involves microRNAs (miRNAs) which are small, non-coding RNA molecules that inhibit gene expression post-transcriptionally. They accomplish this by binding to the 3' untranslated region (3'UTR) of target messengerRNA (mRNA), resulting in either their degradation or inhibition of translation, depending on the degree of complementary base pairing. They are transcribed by RNA polymerase II and are formed into mature miRNAs via two steps, each catalyzed by a different ribonuclease III (RNaseIII). Cross-species comparisons demonstrate that miRNAs are evolutionarily conserved and play important roles in a wide array of normal biological processes. Importantly, aberrant miRNA expression is correlated with human disease, especially in the development of cancer. Recent research has identified targets and functions of miRNAs, illustrating that some are oncogenic in nature while others show tumor suppressor activity. The miRNAs have also been characterized as having high potential in the clinical arena and, as such, have been a target for exploitation toward cancer therapy. Not only has it been shown that miRNA expression profiles may prove useful as diagnostic and prognostic markers in cancer, various miRNA-based therapies show promise as well. It is anticipated that further research will elucidate the benefits of using miRNAs as clinical agents in the battle against cancer and other chronic diseases.
journal_name
Curr Genomicsjournal_title
Current genomicsauthors
Vandenboom Ii TG,Li Y,Philip PA,Sarkar FHdoi
10.2174/138920208784139555subject
Has Abstractpub_date
2008-04-01 00:00:00pages
97-109issue
2eissn
1389-2029issn
1875-5488journal_volume
9pub_type
杂志文章相关文献
CURRENT GENOMICS文献大全abstract::Transcriptional regulation plays vital roles in many fundamental biological processes. Reverse engineering of genome-wide regulatory networks from high-throughput transcriptomic data provides a promising way to characterize the global scenario of regulatory relationships between regulators and their targets. In this r...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202915666141110210634
更新日期:2015-02-01 00:00:00
abstract::The term retinitis pigmentosa (RP) indicates a heterogeneous group of genetic rare ocular diseases in which either rods or cones are prevalently damaged. RP represents the most common hereditary cause of blindness in people from 20 to 60 years old. In general, the different RP forms consist of progressive photo-recept...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920211795860125
更新日期:2011-06-01 00:00:00
abstract::The study of immune related genes in lampreys and hagfish provides a unique perspective on the evolutionary genetic underpinnings of adaptive immunity and the evolution of vertebrate genomes. Separated from their jawed cousins at the stem of the vertebrate lineage, these jawless vertebrates have many of the gene famil...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920212799860670
更新日期:2012-04-01 00:00:00
abstract::In nature, microbes do not exist in isolation but co-exist in a variety of ecological and biological environments and on various host organisms. Due to their close proximity, these microbes interact among themselves, and also with the hosts in both positive and negative manners. Moreover, these interactions may modula...
journal_title:Current genomics
pub_type: 杂志文章,评审
doi:10.2174/1389202919666180911144055
更新日期:2018-12-01 00:00:00
abstract::The pathogenesis of sporadic Parkinson's disease (PD) remains enigmatic. Mitochondrial complex-I defects are known to occur in the substantia nigra (SN) of PD patients and are also debated in some extracerebral tissues. Early sequencing efforts of the mitochondrial DNA (mtDNA) did not reveal specific mutations, but a ...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920209789503879
更新日期:2009-12-01 00:00:00
abstract::Low or high birth weight is one of the main causes for neonatal morbidity and mortality. They are also associated with adulthood chronic illness. Birth weight is a complex trait which is affected by baby's genes, maternal environments as well as the complex interactions between them. To understand the genetic basis of...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202917666160726152033
更新日期:2016-10-01 00:00:00
abstract::Controlling for the multiplicity effect is an essential part of determining statistical significance in large-scale single-locus association genome scans on Single Nucleotide Polymorphisms (SNPs). Bonferroni adjustment is a commonly used approach due to its simplicity, but is conservative and has low power for large-s...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920291505141106103959
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:Helicobacter pylori is associated with inflammation of different areas, such as the duodenum and stomach, causing gastritis and gastric ulcers leading to lymphoma and cancer. Pathogenic islands are a type of clustered mobile elements ranging from 10-200 Kb contributing to the virulence of the respective path...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202918666170705160615
更新日期:2017-10-01 00:00:00
abstract::Oils of plant origin have been predominantly used for food-based applications. Plant oils not only represent a non-polluting renewable resource but also provide a wide diversity in fatty acids (FAs) composition with diverse applications. Besides being edible, they are now increasingly being used in industrial applicat...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202917666160202220107
更新日期:2016-06-01 00:00:00
abstract:Background:Duchenne Muscular Dystrophy (DMD) is a progressive, fatal neuromuscular disorder caused by mutations in the DMD gene. Emerging antisense oligomer based exon skipping therapy provides hope for the restoration of the reading frame. Objectives:Population-based DMD mutation database may enable exon skipping to ...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202920666191107142754
更新日期:2019-11-01 00:00:00
abstract:Introduction:As a consequence of a sessile lifestyle, plants often have to face a number of life threatening abiotic and biotic stresses. Plants counteract the stresses through morphological and physiological adaptations, which are imparted through flexible and well-coordinated network of signalling and effector molecu...
journal_title:Current genomics
pub_type: 杂志文章,评审
doi:10.2174/1389202918666170608093327
更新日期:2017-12-01 00:00:00
abstract::Circadian clocks are intrinsic, time-tracking systems that bestow upon organisms a survival advantage. Under natural conditions, organisms are trained to follow a 24-h cycle under environmental time cues such as light to maximize their physiological efficiency. The exact timing of this rhythm is established via cell-a...
journal_title:Current genomics
pub_type: 杂志文章,评审
doi:10.2174/1389202919666191014094349
更新日期:2019-08-01 00:00:00
abstract::After human genome sequencing and rapid changes in genome sequencing methods, we have entered into the era of rapidly accumulating genome-sequencing data. This has derived the development of several types of methods for representing results of genome sequencing data. Circular genome visual-ization tools are also criti...
journal_title:Current genomics
pub_type: 杂志文章,评审
doi:10.2174/1389202920666190314092044
更新日期:2019-02-01 00:00:00
abstract::In recent years, genomic, animal and cell biology studies have implicated deficiencies in retromer-mediated trafficking of proteins in an increasing number of neurodegenerative diseases including Alzheimer's Disease (AD), Parkinson's Disease (PD) and Frontotemporal Lobar Degener-ation (FTLD). The retromer complex, whi...
journal_title:Current genomics
pub_type: 杂志文章,评审
doi:10.2174/1389202919666171024122809
更新日期:2018-05-01 00:00:00
abstract::Women outlive men, but life expectancy is not influenced by hormone replacement (estrogen + progestin) therapy. Estrogens appear to protect brain, cardiovascular tissues, and bone from aging. Estrogens regulate genes directly through binding to estrogen receptors alpha and beta (ERalpha and ERbeta) that are ligand-act...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920209788185289
更新日期:2009-05-01 00:00:00
abstract::Spinal Muscular Atrophy (SMA) is a neuromuscular disorder caused by mutations in the SMN1 gene. Being a monogenic disease, it is characterized by high clinical heterogeneity. Variations in penetrance and severity of symptoms, as well as clinical discrepancies between affected family members can result from modifier ge...
journal_title:Current genomics
pub_type: 杂志文章,评审
doi:10.2174/1389202919666180101154916
更新日期:2018-08-01 00:00:00
abstract::Thyroid gland presents a wide spectrum of tumours derived from follicular cells that range from well differentiated, papillary and follicular carcinoma (PTC and FTC, respectively), usually carrying a good prognosis, to the clinically aggressive, poorly differentiated (PDTC) and undifferentiated thyroid carcinoma (UTC)...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920211798120853
更新日期:2011-12-01 00:00:00
abstract::Antigenic differences between normal and malignant cells of the cancer patient form the rationale for clinical immunotherapeutic strategies. Because the antigenic phenotype of neoplastic cells varies widely among different cells within the same malignant cell-population, immunization with a vaccine that stimulates imm...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920206778426951
更新日期:2006-06-01 00:00:00
abstract::MicroRNAs (miRNAs) are short, noncoding, and single-stranded RNA molecules that negatively regulate gene expression. They are evolutionarily conserved from plants to animals. During the last decade, miRNAs have been demonstrated as regulators in fundamental biological processes, including cell growth, proliferation, d...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920210790886853
更新日期:2010-04-01 00:00:00
abstract::RNA-Seq is a recently developed sequencing technology, that through the analysis of cDNA allows for unique insights into the transcriptome of a cell. The data generated by RNA-Seq provides information on gene expression, alternative splicing events and the presence of non-coding RNAs. It has been realised non-coding R...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202911314030003
更新日期:2013-05-01 00:00:00
abstract::Bcl-2 proteins are critical regulators of mitochondrial membrane permeability and the proapoptotic mitochondrial pathway. The family encloses pro- and antiapoptotic factors encoded by over 15 genes, which frequently give rise to alternative splice products. Antiapoptotic, proapoptotic multidomain, and proapoptotic BH3...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920208785699571
更新日期:2008-09-01 00:00:00
abstract:Background:The postgenomic era is featured by massive data collection and analyses from various large scale-omics studies. Despite the promising capability of systems biology and bioinformatics to handle large data sets, data interpretation, especially the translation of -omics data into clinical implications, has been...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202918666170717145716
更新日期:2018-04-01 00:00:00
abstract:Background:Cancer is a complex disease with a lucid etiology and in understanding the causation, we need to appreciate this complexity. Objective:Here we are aiming to gain insights into the genetic associations of prostate cancer through a network-based systems approach using the BC3Net algorithm. Methods:Specifical...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202919666181107122005
更新日期:2019-01-01 00:00:00
abstract::Alström syndrome is a rare autosomal recessive genetic disorder characterized by cone-rod dystrophy, hearing loss, childhood truncal obesity, insulin resistance and hyperinsulinemia, type 2 diabetes, hypertriglyceridemia, short stature in adulthood, cardiomyopathy, and progressive pulmonary, hepatic, and renal dysfunc...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920211795677912
更新日期:2011-05-01 00:00:00
abstract::Cancers arise as a result of stepwise accumulation of mutations which may occur at the nucleotide level and/or the gross chromosomal level. Many cancers particularly those of the colon display a form of genomic instability which may facilitate and speed up tumor initiation and development. In few instances, a "mutator...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920208786847926
更新日期:2008-12-01 00:00:00
abstract:Introduction:Hydroxylation is one of the most important post-translational modifications (PTM) in cellular functions and is linked to various diseases. The addition of one of the hydroxyl groups (OH) to the lysine sites produces hydroxylysine when undergoes chemical modification. Methods:The method which is used in th...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202921999200831142629
更新日期:2020-11-01 00:00:00
abstract::Plant cryobiology has primarily emerged from the classical fields of cryobiology and plant stress physiology. Cryopreservation tools are now available to geneticists for germplasm preservation and the field itself is advancing significantly through the use of molecular techniques. Long-term preservation of vegetativel...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920210790217945
更新日期:2010-03-01 00:00:00
abstract::Uncertainty about linkage phases of multiple single nucleotide polymorphisms (SNPs) in heterozygous diploids challenges the identification of specific DNA sequence variants that encode a complex trait. A statistical technique implemented with the EM algorithm has been developed to infer the effects of SNP haplotypes f...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920207782446179
更新日期:2007-08-01 00:00:00
abstract::Microarray studies have successfully shed light on various aspects of the molecular mechanisms behind the development of hepatocellular carcinoma (HCC), such as the identification of novel molecular subgroups and the genetic profiles associated with metastasis and venous invasion. These experiments, mainly comprising ...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920210791233063
更新日期:2010-06-01 00:00:00
abstract::According to the Developmental Origin of Health and Disease (DOHaD) concept, maternal obesity and the resulting accelerated growth in neonates predispose offspring to obesity and associated metabolic diseases that may persist across generations. In this context, the adipose tissue has emerged as an important player du...
journal_title:Current genomics
pub_type: 杂志文章,评审
doi:10.2174/1389202920666191118092852
更新日期:2019-09-01 00:00:00