Abstract:
:Papillary microcarcinoma of the thyroid (mPTC) is defined by the WHO as a papillary thy-roid cancer measuring 10mm or less in diameter and it is nowadays a topic of intense debate among the members of the medical community due to its apparent "epidemic" rise. Although these tumors follow almost always an indolent clinical course and carry an excellent prognosis, it is known that a small sub-set may display a potentially aggressive behavior. Nevertheless, we still lack an accurate way of predict-ing those which will cause significant disease. In an attempt to address this problem, a number of clini-co-pathologic features have been studied as poor prognostic markers in mPTC, and their association with known genetic alterations in thyroid cancer has been evaluated. Herein we review the present knowledge concerning mPTC's genetic profile, namely the prevalence of BRAF (V600E), RAS and TERT promoter mutations and RET/PTC and PAX8-PPARG rearrangements and report the results of the evaluation in the putative prognostic value of these genetic alterations in mPTC.
journal_name
Curr Genomicsjournal_title
Current genomicsauthors
Rodrigues AC,Penna G,Rodrigues E,Castro P,Sobrinho-Simões M,Soares Pdoi
10.2174/1389202918666170105094459subject
Has Abstractpub_date
2017-06-01 00:00:00pages
244-254issue
3eissn
1389-2029issn
1875-5488pii
CG-18-244journal_volume
18pub_type
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