Abstract:
:Women outlive men, but life expectancy is not influenced by hormone replacement (estrogen + progestin) therapy. Estrogens appear to protect brain, cardiovascular tissues, and bone from aging. Estrogens regulate genes directly through binding to estrogen receptors alpha and beta (ERalpha and ERbeta) that are ligand-activated transcription factors and indirectly by activating plasma membrane-associated ER which, in turns, activates intracellular signaling cascades leading to altered gene expression. MicroRNAs (miRNAs) are short (19-25 nucleotides), naturally-occurring, non-coding RNA molecules that base-pair with the 3' untranslated region of target mRNAs. This interaction either blocks translation of the mRNA or targets the mRNA transcript to be degraded. The human genome contains ~ 700-1,200 miRNAs. Aberrant patterns of miRNA expression are implicated in human diseases including breast cancer. Recent studies have identified miRNAs regulated by estrogens in human breast cancer cells, human endometrial stromal and myometrial smooth muscle cells, rat mammary gland, and mouse uterus. The decline of estradiol levels in postmenopausal women has been implicated in various age-associated disorders. The role of estrogen-regulated miRNA expression, the target genes of these miRNAs, and the role of miRNAs in aging has yet to be explored.
journal_name
Curr Genomicsjournal_title
Current genomicsauthors
Klinge CMdoi
10.2174/138920209788185289subject
Has Abstractpub_date
2009-05-01 00:00:00pages
169-83issue
3eissn
1389-2029issn
1875-5488journal_volume
10pub_type
杂志文章相关文献
CURRENT GENOMICS文献大全abstract::Spinal Muscular Atrophy (SMA) is a neuromuscular disorder caused by mutations in the SMN1 gene. Being a monogenic disease, it is characterized by high clinical heterogeneity. Variations in penetrance and severity of symptoms, as well as clinical discrepancies between affected family members can result from modifier ge...
journal_title:Current genomics
pub_type: 杂志文章,评审
doi:10.2174/1389202919666180101154916
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:This study was carried out to classify the diversity of the deep marine psychrotolerant actinomycetes sp. nov., in the Bay of Bengal and exploit the production of cold-active industrial and pharmaceutical biomolecules. OBJECTIVE:1) Characterization, optimum the growth conditions and classify the diversity o...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202921666200330150642
更新日期:2020-05-01 00:00:00
abstract::Antigenic differences between normal and malignant cells of the cancer patient form the rationale for clinical immunotherapeutic strategies. Because the antigenic phenotype of neoplastic cells varies widely among different cells within the same malignant cell-population, immunization with a vaccine that stimulates imm...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920206778426951
更新日期:2006-06-01 00:00:00
abstract::Preterm Birth (PTB) accounts for approximately 11% of all births worldwide each year and is a profound physiological stressor in early life. The burden of neuropsychiatric and developmental impairment is high, with severity and prevalence correlated with gestational age at delivery. PTB is a major risk factor for the ...
journal_title:Current genomics
pub_type: 杂志文章,评审
doi:10.2174/1389202919666171229144807
更新日期:2018-11-01 00:00:00
abstract::Circadian clocks are intrinsic, time-tracking systems that bestow upon organisms a survival advantage. Under natural conditions, organisms are trained to follow a 24-h cycle under environmental time cues such as light to maximize their physiological efficiency. The exact timing of this rhythm is established via cell-a...
journal_title:Current genomics
pub_type: 杂志文章,评审
doi:10.2174/1389202919666191014094349
更新日期:2019-08-01 00:00:00
abstract::Controlling for the multiplicity effect is an essential part of determining statistical significance in large-scale single-locus association genome scans on Single Nucleotide Polymorphisms (SNPs). Bonferroni adjustment is a commonly used approach due to its simplicity, but is conservative and has low power for large-s...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920291505141106103959
更新日期:2014-10-01 00:00:00
abstract::Increasing evidence links genomic and epigenomic instability, including multiple fragile sites regions to neuropsychiatric diseases including schizophrenia and autism. Cancer is the only other disease associated with multiple fragile site regions, and genome and epigenomic instability is a characteristic of cancer. Re...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920210793176001
更新日期:2010-09-01 00:00:00
abstract::The mode of action of a huge amount of agents on biological systems is still unknown. One example where more questions than answers exist is covered by the term electromagnetic fields (EMF). Use of wireless communication, e.g. mobile phones, has been escalated in the last few years. Due to this fact, a lot of discussi...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920209787847050
更新日期:2009-04-01 00:00:00
abstract::The study of immune related genes in lampreys and hagfish provides a unique perspective on the evolutionary genetic underpinnings of adaptive immunity and the evolution of vertebrate genomes. Separated from their jawed cousins at the stem of the vertebrate lineage, these jawless vertebrates have many of the gene famil...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920212799860670
更新日期:2012-04-01 00:00:00
abstract::Carcinogenesis involves the inactivation or inhibition of genes that function as tumor suppressors. Deletions, mutations, or epigenetic silencing of tumor suppressor genes can lead to altered growth, differentiation, and apoptosis. DNA methylation and histone modifications are important epigenetic mechanisms of gene r...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920208783884892
更新日期:2008-03-01 00:00:00
abstract::Alternative splicing contributes to the complexity of proteome by producing multiple mRNAs from a single gene. Affymetrix exon arrays and experiments in vivo or in vitro demonstrated that alternative splicing was regulated by mechanical stress. Expression of mechano-growth factor (MGF) which is the splicing isoform of...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920213804999156
更新日期:2013-03-01 00:00:00
abstract::The genetic background is unknown for the 50-60% of the HNPCC families, who fulfill the Amsterdam criteria, but do not have a mutation in an MMR gene, and is referred to as FCCTX. This study reviews the clinical, morphological and molecular characteristics of FCCTX, and discusses the molecular genetic methods used to ...
journal_title:Current genomics
pub_type: 杂志文章,评审
doi:10.2174/1389202918666170307161643
更新日期:2017-08-01 00:00:00
abstract:Background:Lung cancer (LC) development is a process that depends on genetic mutations. The DNA methylation, an important epigenetic modification, is associated with the expression of non-coding RNAs, such as microRNAs. MicroRNAs are particularly essential for cell physiology, since they play a critical role in tumor s...
journal_title:Current genomics
pub_type: 杂志文章,评审
doi:10.2174/1389202921999200630144712
更新日期:2020-08-01 00:00:00
abstract:Background:The cardiac system is a combination of a complex structure, various cells, and versatile specified functions and sophisticated regulatory mechanisms. Moreover, cardiac diseases that encompass a wide range of endogenous conditions, remain a serious health burden worldwide. Recent genome-wide profiling techniq...
journal_title:Current genomics
pub_type: 杂志文章,评审
doi:10.2174/1389202921999200604123914
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Helicobacter pylori is associated with inflammation of different areas, such as the duodenum and stomach, causing gastritis and gastric ulcers leading to lymphoma and cancer. Pathogenic islands are a type of clustered mobile elements ranging from 10-200 Kb contributing to the virulence of the respective path...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202918666170705160615
更新日期:2017-10-01 00:00:00
abstract::Plant cryobiology has primarily emerged from the classical fields of cryobiology and plant stress physiology. Cryopreservation tools are now available to geneticists for germplasm preservation and the field itself is advancing significantly through the use of molecular techniques. Long-term preservation of vegetativel...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920210790217945
更新日期:2010-03-01 00:00:00
abstract::After human genome sequencing and rapid changes in genome sequencing methods, we have entered into the era of rapidly accumulating genome-sequencing data. This has derived the development of several types of methods for representing results of genome sequencing data. Circular genome visual-ization tools are also criti...
journal_title:Current genomics
pub_type: 杂志文章,评审
doi:10.2174/1389202920666190314092044
更新日期:2019-02-01 00:00:00
abstract::Until recently, understanding the regulatory behavior of cells has been pursued through independent analysis of the transcriptome or the proteome. Based on the central dogma, it was generally assumed that there exist a direct correspondence between mRNA transcripts and generated protein expressions. However, recent st...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202911314020003
更新日期:2013-04-01 00:00:00
abstract::Genomic disorders are a clinically diverse group of conditions caused by gain, loss or re-orientation of a genomic region containing dosage-sensitive genes. One class of genomic disorder is caused by hemizygous deletions resulting in haploinsufficiency of a single or, more usually, several genes. For example, the hete...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920208784340795
更新日期:2008-05-01 00:00:00
abstract::The presence of chromosomes with diffuse centromeres (holocentric chromosomes) has been reported in several taxa since more than fifty years, but a full understanding of their origin is still lacking. Comparative and functional genomics are nowadays furnishing new data to better understand holocentric chromosome evolu...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920212801619250
更新日期:2012-08-01 00:00:00
abstract:Background:Copy Number Variants (CNVs) represent a prevailing type of structural variation (deletions or duplications) in the human genome. In the last few years, several studies have demonstrated that CNVs represent significant mutations in Alzheimer's Disease (AD) hereditability. Currently, innovative high-throughput...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202919666180122141425
更新日期:2018-09-01 00:00:00
abstract::Human chromosomal fragile sites are specific genomic regions which exhibit gaps or breaks on metaphase chromosomes following conditions of partial replication stress. Fragile sites often coincide with genes that are frequently rearranged or deleted in human cancers, with over half of cancer-specific translocations con...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920210791616699
更新日期:2010-08-01 00:00:00
abstract:Background:The postgenomic era is featured by massive data collection and analyses from various large scale-omics studies. Despite the promising capability of systems biology and bioinformatics to handle large data sets, data interpretation, especially the translation of -omics data into clinical implications, has been...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202918666170717145716
更新日期:2018-04-01 00:00:00
abstract::Protein folding and clearance networks sense and respond to misfolded and aggregation-prone proteins by activating cytoprotective cell stress responses that safeguard the proteome against damage, maintain the health of the cell, and enhance lifespan. Surprisingly, cellular proteostasis undergoes a sudden and widesprea...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202915666140221005023
更新日期:2014-04-01 00:00:00
abstract::The advent of genomics in the study of developmental mechanisms has brought a trove of information on gene datasets and regulation during development, where the Zic family of zinc-finger proteins plays an important role. Genomic analysis of the modes of action of Zic3 in pluripotent cells demonstrated its requirement ...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202916666150205124519
更新日期:2015-04-01 00:00:00
abstract::The study of local adaptation is a main focus of evolutionary biology since it may contribute to explain the current species diversity. The genomic scan procedures permit for the first time to study the connection between specific DNA patterns and processes as natural selection, genetic drift, recombination, mutation ...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202916666150313230943
更新日期:2015-06-01 00:00:00
abstract::Whole-genome studies involving a phenotype of interest are increasingly prevalent, in part due to a dramatic increase in speed at which many high throughput technologies can be performed coupled to simultaneous decreases in cost. This type of genome-scale methodology has been applied to the phenotype of lifespan, as w...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920212803251454
更新日期:2012-11-01 00:00:00
abstract::Spliceosomal introns in higher eukaryotes are present in a high percentage of protein coding genes and represent a high proportion of transcribed nuclear DNA. In the last fifteen years, a growing mass of data concerning functional roles carried out by such intervening sequences elevated them from a selfish burden carr...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920208784533629
更新日期:2008-06-01 00:00:00
abstract::In the recent years, glyoxalase pathway has been an active area of research in both human and plants. This pathway is reported to confer stress tolerance in plants, by modulating the glutathione homeostasis to achieve detoxification of a potent cytotoxic and mutagenic compound, methylglyoxal. The microRNAs (miRNAs) ar...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202918666170228134530
更新日期:2018-01-01 00:00:00
abstract::Squamous cell carcinoma of the head and neck is one of the most common cancer types worldwide. It initiates on the epithelial lining of the upper aerodigestive tract, at most instances as a consequence of tobacco and alcohol consumption. Treatment options based on conventional therapies or targeted therapies under dev...
journal_title:Current genomics
pub_type: 杂志文章,评审
doi:10.2174/1389202917666160803160934
更新日期:2017-02-01 00:00:00