解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:Background:The cardiac system is a combination of a complex structure, various cells, and versatile specified functions and sophisticated regulatory mechanisms. Moreover, cardiac diseases that encompass a wide range of endogenous conditions, remain a serious health burden worldwide. Recent genome-wide profiling techniq...
journal_title:Current genomics
pub_type: 杂志文章,评审
doi:10.2174/1389202921999200604123914
更新日期:2020-12-01 00:00:00
abstract:Introduction:Hydroxylation is one of the most important post-translational modifications (PTM) in cellular functions and is linked to various diseases. The addition of one of the hydroxyl groups (OH) to the lysine sites produces hydroxylysine when undergoes chemical modification. Methods:The method which is used in th...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202921999200831142629
更新日期:2020-11-01 00:00:00
abstract:Background:Lung cancer (LC) development is a process that depends on genetic mutations. The DNA methylation, an important epigenetic modification, is associated with the expression of non-coding RNAs, such as microRNAs. MicroRNAs are particularly essential for cell physiology, since they play a critical role in tumor s...
journal_title:Current genomics
pub_type: 杂志文章,评审
doi:10.2174/1389202921999200630144712
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:This study was carried out to classify the diversity of the deep marine psychrotolerant actinomycetes sp. nov., in the Bay of Bengal and exploit the production of cold-active industrial and pharmaceutical biomolecules. OBJECTIVE:1) Characterization, optimum the growth conditions and classify the diversity o...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202921666200330150642
更新日期:2020-05-01 00:00:00
abstract::Microorganisms that are capable of live and adapt in hostile habitats of different environmental factors such as extremes temperature, salinity, nutrient availability and pressure are known as extremophiles. Exposure to xenobiotic compounds is global concern influencing the world population as a health hazard. Hence t...
journal_title:Current genomics
pub_type: 杂志文章,评审
doi:10.2174/1389202921999200422122253
更新日期:2020-04-01 00:00:00
abstract:Introduction:N6-methyladenosine (m6A) is one of the most widely studied epigenetic modifications. It plays important roles in various biological processes, such as splicing, RNA localization and degradation, many of which are related to the functions of introns. Although a number of computational approaches have been p...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202921666200211104140
更新日期:2020-01-01 00:00:00
abstract:Background:Duchenne Muscular Dystrophy (DMD) is a progressive, fatal neuromuscular disorder caused by mutations in the DMD gene. Emerging antisense oligomer based exon skipping therapy provides hope for the restoration of the reading frame. Objectives:Population-based DMD mutation database may enable exon skipping to ...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202920666191107142754
更新日期:2019-11-01 00:00:00
abstract::According to the Developmental Origin of Health and Disease (DOHaD) concept, maternal obesity and the resulting accelerated growth in neonates predispose offspring to obesity and associated metabolic diseases that may persist across generations. In this context, the adipose tissue has emerged as an important player du...
journal_title:Current genomics
pub_type: 杂志文章,评审
doi:10.2174/1389202920666191118092852
更新日期:2019-09-01 00:00:00
abstract::Circadian clocks are intrinsic, time-tracking systems that bestow upon organisms a survival advantage. Under natural conditions, organisms are trained to follow a 24-h cycle under environmental time cues such as light to maximize their physiological efficiency. The exact timing of this rhythm is established via cell-a...
journal_title:Current genomics
pub_type: 杂志文章,评审
doi:10.2174/1389202919666191014094349
更新日期:2019-08-01 00:00:00
abstract::After human genome sequencing and rapid changes in genome sequencing methods, we have entered into the era of rapidly accumulating genome-sequencing data. This has derived the development of several types of methods for representing results of genome sequencing data. Circular genome visual-ization tools are also criti...
journal_title:Current genomics
pub_type: 杂志文章,评审
doi:10.2174/1389202920666190314092044
更新日期:2019-02-01 00:00:00
abstract:Background:Cancer is a complex disease with a lucid etiology and in understanding the causation, we need to appreciate this complexity. Objective:Here we are aiming to gain insights into the genetic associations of prostate cancer through a network-based systems approach using the BC3Net algorithm. Methods:Specifical...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202919666181107122005
更新日期:2019-01-01 00:00:00
abstract::In nature, microbes do not exist in isolation but co-exist in a variety of ecological and biological environments and on various host organisms. Due to their close proximity, these microbes interact among themselves, and also with the hosts in both positive and negative manners. Moreover, these interactions may modula...
journal_title:Current genomics
pub_type: 杂志文章,评审
doi:10.2174/1389202919666180911144055
更新日期:2018-12-01 00:00:00
abstract::Preterm Birth (PTB) accounts for approximately 11% of all births worldwide each year and is a profound physiological stressor in early life. The burden of neuropsychiatric and developmental impairment is high, with severity and prevalence correlated with gestational age at delivery. PTB is a major risk factor for the ...
journal_title:Current genomics
pub_type: 杂志文章,评审
doi:10.2174/1389202919666171229144807
更新日期:2018-11-01 00:00:00
abstract:Background:Copy Number Variants (CNVs) represent a prevailing type of structural variation (deletions or duplications) in the human genome. In the last few years, several studies have demonstrated that CNVs represent significant mutations in Alzheimer's Disease (AD) hereditability. Currently, innovative high-throughput...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202919666180122141425
更新日期:2018-09-01 00:00:00
abstract::Spinal Muscular Atrophy (SMA) is a neuromuscular disorder caused by mutations in the SMN1 gene. Being a monogenic disease, it is characterized by high clinical heterogeneity. Variations in penetrance and severity of symptoms, as well as clinical discrepancies between affected family members can result from modifier ge...
journal_title:Current genomics
pub_type: 杂志文章,评审
doi:10.2174/1389202919666180101154916
更新日期:2018-08-01 00:00:00
abstract::In recent years, genomic, animal and cell biology studies have implicated deficiencies in retromer-mediated trafficking of proteins in an increasing number of neurodegenerative diseases including Alzheimer's Disease (AD), Parkinson's Disease (PD) and Frontotemporal Lobar Degener-ation (FTLD). The retromer complex, whi...
journal_title:Current genomics
pub_type: 杂志文章,评审
doi:10.2174/1389202919666171024122809
更新日期:2018-05-01 00:00:00
abstract:Background:The postgenomic era is featured by massive data collection and analyses from various large scale-omics studies. Despite the promising capability of systems biology and bioinformatics to handle large data sets, data interpretation, especially the translation of -omics data into clinical implications, has been...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202918666170717145716
更新日期:2018-04-01 00:00:00
abstract:Introduction:Trypanosoma brucei uses antigenic variation to evade the host antibody clearance by periodically changing its Variant Surface Glycoprotein (VSGs) coat. T. brucei encode over 2,500 VSG genes and pseudogenes, however they transcribe only one VSG gene at time from one of the 20 telomeric Expression Sites (ESs...
journal_title:Current genomics
pub_type: 杂志文章,评审
doi:10.2174/1389202918666170911161831
更新日期:2018-02-01 00:00:00
abstract::In the recent years, glyoxalase pathway has been an active area of research in both human and plants. This pathway is reported to confer stress tolerance in plants, by modulating the glutathione homeostasis to achieve detoxification of a potent cytotoxic and mutagenic compound, methylglyoxal. The microRNAs (miRNAs) ar...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202918666170228134530
更新日期:2018-01-01 00:00:00
abstract:Introduction:As a consequence of a sessile lifestyle, plants often have to face a number of life threatening abiotic and biotic stresses. Plants counteract the stresses through morphological and physiological adaptations, which are imparted through flexible and well-coordinated network of signalling and effector molecu...
journal_title:Current genomics
pub_type: 杂志文章,评审
doi:10.2174/1389202918666170608093327
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Helicobacter pylori is associated with inflammation of different areas, such as the duodenum and stomach, causing gastritis and gastric ulcers leading to lymphoma and cancer. Pathogenic islands are a type of clustered mobile elements ranging from 10-200 Kb contributing to the virulence of the respective path...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202918666170705160615
更新日期:2017-10-01 00:00:00
abstract::The genetic background is unknown for the 50-60% of the HNPCC families, who fulfill the Amsterdam criteria, but do not have a mutation in an MMR gene, and is referred to as FCCTX. This study reviews the clinical, morphological and molecular characteristics of FCCTX, and discusses the molecular genetic methods used to ...
journal_title:Current genomics
pub_type: 杂志文章,评审
doi:10.2174/1389202918666170307161643
更新日期:2017-08-01 00:00:00
abstract::Papillary microcarcinoma of the thyroid (mPTC) is defined by the WHO as a papillary thy-roid cancer measuring 10mm or less in diameter and it is nowadays a topic of intense debate among the members of the medical community due to its apparent "epidemic" rise. Although these tumors follow almost always an indolent clin...
journal_title:Current genomics
pub_type: 杂志文章,评审
doi:10.2174/1389202918666170105094459
更新日期:2017-06-01 00:00:00
abstract::Squamous cell carcinoma of the head and neck is one of the most common cancer types worldwide. It initiates on the epithelial lining of the upper aerodigestive tract, at most instances as a consequence of tobacco and alcohol consumption. Treatment options based on conventional therapies or targeted therapies under dev...
journal_title:Current genomics
pub_type: 杂志文章,评审
doi:10.2174/1389202917666160803160934
更新日期:2017-02-01 00:00:00
abstract::Low or high birth weight is one of the main causes for neonatal morbidity and mortality. They are also associated with adulthood chronic illness. Birth weight is a complex trait which is affected by baby's genes, maternal environments as well as the complex interactions between them. To understand the genetic basis of...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202917666160726152033
更新日期:2016-10-01 00:00:00
abstract::Phosphorus (P) is an essential macronutrient for plant growth and development. Inorganic phosphate (Pi) is the major form of P taken up from the soil by plant roots. It is well established that under Pi deficiency condition, plant roots undergo striking morphological changes; mainly a reduction in primary root length ...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202917666160331201812
更新日期:2016-08-01 00:00:00
abstract::Oils of plant origin have been predominantly used for food-based applications. Plant oils not only represent a non-polluting renewable resource but also provide a wide diversity in fatty acids (FAs) composition with diverse applications. Besides being edible, they are now increasingly being used in industrial applicat...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202917666160202220107
更新日期:2016-06-01 00:00:00
abstract::The ascomycete Trichoderma reesei is used for the production of plant cell wall-degrading enzymes in industrial scale. The interplay of the transactivator Xyr1 and the repressor Cre1 mainly regulates the expression of these enzymes. During induc-ing conditions, such as in the presence of sophorose, the transcription o...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202917666151116211812
更新日期:2016-04-01 00:00:00
abstract::Malignant gliomas are lethal primary intracranial tumors. To date, little information on the role of deregulated genes in gliomas have been identified. As the involvement of miRNAs in the carcinogenesis is well known, we carried out a pilot study to identify, as potential biomarkers, differentially expressed microRNAs...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202916666150707155610
更新日期:2015-10-01 00:00:00
abstract::Analytical models usually assume an additive sex effect by treating it as a covariate to identify genetic associations with sex-influenced traits. Their underlying assumptions are violated by ignoring interactions of sex with genetic factors and heterogeneous genetic effects by sex. Methods to deal with the problems a...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202917666160420142601
更新日期:2015-10-01 00:00:00
abstract::A genome-wide scanning of Sorghum bicolor resulted in the identification of 25 SbHsf genes. Phylogenetic analysis shows the ortholog genes that are clustered with only rice, representing a common ancestor. Promoter analysis revealed the identification of different cis-acting elements that are responsible for abiotic a...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202916666150313230812
更新日期:2015-08-01 00:00:00
abstract::The study of local adaptation is a main focus of evolutionary biology since it may contribute to explain the current species diversity. The genomic scan procedures permit for the first time to study the connection between specific DNA patterns and processes as natural selection, genetic drift, recombination, mutation ...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202916666150313230943
更新日期:2015-06-01 00:00:00
abstract::The advent of genomics in the study of developmental mechanisms has brought a trove of information on gene datasets and regulation during development, where the Zic family of zinc-finger proteins plays an important role. Genomic analysis of the modes of action of Zic3 in pluripotent cells demonstrated its requirement ...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202916666150205124519
更新日期:2015-04-01 00:00:00
abstract::Transcriptional regulation plays vital roles in many fundamental biological processes. Reverse engineering of genome-wide regulatory networks from high-throughput transcriptomic data provides a promising way to characterize the global scenario of regulatory relationships between regulators and their targets. In this r...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202915666141110210634
更新日期:2015-02-01 00:00:00
abstract::Controlling for the multiplicity effect is an essential part of determining statistical significance in large-scale single-locus association genome scans on Single Nucleotide Polymorphisms (SNPs). Bonferroni adjustment is a commonly used approach due to its simplicity, but is conservative and has low power for large-s...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920291505141106103959
更新日期:2014-10-01 00:00:00
abstract::MicroRNAs(miRNAs) have become the center of interest in oncology. In recent years, various studies have demonstrated that miRNAs regulate gene expression by influencing important regulatory genes and thus are responsible for causing cervical cancer. Cervical cancer being the third most diagnosed cancer among the femal...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202915666140528003249
更新日期:2014-08-01 00:00:00
abstract::Highly regenerative adult tissues are supported by rare populations of stem cells that continuously divide to self-renew and generate differentiated progeny. This process is tightly regulated by signals emanating from surrounding cells to fulfill the dynamic demands of the tissue. One of the hallmarks of aging is slow...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202915666140421213243
更新日期:2014-06-01 00:00:00
abstract::Protein folding and clearance networks sense and respond to misfolded and aggregation-prone proteins by activating cytoprotective cell stress responses that safeguard the proteome against damage, maintain the health of the cell, and enhance lifespan. Surprisingly, cellular proteostasis undergoes a sudden and widesprea...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202915666140221005023
更新日期:2014-04-01 00:00:00
abstract::Knowledge on the genetics of movement disorders has advanced significantly in recent years. It is now recognized that disorders of the basal ganglia have genetic basis and it is suggested that molecular genetic data will provide clues to the pathophysiology of normal and abnormal motor control. Progress in molecular g...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202914666131210213327
更新日期:2014-02-01 00:00:00
abstract::The important role of non coding RNAs (ncRNAs) in the cell has made their identification a critical issue in the biological research. However, traditional approaches such as PT-PCR and Northern Blot are costly. With recent progress in bioinformatics and computational prediction technology, the discovery of ncRNAs has ...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/13892029113149990005
更新日期:2013-09-01 00:00:00