Abstract:
Background:The cardiac system is a combination of a complex structure, various cells, and versatile specified functions and sophisticated regulatory mechanisms. Moreover, cardiac diseases that encompass a wide range of endogenous conditions, remain a serious health burden worldwide. Recent genome-wide profiling techniques have taken the lead in uncovering a new realm of cell types and molecular programs driving physiological and pathological processes in various organs and diseases. In particular, the emerging technique single-cell RNA sequencing dominates a breakthrough in decoding the cell heterogeneity, phenotype transition, and developmental dynamics in cardiovascular science. Conclusion:Herein, we review recent advances in single cellular studies of cardiovascular system and summarize new insights provided by single-cell RNA sequencing in heart developmental sciences, stem-cell researches as well as normal or disease-related working mechanisms.
journal_name
Curr Genomicsjournal_title
Current genomicsauthors
Chen Z,Wei L,Duru F,Chen Ldoi
10.2174/1389202921999200604123914subject
Has Abstractpub_date
2020-12-01 00:00:00pages
585-601issue
8eissn
1389-2029issn
1875-5488pii
CG-21-585journal_volume
21pub_type
杂志文章,评审相关文献
CURRENT GENOMICS文献大全abstract::The study of local adaptation is a main focus of evolutionary biology since it may contribute to explain the current species diversity. The genomic scan procedures permit for the first time to study the connection between specific DNA patterns and processes as natural selection, genetic drift, recombination, mutation ...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202916666150313230943
更新日期:2015-06-01 00:00:00
abstract::Cancer is currently a major public health problem and, as such, emerging research is making significant progress in identifying major players in its biology. One recent topic of interest involves microRNAs (miRNAs) which are small, non-coding RNA molecules that inhibit gene expression post-transcriptionally. They acco...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920208784139555
更新日期:2008-04-01 00:00:00
abstract::In the recent years, glyoxalase pathway has been an active area of research in both human and plants. This pathway is reported to confer stress tolerance in plants, by modulating the glutathione homeostasis to achieve detoxification of a potent cytotoxic and mutagenic compound, methylglyoxal. The microRNAs (miRNAs) ar...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202918666170228134530
更新日期:2018-01-01 00:00:00
abstract::Protein folding and clearance networks sense and respond to misfolded and aggregation-prone proteins by activating cytoprotective cell stress responses that safeguard the proteome against damage, maintain the health of the cell, and enhance lifespan. Surprisingly, cellular proteostasis undergoes a sudden and widesprea...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202915666140221005023
更新日期:2014-04-01 00:00:00
abstract::Knowledge on the genetics of movement disorders has advanced significantly in recent years. It is now recognized that disorders of the basal ganglia have genetic basis and it is suggested that molecular genetic data will provide clues to the pathophysiology of normal and abnormal motor control. Progress in molecular g...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202914666131210213327
更新日期:2014-02-01 00:00:00
abstract::Highly regenerative adult tissues are supported by rare populations of stem cells that continuously divide to self-renew and generate differentiated progeny. This process is tightly regulated by signals emanating from surrounding cells to fulfill the dynamic demands of the tissue. One of the hallmarks of aging is slow...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202915666140421213243
更新日期:2014-06-01 00:00:00
abstract::Analytical models usually assume an additive sex effect by treating it as a covariate to identify genetic associations with sex-influenced traits. Their underlying assumptions are violated by ignoring interactions of sex with genetic factors and heterogeneous genetic effects by sex. Methods to deal with the problems a...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202917666160420142601
更新日期:2015-10-01 00:00:00
abstract::Triatoma infestans (Klug) is the main vector of Chagas' disease in the Southern Cone of Latin America between the latitudes 10° S and 46° S. The long-term effectiveness of the control campaigns is greatly dependent upon the vector population structure. Mitochondrial DNA (mtDNA) genes have been used in a number of T. i...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/13892029113149990006
更新日期:2013-08-01 00:00:00
abstract::Papillary microcarcinoma of the thyroid (mPTC) is defined by the WHO as a papillary thy-roid cancer measuring 10mm or less in diameter and it is nowadays a topic of intense debate among the members of the medical community due to its apparent "epidemic" rise. Although these tumors follow almost always an indolent clin...
journal_title:Current genomics
pub_type: 杂志文章,评审
doi:10.2174/1389202918666170105094459
更新日期:2017-06-01 00:00:00
abstract::According to the Developmental Origin of Health and Disease (DOHaD) concept, maternal obesity and the resulting accelerated growth in neonates predispose offspring to obesity and associated metabolic diseases that may persist across generations. In this context, the adipose tissue has emerged as an important player du...
journal_title:Current genomics
pub_type: 杂志文章,评审
doi:10.2174/1389202920666191118092852
更新日期:2019-09-01 00:00:00
abstract::In recent years, genomic, animal and cell biology studies have implicated deficiencies in retromer-mediated trafficking of proteins in an increasing number of neurodegenerative diseases including Alzheimer's Disease (AD), Parkinson's Disease (PD) and Frontotemporal Lobar Degener-ation (FTLD). The retromer complex, whi...
journal_title:Current genomics
pub_type: 杂志文章,评审
doi:10.2174/1389202919666171024122809
更新日期:2018-05-01 00:00:00
abstract::MicroRNAs(miRNAs) have become the center of interest in oncology. In recent years, various studies have demonstrated that miRNAs regulate gene expression by influencing important regulatory genes and thus are responsible for causing cervical cancer. Cervical cancer being the third most diagnosed cancer among the femal...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202915666140528003249
更新日期:2014-08-01 00:00:00
abstract::Women outlive men, but life expectancy is not influenced by hormone replacement (estrogen + progestin) therapy. Estrogens appear to protect brain, cardiovascular tissues, and bone from aging. Estrogens regulate genes directly through binding to estrogen receptors alpha and beta (ERalpha and ERbeta) that are ligand-act...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920209788185289
更新日期:2009-05-01 00:00:00
abstract::In nature, microbes do not exist in isolation but co-exist in a variety of ecological and biological environments and on various host organisms. Due to their close proximity, these microbes interact among themselves, and also with the hosts in both positive and negative manners. Moreover, these interactions may modula...
journal_title:Current genomics
pub_type: 杂志文章,评审
doi:10.2174/1389202919666180911144055
更新日期:2018-12-01 00:00:00
abstract::Low or high birth weight is one of the main causes for neonatal morbidity and mortality. They are also associated with adulthood chronic illness. Birth weight is a complex trait which is affected by baby's genes, maternal environments as well as the complex interactions between them. To understand the genetic basis of...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202917666160726152033
更新日期:2016-10-01 00:00:00
abstract::The mode of action of a huge amount of agents on biological systems is still unknown. One example where more questions than answers exist is covered by the term electromagnetic fields (EMF). Use of wireless communication, e.g. mobile phones, has been escalated in the last few years. Due to this fact, a lot of discussi...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920209787847050
更新日期:2009-04-01 00:00:00
abstract::Inheritance of genetic material requires that chromosomes segregate faithfully during cell division. Failure in this process can drive to aneuploidy phenomenon. Kinetochores are unique centromere macromolecular protein structures that attach chromosomes to the spindle for a proper movement and segregation. A unique ty...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920209788920985
更新日期:2009-08-01 00:00:00
abstract::Laccases (p-diphenol oxidase, EC 1.10.3.2) are blue multicopper oxidases that catalyze the reduction of dioxygen to water, with a concomitant oxidation of small organic substrates. Since the description at the end of the nineteenth century of a factor catalyzing the rapid hardening of the latex of the Japanese lacquer...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920211795564340
更新日期:2011-04-01 00:00:00
abstract::Thyroid gland presents a wide spectrum of tumours derived from follicular cells that range from well differentiated, papillary and follicular carcinoma (PTC and FTC, respectively), usually carrying a good prognosis, to the clinically aggressive, poorly differentiated (PDTC) and undifferentiated thyroid carcinoma (UTC)...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920211798120853
更新日期:2011-12-01 00:00:00
abstract::Malignant gliomas are lethal primary intracranial tumors. To date, little information on the role of deregulated genes in gliomas have been identified. As the involvement of miRNAs in the carcinogenesis is well known, we carried out a pilot study to identify, as potential biomarkers, differentially expressed microRNAs...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202916666150707155610
更新日期:2015-10-01 00:00:00
abstract::The advent of genomics in the study of developmental mechanisms has brought a trove of information on gene datasets and regulation during development, where the Zic family of zinc-finger proteins plays an important role. Genomic analysis of the modes of action of Zic3 in pluripotent cells demonstrated its requirement ...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202916666150205124519
更新日期:2015-04-01 00:00:00
abstract::Microarray studies have successfully shed light on various aspects of the molecular mechanisms behind the development of hepatocellular carcinoma (HCC), such as the identification of novel molecular subgroups and the genetic profiles associated with metastasis and venous invasion. These experiments, mainly comprising ...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920210791233063
更新日期:2010-06-01 00:00:00
abstract::Embryonic stem (ES) cells are characterized by the expression of an extensive and interconnected network of pluripotency factors which are downregulated in specialized cells. Epigenetic mechanisms, including DNA methylation and histone modifications, are also important in maintaining this pluripotency program in ES ce...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920212803759730
更新日期:2012-12-01 00:00:00
abstract:Introduction:As a consequence of a sessile lifestyle, plants often have to face a number of life threatening abiotic and biotic stresses. Plants counteract the stresses through morphological and physiological adaptations, which are imparted through flexible and well-coordinated network of signalling and effector molecu...
journal_title:Current genomics
pub_type: 杂志文章,评审
doi:10.2174/1389202918666170608093327
更新日期:2017-12-01 00:00:00
abstract::The presence of chromosomes with diffuse centromeres (holocentric chromosomes) has been reported in several taxa since more than fifty years, but a full understanding of their origin is still lacking. Comparative and functional genomics are nowadays furnishing new data to better understand holocentric chromosome evolu...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920212801619250
更新日期:2012-08-01 00:00:00
abstract::MDM family proteins are crucial regulators of the oncosuppressor p53. Alterations of their gene status, mainly amplification events, have been frequently observed in human tumors.MDM4 is one of the two members of the MDM family. The human gene is located on chromosome 1 at q32-33 and codes for a protein of 490aa. In a...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920209787581280
更新日期:2009-03-01 00:00:00
abstract::Human chromosomal fragile sites are specific genomic regions which exhibit gaps or breaks on metaphase chromosomes following conditions of partial replication stress. Fragile sites often coincide with genes that are frequently rearranged or deleted in human cancers, with over half of cancer-specific translocations con...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920210791616699
更新日期:2010-08-01 00:00:00
abstract::Carcinogenesis involves the inactivation or inhibition of genes that function as tumor suppressors. Deletions, mutations, or epigenetic silencing of tumor suppressor genes can lead to altered growth, differentiation, and apoptosis. DNA methylation and histone modifications are important epigenetic mechanisms of gene r...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920208783884892
更新日期:2008-03-01 00:00:00
abstract:Background:The postgenomic era is featured by massive data collection and analyses from various large scale-omics studies. Despite the promising capability of systems biology and bioinformatics to handle large data sets, data interpretation, especially the translation of -omics data into clinical implications, has been...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202918666170717145716
更新日期:2018-04-01 00:00:00
abstract::Plant breeding has been very successful in developing improved varieties using conventional tools and methodologies. Nowadays, the availability of genomic tools and resources is leading to a new revolution of plant breeding, as they facilitate the study of the genotype and its relationship with the phenotype, in parti...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920212800543084
更新日期:2012-05-01 00:00:00