Abstract:
:After completion of the human genome, genome-wide association studies were conducted to identify single nucleotide polymorphisms (SNPs) associated with cancer initiation and progression. Most of the studies identified SNPs that were located outside the coding region, and the odds ratios were too low to implement in clinical practice. Although the genome gives information about genome sequence and structure, the human epigenome provides functional aspects of the genome. Epigenome-wide association studies (EWAS) provide an opportunity to identify genome-wide epigenetic variants that are associated with cancer. However, there are problems and issues in implementing EWAS to establish an association between epigenetic profiles and cancer. Few challenges include selection and handling of samples, choice of population and sample size, accurate measurement of exposure, integrating data, and insufficient information about the role of repeat sequences. The current status of EWAS, challenges in the field, and their potential solutions are discussed in this article.
journal_name
Curr Genomicsjournal_title
Current genomicsauthors
Verma Mdoi
10.2174/138920212800793294subject
Has Abstractpub_date
2012-06-01 00:00:00pages
308-13issue
4eissn
1389-2029issn
1875-5488pii
CG-13-308journal_volume
13pub_type
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