Abstract:
:Whole-genome studies involving a phenotype of interest are increasingly prevalent, in part due to a dramatic increase in speed at which many high throughput technologies can be performed coupled to simultaneous decreases in cost. This type of genome-scale methodology has been applied to the phenotype of lifespan, as well as to whole-transcriptome changes during the aging process or in mutants affecting aging. The value of high throughput discovery-based science in this field is clearly evident, but will it yield a true systems-level understanding of the aging process? Here we review some of this work to date, focusing on recent findings and the unanswered puzzles to which they point. In this context, we also discuss recent technological advances and some of the likely future directions that they portend.
journal_name
Curr Genomicsjournal_title
Current genomicsauthors
McCormick MA,Kennedy BKdoi
10.2174/138920212803251454subject
Has Abstractpub_date
2012-11-01 00:00:00pages
500-7issue
7eissn
1389-2029issn
1875-5488pii
CG-13-500journal_volume
13pub_type
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