Abstract:
:The mode of action of a huge amount of agents on biological systems is still unknown. One example where more questions than answers exist is covered by the term electromagnetic fields (EMF). Use of wireless communication, e.g. mobile phones, has been escalated in the last few years. Due to this fact, a lot of discussions dealt with health consequences of EMF emitted by these devices and led to an increased investigation of their effects to biological systems, mainly by using traditional methods. Omics technologies have the advantage to contain methods for investigations on DNA-, RNA- and protein level as well as changes in the metabolism.This literature survey is an overview of the available scientific publications regarding biological and health effects of EMF and the application of new high-throughput technologies. The aim of the study was to analyse the amount and the distribution of these technologies and to evaluate their relevance to the risk analysis of EMF. At present, only transcriptomics is able to analyse almost all of the specific molecules. In comparison to ionising radiation, fewer articles dealt with health effects of EMF. Interestingly, most of the EMF articles came from European institutions.Although omics techniques allow exact and simultaneous examinations of thousands of genes, proteins and metabolites in high-throughput technologies, it will be an absolute prerequisite to use standardised protocols and to independently validate the results for comparability and eventually for sound standing statements concerning possible effects of agents like EMF on biological systems.
journal_name
Curr Genomicsjournal_title
Current genomicsauthors
Blankenburg M,Haberland L,Elvers HD,Tannert C,Jandrig Bdoi
10.2174/138920209787847050subject
Has Abstractpub_date
2009-04-01 00:00:00pages
86-92issue
2eissn
1389-2029issn
1875-5488journal_volume
10pub_type
杂志文章相关文献
CURRENT GENOMICS文献大全abstract::In recent years, genomic, animal and cell biology studies have implicated deficiencies in retromer-mediated trafficking of proteins in an increasing number of neurodegenerative diseases including Alzheimer's Disease (AD), Parkinson's Disease (PD) and Frontotemporal Lobar Degener-ation (FTLD). The retromer complex, whi...
journal_title:Current genomics
pub_type: 杂志文章,评审
doi:10.2174/1389202919666171024122809
更新日期:2018-05-01 00:00:00
abstract::Phosphorus (P) is an essential macronutrient for plant growth and development. Inorganic phosphate (Pi) is the major form of P taken up from the soil by plant roots. It is well established that under Pi deficiency condition, plant roots undergo striking morphological changes; mainly a reduction in primary root length ...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202917666160331201812
更新日期:2016-08-01 00:00:00
abstract::The advent of genomics in the study of developmental mechanisms has brought a trove of information on gene datasets and regulation during development, where the Zic family of zinc-finger proteins plays an important role. Genomic analysis of the modes of action of Zic3 in pluripotent cells demonstrated its requirement ...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202916666150205124519
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:This study was carried out to classify the diversity of the deep marine psychrotolerant actinomycetes sp. nov., in the Bay of Bengal and exploit the production of cold-active industrial and pharmaceutical biomolecules. OBJECTIVE:1) Characterization, optimum the growth conditions and classify the diversity o...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202921666200330150642
更新日期:2020-05-01 00:00:00
abstract::MicroRNAs (miRNAs) are short, noncoding, and single-stranded RNA molecules that negatively regulate gene expression. They are evolutionarily conserved from plants to animals. During the last decade, miRNAs have been demonstrated as regulators in fundamental biological processes, including cell growth, proliferation, d...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920210790886853
更新日期:2010-04-01 00:00:00
abstract::Spliceosomal introns in higher eukaryotes are present in a high percentage of protein coding genes and represent a high proportion of transcribed nuclear DNA. In the last fifteen years, a growing mass of data concerning functional roles carried out by such intervening sequences elevated them from a selfish burden carr...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920208784533629
更新日期:2008-06-01 00:00:00
abstract::The term retinitis pigmentosa (RP) indicates a heterogeneous group of genetic rare ocular diseases in which either rods or cones are prevalently damaged. RP represents the most common hereditary cause of blindness in people from 20 to 60 years old. In general, the different RP forms consist of progressive photo-recept...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920211795860125
更新日期:2011-06-01 00:00:00
abstract::Genomic disorders are a clinically diverse group of conditions caused by gain, loss or re-orientation of a genomic region containing dosage-sensitive genes. One class of genomic disorder is caused by hemizygous deletions resulting in haploinsufficiency of a single or, more usually, several genes. For example, the hete...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920208784340795
更新日期:2008-05-01 00:00:00
abstract:Background:Duchenne Muscular Dystrophy (DMD) is a progressive, fatal neuromuscular disorder caused by mutations in the DMD gene. Emerging antisense oligomer based exon skipping therapy provides hope for the restoration of the reading frame. Objectives:Population-based DMD mutation database may enable exon skipping to ...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202920666191107142754
更新日期:2019-11-01 00:00:00
abstract::Bcl-2 proteins are critical regulators of mitochondrial membrane permeability and the proapoptotic mitochondrial pathway. The family encloses pro- and antiapoptotic factors encoded by over 15 genes, which frequently give rise to alternative splice products. Antiapoptotic, proapoptotic multidomain, and proapoptotic BH3...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920208785699571
更新日期:2008-09-01 00:00:00
abstract::The pathogenesis of sporadic Parkinson's disease (PD) remains enigmatic. Mitochondrial complex-I defects are known to occur in the substantia nigra (SN) of PD patients and are also debated in some extracerebral tissues. Early sequencing efforts of the mitochondrial DNA (mtDNA) did not reveal specific mutations, but a ...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920209789503879
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND:Helicobacter pylori is associated with inflammation of different areas, such as the duodenum and stomach, causing gastritis and gastric ulcers leading to lymphoma and cancer. Pathogenic islands are a type of clustered mobile elements ranging from 10-200 Kb contributing to the virulence of the respective path...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202918666170705160615
更新日期:2017-10-01 00:00:00
abstract::Transcriptional regulation plays vital roles in many fundamental biological processes. Reverse engineering of genome-wide regulatory networks from high-throughput transcriptomic data provides a promising way to characterize the global scenario of regulatory relationships between regulators and their targets. In this r...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202915666141110210634
更新日期:2015-02-01 00:00:00
abstract:Background:The cardiac system is a combination of a complex structure, various cells, and versatile specified functions and sophisticated regulatory mechanisms. Moreover, cardiac diseases that encompass a wide range of endogenous conditions, remain a serious health burden worldwide. Recent genome-wide profiling techniq...
journal_title:Current genomics
pub_type: 杂志文章,评审
doi:10.2174/1389202921999200604123914
更新日期:2020-12-01 00:00:00
abstract::Knowledge on the genetics of movement disorders has advanced significantly in recent years. It is now recognized that disorders of the basal ganglia have genetic basis and it is suggested that molecular genetic data will provide clues to the pathophysiology of normal and abnormal motor control. Progress in molecular g...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202914666131210213327
更新日期:2014-02-01 00:00:00
abstract::The availability of complete human and other metazoan genome sequences has greatly facilitated positioning and analysis of various genomic functional elements, with initial emphasis on coding sequences. However, complete functional maps of sequenced eukaryotic genomes should include also positions of all non-coding re...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920207780368178
更新日期:2007-04-01 00:00:00
abstract::Alternative splicing contributes to the complexity of proteome by producing multiple mRNAs from a single gene. Affymetrix exon arrays and experiments in vivo or in vitro demonstrated that alternative splicing was regulated by mechanical stress. Expression of mechano-growth factor (MGF) which is the splicing isoform of...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920213804999156
更新日期:2013-03-01 00:00:00
abstract::The study of immune related genes in lampreys and hagfish provides a unique perspective on the evolutionary genetic underpinnings of adaptive immunity and the evolution of vertebrate genomes. Separated from their jawed cousins at the stem of the vertebrate lineage, these jawless vertebrates have many of the gene famil...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920212799860670
更新日期:2012-04-01 00:00:00
abstract::Human chromosomal fragile sites are specific genomic regions which exhibit gaps or breaks on metaphase chromosomes following conditions of partial replication stress. Fragile sites often coincide with genes that are frequently rearranged or deleted in human cancers, with over half of cancer-specific translocations con...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920210791616699
更新日期:2010-08-01 00:00:00
abstract::Malignant gliomas are lethal primary intracranial tumors. To date, little information on the role of deregulated genes in gliomas have been identified. As the involvement of miRNAs in the carcinogenesis is well known, we carried out a pilot study to identify, as potential biomarkers, differentially expressed microRNAs...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202916666150707155610
更新日期:2015-10-01 00:00:00
abstract::The ascomycete Trichoderma reesei is used for the production of plant cell wall-degrading enzymes in industrial scale. The interplay of the transactivator Xyr1 and the repressor Cre1 mainly regulates the expression of these enzymes. During induc-ing conditions, such as in the presence of sophorose, the transcription o...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202917666151116211812
更新日期:2016-04-01 00:00:00
abstract::Laccases (p-diphenol oxidase, EC 1.10.3.2) are blue multicopper oxidases that catalyze the reduction of dioxygen to water, with a concomitant oxidation of small organic substrates. Since the description at the end of the nineteenth century of a factor catalyzing the rapid hardening of the latex of the Japanese lacquer...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920211795564340
更新日期:2011-04-01 00:00:00
abstract::Cancers arise as a result of stepwise accumulation of mutations which may occur at the nucleotide level and/or the gross chromosomal level. Many cancers particularly those of the colon display a form of genomic instability which may facilitate and speed up tumor initiation and development. In few instances, a "mutator...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920208786847926
更新日期:2008-12-01 00:00:00
abstract::A genome-wide scanning of Sorghum bicolor resulted in the identification of 25 SbHsf genes. Phylogenetic analysis shows the ortholog genes that are clustered with only rice, representing a common ancestor. Promoter analysis revealed the identification of different cis-acting elements that are responsible for abiotic a...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202916666150313230812
更新日期:2015-08-01 00:00:00
abstract:Introduction:Trypanosoma brucei uses antigenic variation to evade the host antibody clearance by periodically changing its Variant Surface Glycoprotein (VSGs) coat. T. brucei encode over 2,500 VSG genes and pseudogenes, however they transcribe only one VSG gene at time from one of the 20 telomeric Expression Sites (ESs...
journal_title:Current genomics
pub_type: 杂志文章,评审
doi:10.2174/1389202918666170911161831
更新日期:2018-02-01 00:00:00
abstract::Carcinogenesis involves the inactivation or inhibition of genes that function as tumor suppressors. Deletions, mutations, or epigenetic silencing of tumor suppressor genes can lead to altered growth, differentiation, and apoptosis. DNA methylation and histone modifications are important epigenetic mechanisms of gene r...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920208783884892
更新日期:2008-03-01 00:00:00
abstract:Introduction:Hydroxylation is one of the most important post-translational modifications (PTM) in cellular functions and is linked to various diseases. The addition of one of the hydroxyl groups (OH) to the lysine sites produces hydroxylysine when undergoes chemical modification. Methods:The method which is used in th...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202921999200831142629
更新日期:2020-11-01 00:00:00
abstract::Papillary microcarcinoma of the thyroid (mPTC) is defined by the WHO as a papillary thy-roid cancer measuring 10mm or less in diameter and it is nowadays a topic of intense debate among the members of the medical community due to its apparent "epidemic" rise. Although these tumors follow almost always an indolent clin...
journal_title:Current genomics
pub_type: 杂志文章,评审
doi:10.2174/1389202918666170105094459
更新日期:2017-06-01 00:00:00
abstract::In nature, microbes do not exist in isolation but co-exist in a variety of ecological and biological environments and on various host organisms. Due to their close proximity, these microbes interact among themselves, and also with the hosts in both positive and negative manners. Moreover, these interactions may modula...
journal_title:Current genomics
pub_type: 杂志文章,评审
doi:10.2174/1389202919666180911144055
更新日期:2018-12-01 00:00:00
abstract::Protein folding and clearance networks sense and respond to misfolded and aggregation-prone proteins by activating cytoprotective cell stress responses that safeguard the proteome against damage, maintain the health of the cell, and enhance lifespan. Surprisingly, cellular proteostasis undergoes a sudden and widesprea...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202915666140221005023
更新日期:2014-04-01 00:00:00