Abstract:
:The advent of genomics in the study of developmental mechanisms has brought a trove of information on gene datasets and regulation during development, where the Zic family of zinc-finger proteins plays an important role. Genomic analysis of the modes of action of Zic3 in pluripotent cells demonstrated its requirement for maintenance of stem cells pluripotency upon binding to the proximal regulatory regions (promoters) of genes associated with cell pluripotency (Nanog, Sox2, Oct4, etc.) as well as cell cycle, proliferation, oncogenesis and early embryogenesis. In contrast, during gastrulation and neurulation Zic3 acts by binding the distal regulatory regions (enhancers, etc) associated with control of gene transcription in the Nodal and Wnt signaling pathways, including genes that act to break body symmetry. This illustrates a general role of Zic3 as a transcriptional regulator that acts not only alone, but in many instances in conjunction with other transcription factors. The latter is done by binding to adjacent sites in the context of multi-transcription factor complexes associated with regulatory elements.
journal_name
Curr Genomicsjournal_title
Current genomicsauthors
Winata CL,Kondrychyn I,Korzh Vdoi
10.2174/1389202916666150205124519subject
Has Abstractpub_date
2015-04-01 00:00:00pages
117-27issue
2eissn
1389-2029issn
1875-5488pii
CG-16-117journal_volume
16pub_type
杂志文章相关文献
CURRENT GENOMICS文献大全abstract::Alternative splicing contributes to the complexity of proteome by producing multiple mRNAs from a single gene. Affymetrix exon arrays and experiments in vivo or in vitro demonstrated that alternative splicing was regulated by mechanical stress. Expression of mechano-growth factor (MGF) which is the splicing isoform of...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920213804999156
更新日期:2013-03-01 00:00:00
abstract::Microorganisms that are capable of live and adapt in hostile habitats of different environmental factors such as extremes temperature, salinity, nutrient availability and pressure are known as extremophiles. Exposure to xenobiotic compounds is global concern influencing the world population as a health hazard. Hence t...
journal_title:Current genomics
pub_type: 杂志文章,评审
doi:10.2174/1389202921999200422122253
更新日期:2020-04-01 00:00:00
abstract::Spinal Muscular Atrophy (SMA) is a neuromuscular disorder caused by mutations in the SMN1 gene. Being a monogenic disease, it is characterized by high clinical heterogeneity. Variations in penetrance and severity of symptoms, as well as clinical discrepancies between affected family members can result from modifier ge...
journal_title:Current genomics
pub_type: 杂志文章,评审
doi:10.2174/1389202919666180101154916
更新日期:2018-08-01 00:00:00
abstract::In the recent years, glyoxalase pathway has been an active area of research in both human and plants. This pathway is reported to confer stress tolerance in plants, by modulating the glutathione homeostasis to achieve detoxification of a potent cytotoxic and mutagenic compound, methylglyoxal. The microRNAs (miRNAs) ar...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202918666170228134530
更新日期:2018-01-01 00:00:00
abstract::Controlling for the multiplicity effect is an essential part of determining statistical significance in large-scale single-locus association genome scans on Single Nucleotide Polymorphisms (SNPs). Bonferroni adjustment is a commonly used approach due to its simplicity, but is conservative and has low power for large-s...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920291505141106103959
更新日期:2014-10-01 00:00:00
abstract::Microarray studies have successfully shed light on various aspects of the molecular mechanisms behind the development of hepatocellular carcinoma (HCC), such as the identification of novel molecular subgroups and the genetic profiles associated with metastasis and venous invasion. These experiments, mainly comprising ...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920210791233063
更新日期:2010-06-01 00:00:00
abstract::Genomic disorders are a clinically diverse group of conditions caused by gain, loss or re-orientation of a genomic region containing dosage-sensitive genes. One class of genomic disorder is caused by hemizygous deletions resulting in haploinsufficiency of a single or, more usually, several genes. For example, the hete...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920208784340795
更新日期:2008-05-01 00:00:00
abstract::MicroRNAs (miRNAs) are short, noncoding, and single-stranded RNA molecules that negatively regulate gene expression. They are evolutionarily conserved from plants to animals. During the last decade, miRNAs have been demonstrated as regulators in fundamental biological processes, including cell growth, proliferation, d...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920210790886853
更新日期:2010-04-01 00:00:00
abstract::In recent years, genomic, animal and cell biology studies have implicated deficiencies in retromer-mediated trafficking of proteins in an increasing number of neurodegenerative diseases including Alzheimer's Disease (AD), Parkinson's Disease (PD) and Frontotemporal Lobar Degener-ation (FTLD). The retromer complex, whi...
journal_title:Current genomics
pub_type: 杂志文章,评审
doi:10.2174/1389202919666171024122809
更新日期:2018-05-01 00:00:00
abstract::Human chromosomal fragile sites are specific genomic regions which exhibit gaps or breaks on metaphase chromosomes following conditions of partial replication stress. Fragile sites often coincide with genes that are frequently rearranged or deleted in human cancers, with over half of cancer-specific translocations con...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920210791616699
更新日期:2010-08-01 00:00:00
abstract::Papillary microcarcinoma of the thyroid (mPTC) is defined by the WHO as a papillary thy-roid cancer measuring 10mm or less in diameter and it is nowadays a topic of intense debate among the members of the medical community due to its apparent "epidemic" rise. Although these tumors follow almost always an indolent clin...
journal_title:Current genomics
pub_type: 杂志文章,评审
doi:10.2174/1389202918666170105094459
更新日期:2017-06-01 00:00:00
abstract::Since the sequencing of the nuclear genome of Arabidopsis thaliana ten years ago, various large-scale analyses of gene function have been performed in this model species. In particular, the availability of collections of lines harbouring random T-DNA or transposon insertions, which include mutants for almost all of th...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920211794520187
更新日期:2011-03-01 00:00:00
abstract::RNA-Seq is a recently developed sequencing technology, that through the analysis of cDNA allows for unique insights into the transcriptome of a cell. The data generated by RNA-Seq provides information on gene expression, alternative splicing events and the presence of non-coding RNAs. It has been realised non-coding R...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202911314030003
更新日期:2013-05-01 00:00:00
abstract::Plant breeding has been very successful in developing improved varieties using conventional tools and methodologies. Nowadays, the availability of genomic tools and resources is leading to a new revolution of plant breeding, as they facilitate the study of the genotype and its relationship with the phenotype, in parti...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920212800543084
更新日期:2012-05-01 00:00:00
abstract::Low or high birth weight is one of the main causes for neonatal morbidity and mortality. They are also associated with adulthood chronic illness. Birth weight is a complex trait which is affected by baby's genes, maternal environments as well as the complex interactions between them. To understand the genetic basis of...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202917666160726152033
更新日期:2016-10-01 00:00:00
abstract::The term retinitis pigmentosa (RP) indicates a heterogeneous group of genetic rare ocular diseases in which either rods or cones are prevalently damaged. RP represents the most common hereditary cause of blindness in people from 20 to 60 years old. In general, the different RP forms consist of progressive photo-recept...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920211795860125
更新日期:2011-06-01 00:00:00
abstract::Thyroid gland presents a wide spectrum of tumours derived from follicular cells that range from well differentiated, papillary and follicular carcinoma (PTC and FTC, respectively), usually carrying a good prognosis, to the clinically aggressive, poorly differentiated (PDTC) and undifferentiated thyroid carcinoma (UTC)...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920211798120853
更新日期:2011-12-01 00:00:00
abstract::The mode of action of a huge amount of agents on biological systems is still unknown. One example where more questions than answers exist is covered by the term electromagnetic fields (EMF). Use of wireless communication, e.g. mobile phones, has been escalated in the last few years. Due to this fact, a lot of discussi...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920209787847050
更新日期:2009-04-01 00:00:00
abstract:Background:The cardiac system is a combination of a complex structure, various cells, and versatile specified functions and sophisticated regulatory mechanisms. Moreover, cardiac diseases that encompass a wide range of endogenous conditions, remain a serious health burden worldwide. Recent genome-wide profiling techniq...
journal_title:Current genomics
pub_type: 杂志文章,评审
doi:10.2174/1389202921999200604123914
更新日期:2020-12-01 00:00:00
abstract::Inheritance of genetic material requires that chromosomes segregate faithfully during cell division. Failure in this process can drive to aneuploidy phenomenon. Kinetochores are unique centromere macromolecular protein structures that attach chromosomes to the spindle for a proper movement and segregation. A unique ty...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920209788920985
更新日期:2009-08-01 00:00:00
abstract::The pathogenesis of sporadic Parkinson's disease (PD) remains enigmatic. Mitochondrial complex-I defects are known to occur in the substantia nigra (SN) of PD patients and are also debated in some extracerebral tissues. Early sequencing efforts of the mitochondrial DNA (mtDNA) did not reveal specific mutations, but a ...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920209789503879
更新日期:2009-12-01 00:00:00
abstract::MDM family proteins are crucial regulators of the oncosuppressor p53. Alterations of their gene status, mainly amplification events, have been frequently observed in human tumors.MDM4 is one of the two members of the MDM family. The human gene is located on chromosome 1 at q32-33 and codes for a protein of 490aa. In a...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920209787581280
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND:This study was carried out to classify the diversity of the deep marine psychrotolerant actinomycetes sp. nov., in the Bay of Bengal and exploit the production of cold-active industrial and pharmaceutical biomolecules. OBJECTIVE:1) Characterization, optimum the growth conditions and classify the diversity o...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202921666200330150642
更新日期:2020-05-01 00:00:00
abstract::Antigenic differences between normal and malignant cells of the cancer patient form the rationale for clinical immunotherapeutic strategies. Because the antigenic phenotype of neoplastic cells varies widely among different cells within the same malignant cell-population, immunization with a vaccine that stimulates imm...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920206778426951
更新日期:2006-06-01 00:00:00
abstract::After human genome sequencing and rapid changes in genome sequencing methods, we have entered into the era of rapidly accumulating genome-sequencing data. This has derived the development of several types of methods for representing results of genome sequencing data. Circular genome visual-ization tools are also criti...
journal_title:Current genomics
pub_type: 杂志文章,评审
doi:10.2174/1389202920666190314092044
更新日期:2019-02-01 00:00:00
abstract::Circadian clocks are intrinsic, time-tracking systems that bestow upon organisms a survival advantage. Under natural conditions, organisms are trained to follow a 24-h cycle under environmental time cues such as light to maximize their physiological efficiency. The exact timing of this rhythm is established via cell-a...
journal_title:Current genomics
pub_type: 杂志文章,评审
doi:10.2174/1389202919666191014094349
更新日期:2019-08-01 00:00:00
abstract::Phosphorus (P) is an essential macronutrient for plant growth and development. Inorganic phosphate (Pi) is the major form of P taken up from the soil by plant roots. It is well established that under Pi deficiency condition, plant roots undergo striking morphological changes; mainly a reduction in primary root length ...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202917666160331201812
更新日期:2016-08-01 00:00:00
abstract::The availability of complete human and other metazoan genome sequences has greatly facilitated positioning and analysis of various genomic functional elements, with initial emphasis on coding sequences. However, complete functional maps of sequenced eukaryotic genomes should include also positions of all non-coding re...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920207780368178
更新日期:2007-04-01 00:00:00
abstract::Spliceosomal introns in higher eukaryotes are present in a high percentage of protein coding genes and represent a high proportion of transcribed nuclear DNA. In the last fifteen years, a growing mass of data concerning functional roles carried out by such intervening sequences elevated them from a selfish burden carr...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/138920208784533629
更新日期:2008-06-01 00:00:00
abstract::Highly regenerative adult tissues are supported by rare populations of stem cells that continuously divide to self-renew and generate differentiated progeny. This process is tightly regulated by signals emanating from surrounding cells to fulfill the dynamic demands of the tissue. One of the hallmarks of aging is slow...
journal_title:Current genomics
pub_type: 杂志文章
doi:10.2174/1389202915666140421213243
更新日期:2014-06-01 00:00:00