Abstract:
:Squamous cell carcinoma of the head and neck is one of the most common cancer types worldwide. It initiates on the epithelial lining of the upper aerodigestive tract, at most instances as a consequence of tobacco and alcohol consumption. Treatment options based on conventional therapies or targeted therapies under development have limited efficacy due to multiple genetic alterations typically found in this cancer type. Natural products derived from plants often possess biological activities that may be valuable in the development of new therapeutic agents for cancer treatment. Several genera from the family Celastraceae have been studied in this context. This review reports studies on chemical constituents isolated from species from the Celastraceae family targeting cancer mechanisms studied to date. These results are then correlated with molecular characteristics of head and neck squamous cell carcinoma in an attempt to identify constituents with potential application in the treatment of this complex disease at the molecular level.
journal_name
Curr Genomicsjournal_title
Current genomicsauthors
Hernandes C,Pereira AMS,Severino Pdoi
10.2174/1389202917666160803160934subject
Has Abstractpub_date
2017-02-01 00:00:00pages
60-74issue
1eissn
1389-2029issn
1875-5488pii
CG-18-60journal_volume
18pub_type
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