Abstract:
BACKGROUND:The aim of this study is to compare the results of magnetic resonance (MR) imaging, particularly the decline in hippocampal volume, of patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI) with healthy age-matched controls, to examine the reliability of hippocampal volumetry in the early diagnosis of AD and the correlation of the severity of hippocampal atrophy with the severity of cognitive decline. METHODS:Twenty-six AD, 22 MCI and 15 normal cognitive status (NCS) patients were scanned with a 3 Tesla MR scanner. Hippocampus volumes were detected manually by Osiris 4.18. RESULTS:Multivariate regression analysis, which was performed to adjust the covariate effects of education, age, gender, hypertension and diabetes mellitus, showed that hippocampal atrophy was correlated with AD and MCI for right hippocampus; AD, MCI and age for left hippocampus independent of other parameters. A second regression analysis revealed that MMSE was correlated with hippocampal volume. CONCLUSIONS:Hippocampal volumetry can be used in early diagnosis of cognitive impairment, as well as grading cognitive decline.
journal_name
Int Psychogeriatrjournal_title
International psychogeriatricsauthors
Yavuz BB,Ariogul S,Cankurtaran M,Oguz KK,Halil M,Dagli N,Cankurtaran ESdoi
10.1017/S1041610206004303subject
Has Abstractpub_date
2007-08-01 00:00:00pages
767-77issue
4eissn
1041-6102issn
1741-203Xpii
S1041610206004303journal_volume
19pub_type
杂志文章abstract:BACKGROUND:Alterations in iron metabolism have been suggested as potential pathological markers in patients with manifest depression. No data on the association between iron and depression exist from population-based studies, in which milder forms of depressive symptoms are much more common. The aim of this study was t...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610205002759
更新日期:2006-09-01 00:00:00
abstract:BACKGROUND:In a previous paper, we presented results from a 12-week study of a Psychomotor DANCe Therapy INtervention (DANCIN) based on Danzón Latin Ballroom that involves motor, emotional-affective, and cognitive domains, using a multiple-baseline single-case design in three care homes. This paper reports the results ...
journal_title:International psychogeriatrics
pub_type: 杂志文章,多中心研究
doi:10.1017/S104161021600171X
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:Seeking medical advice for dementia involves an understanding of norms, values and attitudes towards care-giving and inter-dependency, which are culturally bounded. We hypothesize that local culture and socioeconomic structure affect our Chinese patients who present with forgetfulness to our memory clinic. ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S104161020800817X
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:It is of considerable public health importance to prevent or delay the progression of mild cognitive impairment (MCI) to more severely impaired cognitive states. This study examines the risk of progression from mild to severe cognitive impairment in relation to engagement in social activities while mildly im...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610212002086
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:We examine the association between leisure-time activities and the risk of developing cognitive impairment among Chinese older people, and further investigate whether the association varies by educational level. METHODS:This follow-up study included 6,586 participants (aged 79.5 ± 9.8 years, range 65-105 ye...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610216001769
更新日期:2017-05-01 00:00:00
abstract:OBJECTIVE:To validate a shorter version of the Geriatric Depression Scale (GDS) for older, visually impaired patients. PARTICIPANTS:Subjects were 70 visually impaired adults over age 65 who were presenting for services at a low vision clinic. METHOD:Subjects were interviewed by a geriatric nurse practitioner. A struc...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610200006554
更新日期:2000-12-01 00:00:00
abstract:BACKGROUND:Despite the increasing prevalence of Alzheimer's disease (AD), very few studies have examined advanced preparation for the possibility of becoming sick with AD, and these few studies indicate a general lack of preparation. This study aimed to expand knowledge regarding preparedness for AD among younger and o...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610211001803
更新日期:2012-02-01 00:00:00
abstract:OBJECTIVES:Data on psychotropic medications of older patients with schizophrenia spectrum disorder are scarce. Specifically, information about the use of benzodiazepines among older patients with schizophrenia spectrum disorder is very limited. Because benzodiazepine use in older patients has been associated with many ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610219000358
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:To examine the effects of complex cognitive (mahjong) and physical (Tai Chi) activities on dementia severity in nursing home residents with dementia. METHODS:Cluster-randomized open-label controlled design. 110 residents were randomized by nursing home into three conditions: mahjong, Tai Chi, and simple han...
journal_title:International psychogeriatrics
pub_type: 杂志文章,随机对照试验
doi:10.1017/S1041610213002524
更新日期:2014-04-01 00:00:00
abstract::The authors conducted a survey of members of the International Psychogeriatric Association (IPA) to determine the state of development of both the profession of geriatric psychiatry and services for mentally ill elderly. Ratings for both issues were based on a scale of 1 to 4, with 1 being little to no development and...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610298005444
更新日期:1998-12-01 00:00:00
abstract::Health-related quality of life (HRQL) was investigated in 211 inhabitants of five residential homes in The Netherlands and was assessed again 1 year later. It was examined (a) if HRQL was related to the presence of specific general medical illnesses, (b) if comorbidity resulted in poorer HRQL, independent of the type ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610299006067
更新日期:1999-12-01 00:00:00
abstract:BACKGROUND:The ability to manage everyday technology (ET), such as computers and microwave ovens, is increasingly required in the performance of everyday activities and participation in society. This study aimed to identify aspects that influence the ability to manage ET among older adults with and without cognitive im...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610211002092
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND:The aim of this study was to examine the impact of residential respite care on disruptive behavior displayed by older people, particularly those with dementia. METHODS:A quasi-experimental, repeated-measures, single-group design was used. The participants were a consecutive series of 100 older people with a...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610205002553
更新日期:2006-03-01 00:00:00
abstract:BACKGROUND:Common sense suggests and research indicates relationships between staff factors in residential dementia care and quality of life (QOL) for residents, with poor care increasing suffering. However, we do not have a coherent picture of which staff interventions have an impact on quality of care (QOC) or reside...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610216001083
更新日期:2016-12-01 00:00:00
abstract::Dementia is defined as global cognitive impairment that interferes with function; however, function has been less well measured than cognition in anti-dementia drug trials. In the modern era of anti-dementia clinical trials, measurement of function has improved by differentiating between the aspects of function that h...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610207004966
更新日期:2007-06-01 00:00:00
abstract:BACKGROUND:We studied the suitability of The Consortium to Establish a Registry for Alzheimer's Disease Neuropsychological Battery (CERAD-NB) total score for monitoring Alzheimer's disease (AD) progression in early-diagnosed medicated patients. We also investigated possible differences in progression between patients w...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610213000653
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:The anxiety disorders are a prevalent mental health problem in older age with a considerable impact on quality of life. Until recently there have been few longitudinal studies on anxiety in this age group, consequently most of the evidence to date has been cross-sectional in nature. METHODS:We undertook a l...
journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/S1041610214001847
更新日期:2015-07-01 00:00:00
abstract::ABSTRACTBackground:US suicide rates among older women have substantially increased over the past decade. We examined potential differences in sociodemographic and risk/precipitating factors among older female suicide decedents who died by drug overdose versus firearms, hanging/suffocation, and other means, and postmor...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610218000212
更新日期:2018-10-01 00:00:00
abstract::Most people who work in aged care have a fair idea of what is meant by cognitive impairment or decline, and we have some moderately robust instruments for detecting it and measuring change over time. Frailty is much more difficult to define, but like hard core pornography (Stewart, 1964), many of us "know it when we s...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610217000060
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:One in three adults, most of whom are living in a care home at the time, dies with dementia. Their end-of-life is often in hospital, where they may experience uncomfortable interventions without known benefit and die rapidly with uncontrolled pain and comfort needs. This study aimed to improve end-of-life ca...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610213001221
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:Symptoms of complicated grief are associated with a traumatic death. However, the subjective experience of whether or not the death was considered traumatic has not been substantially explored. This study first examined the difference between objective and subjective traumatic death, and then investigated th...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610216001873
更新日期:2017-03-01 00:00:00
abstract::Few instruments are available with which to measure behavioral and psychological signs and symptoms in Hispanic patients with dementia. Therefore, the aim of the current study was to develop and evaluate a 17-item scale adapted from the Revised Memory and Behavior Problems Checklist. This measure, the Behavior Problem...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610201007438
更新日期:2001-03-01 00:00:00
abstract:BACKGROUND:This study was conducted to estimate prevalence rates and risk factors for late-life depression in a large nationwide representative sample from Taiwan. METHODS:A total of 5,664, randomly sampled individuals aged ≥55 years were enrolled. Clinically, relevant depressive symptoms were classified using the Cen...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610217000199
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:The use of benzodiazepines is associated with increased risk of fall-related injuries in the elderly. However, it is unclear if the risks vary across the products and how they depend on the pattern of use and dosage. Specifically, the possibility of cumulative effects of past benzodiazepine use has not been ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610211002031
更新日期:2012-04-01 00:00:00
abstract::The reliability and validity of the Subjective Burden Scale (SBS) were investigated in 255 Japanese family caregivers of elderly relatives with dementia. Values of the Cronbach's alpha reliability, split-half reliability (r), and test-retest reliability (r) were .87, .80, and .72, respectively. The SBS score was signi...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610299005712
更新日期:1999-06-01 00:00:00
abstract:BACKGROUND:Due to previously reported mixed findings, there is a need for further empirical research on the factorial structure of the commonly used Geriatric Anxiety Inventory (GAI). Therefore, the psychometric properties of the GAI and its short form version (GAI-SF) were evaluated in a psychogeriatric mixed in-and-o...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610217001004
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:It is currently not known whether elderly men and women present with different subtypes of depression and mania/bipolar disorder. The aim of this study was to compare the prevalence of subtypes of a single depressive episode and mania/bipolar disorder according to the ICD-10 for elderly men and women in a na...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S104161020600319X
更新日期:2006-12-01 00:00:00
abstract:BACKGROUND:While dementia is more common in older people and suicide rates in many countries are higher among the elderly, there is some doubt about the association between these two phenomena. METHODS:A search of the major relevant databases was carried out to examine the evidence for this possible association. RESU...
journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/S1041610209009065
更新日期:2009-06-01 00:00:00
abstract::This article reviews the evidence available from natural history studies and randomized clinical trials (RCT) concerning what is now coined as amnestic MCI and vascular MCI and will answer the question about the similarity and difference of their progression toward dementia. The issues to be resolved prior to the use ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610203009293
更新日期:2003-01-01 00:00:00
abstract::Seventy-eight nondemented elderly depressed patients underwent an extensive battery of cognitive tests both before and after seven weeks of treatment with nortriptyline, phenelzine, or placebo. Clinical and cognitive evaluations of the patients were under double-blind conditions. Response to treatment did not appear t...
journal_title:International psychogeriatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1017/s1041610289000141
更新日期:1989-10-01 00:00:00