Hippocampal atrophy correlates with the severity of cognitive decline.

Abstract:

BACKGROUND:The aim of this study is to compare the results of magnetic resonance (MR) imaging, particularly the decline in hippocampal volume, of patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI) with healthy age-matched controls, to examine the reliability of hippocampal volumetry in the early diagnosis of AD and the correlation of the severity of hippocampal atrophy with the severity of cognitive decline. METHODS:Twenty-six AD, 22 MCI and 15 normal cognitive status (NCS) patients were scanned with a 3 Tesla MR scanner. Hippocampus volumes were detected manually by Osiris 4.18. RESULTS:Multivariate regression analysis, which was performed to adjust the covariate effects of education, age, gender, hypertension and diabetes mellitus, showed that hippocampal atrophy was correlated with AD and MCI for right hippocampus; AD, MCI and age for left hippocampus independent of other parameters. A second regression analysis revealed that MMSE was correlated with hippocampal volume. CONCLUSIONS:Hippocampal volumetry can be used in early diagnosis of cognitive impairment, as well as grading cognitive decline.

journal_name

Int Psychogeriatr

authors

Yavuz BB,Ariogul S,Cankurtaran M,Oguz KK,Halil M,Dagli N,Cankurtaran ES

doi

10.1017/S1041610206004303

subject

Has Abstract

pub_date

2007-08-01 00:00:00

pages

767-77

issue

4

eissn

1041-6102

issn

1741-203X

pii

S1041610206004303

journal_volume

19

pub_type

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