The age incidence of chronic myeloid leukemia can be explained by a one-mutation model.

abstract：:Mumps virus (MuV) is a highly contagious pathogen, and despite extensive vaccination campaigns, outbreaks continue to occur worldwide. The virus has a negative-sense, single-stranded RNA genome that is encapsidated by the nucleocapsid protein (N) to form the nucleocapsid (NC). NC serves as the template for both transc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cox R,Pickar A,Qiu S,Tsao J,Rodenburg C,Dokland T,Elson A,He B,Luo M

更新日期：2014-10-21 00:00:00

abstract：:Aberrant promoter hypermethylation is frequently observed in cancer. The potential for this mechanism to contribute to tumor development depends on whether the genes affected are repressed because of their methylation. Many aberrantly methylated genes play important roles in development and are bivalently marked in ES...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sproul D,Nestor C,Culley J,Dickson JH,Dixon JM,Harrison DJ,Meehan RR,Sims AH,Ramsahoye BH

更新日期：2011-03-15 00:00:00

abstract：:Adolescent trauma (AT) is a common risk factor for adult-onset posttraumatic stress disorder (PTSD). However, the vulnerability to AT among different individuals varies dramatically, indicating that other cofactors are important. Despite extensive studies, the identification of those cofactors has had little success. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Joseph A,Tang M,Mamiya T,Chen Q,Yang LL,Jiao J,Yu N,Tang YP

更新日期：2013-04-16 00:00:00

abstract：:The human CMV UL37x1-encoded protein, also known as the viral mitochondria-localized inhibitor of apoptosis, traffics to the endoplasmic reticulum and mitochondria of infected cells. It induces the fragmentation of mitochondria and blocks apoptosis. We demonstrate that UL37x1 protein mobilizes Ca(2+) from the endoplas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sharon-Friling R,Goodhouse J,Colberg-Poley AM,Shenk T

更新日期：2006-12-12 00:00:00

abstract：:To better understand how the relatively flat antigen-combining sites of antibodies interact with the concave shaped substrate-binding clefts of proteases, we determined the structures of two antibodies in complex with the trypsin-like hepatocyte growth-factor activator (HGFA). The two inhibitory antibodies, Ab58 and A...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu Y,Eigenbrot C,Liang WC,Stawicki S,Shia S,Fan B,Ganesan R,Lipari MT,Kirchhofer D

更新日期：2007-12-11 00:00:00

abstract：:We have cloned four lambda light chain constant region (C) genes from mouse embryo DNA. Each carries its own joining (J) segment approximately 1.3 kilobases to its 5' side. The four C genes occur in two clusters, 5' J3C3J1C13' and 5' J2C2J4C43', with C4 being a new C lambda gene. We have also shown that V lambda 1 is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blomberg B,Traunecker A,Eisen H,Tonegawa S

更新日期：1981-06-01 00:00:00

abstract：:Plasma membrane insulin receptors, affinity labeled by covalent crosslinking to receptor-bound 125I-labeled insulin, are shown to appear as a heterogeneous population of three major disulfide-linked complexes (Mr 350,000, 320,000, and 290,000) upon electrophoresis in highly porous dodecyl sulfate/polyacrylamide gels i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Massague J,Pilch PF,Czech MP

更新日期：1980-12-01 00:00:00

abstract：:Nitric oxide (NO) has been implicated as a pathogenic mediator in a variety of central nervous system (CNS) disease states, including the animal model of multiple sclerosis (MS) and experimental allergic encephalomyelitis. We have examined post-mortem brain tissues collected from patients previously diagnosed with MS,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bagasra O,Michaels FH,Zheng YM,Bobroski LE,Spitsin SV,Fu ZF,Tawadros R,Koprowski H

更新日期：1995-12-19 00:00:00

abstract：:The chemical dynamics of lakes and streams affect their suitability as aquatic habitats and as water supplies for human needs. Because water quality is typically monitored only weekly or monthly, however, the higher-frequency dynamics of stream chemistry have remained largely invisible. To illuminate a wider spectrum ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kirchner JW,Neal C

更新日期：2013-07-23 00:00:00

abstract：:Heat-shock protein of 90 kDa (Hsp90) is an essential molecular chaperone that adopts different 3D structures associated with distinct nucleotide states: a wide-open, V-shaped dimer in the apo state and a twisted, N-terminally closed dimer with ATP. Although the N domain is known to mediate ATP binding, how Hsp90 sense...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sung N,Lee J,Kim JH,Chang C,Joachimiak A,Lee S,Tsai FT

更新日期：2016-03-15 00:00:00

abstract：:This study presents, to our knowledge, the first on-line measurement of acetylcholinesterase (AcChoEase) release from brain tissue. It is now well established that a soluble form of the enzyme is released from central nervous system neurons, and it has been proposed on indirect grounds that such release may occur not ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Llinás RR,Greenfield SA

更新日期：1987-05-01 00:00:00

abstract：:A mitochondrial ribosome with an approximate sedimentation coefficient of 60 S has been isolated from the ovary of the South African clawed toad, Xenopus laevis. This ribosome is active in a submitochondrial protein-synthesizing system. It contains two species of RNA, designated as "21S" and 13S RNA, which have sequen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Swanson RF,Dawid IB

更新日期：1970-05-01 00:00:00

abstract：:In the hippocampus, a CA3 pyramidal cell forms excitatory synapses with thousands of other pyramidal cells and inhibitory interneurons. By using sequential paired recordings from three connected cells, we show that the presynaptic properties of CA3 pyramidal cell terminals, belonging to the same axon, differ according...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scanziani M,Gähwiler BH,Charpak S

更新日期：1998-09-29 00:00:00

abstract：:Prostate carcinoma is the second leading cause of death from malignancy in men in the United States. Prostate cancer cells express type I insulin-like growth factor receptor (IGF-IR) and prostate cancer selectively metastazises to bone, which is an environment rich in insulin-like growth factors (IGFs), thereby suppor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burfeind P,Chernicky CL,Rininsland F,Ilan J,Ilan J

更新日期：1996-07-09 00:00:00

abstract：:We have cloned a member of the nuclear receptor superfamily. The cDNA was isolated from a rat liver library and encodes a protein of 446 aa with a predicted mass of 50 kDa. This clone (OR-1) shows no striking homology to any known member of the steroid/thyroid hormone receptor superfamily. The most related receptor is...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Teboul M,Enmark E,Li Q,Wikström AC,Pelto-Huikko M,Gustafsson JA

更新日期：1995-03-14 00:00:00

abstract：:Chronic hypoxia causes pulmonary hypertension with smooth muscle cell proliferation and matrix deposition in the wall of the pulmonary arterioles. We demonstrate here that hypoxia also induces a pronounced inflammation in the lung before the structural changes of the vessel wall. The proinflammatory action of hypoxia ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Minamino T,Christou H,Hsieh CM,Liu Y,Dhawan V,Abraham NG,Perrella MA,Mitsialis SA,Kourembanas S

更新日期：2001-07-17 00:00:00

abstract：:Hereditary hemochromatosis (HH) is a common chronic human genetic disorder whose hallmark is systemic iron overload. Homozygosity for a mutation in the MHC class I heavy chain paralogue gene HFE has been found to be a primary cause of HH. However, many individuals homozygous for the defective allele of HFE do not deve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sproule TJ,Jazwinska EC,Britton RS,Bacon BR,Fleming RE,Sly WS,Roopenian DC

更新日期：2001-04-24 00:00:00

abstract：:Escherichia coli infections, a leading cause of septic shock, remain a major threat to human health because of the fatal action to endotoxin (LPS). Therapeutic attempts to neutralize endotoxin currently focus on inhibiting the interaction of the toxic component lipid A with myeloid differentiating factor 2, which form...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gomery K,Müller-Loennies S,Brooks CL,Brade L,Kosma P,Di Padova F,Brade H,Evans SV

更新日期：2012-12-18 00:00:00

abstract：:Betidamino acids (a contraction of "beta" position and "amide") are N'-monoacylated (optionally, N'-monoacylated and N-mono- or N,N'-dialkylated) aminoglycine derivatives in which each N'acyl/alkyl group may mimic naturally occurring amino acid side chains or introduce novel functionalities. Betidamino acids are most ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rivier JE,Jiang G,Koerber SC,Porter J,Simon L,Craig AG,Hoeger CA

更新日期：1996-03-05 00:00:00

abstract：:Embryonal kidney cell tumors develop in rats given the alkylating agent N-nitroso-N'-methylurea as neonates. These tumors resemble the childhood Wilms tumors in their histopathology. Deletions and mutations in the Wilms tumor suppressor gene, WT1, are present in up to 6% of childhood nephroblastomas. To investigate th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sharma PM,Bowman M,Yu BF,Sukumar S

更新日期：1994-10-11 00:00:00

abstract：:Artificially aminoacylated suppressor tRNAs were used to introduce photoreactive amino acids into model mitochondrial precursor proteins to probe the environment along the protein import pathway. Amino acids with benzophenone side chains of various lengths [DL-2-amino-3-(p-benzoylphenyl)propanoic acid (1) and DL-2-ami...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kanamori T,Nishikawa S,Shin I,Schultz PG,Endo T

更新日期：1997-01-21 00:00:00

abstract：:Surface plasmon resonance biosensor technology was used to directly measure the binding interactions of small molecules to the ligand-binding domain of human estrogen receptor. In a screening mode, specific ligands of the receptor were easily discerned from nonligands. In a high-resolution mode, the association and di...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rich RL,Hoth LR,Geoghegan KF,Brown TA,LeMotte PK,Simons SP,Hensley P,Myszka DG

更新日期：2002-06-25 00:00:00

abstract：:Influenza A virus (IAV) has a segmented genome, which (i) allows for exchange of gene segments in coinfected cells, termed reassortment, and (ii) necessitates a selective packaging mechanism to ensure incorporation of a complete set of segments into virus particles. Packaging signals serve as segment identifiers and e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： White MC,Tao H,Steel J,Lowen AC

更新日期：2019-03-05 00:00:00

abstract：:Extracellular vesicles (EVs) secreted by cells present an attractive strategy for developing new therapies, but progress in the field is limited by several issues: The quality of the EVs varies with the type and physiological status of the producer cells; protocols used to isolate the EVs are difficult to scale up; an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim DK,Nishida H,An SY,Shetty AK,Bartosh TJ,Prockop DJ

更新日期：2016-01-05 00:00:00

abstract：:The molecular basis for the absence of anthocyanins and proanthocyanidins in four independent sodium azide-induced ant18 mutants of barley was examined by sequencing the gene encoding dihydroflavonol 4-reductase in these mutants. Sodium azide generated 21 base substitutions, which corresponds to 0.17% of the 12,704 nu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Olsen O,Wang X,von Wettstein D

更新日期：1993-09-01 00:00:00

abstract：:The bacteriophage T4-encoded RegB endoribonuclease is produced during the early stage of phage development and targets mostly (but not exclusively) the Shine-Dalgarno sequences of early genes. In this work, we show that the degradation of RegB-cleaved mRNAs depends on a functional T4 polynucleotide kinase/phosphatase ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Durand S,Richard G,Bontems F,Uzan M

更新日期：2012-05-01 00:00:00

abstract：:P elements, a class of mobile genetic elements that cause hybrid dysgenesis in Drosophila melanogaster, have thus far been shown to occur only in this species. Using whole genome blot analysis, we present evidence which indicates that sequences homologous to D. melanogaster P elements also occur in Drosophila paulisto...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Daniels SB,Strausbaugh LD,Ehrman L,Armstrong R

更新日期：1984-11-01 00:00:00

abstract：:Nitric oxide (NO) is an antiviral effector of the innate immune system. Viruses that can interfere with NO synthesis may be able to replicate more rapidly than viruses that cannot limit NO synthesis. We show that the adenovirus E1A protein inhibits NO production by decreasing expression of the inducible NO synthase (N...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cao W,Bao C,Lowenstein CJ

更新日期：2003-06-24 00:00:00

abstract：:Activation of an anticancer innate immune response is highly desirable because of its inherent ability to generate an adaptive antitumor T-cell response. However, insufficient safety of innate immune modulators limits clinical use to topical applications. Toll-like receptor 5 (TLR5) agonists are favorably positioned a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brackett CM,Kojouharov B,Veith J,Greene KF,Burdelya LG,Gollnick SO,Abrams SI,Gudkov AV

更新日期：2016-02-16 00:00:00

abstract：:Organelles in the axoplasm from the squid giant axon move along exogenous actin filaments toward their barbed ends. An approximately 235-kDa protein, the only band recognized by a pan-myosin antibody in Western blots of isolated axoplasmic organelles, has been previously proposed to be a motor for these movements. Her...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bearer EL,DeGiorgis JA,Jaffe H,Medeiros NA,Reese TS

更新日期：1996-06-11 00:00:00