H5N8 and H7N9 packaging signals constrain HA reassortment with a seasonal H3N2 influenza A virus.

abstract：:Solution at 2.5-A resolution of the three-dimensional structure of H-2Ld with a single nine-residue peptide provides a structural basis for understanding its unique interaction with beta-2 microglobulin (beta2m) and peptide. Consistent with the biological data that show an unusually weak association of Ld with beta2m,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Balendiran GK,Solheim JC,Young AC,Hansen TH,Nathenson SG,Sacchettini JC

更新日期：1997-06-24 00:00:00

abstract：:Peptides bind MHC class I molecules by anchoring hydrophobic side chains into pockets in the peptide binding groove. Here, we report an immunogenic (in vitro and in vivo) MUC1 glycopeptide (MUC1-8-5GalNAc) bound to H-2Kb, fully crossreactive with the nonglycosylated variant. Molecular modeling showed that the central ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Apostolopoulos V,Yuriev E,Ramsland PA,Halton J,Osinski C,Li W,Plebanski M,Paulsen H,McKenzie IF

更新日期：2003-12-09 00:00:00

abstract：:Analysis of variations in the concentrations or structures of biomolecules (e.g., mRNAs, proteins, peptides, natural products) that occur either naturally or in response to environmental or genetic perturbations can provide important insight into complex biological processes. Many biological samples are mixtures that ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yao S,Anex DS,Caldwell WB,Arnold DW,Smith KB,Schultz PG

更新日期：1999-05-11 00:00:00

abstract：:Morphine produces analgesia at opiate receptors expressed in nociceptive circuits. mu, delta, and kappa opiate receptor subtypes are expressed in circuits that can modulate nociception and receive inputs from endogenous opioid neuropeptide ligands. The roles played by each receptor subtype in nociceptive processing in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sora I,Takahashi N,Funada M,Ujike H,Revay RS,Donovan DM,Miner LL,Uhl GR

更新日期：1997-02-18 00:00:00

abstract：:The phosphatidylinositol 3-kinase subunit PIK3CA is frequently mutated in human cancers. Here we used gene targeting to "knock in" PIK3CA mutations into human breast epithelial cells to identify new therapeutic targets associated with oncogenic PIK3CA. Mutant PIK3CA knockin cells were capable of epidermal growth facto...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gustin JP,Karakas B,Weiss MB,Abukhdeir AM,Lauring J,Garay JP,Cosgrove D,Tamaki A,Konishi H,Konishi Y,Mohseni M,Wang G,Rosen DM,Denmeade SR,Higgins MJ,Vitolo MI,Bachman KE,Park BH

更新日期：2009-02-24 00:00:00

abstract：:Although introduced hemosporidian (malaria) parasites (Apicomplexa: Haemosporida) have hastened the extinction of endemic bird species in the Hawaiian Islands and perhaps elsewhere, little is known about the temporal dynamics of endemic malaria parasite populations. Haemosporidian parasites do not leave informative fo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Soares L,Latta SC,Ricklefs RE

更新日期：2017-06-20 00:00:00

abstract：:Numerous studies have shown that high olive oil intake reduces blood pressure (BP). These positive effects of olive oil have frequently been ascribed to its minor components, such as alpha-tocopherol, polyphenols, and other phenolic compounds that are not present in other oils. However, in this study we demonstrate th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Terés S,Barceló-Coblijn G,Benet M,Alvarez R,Bressani R,Halver JE,Escribá PV

更新日期：2008-09-16 00:00:00

abstract：:The taxonomic status of Neanderthals lies at the center of the modern human origins debate. Proponents of the single-origin model often view this group as a distinct species with little or no contribution to the evolution of modern humans. Adherents to the regional continuity model consider Neanderthals a subspecies o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harvati K,Frost SR,McNulty KP

更新日期：2004-02-03 00:00:00

abstract：:Antigen-independent cell lines were derived from mouse helper T-cell clones by culture in autologous supernatant obtained after stimulation with concanavalin A. A factor, termed P40, supporting the growth of these lines was purified and characterized as a basic 32- to 39-kDa single-chain glycoprotein functionally dist...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Uyttenhove C,Simpson RJ,Van Snick J

更新日期：1988-09-01 00:00:00

abstract：:Purified inside-out vesicles from human erythrocytes were used to investigate the active transport of oxidized glutathione (GSSG). Incubation of vesicles and GSSG in the presence of ATP resulted in the transport of GSSG into the vesicles. When vesicles were incubated with reduced glutathione (GSH), no transport was ob...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kondo T,Dale GL,Beutler E

更新日期：1980-11-01 00:00:00

abstract：:Peptide growth factors were isolated from conditioned medium derived from rice (Oryza sativa L.) suspension cultures and identified to be a sulfated pentapeptide [H-Tyr(SO3H)-Ile-Tyr(SO3H)-Thr-Gln-OH] and its C-terminal-truncated tetrapeptide [H-Tyr(SO3H)-Ile-Tyr(SO3H)-Thr-OH]. These structures were identical to the p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Matsubayashi Y,Takagi L,Sakagami Y

更新日期：1997-11-25 00:00:00

abstract：:Plants require metals for essential functions ranging from respiration to photosynthesis. These metals also contribute to the nutritional value of plants for both humans and livestock. Additionally, plants have the ability to accumulate nonessential metals such as cadmium and lead, and this ability could be harnessed ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rogers EE,Eide DJ,Guerinot ML

更新日期：2000-10-24 00:00:00

abstract：:In the presence of phenylalanine, GTP cyclohydrolase I feedback regulatory protein (GFRP) forms a stimulatory 360-kDa complex with GTP cyclohydrolase I (GTPCHI), which is the rate-limiting enzyme in the biosynthesis of tetrahydrobiopterin. The crystal structure of the stimulatory complex reveals that the GTPCHI decame...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maita N,Okada K,Hatakeyama K,Hakoshima T

更新日期：2002-02-05 00:00:00

abstract：:Optical imaging of the functional architecture of cortex, based on intrinsic signals, is a useful tool for the study of the development, organization, and function of the living mammalian brain. This relatively noninvasive technique is based on small activity-dependent changes of the optical properties of cortex. Thus...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grinvald A,Frostig RD,Siegel RM,Bartfeld E

更新日期：1991-12-15 00:00:00

abstract：:DsrA is an 87-nucleotide regulatory RNA of Escherichia coli that acts in trans by RNA-RNA interactions with two different mRNAs, hns and rpoS. DsrA has opposite effects on these transcriptional regulators. H-NS levels decrease, whereas RpoS (final sigma(s)) levels increase. Here we show that DsrA enhances hns mRNA tur...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lease RA,Belfort M

更新日期：2000-08-29 00:00:00

abstract：:The spatial structure of genetic diversity underlying social variation is a critical determinant of how cooperation and conflict evolve. Here we investigated whether natural social groups of the cooperative soil bacterium Myxococcus xanthus harbor internal genetic and phenotypic variation and thus the potential for so...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kraemer SA,Velicer GJ

更新日期：2011-06-28 00:00:00

abstract：:Although potassium channels play a variety of roles in shaping the electrical properties of neurons, little is known about how these channels are constituted in neurons. To examine the assembly and physiological function of A-type K+ channels in mature differentiated neurons, we have developed a highly efficient gene ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaang BK,Pfaffinger PJ,Grant SG,Kandel ER,Furukawa Y

更新日期：1992-02-01 00:00:00

abstract：:The temperature coefficient of equilibrium isotope fractionation in the heavy elements is shown to be larger at high temperatures than that expected from the well-studied vibrational isotope effects. The difference in the isotopic behavior of the heavy elements as compared with the light elements is due to the large n...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bigeleisen J

更新日期：1996-09-03 00:00:00

abstract：:In vertebrate retinal photoreceptors, photoisomerization of opsin-bound visual chromophore 11-cis-retinal to all-trans-retinal triggers phototransduction events. Regeneration of the chromophore is a critical step in restoring photoreceptors to their dark-adapted state. This regeneration process, called the retinoid cy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Golczak M,Kuksa V,Maeda T,Moise AR,Palczewski K

更新日期：2005-06-07 00:00:00

abstract：:The ever-increasing global need for potable water requires practical, sustainable approaches for purifying abundant alternative sources such as seawater, high-salinity processed water, or underground reservoirs. Evaporation-based solutions are of particular interest for treating high salinity water, since conventional...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dongare PD,Alabastri A,Neumann O,Nordlander P,Halas NJ

更新日期：2019-07-02 00:00:00

abstract：:Fluorescence photobleaching recovery was used to measure the lateral diffusion coefficient and mobile fraction of surface immunoglobulin (sIg), Thy-1 antigen, and a lipid probe in the plasma membrane of mouse lymphocytes. The lipid probe (3,3'-dioctadecylindocarbocyanine) had a mean (+/-SD) diffusion coefficient of (1...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dragsten P,Henkart P,Blumenthal R,Weinstein J,Schlessinger J

更新日期：1979-10-01 00:00:00

abstract：:The survival of motor neurons is controlled by multiple factors that regulate different aspects of their physiology. The identification of these factors is important because of their relationship to motor neuron disease. We investigate here whether Mullerian Inhibiting Substance (MIS) is a motor neuron survival factor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang PY,Koishi K,McGeachie AB,Kimber M,Maclaughlin DT,Donahoe PK,McLennan IS

更新日期：2005-11-08 00:00:00

abstract：:Facial expressions of emotion in humans are believed to be produced by contracting one's facial muscles, generally called action units. However, the surface of the face is also innervated with a large network of blood vessels. Blood flow variations in these vessels yield visible color changes on the face. Here, we stu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benitez-Quiroz CF,Srinivasan R,Martinez AM

更新日期：2018-04-03 00:00:00

abstract：:We introduce a new genetic distance for microsatellite loci, incorporating features of the stepwise mutation model, and test its performance on microsatellite polymorphisms in humans, chimpanzees, and gorillas. We find that it performs well in determining the relations among the primates, but less well than other dist...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goldstein DB,Ruiz Linares A,Cavalli-Sforza LL,Feldman MW

更新日期：1995-07-18 00:00:00

abstract：:Classical studies suggest that high-level cognitive decisions (e.g., choosing between financial options) are suboptimal. In contrast, low-level decisions (e.g., choosing where to put your feet on a rocky ridge) appear near-optimal: the perception-cognition gap. Moreover, in classical tasks, people appear to put too mu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jarvstad A,Hahn U,Rushton SK,Warren PA

更新日期：2013-10-01 00:00:00

abstract：:Superantigens such as the staphylococcal enterotoxins can play an important role in exacerbation of autoimmune disorders such as experimental allergic encephalomyelitis (EAE) in mice. In fact, superantigens can reactivate EAE in PL/J mice that have been sensitized to rat myelin basic protein (MBP). The T-cell subset p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Soos JM,Hobeika AC,Butfiloski EJ,Schiffenbauer J,Johnson HM

更新日期：1995-06-20 00:00:00

abstract：:Normal mammary epithelial cells from BALB/cfC3H midpregnant mice were freed from stromal cell types by Percoll density gradient centrifugation after collagenase digestion and were then embedded within collagen gels. Sustained growth leading to an increase in cell number was accomplished in response to cholera toxin an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang J,Richards J,Guzman R,Imagawa W,Nandi S

更新日期：1980-04-01 00:00:00

abstract：:Major breakthroughs have recently been reported that can help overcome two inherent drawbacks of NMR: the lack of sensitivity and the limited memory of longitudinal magnetization. Dynamic nuclear polarization (DNP) couples nuclear spins to the large reservoir of electrons, thus making it possible to detect dilute endo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vasos PR,Comment A,Sarkar R,Ahuja P,Jannin S,Ansermet JP,Konter JA,Hautle P,van den Brandt B,Bodenhausen G

更新日期：2009-11-03 00:00:00

abstract：:Experiments were performed to ascertain the degree to which the amount of amino acids might be one of the regulatory factors that control the activity of the nucleolar RNA polymerase. Assays of the enzymatic activity were done with isolated nuclei from cells incubated with low and high concentrations of amino acids. S...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Franze-Fernández MT,Pogo AO

更新日期：1971-12-01 00:00:00

abstract：:The global demand for food could double in another 40 y owing to growth in the population and food consumption per capita. To meet the world's future food and sustainability needs for biofuels and renewable materials, the production of starch-rich cereals and cellulose-rich bioenergy plants must grow substantially whi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： You C,Chen H,Myung S,Sathitsuksanoh N,Ma H,Zhang XZ,Li J,Zhang YH

更新日期：2013-04-30 00:00:00