Abstract：
:As an essential mechanism for self-tolerance, immune suppression has attracted much attention since the discovery of suppressor T cells, now called regulatory T cells (Tregs), in the 1990s. Different types of Tregs have been described based on distinct expression patterns of surface markers and cytokines. Cytokines are not only essential for function but also important for the generation of Tregs. Interleukin-2 (IL-2), transforming growth factor-beta, IL-10, and other immunoregulatory molecules have been shown to control the generation of Tregs. The presence of other types of cells, in particular antigen-presenting cells (APCs), is critical for the generation of Tregs. Cytokines can serve as either initiators or intermediates for the interactions between APCs and Tregs. This review discusses our current knowledge of how cytokines regulate the generation and maintenance of Tregs.
journal_name
Immunol Revjournal_title
Immunological reviewsauthors
Wan YY,Flavell RAdoi
10.1111/j.0105-2896.2006.00407.xsubject
Has Abstractpub_date
2006-08-01 00:00:00pages
114-30eissn
0105-2896issn
1600-065Xpii
IMR407journal_volume
212pub_type
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