Abstract:
OBJECTIVE:Meningococcal disease continues to be a serious public health concern, being associated with high morbidity and mortality rates worldwide, particularly in Brazil. In addition to discussing recent changes in the global epidemiology of meningococcal disease, we also analyze the development and impact of new conjugate vaccines on the prevention of meningococcal disease, with emphasis on the different immunization strategies implemented with these vaccines. SOURCES OF DATA:MEDLINE databases were searched from 1996 to 2006, with emphasis on review articles, clinical trials and epidemiological studies. Information was also sought on the Centers for Disease Control and Prevention, Brazilian Ministry of Health and Centro de Vigilância Epidemiológica do Estado de São Paulo websites. SUMMARY OF THE FINDINGS:Five serogroups (A, B, C, W135 and Y) are responsible for virtually all cases of the disease worldwide, with marked regional and temporal differences. The new meningococcal serogroup C conjugate vaccines (MCC) offer unmistakable advantages over polysaccharide vaccines. MCC vaccines generate a more efficient and long-lasting antibody response, inducing immunologic memory and reduction of nasopharyngeal carriage. The immediate results of introducing these vaccines into immunization programs have been encouraging, with a dramatic reduction in the incidence of serogroup C disease, not only in vaccinated, but also in unvaccinated individuals (herd immunity). However, concerns have arisen regarding the long-term effectiveness of these vaccines, especially for infants vaccinated in the routine schedule. CONCLUSIONS:The reported waning of efficacy more than 1 year after routine infant immunization supports alternative schedules incorporating a booster dose of MCC vaccine given at 12-18 months of age, in order to maintain long-term protection. The recent licensure of the tetravalent meningococcal conjugate vaccine represents, at last, a real possibility of a broader protection against meningococcal disease, although the need to develop an effective vaccine against serogroup B remains.
journal_name
J Pediatr (Rio J)journal_title
Jornal de pediatriaauthors
Sáfadi MA,Barros APdoi
10.2223/JPED.1495subject
Has Abstractpub_date
2006-07-01 00:00:00pages
S35-44issue
3 Suppleissn
0021-7557issn
1678-4782journal_volume
82pub_type
杂志文章,评审abstract:OBJECTIVE:To investigate the immune response of preterm infants to hepatitis B vaccination. METHODS:Three doses of recombinant hepatitis B vaccine (5 micro g dose) were administered to 35 preterm and 21 full-term infants within 24 hours after birth and at one and six months of postnatal age. RESULTS:A protective anti...
journal_title:Jornal de pediatria
pub_type: 临床试验,杂志文章
doi:
更新日期:2004-03-01 00:00:00
abstract:PURPOSE:To determine the prevalence of innocent murmur among adolescents, and to evaluate the clinical features in comparison with echocardiogram (two-dimensional, M-mode, Doppler, and color-Doppler) in the assessment of heart murmurs. METHODS:The study was carried out from March to December, 1992, and involved high s...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/jped.636
更新日期:1996-09-01 00:00:00
abstract:OBJECTIVES:The aim of the study was to describe the experience with high-frequency oscillatory ventilation (HFOV) in a Portuguese Pediatric Critical Care Unit, and to evaluate whether HFOV allowed improvement in oxygenation and ventilation. METHODS:This was a retrospective observational cohort study of children ventil...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.1016/j.jped.2013.02.008
更新日期:2013-01-01 00:00:00
abstract::Immediate skin test reactions are the hallmark of atopic diseases. EMLA (eutectic mixture of local anesthetics) is a local anesthetic that reduces the pain and apprehension for skin testing. We studied EMLA effects on the skin prick test with allergen and histamine. Reactions were evaluated by means of wheal and flare...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/jped.613
更新日期:1996-07-01 00:00:00
abstract:OBJECTIVE:To describe the increased risk of acquiring infectious diseases associated with out-of-home childcare and the effectiveness of measures for the control and prevention of diseases transmission at daycare and preschool education centers. SOURCES:A review of literature in the MEDLINE, LILACS and Cochrane Librar...
journal_title:Jornal de pediatria
pub_type: 杂志文章,评审
doi:10.2223/JPED.1649
更新日期:2007-07-01 00:00:00
abstract:OBJECTIVE:To evaluate the trend of pneumonia mortality in Brazilian children aged 4 years and younger from 1991 to 2007. METHODS:We conducted a retrospective study based on the database of the IT Department of the Brazilian Unified Health System (DATASUS), from which we obtained the number of deaths from pneumonia and...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/JPED.2070
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVE:To compare the use of intravenous vs. oral antibiotic therapy. METHODS:All febrile neutropenic patients younger than 18 years old with low risk of complications and receiving chemotherapy were selected. The study was conducted from 2002 to 2005 at the Pediatric Oncology Unit of Hospital de Clínicas de Porto ...
journal_title:Jornal de pediatria
pub_type: 杂志文章,随机对照试验
doi:10.2223/JPED.1956
更新日期:2009-11-01 00:00:00
abstract:OBJECTIVE:Our aim was to determine whether endogenous mononuclear leukocyte DNA strand is a target of phototherapy. METHODS:The study included 65 term infants aged between 3-10 days that had been exposed to intensive (n = 23) or conventional (n = 23) phototherapy for at least 48 hours due to neonatal jaundice, and a c...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/JPED.1765
更新日期:2008-03-01 00:00:00
abstract:OBJECTIVE:to assess the epidemiological and genetic factors associated with severity of acute viral bronchiolitis (AVB) by respiratory syncytial virus (RSV). DATA SOURCE:the key words "bronchiolitis", "risk factor", "genetics" and "respiratory syncytial virus", and all combinations among them were used to perform a se...
journal_title:Jornal de pediatria
pub_type: 杂志文章,评审
doi:10.1016/j.jped.2013.02.022
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVE:Several reports claim that blood pressure (BP) in the radial artery may underestimate the accurate BP in critically ill patients. Here, the authors evaluated differences in mean blood pressure (MBP) between the radial and femoral artery during pediatric cardiac surgery to determine the effectiveness of femora...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.1016/j.jped.2017.03.011
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVES:To assess the prevalence of congenital hypothyroidism and the ability of various neonatal thyroid-stimulating hormone (TSHneo) cutoff values to detect this disease. METHODS:This cohort study was based on the retrospective collection of information available from the Reference Service for Newborn Screening d...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.1016/j.jped.2016.07.006
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:To present an updated review of the most common upper respiratory infections (URI) in children seen by the pediatrician in outpatient clinics, for better diagnostic and therapeutic decisions. SOURCES:References from Medline database were reviewed. The most relevant articles were selected. SUMMARY OF THE FIN...
journal_title:Jornal de pediatria
pub_type: 杂志文章,评审
doi:10.2223/jped.1002
更新日期:2003-05-01 00:00:00
abstract::OBJECTIVES: To identify rubella prevalence in different ages and population groups and rubella susceptibility of pregnant and postpartum women according to age, number of children and spontaneous abortion. METHODS: Cross-sectional study of sero-survey type. Children and students were selected in day-care centers and s...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/jped.470
更新日期:1998-11-01 00:00:00
abstract:OBJECTIVE:To measure the main risk factors associated with the occurrence of accidental injuries in children aged 4-5 years. METHODS:The study included a prospective cohort of children whose parents filled in a diary recording accidents and injuries during a period of one-month. The children represented a systematic s...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:
更新日期:2002-03-01 00:00:00
abstract:OBJECTIVE:To provide recent guidelines to reduce the incidence of diarrheal diseases. We discuss the definition, clinical aspects, pathophysiology, diagnosis, management, and prevention of persistent diarrhea. SOURCES:Electronic search of the MEDLINE database, Google search. SUMMARY OF THE FINDINGS:Acute diarrhea may...
journal_title:Jornal de pediatria
pub_type: 杂志文章,评审
doi:10.2223/JPED.2087
更新日期:2011-05-01 00:00:00
abstract:OBJECTIVES:To rescue medical genetics concepts that are necessary to understand the advances in the genetic-molecular characterization of primary immunodeficiencies, to help in the understanding and adequate interpretation of their results. SOURCE OF DATA:Non-systematic literature review, searching for articles since ...
journal_title:Jornal de pediatria
pub_type: 杂志文章,评审
doi:10.1016/j.jped.2020.09.007
更新日期:2020-10-26 00:00:00
abstract:OBJECTIVE:Cystic fibrosis diagnosis is dependent on the chloride ion concentration in the sweat test (≥60mEq/mL - recognized as the gold standard indicator for cystic fibrosis diagnosis). Moreover, the salivary glands express the CFTR protein in the same manner as sweat glands. Given this context, the objective was to ...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.1016/j.jped.2018.04.005
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:The aim of the present study was to evaluate the agreement between the most used skinfold thickness equations with multi-frequency bioimpedance analysis in the prediction of body fat levels in children. METHOD:A cross-sectional study of healthy Brazilian community-dwelling individuals. The anthropometric ass...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.1016/j.jped.2019.12.006
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVE:To describe the linear growth and growth velocity of preterm infants born small for gestational age according to variables such as weight, length and head circumference, from birth to three months of corrected age. METHODS:Prospective study of one hundred preterm infants born small for gestational age from 2...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:
更新日期:2002-05-01 00:00:00
abstract::Symptoms of psoas muscular abscess in children are nonspecific and differential diagnosis is made among diseases included in childreńs acute hip pain syndrome, imaging tests being necessary for diagnostic confirmation. During the first semester of 1995, 48,550 children were examined in Pronto Socorro do Instituto da C...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/jped.632
更新日期:1996-07-01 00:00:00
abstract:OBJECTIVE:To report a case of an infant with endstage renal failure caused by primary hyperoxaluria. METHODS:The review of the literature showed the rarity of the disease. In France, the prevalence is about 1.05/million and the incidence rate is 0.12/million/year. A survey, performed in international specialized cente...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:
更新日期:2002-03-01 00:00:00
abstract:OBJECTIVE:To correlate different methods of body composition assessment in overweight or obese schoolchildren, using deuterium oxide (D2O) dilution as a reference. METHODS:Percentage of total body water (%TBW), fat free mass (%FFM), and body fat (%BF) were assessed by D2O and tetrapolar electrical bioimpedance analysi...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.1016/j.jped.2015.03.007
更新日期:2016-01-01 00:00:00
abstract::This prospective trial was realized in 371 children previously vaccinated with BCG in the first month of life in whom the Mantoux tuberculin test was done and read 48-72 hours afterwards. Among 371 BCG-vaccinated children, 106 (28.57%) were Mantoux reactive, 10 of whom with clinical tuberculosis. There was no statisti...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/jped.728
更新日期:1994-03-01 00:00:00
abstract::OBJECTIVE: Aiming a better understanding of the distribution of enteropathogens in Brazil, we have investigated the prevalence of enteropathogens in acute infantile diarrhea in children of low economic level from São José do Rio Preto, SP.METHODS: A prospective study with 196 children under age five, all with diarrhea...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/jped.444
更新日期:1998-07-01 00:00:00
abstract::BCG-test reaction was carried out in 91 non-tuberculous children between 2 and 11 years old, who had received BCG vaccination during the first six months of life to critically evaluate the usefulness of this test in Pediatric practice. The BCG-test profile of the vaccinated group was shown to have a unimodal distribut...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/jped.678
更新日期:1994-11-01 00:00:00
abstract::OBJECTIVES: To assess the implementation and the impact of the Breastfeeding Counselling Course WHO/UNICEF on knowledge and skills of health workers. METHODOLOGY: The implementation of the course was assessed by participant observation; the impact on participants was assessed with an experimental controlled study wher...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/jped.267
更新日期:1999-03-01 00:00:00
abstract:OBJECTIVE:To assess the evolution of nutritional status in children admitted to the Teaching Hospital of Universidade Federal de Alagoas. METHODS:A retrospective study was performed on 52 children (0-10 yrs) whose length of hospital stay exceeded 10 days (from February to July/2001). We compared their nutritional stat...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/jped.905
更新日期:2002-11-01 00:00:00
abstract::A prospective study of acute diarrhoeal diseases was carried out from April 1990 to September 1992 with the purpose of assessing the immunogenicity, safety and efficacy of a Rhesus-human reassortant rotavirus ("RRV-TV") vaccine, involving 540 children living in Belém, Pará, Brazil. As half of the children received pla...
journal_title:Jornal de pediatria
pub_type: 临床试验,杂志文章
doi:10.2223/jped.714
更新日期:1994-07-01 00:00:00
abstract:OBJECTIVE:Duchenne muscular dystrophy, an X-linked genetic disease, leads to progressive muscle weakness mainly in the lower limbs. Motor function tests help to monitor disease progression. Can low-cost, simple assessments help in the diagnostic suspicion of Duchenne muscular dystrophy? The authors aim to define the se...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.1016/j.jped.2019.02.003
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the incidence of diarrheal disease (DD) and acute respiratory infection (ARI) in children undergoing supplementation of zinc and other micronutrients through the use of sprinkles, as well as their acceptance by these patients. METHOD:This was a randomized double-blinded clinical trial of 143 heal...
journal_title:Jornal de pediatria
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jped.2012.11.004
更新日期:2013-05-01 00:00:00