Abstract：
:The scapholunate interosseous ligament (SLIL) connects the scaphoid and lunate bones and plays a crucial role in carpal kinematics. Its rupture leads to carpal instability and impairment of radiocarpal joint function. As the ligament is one of the first structures affected in rheumatoid arthritis, we conducted an immunohistochemical study of cadaveric tissue to determine whether it contains known autoantigens for rheumatoid arthritis. We immunolabelled the ligament from one hand in 12 cadavers with monoclonal antibodies directed against a wide range of extracellular matrix (ECM) molecules associated with both fibrous and cartilaginous tissues. The labelling profile has also enabled us to comment on how the molecular composition of the ligament relates to its mechanical function. All regions of the ligament labelled for types I, III and VI collagens, chondroitin 4 and 6 sulphates, keratan sulphate, dermatan sulphate, versican, tenascin and cartilage oligomeric matrix protein (COMP). However, both entheses labelled strongly for type II collagen, aggrecan and link protein and were distinctly fibrocartilaginous. In some regions, the ligament attached to bone via a region of hyaline cartilage that was continuous with articular cartilage. Labelling for cartilage molecules in the midsubstance was most evident dorsally. We conclude that the SLIL has an ECM which is typical of other highly fibrocartilaginous ligaments that experience both tensile load and shear. The presence of aggrecan, link protein, COMP and type II collagen could explain why the ligament may be a target for autoantigenic destruction in some forms of rheumatoid arthritis.
journal_name
J Anatjournal_title
Journal of anatomyauthors
Milz S,Aktas T,Putz R,Benjamin Mdoi
10.1111/j.1469-7580.2006.00552.xsubject
Has Abstractpub_date
2006-06-01 00:00:00pages
671-9issue
6eissn
0021-8782issn
1469-7580pii
JOA552journal_volume
208pub_type
杂志文章abstract：:The hooked element in the pes of turtles was historically identified by most palaeontologists and embryologists as a modified fifth metatarsal, and often used as evidence to unite turtles with other reptiles with a hooked element. Some recent embryological studies, however, revealed that this element might represent a...
journal_title：Journal of anatomy
pub_type： 杂志文章,评审
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abstract：:Pulmonary alveolar septa are thought to contain at least two types of fibroblasts that are termed myofibroblasts and lipofibroblasts based on their morphological characteristics. Lipofibroblasts possess cytoplasmic lipid inclusions (lipid bodies or droplets) and are involved in several important functions, such as sur...
journal_title：Journal of anatomy
pub_type： 杂志文章
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abstract：:The T-tubule system in cardiac muscle cells has been investigated with the electron microscope in 10 adult rats after infiltration with horseradish peroxidase. All cardiac muscle cells possess a T-system, but its complexity varies according to the region of the heart. It is most extensive in the general ventricular my...
journal_title：Journal of anatomy
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doi：
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abstract：:Amoeboid microglial cells (AMC) in the corpus callosum were selectively labelled following a single intraperitoneal (i.p.) injection of the fluorescent dye, rhodamine isothiocyanate (RhIc) into postnatal rats. The frequency of RhIc-labelled cells varied with age, with the largest number occurring in 7-d-old animals. T...
journal_title：Journal of anatomy
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doi：
更新日期：1993-02-01 00:00:00
abstract：:Blind mole-rats (Spalax ehrenbergi) are fossorial solitary rodents that present striking morphological, physiological and behavioural adaptations to the subterranean environment in which they live. Previous studies have shown that mole-rats are specialised in tooth-digging. The rapid eruption-rate of their incisors ha...
journal_title：Journal of anatomy
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journal_title：Journal of anatomy
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pub_type： 杂志文章
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12668
更新日期：2017-11-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1988-08-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1984-03-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1995-04-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1989-10-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
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更新日期：2010-05-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1980-05-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1996-02-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1975-07-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.2002.00048.x
更新日期：2002-05-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2011.01428.x
更新日期：2011-12-01 00:00:00
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journal_title：Journal of anatomy
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doi：
更新日期：1989-04-01 00:00:00
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1986-04-01 00:00:00
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journal_title：Journal of anatomy
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doi：
更新日期：1979-01-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
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更新日期：2006-11-01 00:00:00
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pub_type： 杂志文章
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更新日期：2006-12-01 00:00:00
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journal_title：Journal of anatomy
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journal_title：Journal of anatomy
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journal_title：Journal of anatomy
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