Identification of a genetic cluster influencing memory performance and hippocampal activity in humans.

abstract：:Spermatogonia are the male germ stem cells that continuously produce sperm for the next generation. Spermatogenesis is a complicated process that proceeds through mitotic phase of stem cell renewal and differentiation, meiotic phase, and postmeiotic phase of spermiogenesis. Full recapitulation of spermatogenesis in vi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hong Y,Liu T,Zhao H,Xu H,Wang W,Liu R,Chen T,Deng J,Gui J

更新日期：2004-05-25 00:00:00

abstract：:Although prostate cancer (CaP) is the most frequently diagnosed malignant tumor and the second leading cause of cancer deaths in American men, the mechanisms explaining the development and progression of CaP remain largely unknown. Recent studies have shown that some aberrantly expressed microRNAs (miRNAs) are involve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shi XB,Xue L,Yang J,Ma AH,Zhao J,Xu M,Tepper CG,Evans CP,Kung HJ,deVere White RW

更新日期：2007-12-11 00:00:00

abstract：:Members of the platelet-derived growth factor (PDGF) ligand family are known to play important roles in wound healing and fibrotic disease. We show that both transient and stable expression of PDGF-C results in the development of liver fibrosis consisting of the deposition of collagen in a pericellular and perivenular...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Campbell JS,Hughes SD,Gilbertson DG,Palmer TE,Holdren MS,Haran AC,Odell MM,Bauer RL,Ren HP,Haugen HS,Yeh MM,Fausto N

更新日期：2005-03-01 00:00:00

abstract：:Increasing global temperature and sea-level rise have led to concern about expansions in the distribution and prevalence of complex-lifecycle parasites (CLPs). Indeed, numerous environmental variables can influence the infectivity and reproductive output of many pathogens. Digenean trematodes are CLPs with intermediat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huntley JW,Fürsich FT,Alberti M,Hethke M,Liu C

更新日期：2014-12-23 00:00:00

abstract：:The modern Old World Monkeys (Superfamily Cercopithecoidea, Family Cercopithecidae) can be traced back into the late Miocene, but their origin and subsequent diversification is obscured by the scarcity of terrestrial fossil sites in Africa between 15 and 6 Ma. Here, we document the presence of cercopithecids at 12.5 M...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rossie JB,Gilbert CC,Hill A

更新日期：2013-04-09 00:00:00

abstract：:Serotonin (5-HT) binding sites from bovine and rat cerebral cortex membranes share pharmacological properties that allow both to be subclassified by the same criteria. We show here that [3H]5-HT binding sites from human cortex also possess pharmacological properties that follow the same subclassification scheme as for...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Todd RD,Ciaranello RD

更新日期：1985-01-01 00:00:00

abstract：:The phosphatase and tensin homolog (PTEN) is a tumor suppressor that is inactivated in many human cancers. PTEN loss has been associated with resistance to inhibitors of the epidermal growth factor receptor (EGFR), but the molecular basis of this resistance is unclear. It is believed that unopposed phosphatidylinosito...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vivanco I,Rohle D,Versele M,Iwanami A,Kuga D,Oldrini B,Tanaka K,Dang J,Kubek S,Palaskas N,Hsueh T,Evans M,Mulholland D,Wolle D,Rajasekaran S,Rajasekaran A,Liau LM,Cloughesy TF,Dikic I,Brennan C,Wu H,Mischel PS,

更新日期：2010-04-06 00:00:00

abstract：:Murine embryonic stem (ES) cells are permanent blastocyst-derived cell lines capable of contributing to a wide variety of tissues, including the germ line, after injection into host blastocysts. Recently, we have shown that ES cells can produce all of the cells of the developing fetus after aggregation with developmen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Forrester LM,Bernstein A,Rossant J,Nagy A

更新日期：1991-09-01 00:00:00

abstract：:Most human tumors are clonal in origin, although the cells may be diverse in their properties. Since the tumors evolve through progressive stages over decades of time, it is possible that the conditions that induced the tumor transform many cells, but that selective overgrowth of the fastest growing lead to a clonal p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yao A,Rubin H

更新日期：1993-11-15 00:00:00

abstract：:Increased clouds and precipitation normally decrease the diurnal temperature range (DTR) and thus have commonly been offered as explanation for the trend of reduced DTR observed for many land areas over the last several decades. Observations show, however, that the DTR was reduced most in dry regions and especially in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou L,Dickinson RE,Tian Y,Vose RS,Dai Y

更新日期：2007-11-13 00:00:00

abstract：:The self assembly of phospholipid molecules in the bilayer form was considered in terms of equivalent molecular shapes representing intermolecular forces. The equivalent size of each phospholipid headgroup was approximated by the net atomic volume plus the volume of the associated water molecules, which was derived fr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hui SW,Sen A

更新日期：1989-08-01 00:00:00

abstract：:After more than two decades of study, many fundamental questions remain unanswered about the dynamics of glass-forming materials confined to thin films. Experiments and simulations indicate that free interfaces enhance dynamics over length scales larger than molecular sizes, and this effect strengthens at lower temper...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ivancic RJS,Riggleman RA

更新日期：2020-10-13 00:00:00

abstract：:The apparatus of photosynthetic energy conversion in chloroplasts is quite well characterized with respect to structure and function. Light-driven electron transport in the thylakoid membrane is coupled to synthesis of ATP, used to drive energy-dependent metabolic processes in the stroma and the outer surface of the t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spetea C,Hundal T,Lundin B,Heddad M,Adamska I,Andersson B

更新日期：2004-02-03 00:00:00

abstract：:Vanadyl sulfate and sodium orthovanadate in the concentration range between 5 and 50 microM are shown to be mitogenic for quiescent cultures of Swiss mouse 3T3 and 3T6 cells. The compounds caused a striking shift in the dose-response for the effect of serum on [3H]thymidine incorporation and DNA synthesis. In the abse...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith JB

更新日期：1983-10-01 00:00:00

abstract：:Crises in science concern not only methods, statistics, and results but also, theory development. Beyond the indispensable refinement of tools and procedures, resolving crises would also benefit from a deeper understanding of the concepts and processes guiding research. Usually, theories compete, and some lose, incent...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ellemers N,Fiske ST,Abele AE,Koch A,Yzerbyt V

更新日期：2020-04-07 00:00:00

abstract：:Coacervation is a common phenomenon in natural polymers and has been applied to synthetic materials systems for coatings, adhesives, and encapsulants. Single-component coacervates are formed when block polyampholytes exhibit self-coacervation, phase separating into a dense liquid coacervate phase rich in the polyampho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Danielsen SPO,McCarty J,Shea JE,Delaney KT,Fredrickson GH

更新日期：2019-04-23 00:00:00

abstract：:IL-7 functions as a trophic factor during T lymphocyte development by a mechanism that is partly based on the induction of Bcl-2, which protects cells from apoptosis. Here we report a mechanism by which cytokine withdrawal activates the prodeath protein Bax. On loss of IL-7 in a dependent cell line, Bax protein transl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Khaled AR,Kim K,Hofmeister R,Muegge K,Durum SK

更新日期：1999-12-07 00:00:00

abstract：:Osedax is a recently discovered group of siboglinid annelids that consume bones on the seafloor and whose evolutionary origins have been linked with Cretaceous marine reptiles or to the post-Cretaceous rise of whales. Here we present whale bones from early Oligocene bathyal sediments exposed in Washington State, which...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kiel S,Goedert JL,Kahl WA,Rouse GW

更新日期：2010-05-11 00:00:00

abstract：:Proteins internalized into the endocytic pathway are usually degraded. Efficient proteolysis requires denaturation, induced by acidic conditions within lysosomes, and reduction of inter- and intrachain disulfide bonds. Cytosolic reduction is mediated enzymatically by thioredoxin, but the mechanism of lysosomal reducti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arunachalam B,Phan UT,Geuze HJ,Cresswell P

更新日期：2000-01-18 00:00:00

abstract：:Established T cell dysfunction is a barrier to antitumor responses, and checkpoint blockade presumably reverses this. Many patients fail to respond to treatment and/or develop autoimmune adverse events. The underlying reason for T cell responsiveness remains elusive. Here, we show that susceptibility to checkpoint blo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nelson CE,Mills LJ,McCurtain JL,Thompson EA,Seelig DM,Bhela S,Quarnstrom CF,Fife BT,Vezys V

更新日期：2019-02-12 00:00:00

abstract：:Duchenne muscular dystrophy (DMD) is a lethal genetic disorder caused by an absence of the dystrophin protein in bodywide muscles, including the heart. Cardiomyopathy is a leading cause of death in DMD. Exon skipping via synthetic phosphorodiamidate morpholino oligomers (PMOs) represents one of the most promising ther...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Echigoya Y,Nakamura A,Nagata T,Urasawa N,Lim KRQ,Trieu N,Panesar D,Kuraoka M,Moulton HM,Saito T,Aoki Y,Iversen P,Sazani P,Kole R,Maruyama R,Partridge T,Takeda S,Yokota T

更新日期：2017-04-18 00:00:00

abstract：:Imprinted gene expression associated with Prader-Willi syndrome (PWS) and Angelman syndrome (AS) is controlled by two imprinting centers (ICs), the PWS-IC and the AS-IC. The PWS-IC operates in cis to activate transcription of genes that are expressed exclusively from the paternal allele. We have created a conditional ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： DuBose AJ,Smith EY,Johnstone KA,Resnick JL

更新日期：2012-02-28 00:00:00

abstract：:The regulation of protein function through ligand-induced conformational changes is crucial for many signal transduction processes. The binding of a ligand alters the delicate energy balance within the protein structure, eventually leading to such conformational changes. In this study, we elucidate the energetic and m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bauer D,Merz DR,Pelz B,Theisen KE,Yacyshyn G,Mokranjac D,Dima RI,Rief M,Žoldák G

更新日期：2015-08-18 00:00:00

abstract：:Oxidative stress exacerbates neovascularization (NV) in many disease processes. In this study we investigated the mechanism of that effect. Mice deficient in superoxide dismutase 1 (Sod1(-/-) mice) have increased oxidative stress and show severe ocular NV that is reduced to baseline by antioxidants. Compared with wild...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dong A,Shen J,Zeng M,Campochiaro PA

更新日期：2011-08-30 00:00:00

abstract：:This paper shows that proteins display an unexpectedly wide range of behaviors in buffers containing moderate (0.1-10 mM) concentrations of SDS (complete unfolding, formation of stable intermediate states, specific association with SDS, and various kinetic phenomena); capillary electrophoresis provides a convenient me...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gudiksen KL,Gitlin I,Whitesides GM

更新日期：2006-05-23 00:00:00

abstract：:We report two instances of selective accumulation of herpes simplex 1 RNA transcripts in different compartments of infected HEp-2 cells. In the first, transcripts derived from about 50% of the viral DNA accumulated in the nuclei of cells 8 hr after infection. However, only 40-42% of the DNA was represented in transcri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kozak M,Roizman B

更新日期：1974-11-01 00:00:00

abstract：:The p21(WAF1) (p21) cyclin-dependent kinase inhibitor plays a major role in regulating cell cycle arrest. It was recently reported that the p53-independent elevation of p21 protein levels is essential in mediating the G(1) arrest resulting from signal transduction events initiated by the crosslinking of membrane IgM o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marches R,Hsueh R,Uhr JW

更新日期：1999-07-20 00:00:00

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a potent endogenous activator of the cell death pathway and functions by activating the cell surface death receptors 4 and 5 (DR4 and DR5). TRAIL is nontoxic in vivo and preferentially kills neoplastically transformed cells over normal cells by an unde...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chinnaiyan AM,Prasad U,Shankar S,Hamstra DA,Shanaiah M,Chenevert TL,Ross BD,Rehemtulla A

更新日期：2000-02-15 00:00:00

abstract：:Polycomb-group (Pc-G) proteins ensure late maintenance of transcriptional repression outside the expression domain of target genes in flies and vertebrates. They act in complexes, presumably by modulating chromatin structure. In Drosophila, they have been found to be associated with transcriptionally inactive loci but...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： d Graaff W,Tomotsune D,Oosterveen T,Takihara Y,Koseki H,Deschamps J

更新日期：2003-11-11 00:00:00

abstract：:Amyotrophic lateral sclerosis is a neurodegenerative syndrome associated with 114 mutations in the gene encoding the cytosolic homodimeric enzyme Cu/Zn superoxide dismutase (SOD). In this article, we report that amyotrophic lateral sclerosis-associated SOD mutations with distinctly different disease progression can be...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lindberg MJ,Byström R,Boknäs N,Andersen PM,Oliveberg M

更新日期：2005-07-12 00:00:00