Vanadium ions stimulate DNA synthesis in Swiss mouse 3T3 and 3T6 cells.

abstract：:Patterns of interacting amino acids are so preserved within protein families that the sole analysis of evolutionary comutations can identify pairs of contacting residues. It is also known that evolution conserves functional dynamics, i.e., the concerted motion or displacement of large protein regions or domains. Is it...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Granata D,Ponzoni L,Micheletti C,Carnevale V

更新日期：2017-12-12 00:00:00

abstract：:Trace greenhouse gases are a fundamentally important component of Earth's global climate system sensitive to global change. However, their concentration in the pre-Pleistocene atmosphere during past warm greenhouse climates is highly uncertain because we lack suitable geochemical or biological proxies. This long-stand...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Beerling DJ,Fox A,Stevenson DS,Valdes PJ

更新日期：2011-06-14 00:00:00

abstract：:G9a is an epigenetic regulator that methylates H3K9, generally causing repression of gene expression, and participates in diverse cellular functions. G9a is genetically deregulated in a variety of tumor types and can silence tumor suppressor genes and, therefore, is important for carcinogenesis. Although hypoxia is re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Casciello F,Al-Ejeh F,Kelly G,Brennan DJ,Ngiow SF,Young A,Stoll T,Windloch K,Hill MM,Smyth MJ,Gannon F,Lee JS

更新日期：2017-07-03 00:00:00

abstract：:The integrase protein of human immunodeficiency virus type 1 is necessary for the stable integration of the viral genome into host DNA. Integrase catalyzes the 3' processing of the linear viral DNA and the subsequent DNA strand transfer reaction that inserts the viral DNA ends into host DNA. Although full-length integ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jenkins TM,Hickman AB,Dyda F,Ghirlando R,Davies DR,Craigie R

更新日期：1995-06-20 00:00:00

abstract：:Previous work has demonstrated a role for the E2F1 gene product in signaling apoptosis, both as a result of the deregulation of the Rb/E2F pathway as well as in response to DNA damage. We now show that the ability of cells to suppress the apoptotic potential of E2F1, as might occur during the course of normal cellular...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hallstrom TC,Nevins JR

更新日期：2003-09-16 00:00:00

abstract：:The soybean genome hosts a family of several hundred, relatively homogeneous copies of a large, copia/Ty1-like retroelement designated SIRE-1. A copy of this element has been recovered from a Glycine max genomic library. DNA sequence analysis of two SIRE-1 subclones revealed that SIRE-1 contains a long, uninterrupted,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Laten HM,Majumdar A,Gaucher EA

更新日期：1998-06-09 00:00:00

abstract：:Fibroblast growth factor 1 (FGF-1) is a potent angiogenic and neurotrophic factor whose structure lacks a classical signal sequence for secretion. Although the initiation of these biological activities involves the interaction between FGF-1 and cell surface receptors, the mechanism responsible for the regulation of FG...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jackson A,Friedman S,Zhan X,Engleka KA,Forough R,Maciag T

更新日期：1992-11-15 00:00:00

abstract：:From 25 to 29 April 2020, the state of Indiana undertook testing of 3,658 randomly chosen state residents for the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, the agent causing COVID-19 disease. This was the first statewide randomized study of COVID-19 testing in the United States. Both PC...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yiannoutsos CT,Halverson PK,Menachemi N

更新日期：2021-02-02 00:00:00

abstract：:Bacterial transpeptidase and transglycosylase on the surface are essential for cell wall synthesis, and many antibiotics have been developed to target the transpeptidase; however, the problem of antibiotic resistance has arisen and caused a major threat in bacterial infection. The transglycosylase has been considered ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang CY,Shih HW,Lin LY,Tien YW,Cheng TJ,Cheng WC,Wong CH,Ma C

更新日期：2012-04-24 00:00:00

abstract：:The pivotal step on the mitochondrial pathway to apoptosis is permeabilization of the mitochondrial outer membrane (MOM) by oligomers of the B-cell lymphoma-2 (Bcl-2) family members Bak or Bax. However, how they disrupt MOM integrity is unknown. A longstanding model is that activated Bak and Bax insert two α-helices, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Westphal D,Dewson G,Menard M,Frederick P,Iyer S,Bartolo R,Gibson L,Czabotar PE,Smith BJ,Adams JM,Kluck RM

更新日期：2014-09-30 00:00:00

abstract：:Protein misfolding and aggregation cause serious degenerative conditions such as Alzheimer's, Parkinson, and prion diseases. Damage to membranes is thought to be one of the mechanisms underlying cellular toxicity of a range of amyloid assemblies. Previous studies have indicated that amyloid fibrils can cause membrane ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Milanesi L,Sheynis T,Xue WF,Orlova EV,Hellewell AL,Jelinek R,Hewitt EW,Radford SE,Saibil HR

更新日期：2012-12-11 00:00:00

abstract：:The mangrove killifish (Kryptolebias marmoratus) is the only vertebrate known to be capable of self-fertilization. Its gonad is typically an ovotestis that simultaneously produces eggs and sperm, and fertilization is internal. Although most populations of this species consist primarily or exclusively of hermaphroditic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mackiewicz M,Tatarenkov A,Taylor DS,Turner BJ,Avise JC

更新日期：2006-06-27 00:00:00

abstract：:Agricultural foods and technologies are thought to have eased the mechanical demands of diet-how often or how hard one had to chew-in human populations worldwide. Some evidence suggests correspondingly worldwide changes in skull shape and form across the agricultural transition, although these changes have proved diff...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Katz DC,Grote MN,Weaver TD

更新日期：2017-08-22 00:00:00

abstract：:We describe a single autoregulatory cassette that allows reversible induction of transgene expression in response to tetracycline (tet). This cassette contains all of the necessary components previously described by others on two separate plasmids that are introduced sequentially over a period of months [Gossen, M. & ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hofmann A,Nolan GP,Blau HM

更新日期：1996-05-28 00:00:00

abstract：:The ability of lysosomes to move within the cytoplasm is important for many cellular functions. This ability is particularly critical in neurons, which comprise vast, highly differentiated domains such as the axon and dendrites. The mechanisms that control lysosome movement in these domains, however, remain poorly und...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Farías GG,Guardia CM,De Pace R,Britt DJ,Bonifacino JS

更新日期：2017-04-04 00:00:00

abstract：:Single crystal diamond produced by chemical vapor deposition (CVD) at very high growth rates (up to 150 microm/h) has been successfully annealed without graphitization at temperatures up to 2200 degrees C and pressures <300 torr. Crystals were annealed in a hydrogen environment by using microwave plasma techniques for...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meng YF,Yan CS,Lai J,Krasnicki S,Shu H,Yu T,Liang Q,Mao HK,Hemley RJ

更新日期：2008-11-18 00:00:00

abstract：:A site that is preferentially cleaved by the single-strand-specific endonuclease from Aspergillus oryzae was located in vitro 180 base pairs upstream from the 5' end of the chicken pro-alpha 2(I) collagen gene. It is found in supercoiled plasmids with a negative superhelical density of -0.024 or more but not in linear...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Finer MH,Fodor EJ,Boedtker H,Doty P

更新日期：1984-03-01 00:00:00

abstract：:Estimates of relative rates of molecular evolution from a DNA-hybridization phylogeny for 26 hummingbird species provide evidence for a negative association between elevation and rate of single-copy genome evolution. This effect of elevation on rate remains significant even after taking into account a significant nega...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bleiweiss R

更新日期：1998-01-20 00:00:00

abstract：:Whereas target-specific drugs are available for treating ERBB2-overexpressing and hormone receptor-positive breast cancers, no tailored therapy exists for hormone receptor- and ERBB2-negative ("triple-negative") mammary carcinomas. Triple-negative tumors account for 15% of all breast cancers and frequently harbor defe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rottenberg S,Jaspers JE,Kersbergen A,van der Burg E,Nygren AO,Zander SA,Derksen PW,de Bruin M,Zevenhoven J,Lau A,Boulter R,Cranston A,O'Connor MJ,Martin NM,Borst P,Jonkers J

更新日期：2008-11-04 00:00:00

abstract：:We recently reported that CD3- natural killer (NK) cells express the zeta chain of the T-cell receptor complex (zeta NK) in association with higher molecular weight structures whose expression differs between individual NK cell clones. Because NK cell cytolytic activity is known to be triggered by perturbation of the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Anderson P,Caligiuri M,O'Brien C,Manley T,Ritz J,Schlossman SF

更新日期：1990-03-01 00:00:00

abstract：:Using Drosophila pseudoobscura, we tested the hypothesis that social constraints on the free expression of mate preferences, by both females and males, decrease offspring viability and reproductive success of mating pairs. Mate preference arenas eliminated intrasexual combat and intersexual coercion. The time female a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Anderson WW,Kim YK,Gowaty PA

更新日期：2007-03-13 00:00:00

abstract：:CD4+ T cells recognize major histocompatibility complex (MHC) class II-bound peptides that are primarily obtained from extracellular sources. Endogenously synthesized proteins that readily enter the MHC class I presentation pathway are generally excluded from the MHC class II presentation pathway. We show here that en...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sanderson S,Frauwirth K,Shastri N

更新日期：1995-08-01 00:00:00

abstract：:The understanding of mechanisms controlling zinc absorption and metabolism at the molecular level has advanced recently. Kinetics of zinc transport have been investigated for many years, but only recently have genes coding for proteins thought to be involved in the transport process been cloned. Four putative zinc tra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McMahon RJ,Cousins RJ

更新日期：1998-04-28 00:00:00

abstract：:Pigmentation patterning has long interested biologists, integrating topics in ecology, development, genetics, and physiology. Wild-type neonatal larvae of the silkworm, Bombyx mori, are completely black. By contrast, the epidermis and head of larvae of the homozygous recessive sex-linked chocolate (sch) mutant are red...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu C,Yamamoto K,Cheng TC,Kadono-Okuda K,Narukawa J,Liu SP,Han Y,Futahashi R,Kidokoro K,Noda H,Kobayashi I,Tamura T,Ohnuma A,Banno Y,Dai FY,Xiang ZH,Goldsmith MR,Mita K,Xia QY

更新日期：2010-07-20 00:00:00

abstract：:Subunits A and B of chloroplast glyceraldehyde-3-phosphate dehydrogenase are synthesized as higher molecular weight precursors when polyadenylylated mRNA from angiosperm seedlings is translated in vitro by wheat germ ribosomes. The in vivo levels of mRNA coding for these precursors are strongly light dependent, and th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cerff R,Kloppstech K

更新日期：1982-12-01 00:00:00

abstract：:MXenes, a new family of 2D materials, combine hydrophilic surfaces with metallic conductivity. Delamination of MXene produces single-layer nanosheets with thickness of about a nanometer and lateral size of the order of micrometers. The high aspect ratio of delaminated MXene renders it promising nanofiller in multifunc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ling Z,Ren CE,Zhao MQ,Yang J,Giammarco JM,Qiu J,Barsoum MW,Gogotsi Y

更新日期：2014-11-25 00:00:00

abstract：:A fundamental property of ecosystems is a tradeoff between the number and size of habitats: as the number of habitats within a fixed area increases, the average area per habitat must decrease. This tradeoff is termed the "area-heterogeneity tradeoff." Theoretical models suggest that the reduction in habitat sizes unde...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ben-Hur E,Kadmon R

更新日期：2020-03-03 00:00:00

abstract：:Poly(A)-containing RNA was isolated from ovaries of Xenopus laevis laevis and Triturus cristatus carnifex and used as a template for the synthesis of radioactive complementary DNA with RNA-dependent DNA polymerase. When annealed with an excess of homologous DNA, the complementary DNA is rendered double-stranded with k...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rosbash M,Ford PJ,Bishop JO

更新日期：1974-09-01 00:00:00

abstract：:Mycoplasmas require an external source of sterol for growth. For Mycoplasma capricolum this requirement is met not only by cholesterol but also by the methylcholestane derivatives lanosterol, cycloartenol, 4,4-dimethylcholesterol, and 4beta-methylcholestanol. Cholesteryl methyl ether and 3alpha-methylcholestanol serve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Odriozola JM,Waitzkin E,Smith TL,Bloch K

更新日期：1978-09-01 00:00:00

abstract：:Through use of a synthetic oligonucleotide probe, human insulin-like growth factor I (IGF-I) cDNA clones were isolated from a liver library. Two types of cDNAs were defined by restriction enzyme analysis and DNA sequencing. Both encode IGF-I precursors of either 195 or 153 amino acids. The two predicted protein precur...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rotwein P

更新日期：1986-01-01 00:00:00